The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Self-renewal and expansion of single transplanted muscle stem cells
Open accessAbstract
Adult muscle satellite cells have a principal role in postnatal skeletal muscle growth and regeneration. Satellite cells reside as quiescent cells underneath the basal lamina that surrounds muscle fibres and respond to damage by giving rise to transient amplifying cells (progenitors) and myoblasts that fuse with myofibres. Recent experiments showed that, in contrast to cultured myoblasts, satellite cells freshly isolated or satellite cells derived from the transplantation of one intact myofibre contribute robustly to muscle repair. However, because satellite cells are known to be heterogeneous, clonal analysis is required to demonstrate stem cell function. Here we show that when a single luciferase-expressing muscle stem cell is transplanted into the muscle of mice it is capable of extensive proliferation, contributes to muscle fibres, and Pax7(+)luciferase(+) mononucleated cells can be readily re-isolated, providing evidence of muscle stem cell self-renewal. In addition, we show using in vivo bioluminescence imaging that the dynamics of muscle stem cell behaviour during muscle repair can be followed in a manner not possible using traditional retrospective histological analyses. By imaging luciferase activity, real-time quantitative and kinetic analyses show that donor-derived muscle stem cells proliferate and engraft rapidly after injection until homeostasis is reached. On injury, donor-derived mononucleated cells generate massive waves of cell proliferation. Together, these results show that the progeny of a single luciferase-expressing muscle stem cell can both self-renew and differentiate after transplantation in mice, providing new evidence at the clonal level that self-renewal is an autonomous property of a single adult muscle stem cell.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Subsequently, MuSCs undergo multiple rounds of self-renewing divisions that are essential to their function in regeneration, as demonstrated by transplantation, genetic ablation, and lineage tracing experiments5–12.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [10]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“In mice, transplantation of satellite cells into damaged muscle leads to self-renewal and muscle regeneration466,467.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [467]
In the citing paper
“Skeletal muscle repair is facilitated by a population of dedicated muscle stem cells (MuSCs), also known as satellite cells, that reside in anatomically defined niches within muscle tissues.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [10]
In the citing paper
“By using BLI, single MuSCs isolated from transgenic mice that ubiquitously express a luciferase transgene were shown to give rise to thousands of progeny, differentiate into myofibers, and self-renew upon re-injury10.”
From The central role of muscle stem cells in regenerative failure with aging (2015) · cites this paper as [10]
In the citing paper
“MuSC were then isolated by FACS to >90% purity for all genotypes (Fig. S4), as previously described (Sacco et al., 2008)”
From Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice (2010) · cites this paper as Sacco et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683
Cellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & Rudnicki, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,691
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345
Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
Osawa, M., Hanada, K., Hamada, H., & Nakauchi, H. (1996) · Science · doi:10.1126/science.273.5272.242 · Cited by 2,141
Asymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449
Collins, C. A., Olsen, I., Zammit, P. S., Heslop, L., Petrie, A., Partridge, T. A., & Morgan, J. E. (2005) · Cell · doi:10.1016/j.cell.2005.05.010 · Cited by 1,445
