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Cited by 46Neuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology StudiesNeurogenesis and neuroplasticity mechanisms

Adolescence and “Late Blooming” Synapses of the Prefrontal Cortex

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Delevich, Kristen, Thomas, A. Wren, Wilbrecht, Linda·2018·Cold Spring Harbor Symposia on Quantitative Biology
DOI 10.1101/sqb.2018.83.037507
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Abstract

The maturation of the prefrontal cortex (PFC) during adolescence is thought to be important for cognitive and affective development and mental health risk. Whereas many summaries of adolescent development have focused on dendritic spine pruning and gray matter thinning in the PFC during adolescence, we highlight recent rodent data from our laboratory and others to call attention to continued synapse formation and plasticity in the adolescent period in specific cell types and circuits. In particular, we highlight changes in inhibitory neurotransmission onto intratelencephalic (IT-type) projecting cortical neurons and late expansion of connectivity between the amygdala and PFC and the ventral tegmental area and PFC. Continued work on these "late blooming" synapses in specific cell types and circuits, and their interrelationships, will illuminate new opportunities for understanding and shaping the biology of adolescent development. We also address which aspects of adolescent PFC development are dependent on pubertal processes.

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Cited by

Sorted by citations

Authors
Delevich, K., Thomas, A. W., & Wilbrecht, L.
Affiliations
University of California, Berkeley (US)
ORCID
Venue
Cold Spring Harbor Symposia on Quantitative Biology
Publisher
Cold Spring Harbor Laboratory
Published
2018
Volume
83
Pages
37-43
ISSN
  • 0091-7451 (ISSN-L)
  • 1943-4456
DOI
10.1101/sqb.2018.83.037507
OpenAlex
W2912897320
Cited by
46
References
23
Citations by year
2026: 2 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 3 · 2019: 8 · 2018: 1
Type
posted content
Language
en
Open access
Licence
cc-by-nc
Locations
  • Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
prefrontal cortex maturation, adolescence, synaptogenesis, synaptic plasticity, intratelencephalic neurons, inhibitory neurotransmission, rodent models

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