The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
Abstract
Adiponectin is an anti-diabetic adipokine. Its receptors possess a seven-transmembrane topology with the amino terminus located intracellularly, which is the opposite of G-protein-coupled receptors. Here we provide evidence that adiponectin induces extracellular Ca(2+) influx by adiponectin receptor 1 (AdipoR1), which was necessary for subsequent activation of Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbeta), AMPK and SIRT1, increased expression and decreased acetylation of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), and increased mitochondria in myocytes. Moreover, muscle-specific disruption of AdipoR1 suppressed the adiponectin-mediated increase in intracellular Ca(2+) concentration, and decreased the activation of CaMKK, AMPK and SIRT1 by adiponectin. Suppression of AdipoR1 also resulted in decreased PGC-1alpha expression and deacetylation, decreased mitochondrial content and enzymes, decreased oxidative type I myofibres, and decreased oxidative stress-detoxifying enzymes in skeletal muscle, which were associated with insulin resistance and decreased exercise endurance. Decreased levels of adiponectin and AdipoR1 in obesity may have causal roles in mitochondrial dysfunction and insulin resistance seen in diabetes.
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“Additionally, AMPK upregulates the expression of enzymes involved in reducing oxidative stress, particularly stress resulting from increased FAs”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [104]
In the citing paper
“AdipoR1 is tightly linked to activation of AMP-activated protein kinase (AMPK) pathways, while AdipoR2 seems to be associated with activation of peroxisome proliferator-activated receptor (PPAR)-α pathways [9,11].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [11]
In the citing paper
“In turn, PGC-1α increases the activity of several transcriptions factors (TF), thus stimulating the expression of target genes leading to an increase of mitochondrial biogenesis and a shift towards an oxidative metabolism [11] (Figure 2).”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [11]
In the citing paper
“Mice with muscle-specific disruption of AdipoR1 also exhibited a local decrease in oxidative-stress-detoxifying enzymes [11].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [11]
In the citing paper
“Likewise, mice with muscle-specific disruption of AdipoR1 exhibited decreased PGC-1α expression and activity, decreased mitochondrial content and function, as well as decreased oxidative type 1 myofibers and oxidative-stress detoxifying enzymes. All these abnormalities were associated with decreased insulin sensitivity in muscle and reduced endurance capacity as assessed by treadmill running [11].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [11]
In the citing paper
“Upon phosphorylation, PGC-1α is recognized as a deacetylation target by SIRT1 (Canto & Auwerx, 2009; Iwabu et al, 2010).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Iwabu et al, 2010
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Cites
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
Self-citationWu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799
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Iwabu, M., Okada‐Iwabu, M., Yamauchi, T., & Kadowaki, T. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00116 · Cited by 79
FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway
Deng, K., Fan, Y., Liang, Y., Cai, Y., Zhang, G., Deng, M., Wang, Z., Lu, J., Shi, J., Wang, F., et al. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.06.013 · Cited by 77
A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism
Shahgaldi, S., & Kahmini, F. R. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119803 · Cited by 81
Chen, Y., Lin, Y., Lin, J., Yang, N., & Chen, M. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700903 · Cited by 77
Fu, Z., Lofqvist, C. A., Shao, Z., Sun, Y., Joyal, J.-S., Hurst, C. G., Cui, R. Z., Evans, L. P., Tian, K., SanGiovanni, J. P., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.099291 · Cited by 76
Ahmad, A., Ali, T., Kim, M. W., Khan, A., Jo, M. H., Rehman, S. U., Khan, M. S., Abid, N. B., Khan, M., Ullah, R., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2018.10.004 · Cited by 76
Hansen, S., Svendsen, P., Jeppesen, J., Høeg, L. D., Andersen, N. R., Kristensen, J. M., Nilas, L., Lundsgaard, A., Wojtaszewski, J., Madsbad, S., et al. (2018) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2018-01771 · Cited by 69
From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions
Lee, T. H.-Y., & Yau, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010201 · Cited by 78
Wang, X., Feng, S., Wang, Z., Chen, N., & Zhang, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105433 · Cited by 76
Obesity, Inflammation, and Lung Injury (OILI): The Good
Wang, C. (2014) · Mediators of Inflammation · doi:10.1155/2014/978463 · Cited by 78
The multimerization and secretion of adiponectin are regulated by TNF-alpha
He, Y., Lu, L., Wei, X., Jin, D., Qian, T., An, Y., Sun, J., Cui, J., & Yang, Z. (2015) · Endocrine · doi:10.1007/s12020-015-0741-4 · Cited by 77
Adiponectin and Its Isoforms in Pathophysiology
van Andel, M., Heijboer, A. C., & Drent, M. L. (2018) · Advances in clinical chemistry · doi:10.1016/bs.acc.2018.02.007 · Cited by 80
Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis
Zhou, B., Luo, Y., Ji, N., Hu, C., & Lu, Y. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00627-4 · Cited by 75
A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism
Thind, M. K., Uhlig, H. H., Glogauer, M., Palaniyar, N., Bourdon, C., Gwela, A., Lancioni, C., Berkley, J. A., Bandsma, R., & Farooqui, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1334205 · Cited by 78
Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72
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Sobrevía, L., Valero, P., Grismaldo, A., Villalobos-Labra, R., Pardo, F., Subiabre, M., Armstrong, G. A., Toledo, F., Vega, S., Cornejo, M., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165948 · Cited by 75
Lv, J., Li, Y., Shi, S., Xu, X., Wu, H., Zhang, B., & Song, Q. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113833 · Cited by 74
Factors Determining Insulin Resistance in Chronic Hemodialysis Patients
Hung, A. M., & Ikizler, T. A. (2011) · Contributions to nephrology · doi:10.1159/000327177 · Cited by 72
Khan, M. P., Singh, A. K., Joharapurkar, A. A., Yadav, M., Shree, S., Kumar, H., Gurjar, A. A., Mishra, J. S., Tiwari, M. C., Nagar, G. K., et al. (2015) · Diabetes · doi:10.2337/db14-1611 · Cited by 73
An, H., Jang, Y., Choi, J.-I., Hur, J., Kim, S., & Kwon, Y. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.188 · Cited by 75
Almabouada, F., Díaz‐Ruiz, A., Rabanal‐Ruiz, Y., Peinado, J. R., Vázquez‐Martínez, R., & Malagón, M. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.404624 · Cited by 70
Kim, M. W., Abid, N. B., Jo, M. G., Jo, M. G., Yoon, G. H., & Kim, M. O. (2017) · Scientific Reports · doi:10.1038/s41598-017-12632-9 · Cited by 72
Liu, Y., Vu, V., & Sweeney, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00842 · Cited by 69
Ruiz, M., Ståhlman, M., Borén, J., & Pilon, M. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m092494 · Cited by 69
Role of Adiponectin in Cardiovascular Diseases Related to Glucose and Lipid Metabolism Disorders
Han, W., Yang, S., Xiao, H., Wang, M., Ye, J., Cao, L., & Sun, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415627 · Cited by 77
Adiponectin Deficit During the Precarious Glucose Economy of Early Lactation in Dairy Cows
Giesy, S. L., Yoon, B., Currie, W. B., Kim, J. W., & Boisclair, Y. R. (2012) · Endocrinology · doi:10.1210/en.2012-1765 · Cited by 75
Adipokines and Aging: Findings From Centenarians and the Very Old
Arai, Y., Kamide, K., & Hirose, N. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00142 · Cited by 71
Deepa, S. S., Zhou, L., Ryu, J., Wang, C., Mao, X., Cai, L., Zhang, N., Musi, N., DeFronzo, R. A., Liu, F., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0082 · Cited by 69
Koyanagi, M., Asahara, S., Matsuda, T., Hashimoto, N., Shigeyama, Y., Shibutani, Y., Kanno, A., Fuchita, M., Mikami, T., Hosooka, T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023238 · Cited by 69
Regulatory role of mitochondria in oxidative stress and atherosclerosis
Chang, J. (2010) · World Journal of Cardiology · doi:10.4330/wjc.v2.i6.150 · Cited by 71
Ren, Y., Li, Y., Yan, J., Ma, M., Zhou, D., Xue, Z., Zhang, Z., Liu, H., Yang, H., Jia, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03319-2 · Cited by 70
Lipodystrophy: A paradigm for understanding the consequences of "overloading" adipose tissue
Lim, K., Haider, A., Adams, C., Sleigh, A., & Savage, D. B. (2020) · Physiological Reviews · doi:10.1152/physrev.00032.2020 · Cited by 71
Role of mitochondria in pathogenesis and therapy of renal fibrosis
Zhao, X., Li, Y., Yu, J., Teng, H., Wu, S., Wang, Y., Zhou, H., & Li, F. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155913 · Cited by 71
Corbi, G., Bianco, A., Turchiarelli, V., Cellurale, M., Fatica, F., Daniele, A., Mazzarella, G., & Ferrara, N. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612696 · Cited by 68
