The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Central nervous system control of food intake and body weight
Abstract
The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“AOMs are indicated as an adjunct to lifestyle modification for individuals with a body mass index (BMI) of 27 kg/m 2 or greater with at least one weight-related complication or those with a BMI of 30 kg/m 2 or greater [16]”
From Nutritional considerations with antiobesity medications (2024) · cites this paper as [16]
In the citing paper
“This network regulates appetite, active energy expenditure, and basal metabolic rate, and it is made up of a complex network of central (e.g., cortical centers that control cognitive, visual, and “reward” cues) and peripheral (e.g., satiety and hunger hormones) signals [87,88].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“Neurohormonal dysfunction has been implicated in the pathogenesis of diseases of insulin resistance, such as that present in GDM.”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“A dominant role of genetic factors in obesity pathogenesis has also been demonstrated in studies comparing the concordance of body weight among fraternal versus identical twins91, for example, as well as studies of adults adopted as infants compared with their biological and adoptive parents77,92.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“Such mechanisms include a paradoxical decrease in appetite and increase in metabolic rate, which change adaptively in the opposite directions to those following most non-surgical weight loss77.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“and they are stimulated by hunger signals [21, 22]”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [21]
In the citing paper
“Leptin and insulin resistance are common in obesity and, considering their important functions in homeostatic processes, may play a role in poor appetite control [11].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
In the citing paper
“In addition, these meal-related humeral signals can be modulated by the more tonic, or long-term, homeostatic signals which are influenced by body energy stores, namely leptin, insulin [11,12], and ghrelin [13].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citationGhrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940
Self-citationCritical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Marina, K., Dellinger, E. P., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,271
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 901–1,000 of 1,007
van Vliet‐Ostaptchouk, J. V., Onland‐Moret, N. C., Shiri‐Sverdlov, R., van Gorp, P. J., Custers, A., Peeters, P. H. M., Wijmenga, C., Hofker, M. H., & van der Schouw, Y. T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001405 · Cited by 33
Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides
Sekar, R., Wang, L., & Chow, B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00018 · Cited by 33
Obesity Knowledge among Final-Year Medical Students in Norway
Martins, C., & Norsett-Carr, A. (2017) · Obesity Facts · doi:10.1159/000481351 · Cited by 33
Insulin signalling in hypothalamic neurones
Belsham, D. D., & Dalvi, P. S. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12919 · Cited by 35
Ommerborn, M. A., Giraki, M., Schneider, C. B., Fuck, L.-M., Handschel, J. G., Franz, M., Raab, W. H.-M., & Schäfer, R. B. (2012) · International Journal of Oral Science · doi:10.1038/ijos.2012.48 · Cited by 33
Kobayashi, K., Amuzie, C. J., Flannery, B. M., & Pestka, J. J. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000640 · Cited by 33
Williams, D. L., Schwartz, M. W., Bastian, L. S., Blevins, J. E., & Baskin, D. G. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.7a7331.2007 · Cited by 33
Self-citationRole of orexin receptors in obesity: from cellular to behavioral evidence
Perez‐Leighton, C. E., Butterick-Peterson, T. A., Billington, C. J., & Kotz, C. M. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.30 · Cited by 35
He, S., Liang, X., Li, L., Sun, J., & Shen, D. (2013) · Aquaculture · doi:10.1016/j.aquaculture.2013.06.015 · Cited by 33
Trevaskis, J. L., Meyer, E. A., Galgani, J. E., & Butler, A. A. (2007) · Endocrinology · doi:10.1210/en.2007-0868 · Cited by 33
Ciliary dysfunction and obesity
Mok, C. A., Héon, E., & Zhen, M. (2009) · Clinical Genetics · doi:10.1111/j.1399-0004.2009.01305.x · Cited by 33
Liu, L., & LiXian, Z. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2012.12153 · Cited by 33
