The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Central nervous system control of food intake and body weight
Abstract
The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.
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“AOMs are indicated as an adjunct to lifestyle modification for individuals with a body mass index (BMI) of 27 kg/m 2 or greater with at least one weight-related complication or those with a BMI of 30 kg/m 2 or greater [16]”
From Nutritional considerations with antiobesity medications (2024) · cites this paper as [16]
In the citing paper
“This network regulates appetite, active energy expenditure, and basal metabolic rate, and it is made up of a complex network of central (e.g., cortical centers that control cognitive, visual, and “reward” cues) and peripheral (e.g., satiety and hunger hormones) signals [87,88].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“Neurohormonal dysfunction has been implicated in the pathogenesis of diseases of insulin resistance, such as that present in GDM.”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [87]
In the citing paper
“A dominant role of genetic factors in obesity pathogenesis has also been demonstrated in studies comparing the concordance of body weight among fraternal versus identical twins91, for example, as well as studies of adults adopted as infants compared with their biological and adoptive parents77,92.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“Such mechanisms include a paradoxical decrease in appetite and increase in metabolic rate, which change adaptively in the opposite directions to those following most non-surgical weight loss77.”
From Joint international consensus statement for ending stigma of obesity (2020) · cites this paper as [77]
In the citing paper
“and they are stimulated by hunger signals [21, 22]”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [21]
In the citing paper
“Leptin and insulin resistance are common in obesity and, considering their important functions in homeostatic processes, may play a role in poor appetite control [11].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
In the citing paper
“In addition, these meal-related humeral signals can be modulated by the more tonic, or long-term, homeostatic signals which are influenced by body energy stores, namely leptin, insulin [11,12], and ghrelin [13].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [11]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citationGhrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940
Self-citationCritical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Marina, K., Dellinger, E. P., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,271
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Models for estimating feed intake in small ruminants
Pulina, G., Avondo, M., Molle, G., Francesconi, A. H. D., Atzori, A. S., & Cannas, A. (2013) · Revista Brasileira de Zootecnia · doi:10.1590/s1516-35982013000900010 · Cited by 74
Voluntary exercise improves hypothalamic and metabolic function in obese mice
Laing, B. T., Do, K., Matsubara, T., Wert, D., Avery, M. J., Langdon, E. M., Zheng, D., & Hu, H. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0510 · Cited by 74
Role of Somatostatin in the Regulation of Central and Peripheral Factors of Satiety and Obesity
Kumar, U., & Singh, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072568 · Cited by 73
Doan, K. V., Choi, Y., Moh, S. H., Kinyua, A. W., & Kim, K. W. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00846 · Cited by 71
Effect of oral processing behaviour on food intake and satiety
Hogenkamp, P. S., & Schiöth, H. B. (2013) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2013.08.010 · Cited by 75
Constitutive Activity in Melanocortin-4 Receptor
Tao, Y. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-417197-8.00005-5 · Cited by 71
Roman, E. A. F. R., Reis, D., Romanatto, T., Maimoni, D., Ferreira, E. A., Santos, G. A., Torsoni, A. S., Velloso, L. A., & Torsoni, M. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.007 · Cited by 71
n-3 Fatty Acids Induce Neurogenesis of Predominantly POMC-Expressing Cells in the Hypothalamus
do Nascimento, L. F. R., de Souza, G. F. P., Morari, J., Barbosa, G. O., Solon, C., de Moura, R. F., Victorio, S. C. D. S., Ignácio-Souza, L. M., Razolli, D. S., Carvalho, H. F., et al. (2015) · Diabetes · doi:10.2337/db15-0008 · Cited by 76
Petrovich, G. D., Hobin, M., & Reppucci, C. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.036 · Cited by 73
Orexin Receptor Antagonists: A New Concept In CNS Disorders?