Hung, A. M., Sundell, M. B., Egbert, P., Siew, E. D., Shintani, A., Ellis, C. D., Bian, A., & Ikizler, T. A. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.08070910 · Cited by 69
Tang, Y., Mi, C., Liu, J., Gao, F., & Long, J. (2013) · Cardiovascular Pathology · doi:10.1016/j.carpath.2013.11.002 · Cited by 70
Maruta, H., & Yamashita, H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239428 · Cited by 72
Piao, L., Zhao, G., Zhu, E., Inoue, A., Shibata, R., Lei, Y., Hu, L., Yu, C., Yang, G., Wu, H., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006421 · Cited by 65
Patel, S. A., Hoehn, K. L., Lawrence, R., Sawbridge, L., Talbot, N. A., Tomsig, J. L., Turner, N. A., Cooney, G. J., Whitehead, J. P., Kraegen, E. W., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1368 · Cited by 66
Heo, M.-G., & Choung, S. (2018) · Food & Function · doi:10.1039/c8fo00986d · Cited by 67
Kim, Y., Lim, J. H., Kim, E. N., Hong, Y. A., Park, H., Chung, S., Choi, B. S., Kim, Y., Park, J. Y., Kim, H. W., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04726-8 · Cited by 68
Tvarijonaviciute, A., Cerón, J., Holden, S., Morris, P., Biourge, V., & German, A. J. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2011.10.003 · Cited by 68
Tanaka, K., Wilson, R. M., Essick, E. E., Duffen, J., Scherer, P. E., Ouchi, N., & Sam, F. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001279 · Cited by 67
Sakurai, T., Ogasawara, J., Shirato, K., Izawa, T., Oh‐ishi, S., Ishibashi, Y., Radak, Z. O., Ohno, H., & Kizaki, T. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9410954 · Cited by 69
Distinctive Roles of Sirtuins on Diabetes, Protective or Detrimental?
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Cardiometabolic effects of adiponectin
Parker, J., & Walsh, K. X. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.09.001 · Cited by 64
Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases
Pan, Z., Dong, H., Huang, N., & Fang, J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.953078 · Cited by 67
Gu, X., Wang, L., Liu, S., & Shan, T. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155379 · Cited by 74
Vijayakumar, A., Wu, Y., Sun, H., Li, X., Jeddy, Z., Liu, C., Schwartz, G. J., Yakar, S., & LeRoith, D. (2011) · Diabetes · doi:10.2337/db11-0814 · Cited by 65
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Roy, B., & Palaniyandi, S. S. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00587-4 · Cited by 65
Adiponectin: friend or foe in obesity and inflammation
Luo, L., & Liu, M. (2022) · Medical Review · doi:10.1515/mr-2022-0002 · Cited by 71
Chen, Z., Zhang, L., Yi, J., Yang, Z., Zhang, Z., & Li, Z. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24232 · Cited by 64
Insulin-sensitizing properties of adiponectin
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Kadowaki, T., & Yamauchi, T. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.012 · Cited by 65
Shiota, A., Shimabukuro, M., Fukuda, D., Soeki, T., Sato, H., Uematsu, E., Hirata, Y., Kurobe, H., Maeda, N., Sakaue, H., et al. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-139 · Cited by 65
Suyama, S., Maekawa, F., Maejima, Y., Kubota, N., Kadowaki, T., & Yada, T. (2016) · Scientific Reports · doi:10.1038/srep30796 · Cited by 61
Protective role of mitoquinone against impaired mitochondrial homeostasis in metabolic syndrome
Yang, J., Suo, H., & Song, J. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1809344 · Cited by 65
MitoTimer: a novel protein for monitoring mitochondrial turnover in the heart
Gottlieb, R. A., & Stotland, A. B. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1230-6 · Cited by 66
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Svensson, E., Olsen, L. C. B., Mörck, C., Brackmann, C., Enejder, A. M. K., Færgeman, N. J., & Pilon, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021343 · Cited by 59
The effect of transcutaneous application of carbon dioxide (CO2) on skeletal muscle
Oe, K., Ueha, T., Sakai, Y., Niikura, T., Lee, S. Y., Koh, A., Hasegawa, T., Tanaka, M., Miwa, M., & Kurosaka, M. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.02.128 · Cited by 62
Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis
Little, J. P., Safdar, A., Benton, C. R., & Wright, D. C. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-076 · Cited by 62
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Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101829 · Cited by 62
Wang, M., Ma, H., Guan, S., Luo, T., Zhao, C., Cai, G., Zheng, Y., Jia, X., Di, J., Li, R., et al. (2021) · Food & Function · doi:10.1039/d1fo01495a · Cited by 63
Joven, J., Rull, A., Rodríguez‐Gallego, E., Camps, J., Riera-Borrull, M., Hernández‐Aguilera, A., Martín-Paredero, V., Segura‐Carretero, A., Micol, V., Alonso‐Villaverde, C., et al. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.10.004 · Cited by 65
