Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration
Open accessAbstract
Satellite cells are skeletal muscle stem cells capable of self-renewal and differentiation after transplantation, but whether they contribute to endogenous muscle fiber repair has been unclear. The transcription factor Pax7 marks satellite cells and is critical for establishing the adult satellite cell pool. By using a lineage tracing approach, we show that after injury, quiescent adult Pax7(+) cells enter the cell cycle; a subpopulation returns to quiescence to replenish the satellite cell compartment, while others contribute to muscle fiber formation. We demonstrate that Sprouty1 (Spry1), a receptor tyrosine kinase signaling inhibitor, is expressed in quiescent Pax7(+) satellite cells in uninjured muscle, downregulated in proliferating myogenic cells after injury, and reinduced as Pax7(+) cells re-enter quiescence. We show that Spry1 is required for the return to quiescence and homeostasis of the satellite cell pool during repair. Our results therefore define a role for Spry1 in adult muscle stem cell biology and tissue repair.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In MuSCs, the activation process is canonically characterized by expression of Myod1, loss of Spry1 and Pax7, and entry into the cell cycle.
“In MuSCs, the activation process is canonically characterized by expression of Myod1 (Grounds et al., 1992; Yablonka-Reuveni and Rivera, 1994), loss of Spry1 and Pax7, and entry into the cell cycle (Shea et al., 2010).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Shea et al., 2010
The quiescence marker Spry1 displayed a monotonic decrease with activation and Myod1 displayed a monotonic increase.
“By contrast, the quiescence marker Spry1 (Shea et al., 2010) displayed a monotonic decrease with activation and Myod1 displayed a monotonic increase (Fig. 2G).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Shea et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
β-catenin promotes self-renewal of skeletal-muscle satellite cells
Ruiz, A. P., Ono, Y., Gnocchi, V. F., & Zammit, P. S. (2008) · Journal of Cell Science · doi:10.1242/jcs.024885 · Cited by 70 · see citing works
RetractedGeneralized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237 · see citing works
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thum, T., Gross, C., Fiedler, J., Fischer, T., Kissler, S., Bussen, M., Galuppo, P., Just, S., Rottbauer, W., Frantz, S., et al. (2008) · Nature · doi:10.1038/nature07511 · Cited by 2,349 · see citing works
Self-citationPax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345 · see citing works
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564 · see citing works
Self-citationAsymmetric self-renewal and commitment of satellite stem cells in muscle
Kuang, S., Kuroda, K., Le Grand, F., & Rudnicki, M. A. (2007) · Cell · doi:10.1016/j.cell.2007.03.044 · Cited by 1,449 · see citing works
Collins, C. A., Olsen, I., Zammit, P. S., Heslop, L., Petrie, A., Partridge, T. A., & Morgan, J. E. (2005) · Cell · doi:10.1016/j.cell.2005.05.010 · Cited by 1,445 · see citing works
Direct Isolation of Satellite Cells for Skeletal Muscle Regeneration
Montarras, D., Morgan, J., Collins, C., Relaix, F., Zaffran, S., Cumano, A., Partridge, T., & Buckingham, M. (2005) · Science · doi:10.1126/science.1114758 · Cited by 1,100 · see citing works
Muscle satellite cells adopt divergent fates
Zammit, P. S., Golding, J. P., Nagata, Y., Hudon, V., Partridge, T. A., & Beauchamp, J. R. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312007 · Cited by 924 · see citing works
Self-renewal and expansion of single transplanted muscle stem cells
Sacco, A., Doyonnas, R., Kraft, P., Vitorovic, S., & Blau, H. M. (2008) · Nature · doi:10.1038/nature07384 · Cited by 901 · see citing works
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
Orford, K. W., & Scadden, D. T. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2269 · Cited by 851 · see citing works
Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells
Relaix, F., Montarras, D., Zaffran, S., Gayraud-Morel, B., Rocancourt, D., Tajbakhsh, S., Mansouri, A., Cumano, A., & BUCKINGHAM, M. E. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200508044 · Cited by 736 · see citing works
Brack, A. S., Conboy, I. M., Conboy, M. J., Shen, J., & Rando, T. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.10.006 · Cited by 682 · see citing works
Self-citationAdult satellite cells and embryonic muscle progenitors have distinct genetic requirements
Lepper, C., Conway, S. J., & Fan, C. (2009) · Nature · doi:10.1038/nature08209 · Cited by 580 · see citing works
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
Hanafusa, H., Torii, S., Yasunaga, T., & Nishida, E. (2002) · Nature Cell Biology · doi:10.1038/ncb867 · Cited by 566 · see citing works
Grand, F. L., Jones, A., Seale, V., Scimè, A., & Rudnicki, M. A. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.03.013 · Cited by 531 · see citing works
Oustanina, S., Hause, G., & Braun, T. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600346 · Cited by 531 · see citing works
Molecular Signature of Quiescent Satellite Cells in Adult Skeletal Muscle
Fukada, S.-I., Uezumi, A., Ikemoto, M., Masuda, S., Segawa, M., Tanimura, N., Yamamoto, H., Miyagoe-Suzuki, Y., & Takeda, S. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0019 · Cited by 506 · see citing works
Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis
Kuang, S., CHARGÉ, S. B. P., Seale, P., Huh, M. S., & Rudnicki, M. A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508001 · Cited by 490 · see citing works
Clegg, C. H., Linkhart, T. A., Olwin, B. B., & Hauschka, S. D. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.2.949 · Cited by 478 · see citing works
Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles
Cerletti, M., Jurga, S., Witczak, C. A., Hirshman, M. F., Shadrach, J. L., Goodyear, L. J., & Wagers, A. J. (2008) · Cell · doi:10.1016/j.cell.2008.05.049 · Cited by 472 · see citing works
Sprouty, an intracellular inhibitor of Ras signaling
Casci, T., Vinós, J., & Freeman, M. (1999) · Cell · doi:10.1016/s0092-8674(00)80576-0 · Cited by 467 · see citing works
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
Mason, J. M., Morrison, D. J., Basson, M. A., & Licht, J. D. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.11.004 · Cited by 426 · see citing works
Self-citationYoshida, N., Yoshida, S., Koishi, K., Masuda, K., & Nabeshima, Y.-I. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.6.769 · Cited by 425 · see citing works
Modulation of signalling by Sprouty: a developing story
Kim, H. J., & Bar‐Sagi, D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1400 · Cited by 373 · see citing works
Sprouty1 Is a Critical Regulator of GDNF/RET-Mediated Kidney Induction
Basson, M. A., Akbulut, S., Watson-Johnson, J., Simon, R., Carroll, T. J., Shakya, R., Groß, I., Martin, G. R., Lufkin, T., McMahon, A. P., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.12.004 · Cited by 362 · see citing works
Self-citationFgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
Lee, Y., Grill, S., Sanchez, A., Murphy‐Ryan, M., & Poss, K. D. (2005) · Development · doi:10.1242/dev.02101 · Cited by 340 · see citing works
Roles for Fgf Signaling during Zebrafish Fin Regeneration
Poss, K. D., Shen, J., Nechiporuk, A. V., McMahon, G., Thisse, B., Thisse, C., & Keating, M. T. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9722 · Cited by 332 · see citing works
Control of the Reversibility of Cellular Quiescence by the Transcriptional Repressor HES1
Sang, L., Coller, H. A., & Roberts, J. M. (2008) · Science · doi:10.1126/science.1155998 · Cited by 313 · cited 1× · see citing works
“The ability of a cell to undergo reversible quiescence is critical for maintenance of the stem cell pool (Sang et al., 2008).”