Gatfield, J., Roch, C., Jenck, F., & Boss, C. (2010) · ChemMedChem · doi:10.1002/cmdc.201000132 · Cited by 72
Benedict, C., Shostak, A., Lange, T., Brooks, S. J., Schiöth, H. B., Schultes, B., Jan Born, A., Oster, H., & Hallschmid, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2241 · Cited by 67
Combination therapy with naltrexone and bupropion for obesity
Billes, S. K., & Greenway, F. L. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.591382 · Cited by 74
The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans
SEWAYBRICKER, L. E., Huang, A., Chandrasekaran, S., Melhorn, S. J., & Schur, E. A. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac023 · Cited by 78
Sebert, S. P., Hyatt, M. A., Chan, L. L. Y., Patel, N. N., Bell, R. C., Keisler, D. H., Stephenson, T. J., Budge, H., Symonds, M. E., & Gardner, D. S. (2008) · Endocrinology · doi:10.1210/en.2008-0542 · Cited by 70
Hypothalamic lipotoxicity and the metabolic syndrome
de Morentin, P. B. M., Varela, L., Fernø, J., Nogueiras, R., Diéguez, C., & López, M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.016 · Cited by 73
Liu, X., Zhu, Z., Kalyani, M., Janik, J. M., & Shi, H. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.03.028 · Cited by 70
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Fukuda, M., Jones, J. E., Olson, D. P., Hill, J. W., Lee, C. E., Gautron, L., Choi, M. J., Zigman, J. M., Lowell, B. B., & Elmquist, J. K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4023-08.2008 · Cited by 72
Neuronal Receptor Activity–Modifying Protein 1 Promotes Energy Expenditure in Mice
Zhang, Z., Liu, X., Morgan, D. A., Kuburas, A., Thedens, D. R., Russo, A. F., & Rahmouni, K. (2011) · Diabetes · doi:10.2337/db10-0692 · Cited by 70
Stubbs, R. J., Hopkins, M., Finlayson, G., Duarte, C., Gibbons, C., & Blundell, J. E. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0146-6 · Cited by 74
He, X., Lu, Z., Ma, B., Zhang, L., Li, J., Jiang, Y., Zhou, G., & Gao, F. (2019) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2019.02.025 · Cited by 74
Plants' Metabolites as Potential Antiobesity Agents
Sahib, N. G., Saari, N., Ismail, A., Khatib, A., Mahomoodally, M. F., & Hamid, A. A. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/436039 · Cited by 69
Kampe, J., Tschöp, M. H., Hollis, J. H., & Oldfield, B. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06818.x · Cited by 69
Stefanou, N., Papanikolaou, V., Furukawa, Y., Nakamura, Y., & Tsezou, A. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-442 · Cited by 72
Sun, L., Li, Q., Li, Q., Zhang, Y., Liu, D., Jiang, H., Pan, F., & Yew, D. T. W. (2012) · Addiction Biology · doi:10.1111/adb.12004 · Cited by 69
Oxytocin in survivors of childhood-onset craniopharyngioma
Daubenbüchel, A. M. M., Hoffmann, A., Eveslage, M., Özyurt, J., Lohle, K., Reichel, J. F., Thiel, C. M., Martens, H., Geenen, V. G., & Muller, H. L. (2016) · Endocrine · doi:10.1007/s12020-016-1084-5 · Cited by 69
Edwards, A., & Abizaid, A. B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040859 · Cited by 71
Hao, S., Yang, H., Wang, X., He, Y., Xu, H., Wu, X., Pan, L., Liu, Y., Lou, H., Xu, H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.051 · Cited by 71
Liu, X., & Shi, H. (2015) · International Journal of Endocrinology · doi:10.1155/2015/949085 · Cited by 70
Insights into amylin–leptin synergy
Trevaskis, J. L., Parkes, D. G., & Roth, J. D. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.03.006 · Cited by 69
Yuan, L., Ni, Y., Barth, S., Wang, Y., Großmann, R., & Zhao, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.052 · Cited by 68
Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis
Caron, A., & Richard, D. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13263 · Cited by 69
Wang, X., & Li, L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.722028 · Cited by 71
Treatment of Acquired Hypothalamic Obesity: Now and the Future
Dimitri, P. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.846880 · Cited by 67
Wang, S., Essien‐Baidoo, S., Liu, Y., Zhu, C., Tian, J., Ma, J., Tong, J., Chen, J., Tang, X., Xu, H., et al. (2012) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2012.04670.x · Cited by 68
The Loss of Metabolic Control on Alcohol Drinking in Heavy Drinking Alcohol-Dependent Subjects
de Timary, P., Cani, P. D., Duchemin, J., Neyrinck, A. M., Gihousse, D., Laterre, P., Badaoui, A., Leclercq, S., Delzenne, N. M., & Stärkel, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038682 · Cited by 67
Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area
Verhagen, L. A. W., Luijendijk, M. C. M., & Adan, R. A. H. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.11.006 · Cited by 69
PDK-1/FoxO1 pathway in POMC neurons regulatesPomcexpression and food intake
Iskandar, K., Cao, Y., Hayashi, Y., Nakata, M., Takano, E., Yada, T., Zhang, C., Ogawa, W., Oki, M., Chua, S. C., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2009 · Cited by 67
A possible link between BDNF and mTOR in control of food intake
Takei, N., Furukawa, K., Hanyu, O., Sone, H., & Nawa, H. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01093 · Cited by 68
Lorcaserin (Belviq): A Selective Serotonin 5-HT2C Agonist In the Treatment of Obesity.
