Distribution of oxytocin in the brain of a eusocial rodent
Open accessAbstract
Naked mole-rats are highly social rodents that live in large colonies characterized by a rigid social and reproductive hierarchy. Only one female, the queen, breeds. Most colony members are non-reproductive subordinates that work cooperatively to rear the young and maintain an underground burrow system. Little is known about the neurobiological basis of the complex sociality exhibited by this species. The neuropeptide oxytocin (Oxt) modulates social bonding and other social behaviors in many vertebrates. Here we examined the distribution of Oxt immunoreactivity in the brains of male and female naked mole-rats. As in other species, the majority of Oxt-immunoreactive (Oxt-ir) cells were found in the paraventricular and supraoptic nuclei, with additional labeled cells scattered throughout the preoptic and anterior hypothalamic areas. Oxt-ir fibers were found traveling toward and through the median eminence, as well as in the tenia tecta, septum, and nucleus of the diagonal band of Broca. A moderate network of fibers covered the bed nucleus of the stria terminalis and preoptic area, and a particularly dense fiber innervation of the nucleus accumbens and substantia innominata was observed. In the brainstem, Oxt-ir fibers were found in the periaqueductal gray, locus coeruleus, parabrachial nucleus, nucleus of the solitary tract, and nucleus ambiguus. The high levels of Oxt immunoreactivity in the nucleus accumbens and preoptic area are intriguing, given the link in other rodents between Oxt signaling in these regions and maternal behavior. Although only the queen gives birth or nurses pups in a naked mole-rat colony, most individuals actively participate in pup care.
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A single study has shown that OT can increase autistic individuals' ability to recall emotion in a voice intonation task.
“In fact, a single study has shown that OT can increase autistic individuals' ability to recall emotion in a voice intonation task.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [110]
The Introduction describes oxytocin’s general role in social memory and says the study maps its distribution in the naked mole-rat brain. Neither the Introduction nor the retrieved Discussion passages address autistic individuals, emotion recall, or a voice-intonation task; searches for those terms found no supporting passage. Page numbers were not available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredPrior exposure to OT increased the learning ability to subsequent emotional tasks in autistic individuals.
“A more important finding of this study was that prior exposure to OT increased the learning ability to subsequent emotional tasks [110].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [110]
The Introduction (page unavailable) says the paper maps oxytocin distribution in naked mole-rat brains; the Methods describe immunostaining, not an emotional-learning task. Searches for prior oxytocin exposure, autistic individuals, and subsequent emotional tasks found no passage addressing the claimed effect. (LLM, conf=0.76)
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Abbreviations Used for Major Brain Regions
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Oxytocin and social neuroscience - sexually dimorphic OXTR neurons in mouse preoptic area
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- Authors
- Rosen, G. J., de Vries, G. J., Goldman, S. L., Goldman, B. D., & Forger, N. G.
- Affiliations
- University of Massachusetts Amherst (US)
- University of Connecticut (US)
- Corresponding author
- Forger, N.G.
- ORCID
- Forger, N.G.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 155
- Issue
- 3
- Pages
- 809-817
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2614305
- OpenAlex
- W2038970714
- Cited by
- 102
- References
- 71
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 19 · 2019: 8 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 4
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K02MH072825, K02MH001497)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- oxytocin, naked mole-rat, eusociality, social behavior, paraventricular nucleus, supraoptic nucleus, preoptic area, nucleus accumbens, substantia innominata, bed nucleus of the stria terminalis, median eminence, maternal behavior, pup care, social hierarchy
- MeSH terms
- Animals, Brain, Brain Mapping, Oxytocin, Mole Rats
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