Differential plasticity of size and mass to environmental change in a hibernating mammal
Canale, C. I., Özgül, A., Allainé, D., & Cohas, A. (2016) · Global Change Biology · doi:10.1111/gcb.13286 · Cited by 33
Anatomy and physiology of the nutritional system
Cinti, S. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.04.001 · Cited by 37
IUPHAR review: Microbiota-gut-brain axis and its role in neuropsychiatric disorders
Lee, S.-H., Han, C., & Shin, C. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107749 · Cited by 38
Modulatory role of serotonin on feeding behavior
Magalhães, C. P., de Freitas, M. F. L., Nogueira, M. I., Campina, R. C. D. F., Takase, L. F., de Souza, S. L., & Manhães‐de‐Castro, R. (2010) · Nutritional Neuroscience · doi:10.1179/147683010x12611460764723 · Cited by 32
King, J. A., Garnham, J. O., Jackson, A. P., Kelly, B. M., Xenophontos, S., & Nimmo, M. A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.12.050 · Cited by 35
Jejunal Leptin-PI3K Signaling Lowers Glucose Production
Rasmussen, B. A., Breen, D. M., Duca, F. A., Côté, C. D., Zadeh‐Tahmasebi, M., Filippi, B., & Lam, T. K. T. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.014 · Cited by 34
Regulation of expression of relaxin-3 and its receptor RXFP3 in the brain of diet-induced obese rats
Lenglos, C., Mitra, A., Guèvremont, G., & Timofeeva, E. (2014) · Neuropeptides · doi:10.1016/j.npep.2014.02.002 · Cited by 32
Bariatric surgery, adipose tissue and gut microbiota
Clément, K. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.141 · Cited by 33
COUP - TF Genes, Human Diseases, and the Development of the Central Nervous System in Murine Models
Yang, X. W., Feng, S., & Tang, K. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.12.002 · Cited by 30
Neuroactive steroids and diabetic complications in the nervous system
Giatti, S., Mastrangelo, R., D’Antonio, M., Pesaresi, M., Romano, S., Diviccaro, S., Caruso, D., Mitro, N., & Melcangi, R. C. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.07.006 · Cited by 32
Role of impulsivity and reward in the anti-obesity actions of 5-HT 2C receptor agonists
Higgins, G. A., Zeeb, F. D., & Fletcher, P. J. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117735797 · Cited by 34
Kimura, A., Sugimoto, T., Niida, S., Toba, K., & Sakurai, T. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00128 · Cited by 34
Obesity an overview: Genetic conditions and recent developments in therapeutic interventions
Rao, V., Candasamy, M., & Bhattamisra, S. K. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.05.004 · Cited by 33
mTOR Pathway is Involved in Energy Homeostasis Regulation as a Part of the Gut–Brain Axis
Pena-León, V., Pérez-Lois, R., & Seoane, L. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165715 · Cited by 33
Human torpor: translating insights from nature into manned deep space expedition
Shi, Z., Qin, M., Huang, L., Xu, T., Chen, Y., Hu, Q., Peng, S., Peng, Z., Qu, L., Chen, S., et al. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12671 · Cited by 31
Food Addiction and Tobacco Use Disorder: Common Liability and Shared Mechanisms
Zawertailo, L. A., Attwells, S., deRuiter, W. K., Le, T. L., Dawson, D., & Selby, P. L. (2020) · Nutrients · doi:10.3390/nu12123834 · Cited by 37
Intracellular lipid surveillance by small G protein geranylgeranylation
Watterson, A., Tatge, L., Wajahat, N., Arneaud, S. L. B., Fonseca, R. S., Beheshti, S. T., Metang, P., Mihelakis, M., Zuurbier, K. R., Corley, C. D., et al. (2022) · Nature · doi:10.1038/s41586-022-04729-7 · Cited by 32
Cannabinoids, eating behaviour, and energy homeostasis
Romero‐Zerbo, S., & Bermúdez‐Silva, F. J. (2013) · Drug Testing and Analysis · doi:10.1002/dta.1594 · Cited by 32
Patel, M. P., Fabersunne, C. C., Yang, Y., Kaelin, C. B., Barsh, G. S., & Millhauser, G. L. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.08.054 · Cited by 32
Self-citationEiholzer, U., Meinhardt, U. J., Petrò, R., Witassek, F., Gutzwiller, F., & Gasser, T. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.08.039 · Cited by 32
Gutiérrez, E., Churruca, I., Zárate, J., Carrera, O., Portillo, M. P., Cerrato, M., Vázquez, R., & Echevarrı́a, E. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.003 · Cited by 32
Schilder, R. J., Kimball, S. R., Marden, J. H., & Jefferson, L. S. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.051763 · Cited by 29
Protein digestion and energy homeostasis: How generated peptides may impact intestinal hormones?
