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A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Open accessAbstract
Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF7)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein-Barr virus induced gene 2 (Ebi2, also known as Gpr183), which lies at this locus and controls B lymphocyte migration, is expressed in macrophages and regulates the IDIN. The human orthologous locus on chromosome 13q32 controlled the human equivalent of the IDIN, which was conserved in monocytes. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D)-a macrophage-associated autoimmune disease-than randomly selected immune response genes (P = 8.85 × 10(-6)). The human locus controlling the IDIN was associated with the risk of T1D at single nucleotide polymorphism rs9585056 (P = 7.0 × 10(-10); odds ratio, 1.15), which was one of five single nucleotide polymorphisms in this region associated with EBI2 (GPR183) expression. These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D.
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“Such integration of genetic information with network modeling has been used to highlight pathways that contribute to disease and to identify “key drivers” in biologic processes [72–74, 78].”
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationIRF-7 is the master regulator of type-I interferon-dependent immune responses
Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N., Ohba, Y., Takaoka, A., Yoshida, N., et al. (2005) · Nature · doi:10.1038/nature03464 · Cited by 2,229
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746
Self-citationGenetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452
Genetic Dissection of Transcriptional Regulation in Budding Yeast
Brem, R. B., Yvert, G., Clinton, R., & Kruglyak, L. (2002) · Science · doi:10.1126/science.1069516 · Cited by 1,392
Kawai, T., Sato, S., Ishii, K. J., Coban, C., Hemmi, H., Yamamoto, M., Terai, K., Matsuda, M., Inoue, J., Uematsu, S., et al. (2004) · Nature Immunology · doi:10.1038/ni1118 · Cited by 1,058
The role of inflammation in insulitis and β-cell loss in type 1 diabetes
Eizirik, D. L., Colli, M. L., & Ortis, F. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.21 · Cited by 1,011
Rare Variants of IFIH1 , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
Nejentsev, S., Walker, N., Riches, D., Egholm, M., & Todd, J. A. (2009) · Science · doi:10.1126/science.1167728 · Cited by 958
Self-citationVariations in DNA elucidate molecular networks that cause disease
Chen, Y., Zhu, J., Lum, P. Y., Yang, X., Pinto, S., MacNeil, D. J., Zhang, C., Lamb, J., Edwards, S., Sieberts, S. K., et al. (2008) · Nature · doi:10.1038/nature06757 · Cited by 887
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Hasin, Y., Seldin, M., & Lusis, A. (2017) · Genome Biology · doi:10.1186/s13059-017-1215-1 · Cited by 2,953
Systematic identification of trans eQTLs as putative drivers of known disease associations
Westra, H.-J., Peters, M. J., Esko, T., Yaghootkar, H., Schurmann, C., Kettunen, J., Christiansen, M. W., Fairfax, B. P., Schramm, K., Powell, J. E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2756 · Cited by 1,658
Self-citationThe role of regulatory variation in complex traits and disease
Albert, F. W., & Kruglyak, L. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3891 · Cited by 1,047
Bentham, J., Morris, D. L., Graham, D. S. C., Pinder, C. L., Tombleson, P., Behrens, T. W., Martin, J. J., Fairfax, B. P., Knight, J. C., Chen, L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3434 · Cited by 1,004
DNA methylation and body-mass index: a genome-wide analysis
Dick, K. J., Nelson, C. P., Tsaprouni, L., Sandling, J. K., Aïssi, D., Wahl, S., Meduri, E., Morange, P.-E., Gagnon, F., Grallert, H., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62674-4 · Cited by 778
Self-citationMapping cis- and trans-regulatory effects across multiple tissues in twins
The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Grundberg, E., Small, K. S., Hedman, Å. K., Nica, A. C., Buil, A., Keildson, S., Bell, J. T., Yang, T.-P., Meduri, E., et al. (2012) · Nature Genetics · doi:10.1038/ng.2394 · Cited by 729
Önengüt-Gümüşcü, S., Chen, W., Burren, O. S., Cooper, N. J., Quinlan, A. R., Mychaleckyj, J. C., Farber, E., Bonnie, J. K., Szpak, M., Schofield, E. C., et al. (2015) · Nature Genetics · doi:10.1038/ng.3245 · Cited by 694
Self-citationSystems genetics approaches to understand complex traits
Civelek, M., & Lusis, A. J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3575 · Cited by 621
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Ning, S., Pagano, J. S., & Barber, G. N. (2011) · Genes and Immunity · doi:10.1038/gene.2011.21 · Cited by 611
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Hannedouche, S., Zhang, J., Yi, T., Shen, W., Nguyen, D. G., Pereira, J. P., Guerini, D., Baumgarten, B. U., Roggo, S. P., Wen, B. G., et al. (2011) · Nature · doi:10.1038/nature10280 · Cited by 509
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Self-citationVillard, E., Perret, C., Gary, F., Proust, C., Dilanian, G., Hengstenberg, C., Ruppert, V., Arbustini, E., Wichter, T., Germain, M., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr105 · Cited by 349
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Bradfield, J. P., Qu, H., Wang, K., Zhang, H., Abou‐Sleiman, P. M., Kim, C. E., Mentch, F. D., Qiu, H., Glessner, J., Thomas, K., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002293 · Cited by 348
Ferreira, R. C., Guo, H., Coulson, R., Smyth, D. J., Pękalski, M. Ł., Burren, O. S., Cutler, A. J., Doecke, J. D., Flint, S. M., McKinney, E. F., et al. (2014) · Diabetes · doi:10.2337/db13-1777 · Cited by 323
Self-citationFast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics
Lamparter, D., Marbach, D., Rueedi, R., Kutalik, Z., & Bergmann, S. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004714 · Cited by 319
Viral infections in type 1 diabetes mellitus — why the β cells?