Gustafson, A., King, C. T., & Rey, J. A. (2013) · Europe PMC (PubMed Central) · Cited by 66
Understanding the Effects of Antipsychotics on Appetite Control
Mukherjee, S., Skrede, S., Milbank, E., Andriantsitohaina, R., López, M., & Fernø, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.815456 · Cited by 73
Borer, K. T., Wuorinen, E. C., Ku, K. P., & Burant, C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2495 · Cited by 69
Simon, J. J., Skunde, M., Wu, M., Schnell, K., Herpertz, S. C., Bendszus, M., Herzog, W., & Friederich, H. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu162 · Cited by 66
Targeted Orexin and Hypothalamic Neuropeptides for Migraine
Strother, L. C., Srikiatkhachorn, A., & Supronsinchai, W. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0602-3 · Cited by 66
Gomes, R. M., Bueno, F. G., Schamber, C. R., de Mello, J. C. P., de Oliveira, J. C., Francisco, F. A., Moreira, V. M., Ferreira-Junior, M. D., Pedrino, G. R., Mathias, P. C. D. F., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.006 · Cited by 66
Elabela, a newly discovered APJ ligand: Similarities and differences with Apelin
Zhang, Y., Wang, Y., Lou, Y., Luo, M., Lu, Y., Li, Z., Wang, Y., & Miao, L. (2018) · Peptides · doi:10.1016/j.peptides.2018.09.006 · Cited by 66
Cheng, Y., Zhang, Q., Meng, Q., Xia, T., Huang, Z., Wang, C., Liu, B., Chen, S., Xiao, F., Du, Y., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0028 · Cited by 65
The neural basis of sugar preference
Liu, W. W., & Bohórquez, D. V. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00613-5 · Cited by 65
Mastication and Risk for Diabetes in a Japanese Population: A Cross-Sectional Study
Yamazaki, T., Yamori, M., Asai, K., Nakano-Araki, I., Yamaguchi, A., Takahashi, K., Sekine, A., Matsuda, F., Kosugi, S., Nakayama, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064113 · Cited by 65
Hypothalamic eIF2α Signaling Regulates Food Intake
Maurin, A., Bénani, A., Lorsignol, A., Brénachot, X., Parry, L., Carraro, V., Guissard, C., Avérous, J., Jousse, C., Bruhat, A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.01.006 · Cited by 71
Wittmann, G., Füzesi, T., Singru, P. S., Liposits, Z., Lechan, R. M., & Fekete, C. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22017 · Cited by 63
Rivera, P., Pérez-Martín, M., Pavón, F. J., Serrano, A., Crespillo, A., Cifuentes, M., López-Ávalos, M.-D., Grondona, J. M., Vida, M., Fernández-Llebrez, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064750 · Cited by 65
Denis, R., Arruda, A. P., Romanatto, T., Milanski, M., Coope, A., Solon, C., Razolli, D. S., & Velloso, L. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.013 · Cited by 65
Taïb, B., Bouyakdan, K., Hryhorczuk, C., Rodaros, D., Fulton, S., & Alquier, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.506238 · Cited by 65
Nordström, V., Willershäuser, M., Herzer, S., Rozman, J., Halbach, O. V. B. U., Meldner, S., Rothermel, U., Kaden, S., Roth, F. C., Waldeck, C., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001506 · Cited by 67
Microbiome to Brain: Unravelling the Multidirectional Axes of Communication
Aidy, S. E., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-20215-0_15 · Cited by 65
Bugajski, A. J., Gil, K., Ziomber, A., Zurowski, D., Zaraska, W., & Thor, P. (2007) · PubMed · Cited by 65
Association of Body Mass and Brain Activation during Gastric Distention: Implications for Obesity
Tomasi, D., Wang, G.-J., Wang, R., Backus, W., Geliebter, A., Telang, F., Jayne, M. C., Wong, C., Fowler, J. S., & Volkow, N. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006847 · Cited by 64
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R. Araujo, J., & Martel, F. (2012) · Current Neuropharmacology · doi:10.2174/157015912799362788 · Cited by 64
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Zhang, J., Li, X., Zhou, Y., Cui, L., Li, J., Wu, C., Wan, Y., Li, J., & Wang, Y. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0131 · Cited by 67
Bailey, D. P., Smith, L. R., Chrismas, B. C. R., Taylor, L. K., Stensel, D. J., Deighton, K., Douglas, J. A., & Kerr, C. J. (2015) · Appetite · doi:10.1016/j.appet.2015.02.019 · Cited by 64
Sadagurski, M., Leshan, R. L., Patterson, C. M., Rozzo, A., Kuznetsova, A., Skorupski, J. C., Jones, J. C., DePinho, R. A., Myers, M. G., & White, M. F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.011 · Cited by 66