Caron, J., Domenger, D., Belguesmia, Y., Kouach, M., Lésage, J., Goossens, J., Dhulster, P., Ravallec, R., & Cudennec, B. (2015) · Food Research International · doi:10.1016/j.foodres.2015.12.018 · Cited by 32
Neuronal O-GlcNAc transferase regulates appetite, body weight, and peripheral insulin resistance
Dai, C., Gu, J., Liu, F., Iqbal, K., & Gong, C. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.05.036 · Cited by 34
EDITORIAL: Ghrelin: a link between energy homeostasis and drug abuse?
Cummings, D. E., Naleid, A. M., & Lattemann, D. F. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00053.x · Cited by 31
Self-citationKNDy neurones and GnRH / LH pulse generation: Current understanding and future aspects
Uenoyama, Y., & Tsukamura, H. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13285 · Cited by 32
Feed Intake Regulation in Fish: Implications for Aquaculture
Soengas, J. L., Comesaña, S., Blanco, A. M., & Conde‐Sieira, M. (2024) · Reviews in Fisheries Science & Aquaculture · doi:10.1080/23308249.2024.2374259 · Cited by 33
da Silva, R. S., de Paiva, I. H. R., Mendonça, I. P., de Souza, J. R. B., Lucena‐Silva, N., & Peixoto, C. A. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01603-y · Cited by 36
Yamamoto, R., Akazawa, H., Fujihara, H., Ozasa, Y., Yasuda, N., Ito, K., Kudo, Y., Qin, Y., Ueta, Y., & Komuro, I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.192260 · Cited by 32
Dynamic 5-HT2C Receptor Editing in a Mouse Model of Obesity
Schellekens, H., Clarke, G. A., Jeffery, I. B., Dinan, T. G., & Cryan, J. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032266 · Cited by 31
Lima, N. D. S., OLIVEIRA, E. B. D., da Silva, A. P. S., Maia, L. D. A., de Moura, E. G., & Lisboa, P. C. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.09.003 · Cited by 31
Anorexia and Impaired Glucose Metabolism in Mice With Hypothalamic Ablation of Glut4 Neurons
Ren, H., Lu, T. Y., McGraw, T. E., & Accili, D. (2014) · Diabetes · doi:10.2337/db14-0752 · Cited by 31
Jeong, J. H., Woo, Y. J., Chua, S. C., & Jo, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162839 · Cited by 33
Slomp, M., Belegri, E., Blancas‐Velazquez, A. S., Diepenbroek, C., Eggels, L., Gumbs, M. C. R., Joshi, A., Koekkoek, L. L., Lamuadni, K., Ugur, M., et al. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12718 · Cited by 34
Appetite regulation by plant-derived bioactive peptides for promoting health
Kaneko, K. (2021) · Peptides · doi:10.1016/j.peptides.2021.170608 · Cited by 32
Huang, X., Wang, Y., & Xiang, Y. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104263 · Cited by 32
Monarca, R. I., Mathias, M. D. L., & Speakman, J. R. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.06.037 · Cited by 31
Klingenspor, M., & Fromme, T. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_3 · Cited by 30
Schultes, B., Schmid, S. M., Wilms, B., Jauch‐Chara, K., Oltmanns, K. M., & Hallschmid, M. (2012) · Appetite · doi:10.1016/j.appet.2012.01.022 · Cited by 31
Genetic variation in the hypothalamic pathways and its role on obesity
van Vliet‐Ostaptchouk, J. V., Hofker, M. H., van der Schouw, Y. T., Wijmenga, C., & Onland‐Moret, N. C. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00597.x · Cited by 32