BackgroundConboy, M. J., Karasov, A. O., & Rando, T. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050102 · Cited by 287 · cited 2× · see citing works
“Satellite cell heterogeneity (Kuang et al., 2007), asymmetric inheritance of fate determinants (Conboy et al., 2007; Shinin et al., 2009) and modulation of signaling cascades such as Notch, Wnt and MAPK pathways (Jones et al., 2005; Kuang et al., 2007; Perez-Ruiz et al., 2008; Abou-Khalil et al.,…”
BackgroundThe p38α/β MAPK functions as a molecular switch to activate the quiescent satellite cell
Jones, N. C., Tyner, K. J., Nibarger, L., Stanley, H. M., Cornelison, D., Fedorov, Y. V., & Olwin, B. B. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200408066 · Cited by 272 · see citing works
Sprouty is a general inhibitor of receptor tyrosine kinase signaling
Reich, A., Sapir, A., & Shilo, B. (1999) · Development · doi:10.1242/dev.126.18.4139 · Cited by 262 · see citing works
Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila
Krämer, S., Okabe, M., Hacohen, N., Krasnow, M. A., & Hiromi, Y. (1999) · Development · doi:10.1242/dev.126.11.2515 · Cited by 254 · see citing works
Autocrine and Paracrine Angiopoietin 1/Tie-2 Signaling Promotes Muscle Satellite Cell Self-Renewal
Abou-Khalil, R., Grand, F. L., Pallafacchina, G., Valable, S., Authier, F., Rudnicki, M. A., Gherardi, R. K., Germain, S., Chrétien, F. C., Sotiropoulos, A., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.06.001 · Cited by 236 · see citing works
Somitic origin of limb muscle satellite and side population cells
Schienda, J., Engleka, K. A., Jun, S. J., Hansen, M. S. T., Epstein, J. A., Tabin, C. J., Kunkel, L. M., & Kardon, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510164103 · Cited by 216 · see citing works
Yablonka‐Reuveni, Z., Seger, R., & Rivera, A. J. (1999) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549904700104 · Cited by 215 · see citing works
Progenitors of skeletal muscle satellite cells express the muscle determination gene, MyoD
Kanisicak, O., Mendez, J. J., Yamamoto, S., Yamamoto, M., & Goldhamer, D. J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.05.554 · Cited by 192 · see citing works
Cristofaro, M. F. D., Betz, B. L., Rorie, C. J., Reisman, D., Wang, W., & Weissman, B. E. (2001) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200101)186:1 · Cited by 161 · see citing works
Lagha, M., Kormish, J. D., Rocancourt, D., Manceau, M., Epstein, J. A., Zaret, K. S., Relaix, F., & BUCKINGHAM, M. E. (2008) · Genes & Development · doi:10.1101/gad.477908 · Cited by 143 · see citing works
Allen, R. E., Dodson, M. V., & Luiten, L. S. (1984) · Experimental Cell Research · doi:10.1016/0014-4827(84)90239-8 · Cited by 140 · see citing works
Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury
Schuh, K., & Pahl, A. M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.03.012 · Cited by 134 · see citing works
Biomarker system for studying muscle, stem cells, and cancer in vivo
Nishijo, K., Hosoyama, T., Bjornson, C. R. R., Schaffer, B. S., Prajapati, S. I., Bahadur, A. N., Hansen, M. S. T., Blandford, M. C., McCleish, A. T., Rubin, B. P., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-128116 · Cited by 132 · see citing works
Self-citationBockhold, K. J., Rosenblatt, J. D., & Partridge, T. A. (1998) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199802)21:2 · Cited by 129 · see citing works
Brack, A. S., Murphy-Seiler, F., Hanifi, J. M., Deka, J., Eyckerman, S., Keller, C., Aguet, M., & Rando, T. A. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.08.014 · Cited by 107 · see citing works
Self-citationJohnson, R. L., Riddle, R. D., & Tabin, C. J. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90069-f · Cited by 83 · see citing works
Fedorov, Y. V., Jones, N. C., & Olwin, B. B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5780 · Cited by 62 · see citing works
Gene therapy using SV40-derived vectors: What does the future hold?
