The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Central nervous system control of food intake and body weight
Abstract
The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“AOMs are indicated as an adjunct to lifestyle modification for individuals with a body mass index (BMI) of 27 kg/m 2 or greater with at least one weight-related complication or those with a BMI of 30 kg/m 2 or greater [16]”
From Nutritional considerations with antiobesity medications (2024) · cites this paper as [16]
In the citing paper
“This network regulates appetite, active energy expenditure, and basal metabolic rate, and it is made up of a complex network of central (e.g., cortical centers that control cognitive, visual, and “reward” cues) and peripheral (e.g., satiety and hunger hormones) signals [87,88].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“Neurohormonal dysfunction has been implicated in the pathogenesis of diseases of insulin resistance, such as that present in GDM.”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“A dominant role of genetic factors in obesity pathogenesis has also been demonstrated in studies comparing the concordance of body weight among fraternal versus identical twins91, for example, as well as studies of adults adopted as infants compared with their biological and adoptive parents77,92.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“Such mechanisms include a paradoxical decrease in appetite and increase in metabolic rate, which change adaptively in the opposite directions to those following most non-surgical weight loss77.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“and they are stimulated by hunger signals [21, 22]”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [21]
In the citing paper
“Leptin and insulin resistance are common in obesity and, considering their important functions in homeostatic processes, may play a role in poor appetite control [11].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
In the citing paper
“In addition, these meal-related humeral signals can be modulated by the more tonic, or long-term, homeostatic signals which are influenced by body energy stores, namely leptin, insulin [11,12], and ghrelin [13].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citationGhrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940
Self-citationCritical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Marina, K., Dellinger, E. P., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,271
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 1,007
Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster
Jumbo‐Lucioni, P. P., Ayroles, J. F., Chambers, M. M., Jordan, K. W., Leips, J., Mackay, T. F. C., & Luca, M. D. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-297 · Cited by 90
Galhardo, J., Hunt, L. P., Lightman, S. L., Sabin, M. A., Bergh, C., Sodersten, P., & Shield, J. P. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1999 · Cited by 89
Mechanisms mediating renal sympathetic activation to leptin in obesity
Morgan, D. A., Thedens, D. R., Weiss, R., & Rahmouni, K. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90324.2008 · Cited by 89
Obesity: pathophysiology and therapeutic interventions
Kong, Y., Yang, H., Nie, R., Zhang, X., Zuo, F., Zhang, H., & Nian, X. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00264-9 · Cited by 89
Synaptic changes induced by melanocortin signalling
Caruso, V., Lagerström, M. C., Olszewski, P. K., Fredriksson, R., & Schiöth, H. B. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3657 · Cited by 90
