The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Central nervous system control of food intake and body weight
Abstract
The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.
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“AOMs are indicated as an adjunct to lifestyle modification for individuals with a body mass index (BMI) of 27 kg/m 2 or greater with at least one weight-related complication or those with a BMI of 30 kg/m 2 or greater [16]”
From Nutritional considerations with antiobesity medications (2024) · cites this paper as [16]
In the citing paper
“This network regulates appetite, active energy expenditure, and basal metabolic rate, and it is made up of a complex network of central (e.g., cortical centers that control cognitive, visual, and “reward” cues) and peripheral (e.g., satiety and hunger hormones) signals [87,88].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“Neurohormonal dysfunction has been implicated in the pathogenesis of diseases of insulin resistance, such as that present in GDM.”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“A dominant role of genetic factors in obesity pathogenesis has also been demonstrated in studies comparing the concordance of body weight among fraternal versus identical twins91, for example, as well as studies of adults adopted as infants compared with their biological and adoptive parents77,92.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“Such mechanisms include a paradoxical decrease in appetite and increase in metabolic rate, which change adaptively in the opposite directions to those following most non-surgical weight loss77.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“and they are stimulated by hunger signals [21, 22]”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [21]
In the citing paper
“Leptin and insulin resistance are common in obesity and, considering their important functions in homeostatic processes, may play a role in poor appetite control [11].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
In the citing paper
“In addition, these meal-related humeral signals can be modulated by the more tonic, or long-term, homeostatic signals which are influenced by body energy stores, namely leptin, insulin [11,12], and ghrelin [13].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citationGhrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940
Self-citationCritical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Marina, K., Dellinger, E. P., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,271
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Items 101–200 of 1,007
p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake
Dagon, Y., Hur, E. E., Zheng, B., Wellenstein, K., Cantley, L. C., & Kahn, B. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.010 · Cited by 297
Marrelli, M., Conforti, F., Araniti, F., & Statti, G. A. (2016) · Molecules · doi:10.3390/molecules21101404 · Cited by 310
Guyenet, S. J., & Schwartz, M. W. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2525 · Cited by 293
Self-citationCalipari, E. S., Godino, A., Peck, E. G., Salery, M., Mervosh, N. L., Landry, J. A., Russo, S. J., Hurd, Y. L., Nestler, E. J., & Kiraly, D. D. (2017) · Nature Communications · doi:10.1038/s41467-017-01881-x · Cited by 281
Antiobesity carbonic anhydrase inhibitors: a literature and patent review
Scozzafava, A., Supuran, C. T., & Carta, F. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.790957 · Cited by 277
Sucrose activates human taste pathways differently from artificial sweetener
Frank, G. K. W., Oberndorfer, T. A., Simmons, A. N., Paulus, M. P., Fudge, J. L., Yang, T. T., & Kaye, W. H. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.061 · Cited by 274
Kim, Y., & Shin, C. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170915141036 · Cited by 281
Issues for DSM-V: Should obesity be included as a brain disorder?
Volkow, N. D., & O’Brien, C. P. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.5.708 · Cited by 271
Nøhr, M. K., Egerod, K. L., Christiansen, S. H., Gille, A., Offermanns, S., Schwartz, T. W., & Møller, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.040 · Cited by 270
Obesity-induced Insulin Resistance and Hyperglycemia
Martyn, J. A. J., Kaneki, M., Yasuhara, S., Warner, D. S., & Warner, M. A. A. (2008) · Anesthesiology · doi:10.1097/aln.0b013e3181799d45 · Cited by 278
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262
Butler, A. A., & Kozak, L. P. (2010) · Diabetes · doi:10.2337/db09-1471 · Cited by 265
Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism
Bruce, K. D., Zsombok, A., & Eckel, R. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00060 · Cited by 279
Brain–gut–microbiome interactions in obesity and food addiction
Gupta, A., Osadchiy, V., & Mayer, E. A. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0341-5 · Cited by 279
Crespo, C. S., Cachero, A. P., Puebla, L., Barrios, V., & Arilla, E. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00058 · Cited by 274
Neuroinflammation and neurodegeneration in overnutrition-induced diseases
Cai, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.11.003 · Cited by 256
Bessesen, D. H. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0520 · Cited by 257
Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis
Williams, K. W., Liu, T., Kong, X., Fukuda, M., Deng, Y., Berglund, E. D., Deng, Z., Gao, Y., Liu, T., Sohn, J., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.002 · Cited by 258
Association between eating rate and obesity: a systematic review and meta-analysis
Ohkuma, T., Hirakawa, Y., Nakamura, U., Kiyohara, Y., Kitazono, T., & Ninomiya, T. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.96 · Cited by 252
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251
Brown fat biology and thermogenesis
Richard, D. (2010) · Frontiers in bioscience · doi:10.2741/3786 · Cited by 251
Regulation of dietary choice by the decision-making circuitry
Rangel, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3561 · Cited by 263
Lam, Q. L. K., & Lu, L. (2007) · PubMed · Cited by 247
Foo, K. S., Brismar, H., & Broberger, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.054 · Cited by 246
Impaired insulin action in the human brain: causes and metabolic consequences
Heni, M., Kullmann, S., Preissl, H., Fritsche, A., & Häring, H.-U. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.173 · Cited by 245
Naltrexone/bupropion for obesity: An investigational combination pharmacotherapy for weight loss
Billes, S. K., Sinnayah, P., & Cowley, M. A. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.04.004 · Cited by 255
Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 256
Central nervous pathways of insulin action in the control of metabolism and food intake
Kullmann, S., Kleinridders, A., Small, D. M., Fritsche, A., Häring, H.-U., Preissl, H., & Heni, M. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30113-3 · Cited by 233
Leptin receptor signaling and the regulation of mammalian physiology
Villanueva, E. C., & Myers, M. G. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.232 · Cited by 237
A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis
Yang, S., Chu, S., Gao, Y., Ai, Q., Liu, Y., Li, X., & Chen, N. (2019) · Cells · doi:10.3390/cells8070738 · Cited by 242
The diversity of sex steroid action: regulation of metabolism by estrogen signaling
Faulds, M. H., Zhao, C., Dahlman-Wright, K., & Gustafsson, J.-Å. (2012) · Journal of Endocrinology · doi:10.1530/joe-11-0044 · Cited by 230
Qiu, J., Zhang, C., Borgquist, A., Nestor, C. C., Smith, A. W., Bosch, M. A., Ku, S., Wagner, E. J., Rønnekleiv, O. K., & Kelly, M. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.004 · Cited by 233
Suzuki, K., Jayasena, C. N., & Bloom, S. R. (2012) · Experimental Diabetes Research · doi:10.1155/2012/824305 · Cited by 241
Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
Rahmouni, K., Fath, M. A., Seo, S., Thedens, D. R., Berry, C. J., Weiss, R. M., Nishimura, D. Y., & Sheffield, V. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32357 · Cited by 234
Lu, M. M., Sarruf, D. A., Talukdar, S., Sharma, S., Li, P., Bandyopadhyay, G. K., Nalbandian, S., Fan, W., Gayen, J. R., Mahata, S. K., et al. (2011) · Nature Medicine · doi:10.1038/nm.2332 · Cited by 227
Self-citationMicroRNAs in Obesity and Related Metabolic Disorders
Landrier, J., Derghal, A., & Mounien, L. (2019) · Cells · doi:10.3390/cells8080859 · Cited by 235
Herbal drug discovery for the treatment of nonalcoholic fatty liver disease
Yan, T., Yan, N., Wang, P., Xia, Y., Hao, H., Wang, G., & Gonzalez, F. J. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.11.017 · Cited by 226
De Novo Neurogenesis in Adult Hypothalamus as a Compensatory Mechanism to Regulate Energy Balance
Pierce, A. A., & Xu, A. W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2479-09.2010 · Cited by 224
Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222
Altered hypothalamic function in diet-induced obesity
Velloso, L. A., & Schwartz, M. W. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.56 · Cited by 225
Self-citationRole of Fructose-Containing Sugars in the Epidemics of Obesity and Metabolic Syndrome
Stanhope, K. L. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-042010-113026 · Cited by 224
Genetic and Epigenetic Causes of Obesity
Thaker, V. (2017) · American Academy of Pediatrics eBooks · doi:10.1542/9781581109405-genetic · Cited by 223
Hedonic Hunger is Increased in Severely Obese Patients and is Reduced After Gastric Bypass Surgery
Schultes, B., Ernst, B., Wilms, B., Thurnheer, M., & Hallschmid, M. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29007 · Cited by 219
Gorissen, M., Bernier, N. J., Nabuurs, S. B., Flik, G., & Huising, M. O. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0034 · Cited by 213
The glucoregulatory actions of leptin
D'souza, A. M., Neumann, U. H., Glavas, M. M., & Kieffer, T. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.011 · Cited by 220
Schéle, E., Grahnemo, L., Anesten, F., Hallén, A., Bäckhed, F., & Jansson, J.-O. (2013) · Endocrinology · doi:10.1210/en.2012-2151 · Cited by 209
Hypothalamic Circuits for Predation and Evasion
Li, Y., Zeng, J., Zhang, J.-E., Yue, C., Zhong, W., Liu, Z., Feng, Q., & Luo, M. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.005 · Cited by 220
Iversen, L. L. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195328240.001.0001 · Cited by 230
How the Brain Represents the Reward Value of Fat in the Mouth
Fabian Grabenhorst, B., Rolls, E. T., Parris, B. A., & D’Souza, A. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp169 · Cited by 210
Stress exposure, food intake and emotional state.