Op de Beeck, A., & Eizirik, D. L. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.30 · Cited by 291
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Wild, P. S., Zeller, T., Beutel, M. E., Blettner, M., Dugi, K. A., Lackner, K. J., Pfeiffer, N., Münzel, T. F., & Blankenberg, S. (2012) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-012-1502-7 · Cited by 240
Self-citationUnderstanding type 1 diabetes through genetics: advances and prospects
Polychronakos, C., & Li, Q. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3069 · Cited by 226
Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome
Charchar, F. J., Bloomer, L. D. S., Barnes, T. A., Cowley, M. J., Nelson, C. P., Wang, Y., Denniff, M. J., Dębiec, R., Christofidou, P., Nankervis, S. A., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61453-0 · Cited by 216
Self-citationMetagenomics and Personalized Medicine
Virgin, H. W., & Todd, J. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.009 · Cited by 205
Self-citationKallionpää, H., Elo, L. L., Laajala, E., Mykkänen, J., Ricaño-Ponce, I., Vaarma, M., Laajala, T. D., Hyöty, H., Ilonen, J., Veijola, R., et al. (2014) · Diabetes · doi:10.2337/db13-1775 · Cited by 187
Genetics of trans-regulatory variation in gene expression
Albert, F. W., Bloom, J. S., Siegel, J. J., Day, L., & Kruglyak, L. (2018) · eLife · doi:10.7554/elife.35471 · Cited by 186
Johnson, M. R., Behmoaras, J. V., Bottolo, L., Krishnan, M. L., Pernhorst, K., Santoscoy, P. L. M., Rossetti, T., Speed, D., Srivastava, P. K., Chadeau‐Hyam, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7031 · Cited by 179
Self-citationFrom genome to function by studying eQTLs
Westra, H.-J., & Franke, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.024 · Cited by 174
Atanur, S. S., Diaz, A. I. G., Maratou, K., Sarkis, A. B., Rotival, M., Gamé, L., Tschannen, M., Kaisaki, P. J., Otto, G., Ma, M. C. J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.040 · Cited by 160
Self-citationEndonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function
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Cooper, J. D., Simmonds, M. J., Walker, N. M., Burren, O. S., Brand, O. J., Guo, H., Wallace, C., Stevens, H. E., Coleman, G., Franklyn, J. A., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds357 · Cited by 149
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Shi, J., Marconett, C. N., Duan, J., Hyland, P. L., Li, P., Wang, Z., Wheeler, W., Zhou, B., Campan, M., Lee, D. S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4365 · Cited by 137
Rotival, M., Zeller, T., Wild, P. S., Maouche, S., Szymczak, S., Schillert, A., Castagné, R., Deiseroth, A., Proust, C., Brocheton, J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002367 · Cited by 140
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Low, T. Y., van Heesch, S., van den Toorn, H., Giansanti, P., Cristobal, A., Toonen, P. W., Schäfer, S., Hübner, N., van Breukelen, B., Mohammed, S., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.041 · Cited by 127
Kelly, L. M., Pereira, J. P., Yi, T., Xu, Y., & Cyster, J. G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101262 · Cited by 125
Self-citationHuang, J., Sabater‐Lleal, M., Asselbergs, F. W., Trégouët, D., Shin, S., Ding, J., Baumert, J., Oudot‐Mellakh, T., Folkersen, L., Johnson, A. D., et al. (2012) · Blood · doi:10.1182/blood-2012-06-436188 · Cited by 124
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Carrero, J. A., Calderón, B., Towfic, F., Artyomov, M. N., & Unanue, E. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059701 · Cited by 119
Davison, L. J., Wallace, C., Cooper, J. D., Cope, N. F., Wilson, N. K., Smyth, D. J., Howson, J. M. M., Saleh, N. M., Aljeffery, A., Angus, K. L., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr468 · Cited by 107
Self-citationZhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., & Liu, F. (2015) · Cell Research · doi:10.1038/cr.2015.109 · Cited by 107
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Hosp, F., Voßfeldt, H., Heinig, M., Vasiljević, D., Arumughan, A., Wyler, E., Landthaler, M., Hübner, N., Wanker, E. E., Lannfelt, L., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.030 · Cited by 106
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Liquet, B., Bottolo, L., Campanella, G., Richardson, S. T., & Chadeau‐Hyam, M. (2016) · Journal of Statistical Software · doi:10.18637/jss.v069.i02 · Cited by 84
