Cited by 102Motor Control and AdaptationNeuroscience and Neuropharmacology ResearchRobotic Locomotion and Control

RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait

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Koch, Stephanie C., Del Barrio, Marta Garcia, Dalet, Antoine, Gatto, Graziana, Günther, Thomas, Zhang, Jingming, Seidler, Barbara, Saur, Dieter +2 more·2017·Neuron

Abstract

Animals depend on sensory feedback from mechanosensory afferents for the dynamic control of movement. This sensory feedback needs to be selectively modulated in a task- and context-dependent manner. Here, we show that inhibitory interneurons (INs) expressing the RORβ orphan nuclear receptor gate sensory feedback to the spinal motor system during walking and are required for the production of a fluid locomotor rhythm. Genetic manipulations that abrogate inhibitory RORβ IN function result in an ataxic gait characterized by exaggerated flexion movements and marked alterations to the step cycle. Inactivation of RORβ in inhibitory neurons leads to reduced presynaptic inhibition and changes to sensory-evoked reflexes, arguing that the RORβ inhibitory INs function to suppress the sensory transmission pathways that activate flexor motor reflexes and interfere with the ongoing locomotor program. VIDEO ABSTRACT.

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Crossref · 10.1016/j.neuron.2017.11.011

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  • The mid inhibitory cell types were grouped as one family comprising Inhib-15, Inhib-16, Inhib-17, Inhib-18, Inhib-19, Inhib-20, and Inhib-21, which expressed Slc6a5 (except Inhib-21) and Gad2, implicating these neurons in sensorimotor processing.

    “The mid inhibitory cell types were grouped as one family comprised of Inhib-15, Inhib-16, Inhib-17, Inhib-18, Inhib-19, Inhib-20, and Inhib-21, which expressed the glycinergic marker Slc6a5 (with the exception of Inhib-21) and also the gaba-ergic marker Gad2, implicating these neurons in sensorimotor processing84–86.”

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Authors
Koch, S. C., Del Barrio, M. G., Dalet, A., Gatto, G., Günther, T., Zhang, J., Seidler, B., Saur, D., Schüle, R., & Goulding, M.
Affiliations
  • Salk Institute for Biological Studies (US)
  • University of Freiburg (DE)
  • TUM Klinikum (DE)
  • German Cancer Research Center (DE)
Corresponding author
Goulding, Martyn
Venue
Neuron
Publisher
Elsevier BV
Published
2017-12
Volume
96
Issue
6
Pages
1419-1431.e5
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2771099696
Cited by
102
References
88
Citations by year
2026: 5 · 2025: 18 · 2024: 9 · 2023: 13 · 2022: 19 · 2021: 11 · 2020: 9 · 2019: 12 · 2018: 6
FWCI
4.24
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders
  • National Institutes of Health (NS080586, NS086372, NS90919)
  • European Union’s Seventh Framework Programme (624861 ADMIP)
  • EMBO Fellowship (ALTF 13-2015)
  • European Research Council (ERC AdGrant 322844)
  • Deutsche Forschungsgemeinschaft (SFB 992)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Physical Sciences › Engineering › Biomedical Engineering › Robotic Locomotion and Control
Keywords
RORβ, orphan nuclear receptor, sensory feedback, locomotion, gait, presynaptic inhibition, ataxia, locomotor rhythm
MeSH terms
Afferent Pathways, Animals, Animals, Newborn, Electric Stimulation, Glutamate Decarboxylase, Hip Joint, Interneurons, Locomotion, Luminescent Proteins, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Reflex, Sensory Thresholds, Spinal Cord, Walking, Muscle, Skeletal, GABA Agents, Glycine Plasma Membrane Transport Proteins, Mice, PAX2 Transcription Factor, Feedback, Sensory, Nuclear Receptor Subfamily 1, Group F, Member 2

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