Strayer, D. S. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199912)181:3 · Cited by 61 · see citing works
Template DNA-Strand Co-Segregation and Asymmetric Cell Division in Skeletal Muscle Stem Cells
Shinin, V., Gayraud-Morel, B., & Tajbakhsh, S. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-060-7_19 · Cited by 43 · see citing works
Control of Myf5 activation in adult skeletal myonuclei requires ERK signalling
Ruiz, A. P., Gnocchi, V. F., & Zammit, P. S. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.03.003 · Cited by 23 · see citing works
Sprouty gene expression is regulated by nerve and FGF6 during regeneration of mouse muscles
Laziz, I., Armand, A., Pariset, C. C., et al. (2007) · Growth Factors · doi:10.1080/08977190701723166 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y.-H., Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.012 · Cited by 2,662 · see citing works
Self-citationSatellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166 · see citing works
Murphy, M. M., Lawson, J. A., Mathew, S. J., Hutcheson, D. A., & Kardon, G. (2011) · Development · doi:10.1242/dev.064162 · Cited by 1,249 · see citing works
Geriatric muscle stem cells switch reversible quiescence into senescence
Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010 · see citing works
FGF/FGFR signaling in health and disease
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904 · see citing works
The aged niche disrupts muscle stem cell quiescence
Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851 · see citing works
Self-citationSatellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719 · see citing works
Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells
Bjornson, C. R. R., Cheung, T. H., Liu, L., Tripathi, P. V., Steeper, K. M., & Rando, T. A. (2012) · Stem Cells · doi:10.1002/stem.773 · Cited by 598 · see citing works
Ryall, J. G., Dell’Orso, S., Derfoul, A., Juan, A., Zare, H., Feng, X., Clermont, D., Koulnis, M., Gutierrez-Cruz, G., Fulco, M., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.12.004 · Cited by 575 · see citing works
Collagen VI regulates satellite cell self-renewal and muscle regeneration
Urciuolo, A., Quarta, M., Morbidoni, V., Gattazzo, F., Molon, S., Grumati, P., Montemurro, F., Tedesco, F. S., Blaauw, B., Cossu, G., et al. (2013) · Nature Communications · doi:10.1038/ncomms2964 · Cited by 511 · see citing works
Intrinsic and extrinsic mechanisms regulating satellite cell function
Dumont, N. A., Wang, Y. X., & Rudnicki, M. A. (2015) · Development · doi:10.1242/dev.114223 · Cited by 491 · see citing works
Control of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476 · see citing works
Fibronectin Regulates Wnt7a Signaling and Satellite Cell Expansion
Bentzinger, C. F., Wang, Y. X., von Maltzahn, J., Soleimani, V. D., Yin, H., & Rudnicki, M. A. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2012.09.015 · Cited by 386 · see citing works
Fry, C. S., Kirby, T. J., Kosmac, K., McCarthy, J. J., & Peterson, C. A. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.09.010 · Cited by 372 · see citing works
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332 · see citing works
Transcriptional profiling of quiescent muscle stem cells in vivo
van Velthoven, C. T. J., de Morree, A., Egner, I. M., Brett, J. O., & Rando, T. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.037 · Cited by 235 · see citing works
FOXO3 Promotes Quiescence in Adult Muscle Stem Cells during the Process of Self-Renewal
Gopinath, S. D., Webb, A. E., Brunet, A., & Rando, T. A. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.02.002 · Cited by 212 · see citing works
Impact of genomic damage and ageing on stem cell function
Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B. (2014) · Nature Cell Biology · doi:10.1038/ncb2928 · Cited by 207 · see citing works
The ins and outs of muscle stem cell aging
Brack, A. S., & Muñoz-Cánoves, P. (2015) · Skeletal Muscle · doi:10.1186/s13395-016-0072-z · Cited by 166 · see citing works
Self-citationMuscle stem cell aging: regulation and rejuvenation
Sousa-Victor, P., García-Prat, L., Serrano, A. L., Perdiguero, E., & Muñoz-Cánoves, P. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.03.006 · Cited by 163 · see citing works
Satellite Cell Heterogeneity in Skeletal Muscle Homeostasis
Tierney, M. T., & Sacco, A. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.02.004 · Cited by 151 · see citing works
“Sprouty-1 (Spry1), an inhibitor of FGF signaling, can overcome this defect [97]; however, its expression is only retained in the LRC fraction.”