Schneeberger, M., Altirriba, J., García, A., Esteban, Y., Castaño, C., García-Lavandeira, M., Álvarez, C. V., Gomis, R., & Claret, M. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.10.001 · Cited by 88
Schlögl, H., Kabisch, S., Horstmann, A., Lohmann, G., Müller, K., Lepsien, J., Busse, F. P., Kratzsch, J., Pleger, B., Villringer, A., et al. (2013) · Diabetes Care · doi:10.2337/dc12-1925 · Cited by 88
Bell, B. B., Harlan, S. M., Morgan, D., Guo, D., Cui, H.-X., & Rahmouni, K. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.12.006 · Cited by 77
Hedonic processing in humans is mediated by an opioidergic mechanism in a mesocorticolimbic system
Büchel, C., Miedl, S. F., & Sprenger, C. (2018) · eLife · doi:10.7554/elife.39648 · Cited by 83
FTO Is Expressed in Neurones throughout the Brain and Its Expression Is Unaltered by Fasting
McTaggart, J. S., Lee, S., Iberl, M., Church, C., Cox, R., & Ashcroft, F. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027968 · Cited by 92
Francesco, V. D., Fantin, F., Omizzolo, F., Residori, L., Bissoli, L., Bosello, O., & Zamboni, M. M. (2007) · Digestive Diseases · doi:10.1159/000099477 · Cited by 90
Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia
Bocchetta, M., Gordón, E., Manning, E. N., Barnes, J., Cash, D. M., Espak, M., Thomas, D. L., Marc Modat, A., Rossor, M. N., Warren, J. D., et al. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7885-2 · Cited by 92
Hill, J. W., Xu, Y., Preitner, F., Fukuda, M., Cho, Y.-R., Luo, J., Balthasar, N., Coppari, R., Cantley, L. C., Kahn, B. B., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0454 · Cited by 90
The CB1 Receptor as the Cornerstone of Exostasis
Piazza, P. V., Cota, D., & Marsicano, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.002 · Cited by 100
A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress
Zhao, Z., Wang, L., Gao, W., Hu, F., Zhang, J.-E., Ren, Y., Lin, R., Feng, Q., Cheng, M., Ju, D., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.031 · Cited by 91
Hypothalamus as an Endocrine Organ
Clarke, I. J. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140019 · Cited by 114
Vagal control of satiety and hormonal regulation of appetite
Owyang, C., & Heldsinger, A. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.338 · Cited by 87
Stress and eating: Definitions, findings, explanations, and implications
Araiza, A. M., & Lobel, M. (2018) · Social and Personality Psychology Compass · doi:10.1111/spc3.12378 · Cited by 101
Peripheral tissue–brain interactions in the regulation of food intake
López, M., Tovar, S. A., Vazquez, M. J., Williams, L. M., & Diéguez, C. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005368 · Cited by 87
Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise
He, Z., Gao, Y., Alhadeff, A. L., Castorena, C. M., Huang, Y., Lieu, L., Afrin, S., Sun, J. M., Betley, J. N., Guo, H., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.011 · Cited by 84
Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
Yang, C. S., Lam, C. K. L., Chari, M., Cheung, G. W. C., Kokorovic, A., Gao, S., Leclerc, I., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes · doi:10.2337/db10-0221 · Cited by 86
Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases
Otto, E., Knapstein, P., Jahn, D., Appelt, J., Frosch, K., Tsitsilonis, S., & Keller, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144946 · Cited by 88
He, S., Liang, X., Sun, J., Li, L., Yu, Y., Huang, W., Qu, C., Cao, L., Bai, X., & Tao, Y. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-601 · Cited by 87
The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expression
Aubert, G., Mansuy‐Aubert, V., Voirol, M., Pellerin, L., & Pralong, F. P. (2010) · Metabolism · doi:10.1016/j.metabol.2010.02.007 · Cited by 89