Gloy, V., Lutz, T. A., Langhans, W., Geary, N., & Hillebrand, J. J. (2010) · Endocrinology · doi:10.1210/en.2010-0439 · Cited by 31
From clock genes to telomeres in the regulation of the healthspan
Kagawa, Y. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00504.x · Cited by 34
Honda, K., Saneyasu, T., Hasegawa, S., & Kamisoyama, H. (2012) · Peptides · doi:10.1016/j.peptides.2012.06.015 · Cited by 31
Kaneko, K., Mizushige, T., Miyazaki, Y., Lazarus, M., Urade, Y., Yoshikawa, M., Kanamoto, R., & Ohinata, K. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00405.2013 · Cited by 31
Effects of leptin on cardiovascular physiology
Tune, J. D., & Considine, R. V. (2007) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2007.04.001 · Cited by 31
Yoshimura, M., Matsuura, T., Ohkubo, J., Ohno, M., Maruyama, T., Ishikura, T., Hashimoto, H., Kakuma, T., Yoshimatsu, H., Terawaki, K., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.04.019 · Cited by 31
Role of Agouti-Related Protein-Expressing Neurons in Lactation
Phillips, C. T., & Palmiter, R. D. (2007) · Endocrinology · doi:10.1210/en.2007-1153 · Cited by 29
Shibata, M., Banno, R., Sugiyama, M., Tominaga, T., Onoue, T., Tsunekawa, T., Azuma, Y., Hagiwara, D., Lu, W., Ito, Y., et al. (2016) · Endocrinology · doi:10.1210/en.2015-1430 · Cited by 31
Anorexic action of deoxynivalenol in hypothalamus and intestine
Tominaga, M., Momonaka, Y., Yokose, C., Tadaishi, M., Shimizu, M., Yamane, T., Oishi, Y., & Kobayashi, K. (2016) · Toxicon · doi:10.1016/j.toxicon.2016.04.036 · Cited by 31
Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors
Elvir, L., Duclot, F., Wang, Z., & Kabbaj, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.030 · Cited by 33
SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity
Deng, Y., Xiao, Y., Yuan, F., Liu, Y., Jiang, X., Deng, J., Fejes‐Tóth, G., Náray‐Fejes‐Tóth, A., Chen, S., Chen, Y., et al. (2018) · Diabetes · doi:10.2337/db17-1069 · Cited by 32
Role of ghrelin in pancreatic development and function
Napolitano, T., Silvano, S., Vieira, A., Balaji, S., Garrido‐Utrilla, A., Friano, M. E., Atlija, J., & Collombat, P. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13385 · Cited by 37
Hypothalamic Control of Hepatic Glucose Production and Its Potential Role in Insulin Resistance
Buettner, C., & Camacho, R. C. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.09.001 · Cited by 31
Robertson, S., Ishida-Takahashi, R., Tawara, I., Hu, J., Patterson, C. M., Jones, J. C., Kulkarni, R. N., & Myers, M. G. (2010) · Diabetes · doi:10.2337/db09-1556 · Cited by 30
Dysregulated systemic metabolism in a Down syndrome mouse model
Sarver, D. C., Xu, C., Vélez, L. M., Aja, S. M., Jaffe, A. E., Seldin, M. M., Reeves, R. H., & Wong, G. W. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101666 · Cited by 32
Hypothalamic Lipids and the Regulation of Energy Homeostasis
Carlos Diégueza, B., Gema Frühbeckb, C., & peza, B. M. L. O. (2009) · Obesity Facts · doi:10.1159/000209251 · Cited by 33
Ding, F., Li, H. H., Li, J. Z., Myers, R., & Francke, U. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009402 · Cited by 30
Li, J.-Y., Chai, B., Zhang, W., Fritze, D. M., Zhang, C., & Mulholland, M. W. (2013) · Endocrinology · doi:10.1210/en.2013-1550 · Cited by 30
Insulin and GH–IGF-I axis: endocrine pacer or endocrine disruptor?
