Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

In the citing paper

“Oxytocin induced LTD in nucleus accumbens medium spiny neurons (Figure 4b), as presynaptic oxytocin receptors on serotoninergic terminals lead to increased serotonin release onto medium spiny neurons and consequent LTD”

In the citing paper

“Dölen et al. (2013) observed PVN oxytocin fibers innervating mouse nucleus accumbens, where oxytocin release was important for social-conditioned place preference and serotonin-dependent long-term depression (LTD).”

In the citing paper

“Specifically, research has demonstrated that VTA dopaminergic neurons become activated in rodents engaged in conspecific interactions, and increased activity in these neurons promotes social reinforcement learning (Bariselli et al., 2018; D ¨ olen et al., 2013; Soli ´ e et al., 2022).”

In the citing paper

“Specifically, research has demonstrated that VTA dopaminergic neurons become activated in rodents engaged in conspecific interactions, and increased activity in these neurons promotes social reinforcement learning (Bariselli et al., 2018; D ¨ olen et al., 2013; Soli ´ e et al., 2022).”

In the citing paper

“In mice, formation of social reward requires coordinated activity of oxytocin and serotonin within the NAcc (Dölen et al., 2013).”

In the citing paper

“Recent research in mice has now shown that OT works in concert with the serotonin system in the NAcc of mice to modulate the rewarding aspects of social interaction (25).”

In the citing paper

“OXTR affects a range of social behaviors in animals including maternal nurturing and bonding (1, 2), social reward and gregariousness (3, 4), social recognition (5), and pair bonding in monogamous species (6–8).”

In the citing paper

“Preclinical studies have found that the neuropeptide, oxytocin, may regulate socialemotional functioning (Dölen et al., 2013;Hicks et al., 2012;Lim and Young, 2006;Lukas et al., 2011;Onaka et al., 2012).”

In the citing paper

“Social interactions can be rewarding and thereby recruit components of the brain’s reward circuitry, including the ventral tegmental area (VTA) dopamine (DA) neurons and the nucleus accumbens (NAc) (Dölen et al., 2013, Gunaydin et al., 2014, Robinson et al., 2002).”

In the citing paper

“In mice, both pharmacologic blockade and molecular ablation of presynaptic OXT receptors in the NAc impaired social reward processing, as assayed by social CPP [41].”

In the citing paper

“More recently, modifications in the CPP assay have been made to expand its use to investigate the rewarding properties of prosocial interactions [40,41].”

In the citing paper

“Additional experimental manipulations suggested that OXT induces 5-HT release from dorsal raphe (DR) inputs in the NAc, which acts on presynaptic 5-HT1b receptors that are also required for social reward [41].”

In the citing paper

“This simple form of 5-HT1b receptor-triggered synaptic plasticity was subsequently found to be generated by bath application of OXT or MDMA [41,51], results consistent with the 5-HT releasing properties of these agents.”

In the citing paper

“Oxytocin promotes maternal nurturing and bonding, enhances social reward, and increases the salience of social stimuli.”

In the citing paper

“For example, Dölen et al (80), using elegant circuit manipulations, demonstrated that PVN OXT and DR serotonin projections to the nucleus accumbens (NAcc) are required for social reward in mice.”

In the citing paper

“Oxytocin mediates a broad spectrum of prosocial behaviors such as empathy, pair bonding, mating and social reward (Dölen et al., 2013; L. W. Hung et al., 2017; Insel and Young, 2001; Nakajima et al., 2014; Rogers-Carter et al., 2018).”

In the citing paper

“the nucleus accumbens (NAc), dorsal raphe nucleus (dRph), and ventral tegmental area (VTA) receive direct or indirect projections from hypothalamic OT neurons (Beier et al., 2015; Dölen et al., 2013; Hung et al., 2017; Nardou et al., 2019)”

In the citing paper

“The hippocampus projects back to basolateral amygdala and nucleus accumbens (NAc), where oxytocinergic, dopaminergic, and serotonergic innervation from the hypothalamic paraventricular nucleus, ventral tegmental area, and dorsal raphe nucleus, respectively, are necessary for social reward learning [21,22].”

In the citing paper

“Previously, we have shown that changes in locomotor activity are unlikely to account for differences in sCPP across a variety of experimental manipulations (Dölen et al., 2013; Nardou et al., 2019)”

In the citing paper

“Prior investigations in rodents and primates, for example, have provided evidence for the presence of neurons that encode information about other individuals, demonstrating changes in activity when the animals observe another’s appetitive or aversive experiences 1–11.”

In the citing paper

“Previous investigations have provided insight into how discrete aspects of another animal’s experience, such as receipt of reward, may be encoded by cells 1–7,9.”

In the citing paper

“The use of microdialysis to measure regionally-specific neuronal release of neuropeptides has provided important mechanistic insights into neuropeptide modulation in a variety of species and a host of social contexts, including maternal behavior, social recognition, social preference, social reward, social memory, and social buffering (Bosch and Neumann, 2012; Dölen et al., 2013; Dumais et al., 20”

In the citing paper

“In an elegant study, authors showed that mice form a preference for social bedding compared to the isolated bedding (Dolen et al. 2013).”

In the citing paper

“Moreover, mice treated with an OT antagonist within the NAcc did not form this preference.”

In the citing paper

“This neuropeptide is crucial in many aspects of social behavior, including affiliation6 and reward.7”

In the citing paper

“OT regulates neuronal activities in multiple neural circuits, such as sensory cortices (Marlin et al., 2015), nucleus accumbens (Dölen et al., 2013), and prefrontal cortex (Nakajima et al., 2014).”

In the citing paper

“Brain regions responding to naturally rewarding stimuli, including the ventral tegmental area (VTA) and the nucleus accumbens (NAc), are crucially involved in social behaviors (Dolen et al., 2013; Gunaydin et al., 2014; Huang and Hessler, 2008).”

In the citing paper

“There are also signs of support for the view that 5-HT and oxytocin interplay in the nucleus accumbens significantly mediate the rewarding aspects of social behavior (Dolen et al., 2013).”