Ohkuma, T., Fujii, H., Iwase, M., Kikuchi, Y., Ogata, S., Idewaki, Y., Ide, H., Doi, Y., Hirakawa, Y., Mukai, N., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2746-3 · Cited by 86
Linoleic acid rescues microglia inflammation triggered by saturated fatty acid
Tu, T. H., Kim, H., Yang, S., Kim, J. K., & Kim, J. G. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.047 · Cited by 84
Soengas, J. L. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.01.015 · Cited by 85
Apelin/APJ system as a therapeutic target in diabetes and its complications
Hu, H., He, L., Li, L., & Chen, L. (2016) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2016.07.012 · Cited by 85
Fetissov, S. O., & Hökfelt, T. G. M. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.07.004 · Cited by 85
(2010) · PubMed
Orexins and Orexin Receptors: From Molecules to Integrative Physiology
Matsuki, T., & Sakurai, T. (2008) · Springer eBooks · doi:10.1007/400_2007_047 · Cited by 85
Mercer, R. E., Michaelson, S. D., Chee, M. J. S., Atallah, T. A., Wevrick, R., & Colmers, W. F. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003207 · Cited by 84
Schilling, T. M., de Sá, D. S. F., Westerhausen, R., Strelzyk, F., Larra, M. F., Hallschmid, M., Savaskan, E., Oitzl, M. S., Busch, H., Naumann, E., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22304 · Cited by 84
Deregulation of brain insulin signaling in Alzheimer’s disease
Chen, Y., Deng, Y., Zhang, B., & Gong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1408-x · Cited by 82
de Lartigue, G., Lür, G., Dimaline, R., Varró, A., Raybould, H. E., & Dockray, G. J. (2010) · Endocrinology · doi:10.1210/en.2010-0106 · Cited by 83
Possible crosstalk between leptin and prolactin during pregnancy
Nagaishi, V. S., Cardinali, L. I., Zampieri, T. T., Furigo, I. C., Metzger, M., & Donato, J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.050 · Cited by 83
The Food-Contaminant Deoxynivalenol Modifies Eating by Targeting Anorexigenic Neurocircuitry
Girardet, C., Bonnet, M. S., Jdir, R., Sadoud, M., Thirion, S., Tardivel, C., Roux, J., Lebrun, B., Wanaverbecq, N., Mounien, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026134 · Cited by 83
Lam, C., Chari, M., Su, B., Cheung, G. W. C., Kokorovic, A., Yang, C. S., Wang, P. Y. T., Lai, T. Y. Y., & Lam, T. K. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.087338 · Cited by 83
A receptor and neuron that activate a circuit limiting sucrose consumption
Joseph, R. M., Sun, J. S., Tam, E., & Carlson, J. R. (2017) · eLife · doi:10.7554/elife.24992 · Cited by 84
Anti‐aging drugs reduce hypothalamic inflammation in a sex‐specific manner
Sadagurski, M., Cady, G., & Miller, R. A. (2017) · Aging Cell · doi:10.1111/acel.12590 · Cited by 79
Metabolism and metabolomics of opiates: A long way of forensic implications to unravel
Dinis‐Oliveira, R. J. (2018) · Journal of Forensic and Legal Medicine · doi:10.1016/j.jflm.2018.12.005 · Cited by 82
Posterior hypothalamus-sparing surgery improves outcome after childhood craniopharyngioma
Bogusz-Wójcik, A., Boekhoff, S., Warmuth‐Metz, M., Calaminus, G., Eveslage, M., & Muller, H. L. (2019) · Endocrine Connections · doi:10.1530/ec-19-0074 · Cited by 85
The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications
van Son, J., Koekkoek, L. L., la Fleur, S. E., Serlie, M. J. M., & Nieuwdorp, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062993 · Cited by 85
Lipid Sensing and Insulin Resistance in the Brain
Yue, J. T. Y., & Lam, T. K. T. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.013 · Cited by 83
Appetite‐Regulating Hormone Changes in Patients With Craniopharyngioma