Giustina, A., Berardelli, R., Gazzaruso, C., & Mazziotti, G. (2014) · Acta Diabetologica · doi:10.1007/s00592-014-0635-6 · Cited by 30
Conjugated linoleic acid and phytosterols counteract obesity induced by high-fat diet
Furlan, C. P. B., Marques, A. Y. C., Marineli, R. D. S., & Maróstica, M. R. (2012) · Food Research International · doi:10.1016/j.foodres.2012.12.023 · Cited by 30
Relation of Serum Leptin With Cardiac Mass and Left Atrial Dimension in Individuals >70 Years of Age
Lieb, W., SULLIVAN, L. M., Aragam, J. R., Harris, T. B., Roubenoff, R., Benjamin, E. J., & Vasan, R. S. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.04.026 · Cited by 30
Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity
Cota, D. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.006 · Cited by 32
Stroe‐Kunold, E., Buckert, M., Friederich, H., Wesche, D., Kopf, S., Herzog, W., & Wild, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166843 · Cited by 31
Human brown adipose tissue — function and therapeutic potential in metabolic disease
Bhatt, P. S., Dhillo, W. S., & Salem, V. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.07.004 · Cited by 34
Neuronal connections of the central amygdalar nucleus with refeeding-activated brain areas in rats
Zséli, G., Vida, B., Szilvásy‐Szabó, A., Tóth, M., Lechan, R. M., & Fekete, C. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1501-4 · Cited by 30
Li, Y., Zhang, H., Tu, Y., Wang, C., Di, J., Yu, H., Zhang, P., Bao, Y., Jia, W., Yang, J., et al. (2019) · Obesity Surgery · doi:10.1007/s11695-018-03623-4 · Cited by 30
Identification of the MC4R start lost mutation in a morbidly obese Brazilian patient
da Fonseca, A. C. P., Abreu, G. D. M., Zembrzuski, V. M., Campos, M., Carneiro, J. R. I., Magno, F. C. C. M., Rosado, E. L., Neto, J. F. N., de Cabello, G. M. K., & Cabello, P. H. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s189455 · Cited by 30
Tejas-Juárez, J. G., Cruz-Martínez, A. M., López-Alonso, V. E., García‐Iglesias, B. B., Díaz, J. M. M., Florán, B., & Escartín-Pérez, R. E. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.040 · Cited by 30
Lanfray, D., Caron, A., Roy, M.-C., Laplante, M., Morin, F., Leprince, J., Tonon, M., & Richard, D. (2016) · eLife · doi:10.7554/elife.11742 · Cited by 30
Yue, J. T. Y., Abraham, M. A., Bauer, P. V., LaPierre, M. P., Wang, P., Duca, F. A., Filippi, B., Chan, O. T. M., & Lam, T. K. T. (2016) · Nature Communications · doi:10.1038/ncomms13501 · Cited by 30
CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake
Vivot, K., Mészáros, G., Pangou, E., Zhang, Z., Qu, M., Erbs, E., Yeghiazaryan, G., Quiñones, M., Grandgirard, E., Schneider, A., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00814-x · Cited by 29
Onu, A., Trofin, D. M., Tutu, A., Onu, I., Galaction, A., Sardaru, D.-P., Trofin, D., Onita, C. A., Iordan, D. A., & Matei, D.-V. (2025) · Life · doi:10.3390/life15050757 · Cited by 34
Anorexia in rats caused by a valine-deficient diet is not ameliorated by systemic ghrelin treatment
Goto, S., Nagao, K., Bannai, M., Takahashi, M., Nakahara, K., Kangawa, K., & MURAKAMI, N. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.013 · Cited by 29
Granado, M., García‐Cáceres, C., Fuente-Martín, E., Díaz, F., Mela, V., Viveros, M., Argente, J., & Chowen, J. A. (2011) · Endocrinology · doi:10.1210/en.2011-1233 · Cited by 29
Ranhel, J. (2012) · IEEE Transactions on Neural Networks and Learning Systems · doi:10.1109/tnnls.2012.2190421 · Cited by 28
Current views on neuropeptide Y and diabetes-related atherosclerosis
Sun, W., Zhu, P., Shi, Y., Zhang, C.-L., Huang, X., Liang, S., Song, Z.-Y., & Lin, S. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164117704380 · Cited by 30
