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Neurons for hunger and thirst transmit a negative-valence teaching signal
Open accessAbstract
Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but motivational processes engaged by physiological need states are incompletely understood. We examined motivational characteristics of two separate neuron populations that regulate energy and fluid homeostasis by using cell-type-specific activity manipulations in mice. We found that starvation-sensitive AGRP neurons exhibit properties consistent with a negative-valence teaching signal. Mice avoided activation of AGRP neurons, indicating that AGRP neuron activity has negative valence. AGRP neuron inhibition conditioned preference for flavours and places. Correspondingly, deep-brain calcium imaging revealed that AGRP neuron activity rapidly reduced in response to food-related cues. Complementary experiments activating thirst-promoting neurons also conditioned avoidance. Therefore, these need-sensing neurons condition preference for environmental cues associated with nutrient or water ingestion, which is learned through reduction of negative-valence signals during restoration of homeostasis.
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“A potentially similar function has been described for arcuate nucleus AgRP neurons and nitric oxide synthase 1 (NOS1) neurons in the subfornical organ (SFO). These neurons show heightened activity during hunger (AgRP) and thirst (NOS1), their activity elicits an aversive state (place avoidance), and they are essential for driving feeding and drinking behaviors, respectively21,227.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [227]
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“However, AgRP activity is rapidly suppressed on sensory detection of food227,228,230, which, surprisingly, suggests that ongoing AgRP activity is dispensable for food consumption.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [227]
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“AgRP neurons are activated in a state of energy deficit228, and their optical stimulation can voraciously promote food consumption, but also elicits real-time place avoidance (indicative of an aversive state) in the absence of food173,227,229.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [227]
In the citing paper
“However, a mouse may subsequently avoid a flavor that was paired with the AgRP neuronal stimulation that made it eat, leading some authors to suggest that stimulated hunger is necessarily an aversive drive that the mouse later associates with the flavor (Betley et al., 2015).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Betley et al., 2015
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Cites
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Avants, B., Epstein, C. L., Grossman, M., & Gee, J. C. (2007) · Medical Image Analysis · doi:10.1016/j.media.2007.06.004 · Cited by 5,924
Skinner, B. F., & Hull, C. L. (1944) · The American Journal of Psychology · doi:10.2307/1416955 · Cited by 4,061
THE BIOLOGY OF HUMAN STARVATION
Keys, A., BROŽEK, J., & Henschel, A. (1951) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1951.tb56499.x · Cited by 2,135
The Biology of Human Starvation: Volume I
KEYS, A., BROŽEK, J., HENSCHEL, A., MICKELSEN, O., & TAYLOR, H. L. (1950) · doi:10.5749/j.ctv9b2tqv · Cited by 2,039
Stevens' Handbook of Experimental Psychology
Pashler, H. (2002) · Wiley eBooks · doi:10.1002/0471214426 · Cited by 1,713
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578
Cabanac, M. (1971) · Science · doi:10.1126/science.173.4002.1103 · Cited by 1,521
Two-process learning theory: Relationships between Pavlovian conditioning and instrumental learning.
Rescorla, R. A., & Solomon, R. L. (1967) · Psychological Review · doi:10.1037/h0024475 · Cited by 1,487
Conditioning and Associative Learning
Hill, W. F., & Mackintosh, N. J. (1984) · The American Journal of Psychology · doi:10.2307/1422540 · Cited by 1,304
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Roth, B. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.040 · Cited by 1,742
Yang, Y., Chen, H., Heidari, A. A., & Gandomi, A. H. (2021) · Expert Systems with Applications · doi:10.1016/j.eswa.2021.114864 · Cited by 1,084
A Neural Circuit for Gut-Induced Reward
Han, W., Téllez, L. A., Perkins, M. H., Pérez-Martínez, I. O., Qu, T., Ferreira, J. G. P., Ferreira, T. L., Quinn, D., Liu, Z.-W., Gao, X., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.049 · Cited by 772
Obesity Pathogenesis: An Endocrine Society Scientific Statement
Schwartz, M. W., Seeley, R. J., Zeltser, L. M., Drewnowski, A., Ravussin, E., Redman, L. M., & Leibel, R. L. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00111 · Cited by 727
Leptin and the endocrine control of energy balance
Friedman, J. M. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0095-y · Cited by 661
Genetically encoded indicators of neuronal activity
Lin, M. Z., & Schnitzer, M. J. (2016) · Nature Neuroscience · doi:10.1038/nn.4359 · Cited by 660
Toward a Wiring Diagram Understanding of Appetite Control
Andermann, M. L., & Lowell, B. B. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.014 · Cited by 633
Blaming the brain for obesity: integration of hedonic and homeostatic mechanisms
Berthoud, H.-R., Münzberg, H., & Morrison, C. D. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.050 · Cited by 445
Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding
Waterson, M. J., & Horváth, T. L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.026 · Cited by 453
Thirst-associated preoptic neurons encode an aversive motivational drive.