Direct Isolation of Satellite Cells for Skeletal Muscle Regeneration
Montarras, D., Morgan, J., Collins, C., Relaix, F., Zaffran, S., Cumano, A., Partridge, T., & Buckingham, M. (2005) · Science · doi:10.1126/science.1114758 · Cited by 1,100
Rando, T. A., & Blau, H. M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.6.1275 · Cited by 944
Self-citationMuscle satellite cells adopt divergent fates
Zammit, P. S., Golding, J. P., Nagata, Y., Hudon, V., Partridge, T. A., & Beauchamp, J. R. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312007 · Cited by 924
Conboy, I. M., & Rando, T. A. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00254-x · Cited by 905
Cited by
Sorted by citations
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690
Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture
Gilbert, P. M., Havenstrite, K. L., Magnusson, K. E. G., Sacco, A., Leonardi, N. A., Kraft, P., Nguyen, N. K., Thrun, S., Lutolf, M. P., & Blau, H. M. (2010) · Science · doi:10.1126/science.1191035 · Cited by 1,587
Self-citationBarczyk, M., Carracedo, S., & Gullberg, D. (2010) · Cell and Tissue Research · doi:10.1007/s00441-009-0834-6 · Cited by 1,512
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382
Murphy, M. M., Lawson, J. A., Mathew, S. J., Hutcheson, D. A., & Kardon, G. (2011) · Development · doi:10.1242/dev.064162 · Cited by 1,249
Lepper, C., Partridge, T. A., & Fan, C.-M. (2011) · Development · doi:10.1242/dev.067595 · Cited by 1,105
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration
Sambasivan, R., Yao, R., Kissenpfennig, A., Van Wittenberghe, L., Paldi, A., Gayraud-Morel, B., Guenou, H., Malissen, B., Tajbakhsh, S., & Galy, A. (2011) · Development · doi:10.1242/dev.067587 · Cited by 939
Relaix, F., & Zammit, P. S. (2012) · Development · doi:10.1242/dev.069088 · Cited by 888
The aged niche disrupts muscle stem cell quiescence
Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Braun, T., & Gautel, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3118 · Cited by 713
Satellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Cosgrove, B. D., Gilbert, P. M., Porpiglia, E., Mourkioti, F., Lee, S. P., Corbel, S. Y., Llewellyn, M. E., Delp, S. L., & Blau, H. M. (2014) · Nature Medicine · doi:10.1038/nm.3464 · Cited by 677
Self-citationRepairing skeletal muscle: regenerative potential of skeletal muscle stem cells.
Tedesco, F. S., Dellavalle, A., Díaz-Manera, J., Messina, G., & Cossu, G. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40373 · Cited by 667
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
McCarthy, J. J., Mula, J., Miyazaki, M., Erfani, R., Garrison, K., Farooqui, A. B., Srikuea, R., Lawson, B. A., Grimes, B., Keller, C., et al. (2011) · Development · doi:10.1242/dev.068858 · Cited by 616
Lee, C. H., Cook, J. L., Mendelson, A., Moioli, E. K., Yao, H., & Mao, J. J. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60668-x · Cited by 614
Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements
Lepper, C., Conway, S. J., & Fan, C. (2009) · Nature · doi:10.1038/nature08209 · Cited by 580
de Lageneste, O. D., Julien, A., Abou-Khalil, R., Frangi, G., Carvalho, C., Cagnard, N., Cordier, C., Conway, S. J., & Colnot, C. (2018) · Nature Communications · doi:10.1038/s41467-018-03124-z · Cited by 573
Grand, F. L., Jones, A., Seale, V., Scimè, A., & Rudnicki, M. A. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.03.013 · Cited by 565
Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice
Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz, J. H., Artandi, S. E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.039 · Cited by 512
Self-citationComparative Study of Injury Models for Studying Muscle Regeneration in Mice
Hardy, D., Besnard, A., Latil, M., Jouvion, G., Briand, D., Thépenier, C., Pascal, Q., Guguin, A., Gayraud-Morel, B., Cavaillon, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147198 · Cited by 546