Targeting AgRP neurons to maintain energy balance: Lessons from animal models
Zagmutt, S., Mera, P., Soler‐Vázquez, M. C., Herrero, L., & Serra, D. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.008 · Cited by 30
Control of non-homeostatic feeding in sated mice using associative learning of contextual food cues
Stern, S. A., Doerig, K. R., Azevedo, E. P., Stoffel, E., & Friedman, J. M. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0072-y · Cited by 29
Abdel-Rafei, M. K., & Thabet, N. M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118410 · Cited by 30
Wang, L., Cheng, M., Wang, Y.-C., Chen, J. W., Xie, F., Huang, L.-H., & Zhan, C. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01543-w · Cited by 28
The Effect of Intermittent Hypoxia on Bodyweight, Serum Glucose and Cholesterol in Obesity Mice
Ling, Q., Wen, S.-L., Jing, R., Zhi, S., Yang, X., & Xiaoqun, Q. (2008) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2008.869.875 · Cited by 29
Hopkins, M., Gibbons, C., Caudwell, P., Webb, D., Hellström, P. M., Näslund, E. B., Blundell, J. E., & Finlayson, G. (2014) · International Journal of Endocrinology · doi:10.1155/2014/323728 · Cited by 31
Metabolic Cycles Are Linked to the Cardiovascular Diurnal Rhythm in Rats with Essential Hypertension
Cui, H., Kohsaka, A., Waki, H., Bhuiyan, M. E. R., Gouraud, S. S., & Maeda, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017339 · Cited by 29
Obesity Pharmacotherapy: Current Perspectives and Future Directions
Misra, M. (2013) · Current Cardiology Reviews · doi:10.2174/157340313805076322 · Cited by 29
Depressive-Like Behaviors in a Rat Model of Chronic Cerebral Hypoperfusion
Lee, S. R., Choi, B., Paul, S., Seo, J.-H., Back, D. B., Han, J., Choi, D., Kwon, K. J., Shin, C. Y., Lee, J., et al. (2014) · Translational Stroke Research · doi:10.1007/s12975-014-0385-3 · Cited by 29
PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin
Harlan, S. M., & Rahmouni, K. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.03.004 · Cited by 30
Vosburg, R. W., El Chaar, M., El Djouzi, S., Docimo, S., Choi, D., LaMasters, T., Srivastava, G., Shukla, A. P., Oviedo, R. J., Fitch, A., et al. (2022) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2022.07.002 · Cited by 24
Cardiovascular and Sympathetic Effects of Disrupting Tyrosine 985 of the Leptin Receptor
Harlan, S. M., Morgan, D. A., Dellsperger, D. J., Myers, M. G., Mark, A. L., & Rahmouni, K. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.166538 · Cited by 24
Metadata
- Authors
- Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W.
- Affiliations
- University of Washington (US)
- Stanford Medicine (US)
- Corresponding author
- Schwartz, M. W.
- Venue
- Nature
- Published
- 2006-09
- Volume
- 443
- Issue
- 7109
- Pages
- 289-295
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2079395662
- Cited by
- 2,503
- References
- 76
- Citations by year
- 2026: 66 · 2025: 79 · 2024: 75 · 2023: 84 · 2022: 107 · 2021: 123 · 2020: 115 · 2019: 118 · 2018: 141 · 2017: 164 · 2016: 161 · 2015: 150 · 2014: 157 · 2013: 182 · 2012: 172
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- M.J. Murdock Charitable Trust
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- food intake regulation, weight management, energy homeostasis, central nervous system, obesity, leptin, satiety, feeding behaviour, body fat stores, anti-obesity drugs, neuronal receptors
- MeSH terms
- Adipose Tissue, Body Weight, Central Nervous System, Feeding Behavior, Neuronal Plasticity, Satiety Response
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