BackgroundYucel, N., Wang, Y. X., Mai, T., Porpiglia, E., Lund, P. J., Markov, G., Garcia, B. A., Bendall, S. C., Angelo, M., & Blau, H. M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.092 · Cited by 159 · see citing works
Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells
García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2013) · The FEBS Journal · doi:10.1111/febs.12221 · Cited by 152 · see citing works
Chakkalakal, J. V., Christensen, J., Xiang, W., Tierney, M. T., Boscolo, F. S., Sacco, A., & Brack, A. S. (2014) · Development · doi:10.1242/dev.100842 · Cited by 148 · see citing works
Self-citationAging induces aberrant state transition kinetics in murine muscle stem cells
Kimmel, J. C., Hwang, A. B., Scaramozza, A., Marshall, W. F., & Brack, A. S. (2020) · Development · doi:10.1242/dev.183855 · Cited by 95 · see citing works
Self-citationScaramozza, A., Park, D., Kollu, S., Beerman, I., Sun, X., Rossi, D. J., Lin, C. P., Scadden, D. T., Crist, C., & Brack, A. S. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.020 · Cited by 93 · see citing works
Self-citationBlood Vessels and the Satellite Cell Niche
Mounier, R., Chrétien, F., & Chazaud, B. (2011) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385940-2.00005-x · Cited by 89 · see citing works
Woodhouse, S., Pugazhendhi, D., Brien, P., & Pell, J. M. (2013) · Journal of Cell Science · doi:10.1242/jcs.114843 · Cited by 84 · see citing works
Geroconversion of aged muscle stem cells under regenerative pressure
Sousa-Victor, P., Perdiguero, E., & Muñoz-Cánoves, P. (2014) · Cell Cycle · doi:10.4161/15384101.2014.965072 · Cited by 68 · see citing works
Kimmel, J. C., Chang, A. Y., Brack, A. S., & Marshall, W. F. (2018) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005927 · Cited by 54 · see citing works
“Mononuclear cells were isolated from limb muscles of adult mice as described [76].”
MethodPisconti, A., Banks, G. B., Babaeijandaghi, F., Betta, N. D., Rossi, F. M. V., Chamberlain, J. S., & Olwin, B. B. (2016) · Skeletal Muscle · doi:10.1186/s13395-016-0104-8 · Cited by 50 · see citing works
Watanabe, S., Hirai, H., Asakura, Y., Tastad, C., Verma, M., Keller, C., Dutton, J. R., & Asakura, A. (2011) · Stem Cells · doi:10.1002/stem.598 · Cited by 44 · see citing works
Self-citationDifferentiation reveals latent features of aging and an energy barrier in murine myogenesis
Kimmel, J. C., Yi, N., Roy, M., Hendrickson, D. G., & Kelley, D. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109046 · Cited by 42 · see citing works
Rb1 Gene Inactivation Expands Satellite Cell and Postnatal Myoblast Pools
Hosoyama, T., Nishijo, K., Prajapati, S. I., Li, G., & Keller, C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.229542 · Cited by 42 · see citing works
Self-citation
- Authors
- Shea, K. L., Xiang, W., LaPorta, V. S., Licht, J. D., Keller, C., Basson, M. A., & Brack, A. S.
- Affiliations
- Harvard University (US)
- Northwestern University (US)
- The University of Texas at San Antonio Health Science Center (US)
- King's College London (GB)
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 6
- Issue
- 2
- Pages
- 117-129
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC2846417
- OpenAlex
- W2109487240
- Cited by
- 351
- References
- 50
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 10 · 2023: 23 · 2022: 17 · 2021: 23 · 2020: 27 · 2019: 40 · 2018: 20 · 2017: 19 · 2016: 23 · 2015: 27 · 2014: 18 · 2013: 20 · 2012: 25
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust (WT080470)
- National Institute for Health and Care Research (G0601104)
- National Cancer Institute (1K08CA90438, R01CA059998, K08CA090438)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Sprouty1, satellite cells, skeletal muscle stem cells, Pax7, quiescence, self-renewal, muscle regeneration, muscle damage, cell cycle re-entry, receptor tyrosine kinase signaling, tissue repair, stem cell homeostasis
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Homeostasis, Membrane Proteins, Mice, Transgenic, Phosphoproteins, Regeneration, Apoptosis, Cell Lineage, Satellite Cells, Skeletal Muscle, Adaptor Proteins, Signal Transducing, Mice, PAX7 Transcription Factor, Adult Stem Cells, Cellular Reprogramming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