Rocheteau, P., Gayraud-Morel, B., Siegl-Cachedenier, I., Blasco, M. A., & Tajbakhsh, S. (2012) · Cell · doi:10.1016/j.cell.2011.11.049 · Cited by 510
Li, F., Huang, Q., Jiang, C., Peng, Y., Roop, D. R., Bedford, J. S., & Li, C. (2010) · Science Signaling · doi:10.1126/scisignal.2000634 · Cited by 510
Intrinsic and extrinsic mechanisms regulating satellite cell function
Dumont, N. A., Wang, Y. X., & Rudnicki, M. A. (2015) · Development · doi:10.1242/dev.114223 · Cited by 491
Single-cell bioluminescence imaging of deep tissue in freely moving animals
Iwano, S., Sugiyama, M., Hama, H., Watakabe, A., Hasegawa, N., Kuchimaru, T., Tanaka, K. Z., Takahashi, M., Ishida, Y., Hata, J., et al. (2018) · Science · doi:10.1126/science.aaq1067 · Cited by 478
Darabi, R., Arpke, R. W., Irion, S., Dimos, J. T., Grskovic, M., Kyba, M., & Perlingeiro, R. C. R. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.02.015 · Cited by 481
The central role of muscle stem cells in regenerative failure with aging
Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437
Self-citationMitchell, K. J., Pannérec, A., Cadot, B., Parlakian, A., Besson, V., Gomes, E. R., Marazzi, G., & Sassoon, D. A. (2010) · Nature Cell Biology · doi:10.1038/ncb2025 · Cited by 442
Qazi, T., Mooney, D., Pumberger, M., Geissler, S., & Duda, G. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.110 · Cited by 386
Advances in understanding tissue regenerative capacity and mechanisms in animals
Poss, K. D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2879 · Cited by 442
Tissue-Specific Stem Cells: Lessons from the Skeletal Muscle Satellite Cell
Brack, A. S., & Rando, T. A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.04.001 · Cited by 421
STAT3 signaling controls satellite cell expansion and skeletal muscle repair
Tierney, M. T., Aydogdu, T., Sala, D., Malecova, B., Gatto, S., Puri, P. L., Latella, L., & Sacco, A. (2014) · Nature Medicine · doi:10.1038/nm.3656 · Cited by 401
Self-citationIsolation of skeletal muscle stem cells by fluorescence-activated cell sorting
Liu, L. A., Cheung, T. H., Charville, G. W., & Rando, T. A. (2015) · Nature Protocols · doi:10.1038/nprot.2015.110 · Cited by 411
Stem Cells and the Niche: A Dynamic Duo
Voog, J., & Jones, D. L. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.01.011 · Cited by 410
Short-term calorie restriction enhances skeletal muscle stem cell function
Cerletti, M., Jang, Y. C., Finley, L. W. S., Haigis, M. C., & Wagers, A. J. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.04.002 · Cited by 371
High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations
Giordani, L., He, G. J., Négroni, E., Sakai, H., Law, J., Siu, M. M., Wan, R., Corneau, A., Tajbakhsh, S., Cheung, T. H., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.026 · Cited by 406
Palacios, D., Mozzetta, C., Consalvi, S., Caretti, G., Saccone, V., Proserpio, V., Marquez, V. E., Valente, S., Mai, A., Forcales, S. V., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.013 · Cited by 392
Chen, F., Wu, L., Zhang, M., Zhang, R., & Sun, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.032 · Cited by 387
De Micheli, A. J., Laurilliard, E. J., Heinke, C. L., Ravichandran, H., Fraczek, P., Soueid-Baumgarten, S., De Vlaminck, I., Elemento, O., & Cosgrove, B. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.067 · Cited by 373
Uraemic sarcopenia: aetiology and implications
Fahal, I. H. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft070 · Cited by 375
Shea, K. L., Xiang, W., LaPorta, V. S., Licht, J. D., Keller, C., Basson, M. A., & Brack, A. S. (2010) · Cell stem cell · doi:10.1016/j.stem.2009.12.015 · Cited by 351
Skeletal muscle stem cells in developmental versus regenerative myogenesis
Tajbakhsh, S. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02158.x · Cited by 333
