The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Central nervous system control of food intake and body weight
Abstract
The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.
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“AOMs are indicated as an adjunct to lifestyle modification for individuals with a body mass index (BMI) of 27 kg/m 2 or greater with at least one weight-related complication or those with a BMI of 30 kg/m 2 or greater [16]”
From Nutritional considerations with antiobesity medications (2024) · cites this paper as [16]
In the citing paper
“This network regulates appetite, active energy expenditure, and basal metabolic rate, and it is made up of a complex network of central (e.g., cortical centers that control cognitive, visual, and “reward” cues) and peripheral (e.g., satiety and hunger hormones) signals [87,88].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“Neurohormonal dysfunction has been implicated in the pathogenesis of diseases of insulin resistance, such as that present in GDM.”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“A dominant role of genetic factors in obesity pathogenesis has also been demonstrated in studies comparing the concordance of body weight among fraternal versus identical twins91, for example, as well as studies of adults adopted as infants compared with their biological and adoptive parents77,92.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“Such mechanisms include a paradoxical decrease in appetite and increase in metabolic rate, which change adaptively in the opposite directions to those following most non-surgical weight loss77.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“and they are stimulated by hunger signals [21, 22]”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [21]
In the citing paper
“Leptin and insulin resistance are common in obesity and, considering their important functions in homeostatic processes, may play a role in poor appetite control [11].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
In the citing paper
“In addition, these meal-related humeral signals can be modulated by the more tonic, or long-term, homeostatic signals which are influenced by body energy stores, namely leptin, insulin [11,12], and ghrelin [13].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citationGhrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940
Self-citationCritical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Marina, K., Dellinger, E. P., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,271
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Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure
An, J. J., Liao, G., Kinney, C. E., Sahibzada, N., & Xu, B. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.008 · Cited by 164
Gofflot, F., Chartoire, N., Vasseur, L., Heikkinen, S., Dembélé, D., Merrer, J. L., & Auwerx, J. H. (2007) · Cell · doi:10.1016/j.cell.2007.09.012 · Cited by 176
Dopamine signaling in food addiction: role of dopamine D2 receptors
Baik, J. (2013) · BMB Reports · doi:10.5483/bmbrep.2013.46.11.207 · Cited by 173
Leshan, R. L., Louis, G. W., Jo, Y., Rhodes, C. J., Münzberg, H., & Myers, M. G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0155-09.2009 · Cited by 162
Delgado, M. J., Cerdá‐Reverter, J. M., & Soengas, J. L. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00354 · Cited by 172
Portion Size: What We Know and What We Need to Know
Benton, D. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.679980 · Cited by 161
Zhang, H.-Y., Tian, J., Lian, F., Li, M., Liu, W., Zhong, Z., Liao, J., & Tong, X. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110857 · Cited by 166
Hypothalamic inflammation: a double‐edged sword to nutritional diseases
Cai, D., & Liu, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06388.x · Cited by 162
Brain-Endocrine Interactions: A Microvascular Route in the Mediobasal Hypothalamus
Ciofi, P., Garret, M., Roca‐Lapirot, O., Lafon, P., Loyens, A., Prévot, V., & Levine, J. E. (2009) · Endocrinology · doi:10.1210/en.2009-0584 · Cited by 161
Melanocortin-4 Receptor Signaling Is Required for Weight Loss after Gastric Bypass Surgery
Hatoum, I. J., Stylopoulos, N., Vanhoose, A. M., Boyd, K. L., Yin, D., Ellacott, K. L. J., Li, L., Blaszczyk, K., Keogh, J. M., Cone, R. D., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3432 · Cited by 164
Al‐Qassab, H., Smith, M. A., Irvine, E. E., Guillermet‐Guibert, J., Claret, M., Choudhury, A. I., Selman, C., Piipari, K., Clements, M., Lingard, S. J., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.008 · Cited by 165
Self-citationHypothalamic inflammation and obesity: a mechanistic review
Seong, J., Kang, J. Y., Sun, J. S., & Kim, K. W. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01138-9 · Cited by 158
Kaiyala, K. J., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db10-0909 · Cited by 159