Roth, C. L., Gebhardt, U., & Müller, H. (2011) · Obesity · doi:10.1038/oby.2010.80 · Cited by 83
Effects of smoking cessation on β-cell function, insulin sensitivity, body weight, and appetite
Stadler, M., Tomann, L., Storka, A., Wolzt, M., Peric, S., Bieglmayer, C., Pacini, G., Dickson, S. L., Brath, H., Bech, P., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0590 · Cited by 84
Morton, G. J., Kaiyala, K. J., Fisher, J. D., Ogimoto, K., Schwartz, M. W., & Wisse, B. E. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00546.2010 · Cited by 81
Self-citationVillanueva, E. C., Münzberg, H., Cota, D., Leshan, R. L., Kopp, K., Ishida-Takahashi, R., Jones, J. C., Fingar, D. C., Seeley, R. J., & Myers, M. G. (2009) · Endocrinology · doi:10.1210/en.2009-0642 · Cited by 82
Central administration of insulin suppresses food intake in chicks
Honda, K., Kamisoyama, H., Saneyasu, T., Sugahara, K., & Hasegawa, S. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.07.004 · Cited by 81
The Histamine H3 Receptor and Eating Behavior
Passani, M. B., Blandina, P., & Torrealba, F. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.171306 · Cited by 81
Ament, S. A., Velarde, R. A., Kolodkin, M. H., Moyse, D., & Robinson, G. E. (2011) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2011.01068.x · Cited by 81
Defective regulation of POMC precedes hypothalamic inflammation in diet-induced obesity
de Souza, G. F. P., Solon, C., do Nascimento, L. F. R., Júnior, J. C. D. L., Nogueira, G. A. S., de Moura, R. F., Rocha, G. Z., Fioravante, M., Bóbbo, V. C. D., Morari, J., et al. (2016) · Scientific Reports · doi:10.1038/srep29290 · Cited by 85
da Fonseca, A. C. P., Mastronardi, C. A., Johar, A., Arcos‐Burgos, M., & Paz-Filho, G. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.04.026 · Cited by 85
5‐Hydroxytryptamine Medications for the Treatment of Obesity
Burke, L. K., & Heisler, L. K. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12287 · Cited by 82
Deighton, K., Karra, E., Batterham, R. L., & Stensel, D. J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0484 · Cited by 81
Gong, L., Yao, F., Hockman, K., Heng, H. H., Morton, G. J., Takeda, K., Akira, S., Low, M. J., Rubinstein, M., & MacKenzie, R. G. (2008) · Endocrinology · doi:10.1210/en.2007-0945 · Cited by 80
Self-citationPerinatal protein restriction reduces the inhibitory action of serotonin on food intake
de Souza, S. L., Orozco-Solís, R., Grit, I., Manhães‐de‐Castro, R., & Bolaños, F. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06105.x · Cited by 80
Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion
Smeets, P. A. M., Vidarsdóttir, S., de Graaf, C., Stafleu, A., van Osch, M. J. P., Viergever, M. A., Pijl, H., & van der Grond, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00231.2007 · Cited by 80
alpha-Melanocyte stimulating hormone: production and degradation
D’Agostino, G., & Diano, S. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0651-0 · Cited by 87
Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test
Serra‐Prat, M., Palomera, E., Clavé, P., & Puig‐Domingo, M. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27076 · Cited by 80
Leptin and its potential interest in assisted reproduction cycles
Catteau, A., Caillon, H., Barrière, P., Denis, M. G., Masson, D., & Fréour, T. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv057 · Cited by 80
Specific amino acids inhibit food intake via the area postrema or vagal afferents
Jordi, J., Herzog, B., Camargo, S. M. R., Boyle, C. N., Lutz, T. A., & Verrey, F. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.258947 · Cited by 79
Hypothalamic inflammation in metabolic disorders and aging