Choi, Y. K., Kim, J.-H., Lee, D.-K., Lee, K.-S., Won, M., Jeoung, D., Lee, H., Ha, K., Kwon, Y., & Kim, Y. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6684 · Cited by 61
Bae, U., Park, J., Park, I. W., Chae, B. M., Oh, M., Jung, S., Ryu, G.-S., Chae, S., & Park, B. (2018) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x18500325 · Cited by 61
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Caselli, C., D’Amico, A., Cabiati, M., Prescimone, T., Ry, S. D., & Giannessi, D. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.03.003 · Cited by 61
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Castillo, Í. M. P., Argilés, J. M. A., Rueda, R., Ramírez, M., & Pedrosa, J. M. L. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09954-9 · Cited by 75
Multiparity leads to obesity and inflammation in mothers and obesity in male offspring
Rebholz, S. L., Jones, T., Burke, K. T., Jaeschke, A., Tso, P., D’Alessio, D. A., & Woollett, L. A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00487.2011 · Cited by 62
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Fu, Z., Löfqvist, C., Liegl, R. G.-H., Wang, Z., Sun, Y., Gong, Y. Q., Liu, C., Meng, S. S., Burnim, S. B., Arellano, I. A., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707966 · Cited by 60
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After the grape rush: Sirtuins as epigenetic drug targets in neurodegenerative disorders
Huber, K., & Superti‐Furga, G. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.01.018 · Cited by 60
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Gelsomino, L., Naimo, G. D., Catalano, S., Mauro, L., & Andò, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092127 · Cited by 60
McDonald, C. M., Ramírez‐Sánchez, I., Oskarsson, B., Joyce, N. C., Aguilar, C., Nicorici, A., Dayan, J. G., Goude, E., Abresch, R. T., Villarreal, F. J., et al. (2020) · Muscle & Nerve · doi:10.1002/mus.27108 · Cited by 56
Lian, B., Zhang, J., Yin, X. L., Wang, J., Li, L., Ju, Q., Wang, Y. J., Jiang, Y., Liu, X., Chen, Y., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101684 · Cited by 64
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Camerino, G. M., Cannone, M., Giustino, A., Massari, A. M., Capogrosso, R. F., Cozzoli, A., & Luca, A. D. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu287 · Cited by 59
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Chen, Y., Lian, C., Sun, Q.-W., Wang, T.-T., Liu, Y.-Y., Ye, J., Gao, L.-L., Yang, Y.-F., Liu, S., Shen, Z.-F., et al. (2022) · Antioxidants · doi:10.3390/antiox11050905 · Cited by 57
Wu, Y., Jia, C., Liu, W., Zhan, W., Chen, Y., Lu, J., Bao, Y., Wang, S., Yu, C., Zheng, L., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.033 · Cited by 55
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Metadata
- Authors
- Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., Ogata, H., Kubota, N., Takamoto, I., Hayashi, Y. K., Yamauchi, N., Waki, H., Fukayama, M., Nishino, I., Tokuyama, K., Ueki, K., Oike, Y., Ishii, S., Hirose, K., Shimizu, T., Touhara, K., & Kadowaki, T.
- Affiliations
- The University of Tokyo (JP)
- Kumamoto University (JP)
- University of Tsukuba (JP)
- National Center of Neurology and Psychiatry (JP)
- Corresponding author
- Yamauchi, Toshimasa
- Kadowaki, Takashi
- ORCID
- Venue
- Nature
- Published
- 2010-04
- Volume
- 464
- Issue
- 7293
- Pages
- 1313-1319
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1993132387
- Cited by
- 971
- References
- 46
- Citations by year
- 2026: 35 · 2025: 35 · 2024: 57 · 2023: 69 · 2022: 68 · 2021: 70 · 2020: 61 · 2019: 63 · 2018: 52 · 2017: 52 · 2016: 60 · 2015: 52 · 2014: 57 · 2013: 71 · 2012: 71
- FWCI
- 51.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (21680035, 20229008, 21390278, 22790244, 19002011)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- adiponectin, AdipoR1, PGC-1α, mitochondrial biogenesis, calcium signaling, CaMKKβ, AMPK, SIRT1, skeletal muscle, insulin resistance, type 2 diabetes, obesity, oxidative stress, exercise endurance, mitochondrial dysfunction, adipokine receptors
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Animals, Calcium, Cell Line, Glucose, Homeostasis, Insulin, Insulin Resistance, Mitochondria, Oocytes, Physical Conditioning, Animal, Transcription Factors, Xenopus laevis, Trans-Activators, Oxidative Stress, Muscle, Skeletal, Calcium Signaling, Muscle Cells, Mice, Adiponectin, Receptors, Adiponectin, Calcium-Calmodulin-Dependent Protein Kinase Kinase, AMP-Activated Protein Kinases, Sirtuin 1
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