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Schurmann, C., Heim, K., Schillert, A., Blankenberg, S., Carstensen, M., Dörr, M., Endlich, K., Felix, S. B., Gieger, C., Grallert, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050938 · Cited by 80
Self-citationSantín, I., Moore, F., Grieco, F. A., Marchetti, P., Brancolini, C., & Eizirik, D. L. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.158 · Cited by 80
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Zeller, T., Blankenberg, S., & Diemert, P. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.170431 · Cited by 78
Self-citationPoitou, C., Perret, C., Mathieu, F., Trương, V., Blum, Y., Durand, H., Alili, R., Chelghoum, N., Pelloux, V., Aron‐Wisnewsky, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125718 · Cited by 77
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Frejo, L., Requena, T., Okawa, S., Gallego‐Martinez, A., Martínez‐Bueno, M., Arán, I., Caletrío, Á. B., Benitez-Rosario, J., Espinosa-Sánchez, J. M., Fraile, J. J., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01739 · Cited by 76
Bloomer, L. D. S., Nelson, C. P., Eales, J., Denniff, M., Christofidou, P., Debiec, R., Moore, J., Consortium, C., Zukowska-Szczechowska, E., Goodall, A. H., et al. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.113.301608 · Cited by 75
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Chen, H., Moreno‐Moral, A., Pesce, F., Devapragash, N., Mancini, M., Heng, E. L., Rotival, M., Srivastava, P. K., Harmston, N., Shkura, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11551-9 · Cited by 76
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Aitman, T. J., Boone, C. M., Churchill, G. A., Hengartner, M. O., Mackay, T. F. C., & Stemple, D. L. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3047 · Cited by 80
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Uusküla-Reimand, L., Männik, J., Rull, K., Minajeva, A., Kõks, S., Vaas, P., Teesalu, P., Reimand, J., & Laan, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049248 · Cited by 81
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Amit, I., Regev, A., & Hacohen, N. (2011) · Nature reviews. Immunology · doi:10.1038/nri3109 · Cited by 74
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Heyne, H. O., Lautenschläger, S., Nelson, R., Besnier, F., Rotival, M., Cagan, A., Kozhemyakina, R., Plyusnina, I. Z., Trut, L., Carlborg, Ö., et al. (2014) · Genetics · doi:10.1534/genetics.114.168948 · Cited by 72
Self-citationHeinig, M., Adriaens, M. E., Schäfer, S., van Deutekom, H. W. M., Lodder, E. M., Ware, J. S., Schneider-Lunitz, V., Felkin, L. E., Creemers, E. E., Meder, B., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1286-z · Cited by 74
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Bottolo, L., Petretto, E. G., Blankenberg, S., Cambien, F., Cook, S. A., Tiret, L., & Richardson, S. T. (2011) · Genetics · doi:10.1534/genetics.111.131425 · Cited by 71
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Moss, C. E., Johnston, S. A., Kimble, J. V., Clements, M., Codd, V., Hamby, S. E., Goodall, A. H., Deshmukh, S., Sudbery, I. M., Coca, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114073 · Cited by 77
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Willinger, T. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12855 · Cited by 73
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Heard, É., Tishkoff, S. A., Todd, J. A., Vidal, M., Wagner, G. P., Wang, J., Weigel, D., & Young, R. A. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2878 · Cited by 71
Self-citationSenatus, L. M., López‐Díez, R., Egaña-Gorroño, L., Liu, J., Hu, J., Daffu, G. K., Li, Q., Rahman, K., Vengrenyuk, Y., Barrett, T. J., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.137289 · Cited by 70
Nevius, E., Pinho, F. O., Dhodapkar, M. M., Jin, H., Nadrah, K., Horowitz, M. C., Kikuta, J., Ishii, M., & Pereira, J. P. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150088 · Cited by 68
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Metadata
- Authors
- Cardiogenics Consortium, Heinig, M., Petretto, E., Wallace, C., Bottolo, L., Rotival, M., Lu, H., Li, Y., Sarwar, R., Langley, S. R., Bauerfeind, A., Hummel, O., Lee, Y.-A., Paskas, S., Rintisch, C., Saar, K., Cooper, J., Buchan, R., Gray, E. E., Cyster, J. G., Erdmann, J., Hengstenberg, C., Maouche, S., Ouwehand, W. H., Rice, C. M., Samani, N. J., Schunkert, H., Goodall, A. H., Schulz, H., Roider, H. G., Vingron, M., Blankenberg, S., Münzel, T., Zeller, T., Szymczak, S., Ziegler, A., Tiret, L., Smyth, D. J., Pravenec, M., Aitman, T. J., Cambien, F., Clayton, D., Todd, J. A., Hubner, N., & Cook, S. A.