Bhusal, A., Rahman, M. H., & Suk, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04019-x · Cited by 87
Nishio, S., Gibert, Y., Berekelya, L., Bernard, L., Brunet, F., Guillot, E., Bail, J.-C. L., Sánchez, J. A., Galzin, A. M., Triqueneaux, G., et al. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1180 · Cited by 79
Fat storage and the biology of energy expenditure
Redinger, R. N. (2009) · Translational research · doi:10.1016/j.trsl.2009.05.003 · Cited by 81
Glucose Ingestion Fails to Inhibit Hypothalamic Neuronal Activity in Patients With Type 2 Diabetes
Vidarsdóttir, S., Smeets, P. A. M., Eichelsheim, D. L., van Osch, M. J. P., Viergever, M. A., Romijn, J. A., van der Grond, J., & Pijl, H. (2007) · Diabetes · doi:10.2337/db07-0193 · Cited by 79
Benrick, A., Schéle, E., Pinnock, S. B., Asterholm, I. W., Dickson, S. L., Karlsson-Lindahl, L., & Jansson, J. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01879.x · Cited by 85
Self-reported eating rate and metabolic syndrome in Japanese people: cross-sectional study
Nagahama, S., Kurotani, K., Pham, N. M., Nanri, A., Kuwahara, K., Dan, M., Nishiwaki, Y., & Mizoue, T. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005241 · Cited by 79
Lorcaserin: A review of its preclinical and clinical pharmacology and therapeutic potential
Higgins, G. A., Fletcher, P. J., & Shanahan, W. R. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107417 · Cited by 80
Current and Future Drug Targets in Weight Management
Witkamp, R. F. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0341-1 · Cited by 81
Fatty-acid-mediated hypothalamic inflammation and epigenetic programming
César, H., & Pisani, L. P. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.08.008 · Cited by 80
Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases
Yamashima, T., Ota, T., Mizukoshi, E., Nakamura, H., Yamamoto, Y., Kikuchi, M., Yamashita, T., & Kaneko, S. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa072 · Cited by 78
Buhmann, H., le Roux, C. W., & Bueter, M. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.07.003 · Cited by 81
Roura, E., Humphrey, B. D., Tedó, G., & Ipharraguerre, I. R. (2008) · Canadian Journal of Animal Science · doi:10.4141/cjas08014 · Cited by 83
Sun, Y., Yang, Y., Qin, Z., Cai, J., Guo, X.-M., Tang, Y., Wan, J., Su, D., & Liu, X. (2016) · Diabetes · doi:10.2337/db15-1193 · Cited by 82
Gut Hormones and Energy Balance, The Future for Obesity Therapy?
Meiliana, A., & Wijaya, A. (2009) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v1i3.99 · Cited by 79
Heni, M., Kullmann, S., Ketterer, C., Guthoff, M., Bayer, M., Staiger, H., Machicao, F. E., Häring, H., Preissl, H. T., Veit, R., et al. (2013) · Human Brain Mapping · doi:10.1002/hbm.22223 · Cited by 77
Wnt Signaling Activation in Adipose Progenitors Promotes Insulin-Independent Muscle Glucose Uptake
Zeve, D., Seo, J. H., Suh, J. M., Stenesen, D., Tang, W., Berglund, E. D., Wan, Y., Williams, L. J., Lim, A., Martinez, M. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.010 · Cited by 77
Creation of Resveratrol-Enriched Rice for the Treatment of Metabolic Syndrome and Related Diseases
Baek, S.-H., Shin, W.-C., Ryu, H.-S., Lee, D., Moon, E., Chun-Sun, S., Hwang, E., Lee, H.-S., Ahn, M., Jeon, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057930 · Cited by 77
Leptin in the regulation of the immunometabolism of adipose tissue-macrophages
Monteiro, L. D. B., Pereira, J. A. D. S., Palhinha, L., & Moraes‐Vieira, P. M. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr1218-478r · Cited by 80
The microbiota, the gut and the brain in eating and alcohol use disorders: A ‘Ménage à Trois’?