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332
Self-citationMolecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease
Almada, A. E., & Wagers, A. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.7 · Cited by 322
Regulatory factors and cell populations involved in skeletal muscle regeneration
Broek, R. W. T., Grefte, S., & den Hoff, J. W. V. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22127 · Cited by 315
Chal, J., Tanoury, Z. A., Hestin, M., Gobert, B., Aivio, S., Hick, A., Cherrier, T., Nesmith, A. P., Parker, K. K., & Pourquié, O. (2016) · Nature Protocols · doi:10.1038/nprot.2016.110 · Cited by 306
Identification and characterization of PDGFRα+ mesenchymal progenitors in human skeletal muscle
Uezumi, A., Fukada, S., Yamamoto, N., Ikemoto‐Uezumi, M., Nakatani, M., Morita, M., Yamaguchi, A., Yamada, H., Nishino, I., Hamada, Y., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.161 · Cited by 304
Bioluminescence imaging: progress and applications
Badr, C. E., & Tannous, B. A. (2011) · Trends in biotechnology · doi:10.1016/j.tibtech.2011.06.010 · Cited by 293
Quarta, M., Cromie, M. J., Chacon, R., Blonigan, J., Garcia, V., Akimenko, I., Hamer, M., Paine, P., Stok, M., Shrager, J. B., et al. (2017) · Nature Communications · doi:10.1038/ncomms15613 · Cited by 282
Joe, A. W., Yi, L., Even, Y., Vogl, A. W., & Rossi, F. M. V. (2009) · Stem Cells · doi:10.1002/stem.190 · Cited by 297
Zahir, N., & Tuan, R. S. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21940 · Cited by 279
Troy, A., Cadwallader, A. B., Fedorov, Y., Tyner, K., Tanaka, K. K., & Olwin, B. B. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.025 · Cited by 268
Mozzetta, C., Consalvi, S., Saccone, V., Tierney, M. T., Diamantini, A., Mitchell, K. J., Marazzi, G., Borsellino, G., Battistini, L., Sassoon, D. A., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202096 · Cited by 261
Self-citationGuided by the light: visualizing biomolecular processes in living animals with bioluminescence
Prescher, J. A., & Contag, C. H. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.11.001 · Cited by 257
Day, K., Shefer, G., Shearer, A., & Yablonka-Reuveni, Z. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.01.006 · Cited by 254
Muscle satellite cell heterogeneity and self-renewal
Motohashi, N., & Asakura, A. (2014) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2014.00001 · Cited by 262
Kelly, K. K., Hall, J. K., Troy, A. A., Cornelison, D., Majka, S. M., & Olwin, B. B. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.01.016 · Cited by 249
Zismanov, V., Chichkov, V., Colangelo, V., Jamet, S., Wang, S., Syme, A., Koromilas, A. E., & Crist, C. G. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.09.020 · Cited by 259
Juhas, M., Engelmayr, G. C., Fontanella, A. N., Palmer, G. M., & Bursac, N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402723111 · Cited by 246
Biomimetic scaffolds for regeneration of volumetric muscle loss in skeletal muscle injuries
Grasman, J. M., Zayas, M. J., Page, R. L., & Pins, G. D. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.07.038 · Cited by 250
Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
de Morrée, A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00568-6 · Cited by 258
Dell'Orso, S., Juan, A. H., Ko, K.-D., Naz, F., Perovanovic, J., Gutierrez-Cruz, G., Feng, X., & Sartorelli, V. (2019) · Development · doi:10.1242/dev.174177 · Cited by 243
Ho, A. T. V., Palla, A. R., Blake, M. R., Yucel, N. D., Wang, Y. X., Magnusson, K. E. G., Holbrook, C. A., Kraft, P. E., Delp, S. L., & Blau, H. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705420114 · Cited by 248
Self-citationIn situ tissue regeneration through host stem cell recruitment
Ko, I. K., Lee, S. J., Atala, A., & Yoo, J. J. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.118 · Cited by 244
Orienting Muscle Stem Cells for Regeneration in Homeostasis, Aging, and Disease