Ulrich‐Lai, Y. M., Fulton, S., Wilson, M., Petrovich, G. D., & Rinaman, L. (2015) · PubMed · doi:10.3109/10253890.2015.1062981 · Cited by 225
Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity
Hopkins, M., & Blundell, J. E. (2016) · Clinical Science · doi:10.1042/cs20160006 · Cited by 227
Анатольевич, П. И., Costa-Nunes, J. P., Kasatkin, V. N., Veniaminova, E. A., Demchenko, A. G., Lyundup, A. V., Lesch, K., Ponomarev, E. D., & Strekalova, T. V. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12866 · Cited by 215
Brain fatty acid synthase activates PPARα to maintain energy homeostasis
Chakravarthy, M. V., Zhu, Y., López, M., Yin, L., Wozniak, D. F., Coleman, T., Hu, Z., Wolfgang, M. J., Vidal‐Puig, A., Lane, M. D., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31183 · Cited by 211
Revisiting leptin’s role in obesity and weight loss
Ahima, R. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36284 · Cited by 209
Serotonin Regulates C. elegans Fat and Feeding through Independent Molecular Mechanisms
Srinivasan, S., Sadegh, L., Elle, I. C., Christensen, A. G. L., Færgeman, N. J., & Ashrafi, K. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.012 · Cited by 205
Neurotrophic factor control of satiety and body weight
Xu, B., & Xie, X. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.24 · Cited by 203
Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin
Liao, G., An, J. J., Gharami, K., Waterhouse, E. G., Vanevski, F., Jones, K. R., & Xu, B. (2012) · Nature Medicine · doi:10.1038/nm.2687 · Cited by 208
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Valdearcos, M., Xu, A. W., & Koliwad, S. K. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071656 · Cited by 209
Nillni, E. A. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.01.001 · Cited by 206
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Mercer, R. E., Chee, M. J. S., & Colmers, W. F. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.06.001 · Cited by 199
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Ducsay, C. A., Goyal, R., Pearce, W. J., Wilson, S. M., Hu, X., & Zhang, L. (2018) · Physiological Reviews · doi:10.1152/physrev.00043.2017 · Cited by 208
Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies
Gerozissis, K. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.050 · Cited by 204
Mantione, M., van de Brink, W., Schuurman, P. R., & Denys, D. (2010) · Neurosurgery · doi:10.1227/01.neu.0000360570.40339.64 · Cited by 194
Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System
Çakır, I., Perelló, M., Lansari, O., Messier, N. J., Vaslet, C. A., & Nillni, E. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008322 · Cited by 195
Eating and hypothalamus changes in behavioral‐variant frontotemporal dementia
Piguet, O., Petersén, Å., Lam, B. Y. K., Gabery, S., Murphy, K., Hodges, J. R., & Halliday, G. M. (2010) · Annals of Neurology · doi:10.1002/ana.22244 · Cited by 207
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Li, X., & Kazgan, N. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.575 · Cited by 196
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Baroncini, M., Jissendi, P., Balland, É., Besson, P., Pruvo, J., Francke, J.-P., Dewailly, D., Blond, S., & Prévot, V. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.013 · Cited by 190
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Rolls, E. T. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.155 · Cited by 186
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Purkayastha, S., Zhang, H., Zhang, G., Ahmed, Z., Wang, Y., & Cai, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006875108 · Cited by 184
Metabolic impact of estrogen signalling through ERalpha and ERbeta
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Raubenheimer, D., Simpson, S. J., & Tait, A. H. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0007 · Cited by 176
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Satoh, A., Stein, L. R., & Imai, S. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_7 · Cited by 175
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Marcelin, G., Jo, Y., Li, X., Schwartz, G. J., Zhang, Y., Dun, N. J., Lyu, R., Blouet, C., Chang, J. K., & Chua, S. C. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.10.002 · Cited by 168
Dougkas, A., Reynolds, C. K., Givens, D. I., Elwood, P. C., & Minihane, A. M. (2011) · Nutrition Research Reviews · doi:10.1017/s095442241000034x · Cited by 174
Schur, E. A., Kleinhans, N. M., Goldberg, J. H., Buchwald, D., Schwartz, M. W., & Maravilla, K. R. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.56 · Cited by 173
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Metadata
- Authors
- Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W.
- Affiliations
- University of Washington (US)
- Stanford Medicine (US)
- Corresponding author
- Schwartz, M. W.
- Venue
- Nature
- Published
- 2006-09
- Volume
- 443
- Issue
- 7109
- Pages
- 289-295
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2079395662
- Cited by
- 2,503
- References
- 76
- Citations by year
- 2026: 66 · 2025: 79 · 2024: 75 · 2023: 84 · 2022: 107 · 2021: 123 · 2020: 115 · 2019: 118 · 2018: 141 · 2017: 164 · 2016: 161 · 2015: 150 · 2014: 157 · 2013: 182 · 2012: 172
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- M.J. Murdock Charitable Trust
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- food intake regulation, weight management, energy homeostasis, central nervous system, obesity, leptin, satiety, feeding behaviour, body fat stores, anti-obesity drugs, neuronal receptors
- MeSH terms
- Adipose Tissue, Body Weight, Central Nervous System, Feeding Behavior, Neuronal Plasticity, Satiety Response
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