Self-citationGómez, E. S., Matias, I., Rueda‐Orozco, P. E., Cisneros, M., Petrosino, S., Navarro, L., Marzo, V. D., & Prospero-Garcia, O. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707313 · Cited by 158
Xu, T., Yang, Y., Ward, R. J., Gao, L., & Liu, Y. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.07.025 · Cited by 162
The central role of hypothalamic inflammation in the acute illness response and cachexia
Burfeind, K. G., Michaelis, K. A., & Marks, D. L. (2016) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.10.038 · Cited by 156
Early life programming of obesity and metabolic disease
Cottrell, E. C., & Ozanne, S. E. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.017 · Cited by 158
Insulin Promotes Glycogen Storage and Cell Proliferation in Primary Human Astrocytes
Heni, M., Hennige, A. M., Peter, A., Siegel-Axel, D. I., Ordelheide, A., Krebs, N., Machicao, F. E., Fritsche, A., Häring, H., & Staiger, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021594 · Cited by 158
Central nervous system regulation of organismal energy and glucose homeostasis
Myers, M. G., Affinati, A. H., Richardson, N. E., & Schwartz, M. W. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00408-5 · Cited by 165
Self-citationSarruf, D. A., Yu, F. Z., Hồng, N. T., Williams, D. L., Printz, R. L., Niswender, K. D., & Schwartz, M. W. (2008) · Endocrinology · doi:10.1210/en.2008-0899 · Cited by 152
Self-citationMechanisms of weight loss and improved metabolism following bariatric surgery
Mulla, C. M., Middelbeek, R. J. W., & Patti, M. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13409 · Cited by 161
Deep brain stimulation in the treatment of obesity
Halpern, C. H., Wolf, J. A., Bale, T. L., Stunkard, A. J., Danish, S. F., Grossman, M., Jaggi, J. L., Grady, M. S., & Baltuch, G. H. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/109/10/0625 · Cited by 154
Lin, H. V., Plum, L., Ono, H., Juárez, R. G., Shanabrough, M., Borók, E., Horváth, T. L., Rossetti, L., & Accili, D. (2009) · Diabetes · doi:10.2337/db09-1303 · Cited by 162
Hypothalamic inflammation and gliosis in obesity
Dorfman, M. D., & Thaler, J. P. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000182 · Cited by 154
Martin, C., Chevrot, M., Poirier, H., Passilly‐Degrace, P., Niot, I., & Besnard, P. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.02.029 · Cited by 162
Kluge, M., Schuld, A., Schacht, A., Himmerich, H., Dalal, M. A., Wehmeier, P. M., Hinze-Selch, D., Kraus, T., Dittmann, R. W., & Pollmächer, T. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.016 · Cited by 146
Molecular Mechanisms of Appetite Regulation
Yu, J. H., & Kim, M. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.6.391 · Cited by 159
van de Sande‐Lee, S., Pereira, F., Cintra, D. E., Fernandes, P. T., Cardoso, A. R., Garlipp, C. R., Chaim, É. A., Pareja, J. C., Geloneze, B., Li, L. M., et al. (2011) · Diabetes · doi:10.2337/db10-1614 · Cited by 148
Morari, J., Anhê, G. F., do Nascimento, L. F. R., de Moura, R. F., Razolli, D. S., Solon, C., Guadagnini, D., de Souza, G. F. P., Mattos, A. H. B., Tobar, N., et al. (2014) · Diabetes · doi:10.2337/db13-1495 · Cited by 161
Taste, olfactory and food texture reward processing in the brain and the control of appetite
Rolls, E. T. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000821 · Cited by 149
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Qiu, J., Fang, Y., Bosch, M. A., Rønnekleiv, O. K., & Kelly, M. J. (2011) · Endocrinology · doi:10.1210/en.2010-1285 · Cited by 150
Neuroinflammatory basis of metabolic syndrome
Purkayastha, S., & Cai, D. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.005 · Cited by 150
Mounien, L., Tourniaire, F., & Landrier, J. (2019) · Nutrients · doi:10.3390/nu11071562 · Cited by 145
Endoplasmic reticulum stress and protein quality control in diabetic cardiomyopathy
Yang, L., Zhao, D., Ren, J. T., & Yang, J. Z. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.006 · Cited by 146
Diet and exercise in the management of obstructive sleep apnoea and cardiovascular disease risk
Dobrosielski, D. A., Papandreou, C., Patil, S. P., & Salas‐Salvadó, J. (2017) · European Respiratory Review · doi:10.1183/16000617.0110-2016 · Cited by 156
Duarte, A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A. I., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.01.008 · Cited by 149
Li, A., Yuan, X., Liang, X., Liu, L., Li, J., Li, B., Fang, J., Li, J., He, S., Xue, M., et al. (2016) · Aquaculture · doi:10.1016/j.aquaculture.2016.01.014 · Cited by 143
The hypothalamic arcuate nucleus and the control of peripheral substrates
Joly‐Amado, A., Cansell, C., Denis, R., Delbès, A.-S., Castel, J., Martinez, S., & Luquet, S. H. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.03.003 · Cited by 153
From Surface to Nuclear Receptors: The Endocannabinoid Family Extends its Assets
Pistis, M., & Melis, M. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790980014 · Cited by 145