- Affiliations
- Max Delbrück Center (DE)
- Hammersmith Hospital (GB)
- University of Cambridge (GB)
- Inserm (FR)
- Howard Hughes Medical Institute (US)
- University of Lübeck (DE)
- University of Regensburg (DE)
- National Health Service (GB)
- Wellcome Sanger Institute (GB)
- University of Leicester (GB)
- Max Planck Institute for Molecular Genetics (DE)
- Johannes Gutenberg University Mainz (DE)
- University Hospital Schleswig-Holstein (DE)
- Czech Academy of Sciences (CZ)
- Corresponding author
- Cook, Stuart A.
- ORCID
- Heinig, Matthias
- Petretto, Enrico
- Wallace, Chris
- Bottolo, Leonardo
- Rotival, Maxime
- Sarwar, Rizwan
- Langley, Sarah R.
- Hummel, Oliver
- Lee, Young-Ae
- Saar, Kathrin
- Cooper, Jason
- Buchan, Rachel
- Gray, Elizabeth E.
- Cyster, Jason G.
- Erdmann, Jeanette
- Maouche, Seraya
- Ouwehand, Willem H.
- Samani, Nilesh J.
- Schunkert, Heribert
- Goodall, Alison H.
- Schulz, Herbert
- Roider, Helge G.
- Vingron, Martin
- Blankenberg, Stefan
- Münzel, Thomas
- Zeller, Tanja
- Szymczak, Silke
- Ziegler, Andreas
- Smyth, Deborah J.
- Pravenec, Michal
- Aitman, Timothy J.
- Clayton, David
- Todd, John A.
- Cook, Stuart A.
- Venue
- Nature
- Published
- 2010-09
- Volume
- 467
- Issue
- 7314
- Pages
- 460-464
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3657719
- OpenAlex
- W2166903146
- Cited by
- 283
- References
- 30
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 23 · 2020: 8 · 2019: 16 · 2018: 13 · 2017: 20 · 2016: 20 · 2015: 22 · 2014: 27 · 2013: 26 · 2012: 38
- FWCI
- 18.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- National University of Singapore (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- ASEP (submittedVersion, public-domain)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Site cant be reached (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Juvenile Diabetes Research Foundation International
- Wellcome Trust (FP7/2007–2013, 061858, 089989, 076113)
- University Hospitals of Leicester NHS Trust
- National Institute for Health and Care Research (FP7/2007–2013, NF-SI-0508-10275)
- British Heart Foundation (P301/10/0290)
- Research Councils UK
- Imperial College London
- European Commission (2007–2013, LSHG-CT-2005-019015, FP7 2007-2013, LSHM-CT 2006–037593, FP7/2007, 241504)
- Fondation Leducq
- Grantová Agentura České Republiky (1M6837805002)
- Medical Research Council
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- type 1 diabetes, IRF7, EBI2, GPR183, macrophages, Epstein-Barr virus, monocytes, gene co-expression network, autoimmune disease susceptibility, systems genetics
- MeSH terms
- Animals, Base Sequence, Chromosomes, Human, Pair 13, Diabetes Mellitus, Type 1, Humans, Immunity, Innate, Inflammation, Macrophages, Organ Specificity, Viruses, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Chromosomes, Mammalian, Quantitative Trait Loci, Receptors, G-Protein-Coupled, Interferon Regulatory Factor-7, Rats, Gene Regulatory Networks, Genome-Wide Association Study, Genetic Loci
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