mTORC1 signaling in energy balance and metabolic disease
Catania, C., Binder, E., & Cota, D. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.208 · Cited by 68
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Rothman, R. B., & Baumann, M. H. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31817fde95 · Cited by 64
Radler, M. E., Hale, M. W., & Kent, S. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.11.014 · Cited by 65
Peripheral signalling involved in energy homeostasis control
Lancha, A., Frühbeck, G., & Gómez‐Ambrosi, J. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422412000145 · Cited by 66
Cansell, C., Castel, J., Denis, R., Rouch, C., Delbes, A.-S., Martinez, S., Mestivier, D., Finan, B., Maldonado‐Avilés, J. G., Rijnsburger, M., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.31 · Cited by 69
Tsunekawa, T., Banno, R., Mizoguchi, A., Sugiyama, M., Tominaga, T., Onoue, T., Hagiwara, D., Ito, Y., Iwama, S., Goto, M., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.01.007 · Cited by 63
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Shainer, I., Michel, M., Marquart, G. D., Bhandiwad, A. A., Zmora, N., Livne, Z. B.-M., Zohar, Y., Hazak, A., Mazon, Y., Förster, D., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.05.021 · Cited by 61
Gut microbiota and its metabolites: Bridge of dietary nutrients and obesity-related diseases
Zhou, M., Johnston, L. J., Wu, C., & Ma, X. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1986466 · Cited by 67
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Ayaz, Z., Naz, S., Khan, N. H., Razzak, I., & Imran, M. A. (2022) · Neural Computing and Applications · doi:10.1007/s00521-021-06626-y · Cited by 68
Asevedo, E. D. M., Rizzo, L. B., Gadelha, A., Mansur, R. B., Ota, V., Berberian, A. D. A., Scarpato, B. S., Teixeira, A. L., Bressan, R. A., & Brietzke, E. M. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.032 · Cited by 63
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McCarty, R. C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.025 · Cited by 65
Energy imbalance alters Ca2+ handling and excitability of POMC neurons
Paeger, L., Pippow, A., Heß, S., Paehler, M., Klein, A., Husch, A., Pouzat, C., Brüning, J. C., & Kloppenburg, P. (2017) · eLife · doi:10.7554/elife.25641 · Cited by 64
Obesity and food addiction: Similarities to drug addiction
Campana, B., Brasiel, P. G. D. A., de Aguiar, A. S., & Dutra, S. C. P. L. (2019) · Obesity Medicine · doi:10.1016/j.obmed.2019.100136 · Cited by 63
Adipocytes in the Tumour Microenvironment
Pallegar, N. K., & Christian, S. L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-37184-5_1 · Cited by 63
Guesdon, B., Paradis, É., Samson, P., & Richard, D. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90556.2008 · Cited by 63
Mao, L., Hochstetter, D., Yao, L., Zhao, Y., Zhou, J., Wang, Y., & Xu, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205081 · Cited by 63
Jiang, L., You, J., Yu, X., Gonzalez, L., Yu, Y., Wang, Q. A., Yang, G., Li, W., Cai, L., & Liu, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804589105 · Cited by 61
Pimentel, G. D., Ropelle, E. R., Rocha, G. Z., & Carvalheira, J. B. C. (2012) · Metabolism · doi:10.1016/j.metabol.2012.07.001 · Cited by 65
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Metadata
- Authors
- Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W.
- Affiliations
- University of Washington (US)
- Stanford Medicine (US)
- Corresponding author
- Schwartz, M. W.
- Venue
- Nature
- Published
- 2006-09
- Volume
- 443
- Issue
- 7109
- Pages
- 289-295
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2079395662
- Cited by
- 2,503
- References
- 76
- Citations by year
- 2026: 66 · 2025: 79 · 2024: 75 · 2023: 84 · 2022: 107 · 2021: 123 · 2020: 115 · 2019: 118 · 2018: 141 · 2017: 164 · 2016: 161 · 2015: 150 · 2014: 157 · 2013: 182 · 2012: 172
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- M.J. Murdock Charitable Trust
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- food intake regulation, weight management, energy homeostasis, central nervous system, obesity, leptin, satiety, feeding behaviour, body fat stores, anti-obesity drugs, neuronal receptors
- MeSH terms
- Adipose Tissue, Body Weight, Central Nervous System, Feeding Behavior, Neuronal Plasticity, Satiety Response
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