Gillum, M. P., Zhang, D., Zhang, X., Erion, D. M., Jamison, R. A., Choi, C., Dong, J., Shanabrough, M., Duenas, H. R., Frederick, D. W., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.043 · Cited by 145
Simopoulos, A. P. (2013) · Nutrients · doi:10.3390/nu5082901 · Cited by 146
Emerging Therapeutic Strategies for Obesity
Foster‐Schubert, K. E., & Cummings, D. E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0041 · Cited by 140
Self-citationNutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis
Conde‐Sieira, M., & Soengas, J. L. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00603 · Cited by 149
Vucetic, Z., & Reyes, T. M. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.77 · Cited by 145
Wadden, T. A., Sarwer, D. B., Fabricatore, A. N., Jones, L. R., Stack, R. M., & Williams, N. N. (2007) · Medical Clinics of North America · doi:10.1016/j.mcna.2007.01.003 · Cited by 139
Hypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolism
Zhang, W., Cline, M. A., & Gilbert, E. R. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-27 · Cited by 144
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de Clercq, N. C., Groen, A. K., Romijn, J. A., & Nieuwdorp, M. (2016) · Advances in Nutrition · doi:10.3945/an.116.012914 · Cited by 140
Ott, V., Benedict, C., Schultes, B., Born, J., & Hallschmid, M. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01490.x · Cited by 139
Hypothalamic AgRP‐neurons control peripheral substrate utilization and nutrient partitioning
Joly‐Amado, A., Denis, R., Castel, J., Lacombe, A., Cansell, C., Rouch, C., Kassis, N., Dairou, J., Cani, P. D., Ventura‐Clapier, R., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.250 · Cited by 156
Olofsson, L. E., Unger, E. K., Cheung, C. C., & Xu, A. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218284110 · Cited by 138
Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources
Beeler, J. A., Frazier, C. R. M., & Zhuang, X. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00049 · Cited by 136
Diet-Induced Inflammation of the Hypothalamus in Obesity
Velloso, L. A., ARAUJO, E. P. D., & de Souza, C. T. (2008) · NeuroImmunoModulation · doi:10.1159/000153423 · Cited by 135
The contribution of animal models to the study of obesity
Speakman, J. R., Hambly, C., Mitchell, S. E., & Król, E. (2008) · Laboratory Animals · doi:10.1258/la.2007.006067 · Cited by 136
Nutritional regulation of division of labor in honey bees: toward a systems biology perspective
Ament, S. A., Wang, Y., & Robinson, G. E. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.73 · Cited by 134
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Rogge, M. M. (2009) · Biological Research For Nursing · doi:10.1177/1099800408329408 · Cited by 142
Nutritional considerations with antiobesity medications
Almandoz, J. P., Wadden, T. A., Tewksbury, C., Apovian, C. M., Fitch, A., Ard, J. D., Li, Z., Richards, J., Butsch, W. S., Jouravskaya, I., et al. (2024) · Obesity · doi:10.1002/oby.24067 · Cited by 134
“Successful obesity treatment involves a fundamental shift in the balance between energy expenditure, energy intake, and energy storage, each of which has multiple contributing factors, including both modifiable and nonmodifiable determinants [11, 12].”
Background“Hypothalamic Microinflammation” Paradigm in Aging and Metabolic Diseases
Cai, D., & Khor, S. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.021 · Cited by 138
GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism
Wu, Q., & Palmiter, R. D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.110 · Cited by 143
Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems
Liu, C. M., & Kanoski, S. E. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.02.011 · Cited by 131
Orbitofrontal cortex volume and brain reward response in obesity
Shott, M. E., Cornier, M.-A., Mittal, V. A., Pryor, T. L., Orr, J. M., Brown, M. S., & Frank, G. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.121 · Cited by 137
Impacts of essential amino acids on energy balance
Xiao, F., & Guo, F. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101393 · Cited by 142
Benedict, C., Brede, S., Schiöth, H. B., Lehnert, H., Schultes, B., Born, J., & Hallschmid, M. (2011) · Diabetes · doi:10.2337/db10-0329 · Cited by 129
Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid
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Stress responses: the contribution of prostaglandin E2 and its receptors
Furuyashiki, T., & Narumiya, S. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.194 · Cited by 132
Leshan, R. L., Opland, D. M., Louis, G. W., Leinninger, G. M., Patterson, C. M., Rhodes, C. J., Münzberg, H., & Myers, M. G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1001-10.2010 · Cited by 127