Temko, J. E., Bouhlal, S., Farokhnia, M., Lee, M. R., Cryan, J. F., & Leggio, L. (2017) · Alcohol and Alcoholism · doi:10.1093/alcalc/agx024 · Cited by 76
Yam, K., Naninck, E. F. G., Schmidt, M. V., Lucassen, P. J., & Kőrösi, A. (2015) · Stress · doi:10.3109/10253890.2015.1064890 · Cited by 79
Cameron, J. D., Sigal, R. J., Kenny, G. P., Alberga, A. S., Prud’homme, D., Phillips, P., Doucette, S. P., & Goldfield, G. S. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0479 · Cited by 80
Wang, X., Kooijman, S., Gao, Y., Tzeplaeff, L., Cosquer, B., Milanova, I. V., Wolff, S. E. C., Korpel, N. L., Champy, M., Petit‐Demoulière, B., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01169-z · Cited by 80
Endocrinopathies and Male Infertility
Sengupta, P., Dutta, S., Karkada, I. R., & Chinni, S. V. (2021) · Life · doi:10.3390/life12010010 · Cited by 114
Molecular Mechanisms and Health Benefits of Ghrelin: A Narrative Review
Jiao, Z., & Luo, Q. (2022) · Nutrients · doi:10.3390/nu14194191 · Cited by 79
Fletcher, P. C., Napolitano, A., Skeggs, A. L., Miller, S. R., Delafont, B., Cambridge, V. C., de Wit, S., Nathan, P. J., Brooke, A. C., O’Rahilly, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3323-10.2010 · Cited by 75
Relationship Between Cerebrospinal Fluid Visfatin (PBEF/Nampt) Levels and Adiposity in Humans
Hallschmid, M., Randeva, H. S., Tan, B. K., Kern, W., & Lehnert, H. (2008) · Diabetes · doi:10.2337/db08-1176 · Cited by 75
Thon, M., Hosoi, T., & Ozawa, K. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00138 · Cited by 75
GLP‐1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities
Roth, J. D., Erickson, M. R., Chen, S., & Parkes, D. G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01537.x · Cited by 74
Ibars, M., Ardid‐Ruiz, A., Suárez, M., Muguerza, B., Bladé, C., & Aragonès, G. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.169 · Cited by 77
Neural integration of satiation and food reward: Role of GLP-1 and orexin pathways
Williams, D. L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.013 · Cited by 74
Sahu, A. (2011) · Neuroendocrinology · doi:10.1159/000326785 · Cited by 74
Deficiency of TNFα Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice
Gelling, R. W., Yan, W., Al‐Noori, S., Pardini, A. W., Morton, G. J., Ogimoto, K., Schwartz, M. W., & Dempsey, P. J. (2008) · Endocrinology · doi:10.1210/en.2008-0775 · Cited by 75
Self-citationOlfactory epithelium changes in germfree mice
François, A., Grébert, D., Rhimi, M., Mariadassou, M., Naudon, L., Rabot, S., & Meunier, N. (2016) · Scientific Reports · doi:10.1038/srep24687 · Cited by 81
The Role of Lipid Metabolism for Neural Stem Cell Regulation
Knobloch, M. (2017) · Brain Plasticity · doi:10.3233/bpl-160035 · Cited by 78
Focus on FKBP51: A molecular link between stress and metabolic disorders
Häusl, A. S., Balsevich, G., Gassen, N. C., & Schmidt, M. V. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.003 · Cited by 73
Farkas, E., Szilvásy‐Szabó, A., Ruska, Y., Sinkó, R., Rasch, M. G., Egebjerg, T., Pyke, C., Gereben, B., Knudsen, L. B., & Fekete, C. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02189-1 · Cited by 80
Dockray, G. J. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.01.009 · Cited by 78
Ziko, I., Luca, S. N. D., Dinan, T., Barwood, J. M., Sominsky, L., Cai, G., Kenny, R., Stokes, L., Jenkins, T. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.014 · Cited by 73
Metadata
- Authors
- Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W.
- Affiliations
- University of Washington (US)
- Stanford Medicine (US)
- Corresponding author
- Schwartz, M. W.
- Venue
- Nature
- Published
- 2006-09
- Volume
- 443
- Issue
- 7109
- Pages
- 289-295
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2079395662
- Cited by
- 2,503
- References
- 76
- Citations by year
- 2026: 66 · 2025: 79 · 2024: 75 · 2023: 84 · 2022: 107 · 2021: 123 · 2020: 115 · 2019: 118 · 2018: 141 · 2017: 164 · 2016: 161 · 2015: 150 · 2014: 157 · 2013: 182 · 2012: 172
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- M.J. Murdock Charitable Trust
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- food intake regulation, weight management, energy homeostasis, central nervous system, obesity, leptin, satiety, feeding behaviour, body fat stores, anti-obesity drugs, neuronal receptors
- MeSH terms
- Adipose Tissue, Body Weight, Central Nervous System, Feeding Behavior, Neuronal Plasticity, Satiety Response
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
