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Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements
Open accessAbstract
Bilaterian animals have a Hox gene cluster essential for patterning the main body axis, and a ParaHox gene cluster. Comparison of Hox and ParaHox genes has led workers to postulate that both clusters originated from the duplication of an ancient cluster named ProtoHox, which contained up to four genes with at least the precursors of anterior and posterior Hox/ParaHox genes. However, the way in which genes diversified within the ProtoHox, Hox and ParaHox clusters remains unclear because no systematic study of non-bilaterian animals exists. Here we characterize the full Hox/ParaHox gene complements and genomic organization in two cnidarian species (Nematostella vectensis and Hydra magnipapillata), and suggest a ProtoHox cluster simpler than originally thought on the basis of three arguments. First, both species possess bilaterian-like anterior Hox genes, but their non-anterior genes do not appear as counterparts of either bilaterian central or posterior genes; second, two clustered ParaHox genes, Gsx and a gene related to Xlox and Cdx, are found in Nematostella vectensis; and third, we do not find clear phylogenetic support for a common origin of bilaterian Cdx and posterior genes, which might therefore have appeared after the ProtoHox cluster duplication. Consequently, the ProtoHox cluster might have consisted of only two anterior genes. Non-anterior genes could have appeared independently in the Hox and ParaHox clusters, possibly after the separation of bilaterians and cnidarians.
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“Seven of the PALs link anemone scaffolds to multiple regions of the human genome in a manner consistent with multiple large-scale duplication events along the vertebrate lineage (reviewed, for example, in (53)).”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [53]
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Metadata
- Authors
- Chourrout, D., Delsuc, F., Chourrout, P., Edvardsen, R. B., Rentzsch, F., Renfer, E., Jensen, M. F., Zhu, B., de Jong, P., Steele, R. E., & Technau, U.
- Affiliations
- University of Bergen (NO)
- Centre National de la Recherche Scientifique (FR)
- Hôpital américain de paris (FR)
- University of California, Irvine (US)
- Corresponding author
- Chourrout, D.
- Technau, U.
- Venue
- Nature
- Published
- 2006-08
- Volume
- 442
- Issue
- 7103
- Pages
- 684-687
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2158564117
- Cited by
- 197
- References
- 21
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 8 · 2018: 9 · 2017: 4 · 2016: 5 · 2015: 12 · 2014: 11 · 2013: 4 · 2012: 11
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- Hox genes, ParaHox genes, gene duplication, Nematostella vectensis, Hydra magnipapillata, Cnidaria, CDX, gene family evolution, genome organization
- MeSH terms
- Animals, Cnidaria, Genes, Homeobox, Multigene Family, Phylogeny, Genome, Homeodomain Proteins, Evolution, Molecular
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