Feige, P., Brun, C. E., Ritso, M., & Rudnicki, M. A. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.10.006 · Cited by 233
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A. T. V., & Blau, H. M. (2021) · Science · doi:10.1126/science.abc8059 · Cited by 232
Self-citationChu, J., Haynes, R. D., Corbel, S. Y., Li, P., González-González, E., Burg, J. S., Ataie, N., Lam, A. J., Cranfill, P. J., Baird, M. A., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2888 · Cited by 231
Self-citationLütolf, M. P., & Blau, H. M. (2009) · Advanced Materials · doi:10.1002/adma.200802582 · Cited by 226
Self-citationOno, Y., Boldrin, L., Knopp, P., Morgan, J. E., & Zammit, P. S. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.005 · Cited by 217
Shefer, G., Rauner, G., Yablonka‐Reuveni, Z., & Benayahu, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013307 · Cited by 220
Clark, A. Y., Martin, K. E., García, J. R., Johnson, C. T., Theriault, H. S., Han, W. M., Zhou, D. W., Botchwey, E. A., & García, A. J. (2020) · Nature Communications · doi:10.1038/s41467-019-14000-9 · Cited by 222
Genetic Background Affects Properties of Satellite Cells and mdx Phenotypes
Fukada, S., Morikawa, D., Yamamoto, Y., Yoshida, T., Sumie, N., Yamaguchi, M., Ito, T., Miyagoe‐Suzuki, Y., Takeda, S., Tsujikawa, K., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090887 · Cited by 216
Close, D. M., Xu, T., Sayler, G. S., & Ripp, S. A. (2010) · Sensors · doi:10.3390/s110100180 · Cited by 211
ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs
Hicks, M. R., Hiserodt, J., Paras, K. I., Fujiwara, W., Eskin, A., Jan, M., Xi, H., Young, C. S., Evseenko, D. A., Nelson, S. F., et al. (2017) · Nature Cell Biology · doi:10.1038/s41556-017-0010-2 · Cited by 202
CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties
Wakabayashi, T., Naito, H., Suehiro, J., Lin, Y., Kawaji, H., Iba, T., Kouno, T., Ishikawa-Kato, S., Furuno, M., Takara, K., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.01.010 · Cited by 203
Quarta, M., Brett, J. O., DiMarco, R. L., de Morrée, A., Boutet, S. C., Chacon, R., Gibbons, M. C., Garcia, V. A., Su, J., Shrager, J. B., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3576 · Cited by 201
Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion
Fu, X., Xiao, J., Wei, Y., Li, S., Liu, Y., Yin, J., Sun, K., Sun, H., Wang, H., Zhang, Z., et al. (2015) · Cell Research · doi:10.1038/cr.2015.58 · Cited by 202
Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells
Charville, G. W., Cheung, T. H., Yoo, B., Santos, P. J. F., Lee, G., Shrager, J. B., & Rando, T. A. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.08.004 · Cited by 196
The therapeutic potential of stem cells
Watt, F. M., & Driskell, R. R. (2009) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2009.0149 · Cited by 207
Judson, R. N., Tremblay, A. M., Knopp, P., White, R. B., Urcia, R., De Bari, C., Zammit, P. S., Camargo, F. D., & Wackerhage, H. (2012) · Journal of Cell Science · doi:10.1242/jcs.109546 · Cited by 190
Transient Inactivation of Rb and ARF Yields Regenerative Cells from Postmitotic Mammalian Muscle
Pajcini, K. V., Corbel, S. Y., Sage, J., Pomerantz, J. H., & Blau, H. M. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.05.022 · Cited by 193
Self-citationInjectable, rapid gelling and highly flexible hydrogel composites as growth factor and cell carriers
Wang, F., Li, Z., Khan, M., Tamama, K., Kuppusamy, P., Wagner, W. R., Sen, C. K., & Guan, J. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.12.011 · Cited by 188
Chen, P., Tao, J., Zhu, S., Cai, Y., Mao, Q., Yu, D., Dai, J., & Ouyang, H. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.049 · Cited by 188
Isolation and Culture of Skeletal Muscle Myofibers as a Means to Analyze Satellite Cells
Keire, P. A., Shearer, A. M., Shefer, G., & Yablonka‐Reuveni, Z. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-128-8_28 · Cited by 187