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Kim, H.-K., Youn, B., Shin, M.-S., NamKoong, C., Park, K. H., Baik, J., Kim, J. B., Park, J., Lee, K., Kim, Y., et al. (2010) · Diabetes · doi:10.2337/db10-0145 · Cited by 133
Appetite Regulation: An Overview
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Cristino, L., Becker, T., & Marzo, V. D. (2014) · BioFactors · doi:10.1002/biof.1168 · Cited by 125
Hopkins, M., Finlayson, G., Duarte, C., Whybrow, S., Ritz, P., Horgan, G. W., Blundell, J. E., & Stubbs, R. J. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.155 · Cited by 132
AMPK: a key regulator of energy stress and calcium-induced autophagy
Saikia, R., & Joseph, J. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02125-8 · Cited by 131
Shimizu, H., Arima, H., Watanabe, M., Goto, M., Banno, R., Sato, I., Ozaki, N., Nagasaki, H., & Oiso, Y. (2008) · Endocrinology · doi:10.1210/en.2008-0229 · Cited by 128
Gaetani, S., Fu, J., Cassano, T., Dipasquale, P., Romano, A., Righetti, L., Cianci, S., Laconca, L., Giannini, E., Scaccianoce, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0036-10.2010 · Cited by 124
Central Administration of Resveratrol Improves Diet-Induced Diabetes
Ramadori, G., Gautron, L., Fujikawa, T., Vianna, C. R., Elmquist, J. K., & Coppari, R. (2009) · Endocrinology · doi:10.1210/en.2009-0528 · Cited by 126
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Aziz, N. A., van der Marck, M. A., Pijl, H., Rikkert, M. G. M. O., Bloem, B. R., & Roos, R. A. C. (2008) · Journal of Neurology · doi:10.1007/s00415-009-0062-8 · Cited by 138
Hong, S.-H., Lee, K., Kwak, S., Kim, A., Bai, H., Jung, M., Kwon, O., Song, W., Tatar, M., & Yu, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002857 · Cited by 123
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Vetter, M. L., Faulconbridge, L. F., Webb, V. L., & Wadden, T. A. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.121 · Cited by 124
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Cardinal, P., Bellocchio, L., Clark, S., Cannich, A., Klugmann, M., Lutz, B., Marsicano, G., & Cota, D. (2012) · Endocrinology · doi:10.1210/en.2012-1405 · Cited by 123
Gotthardt, J. D., Verpeut, J. L., Yeomans, B. L., Yang, J., Yasrebi, A., Roepke, T. A., & Bello, N. T. (2015) · Endocrinology · doi:10.1210/en.2015-1622 · Cited by 125
Corey, K. E., & Kaplan, L. M. (2013) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.09.019 · Cited by 124
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Vieira, M. N. N., Silva, N. M. L. E., Ferreira, S. T., & Felice, F. G. D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00007 · Cited by 123
In vivo characterization of high Basal signaling from the ghrelin receptor
Petersen, P. S., Woldbye, D. P. D., Madsen, A. N., Egerod, K. L., Jin, C., Lang, M., Rasmussen, M., Beck-Sickinger, A. G., & Holst, B. (2009) · Endocrinology · doi:10.1210/en.2008-1638 · Cited by 121
Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators
Sánchez-Lasheras, C., Könner, A. C., & Brüning, J. C. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.08.002 · Cited by 127
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Σάκκου, Μ., Wiedmer, P., Anlag, K., Hamm, A. C., Seuntjens, E., Ettwiller, L. M., Tschöp, M. H., & Treier, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.007 · Cited by 117
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Caron, A., Lemko, H. M. D., Castorena, C. M., Fujikawa, T., Lee, S., Lord, C. C., Ahmed, N. I., Lee, C. E., Holland, W. L., Liu, C., et al. (2018) · eLife · doi:10.7554/elife.33710 · Cited by 122
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Qi, Y., Oldfield, B. J., & Clarke, I. J. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01886.x · Cited by 118
Beaulieu, K., Hopkins, M., Blundell, J. E., & Finlayson, G. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.12.032 · Cited by 130
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Metadata
- Authors
- Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W.
- Affiliations
- University of Washington (US)
- Stanford Medicine (US)
- Corresponding author
- Schwartz, M. W.
- Venue
- Nature
- Published
- 2006-09
- Volume
- 443
- Issue
- 7109
- Pages
- 289-295
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2079395662
- Cited by
- 2,503
- References
- 76
- Citations by year
- 2026: 66 · 2025: 79 · 2024: 75 · 2023: 84 · 2022: 107 · 2021: 123 · 2020: 115 · 2019: 118 · 2018: 141 · 2017: 164 · 2016: 161 · 2015: 150 · 2014: 157 · 2013: 182 · 2012: 172
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- M.J. Murdock Charitable Trust
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- food intake regulation, weight management, energy homeostasis, central nervous system, obesity, leptin, satiety, feeding behaviour, body fat stores, anti-obesity drugs, neuronal receptors
- MeSH terms
- Adipose Tissue, Body Weight, Central Nervous System, Feeding Behavior, Neuronal Plasticity, Satiety Response
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