Danoviz, M. E., & Yablonka‐Reuveni, Z. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-343-1_2 · Cited by 182
Snippert, H. J. G., & Clevers, H. C. (2011) · EMBO Reports · doi:10.1038/embor.2010.216 · Cited by 184
The muscle satellite cell at 50: the formative years
Scharner, J., & Zammit, P. S. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-28 · Cited by 180
MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3
Hirai, H., Verma, M., Watanabe, S., Tastad, C., Asakura, Y., & Asakura, A. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201006025 · Cited by 177
Chang, N. C., & Rudnicki, M. A. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00006-8 · Cited by 190
Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis
Post, Y., & Clevers, H. C. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.07.002 · Cited by 181
Maintaining bovine satellite cells stemness through p38 pathway
Ding, S., Swennen, G., Meßmer, T., Gagliardi, M., Molin, D. G. M., Li, C., Zhou, G., & Post, M. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-28746-7 · Cited by 186
Therapeutic Strategies for Duchenne Muscular Dystrophy: An Update
Sun, C., Shen, L., Zhang, Z., & Xie, X. (2020) · Genes · doi:10.3390/genes11080837 · Cited by 187
A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species
Xu, C., Tabebordbar, M., Iovino, S., Ciarlo, C., Liu, J., Castiglioni, A., Price, E., Liu, M., Barton, E. R., Kahn, C. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.023 · Cited by 172
Attributes of adult stem cells
Alison, M., & Islam, S. (2008) · The Journal of Pathology · doi:10.1002/path.2498 · Cited by 182
Heterogeneity in the muscle satellite cell population
Biressi, S., & Rando, T. A. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.09.003 · Cited by 168
Gnocchi, V. F., White, R. B., Ono, Y., Ellis, J. A., & Zammit, P. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005205 · Cited by 166
Roles of nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle
Uezumi, A., Ikemoto‐Uezumi, M., & Tsuchida, K. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00068 · Cited by 171
Engineering Stem and Stromal Cell Therapies for Musculoskeletal Tissue Repair
Loebel, C., & Burdick, J. A. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.01.014 · Cited by 179
Xi, H., Langerman, J., Sabri, S., Chien, P., Young, C. S., Younesi, S., Hicks, M. R., Gonzalez, K. M., Fujiwara, W., Marzi, J., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.04.017 · Cited by 160
The Skeletal Muscle Satellite Cell
Yablonka‐Reuveni, Z. (2011) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155411426780 · Cited by 164
Metadata
- Authors
- Sacco, A., Doyonnas, R., Kraft, P., Vitorovic, S., & Blau, H. M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Blau, Helen M.
- Venue
- Nature
- Published
- 2008-09-17
- Volume
- 456
- Issue
- 7221
- Pages
- 502-506
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2919355
- OpenAlex
- W2031495223
- Cited by
- 901
- References
- 26
- Citations by year
- 2026: 20 · 2025: 36 · 2024: 37 · 2023: 47 · 2022: 46 · 2021: 54 · 2020: 59 · 2019: 58 · 2018: 52 · 2017: 51 · 2016: 46 · 2015: 66 · 2014: 50 · 2013: 60 · 2012: 67
- FWCI
- 20.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG009521, AG 024987, R37AG009521, R01AG009521, R01AG020961, R01AG024987)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- satellite cells, muscle stem cells, self-renewal, clonal analysis, single-cell transplantation, Pax7, muscle regeneration, muscle damage, bioluminescence imaging, cell proliferation, skeletal muscle
- MeSH terms
- Animals, Cells, Cultured, Homeostasis, Luminescent Measurements, Muscles, Regeneration, Stem Cells, Antigens, CD, Muscle Fibers, Skeletal, Antigens, CD34, Satellite Cells, Skeletal Muscle, Stem Cell Transplantation, Integrin alpha Chains, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