Allen, W. E., DeNardo, L. A., Chen, M. Z., Liu, C. D., Loh, K. M., Fenno, L. E., Ramakrishnan, C., Deisseroth, K., & Luo, L. (2017) · Science · doi:10.1126/science.aan6747 · Cited by 390
Leeners, B., Geary, N., Tobler, P. N., & Asarian, L. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmw045 · Cited by 407
Nieh, E. H., Vander Weele, C. M., Matthews, G. A., Presbrey, K. N., Wichmann, R., Leppla, C. A., Izadmehr, E. M., & Tye, K. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.035 · Cited by 387
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
Rossi, M. A., & Stuber, G. D. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.021 · Cited by 415
Thirst regulates motivated behavior through modulation of brainwide neural population dynamics
Allen, W. E., Chen, M. Z., Pichamoorthy, N., Tien, R. H., Pachitariu, M., Luo, L., & Deisseroth, K. A. (2019) · Science · doi:10.1126/science.aav3932 · Cited by 371
Melanocortin-4 receptor–regulated energy homeostasis
Krashes, M. J., Lowell, B. B., & Garfield, A. S. (2016) · Nature Neuroscience · doi:10.1038/nn.4202 · Cited by 372
“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346
Neural ensemble dynamics underlying a long-term associative memory
Grewe, B. F., Gründemann, J., Kitch, L. J., Lecoq, J. A., Parker, J. G., Marshall, J. D., Larkin, M. C., Jercog, P. E., Grenier, F., Li, J. Z., et al. (2017) · Nature · doi:10.1038/nature21682 · Cited by 351
Three Pillars for the Neural Control of Appetite
Sternson, S. M., & Eiselt, A.-K. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-104948 · Cited by 345
Self-citationResendez, S. L., Jennings, J. H., Ung, R. L., Namboodiri, V. M. K., Zhou, Z. C., Otis, J. M., Nomura, H., McHenry, J. A., Kosyk, O., & Stuber, G. D. (2016) · Nature Protocols · doi:10.1038/nprot.2016.021 · Cited by 326
Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism
García‐Cáceres, C., Balland, É., Prévot, V., Luquet, S. H., Woods, S. C., Koch, M., Horváth, T. L., Yi, C., Chowen, J. A., Verkhratsky, A., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0286-y · Cited by 343
The Homeostatic Force of Ghrelin
Yanagi, S., Sato, T., Kangawa, K., & Nakazato, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.008 · Cited by 332
Homeostatic circuits selectively gate food cue responses in insular cortex
Livneh, Y., Ramesh, R. N., Burgess, C. R., Levandowski, K. M., Madara, J. C., Fenselau, H., Goldey, G. J., Diaz, V. E., Jikomes, N., Resch, J. M., et al. (2017) · Nature · doi:10.1038/nature22375 · Cited by 316
Encoding of danger by parabrachial CGRP neurons
Campos, C., Bowen, A. J., Roman, C. W., & Palmiter, R. D. (2018) · Nature · doi:10.1038/nature25511 · Cited by 323
Hunger-Driven Motivational State Competition
Burnett, C. J., Li, C., Webber, E., Tsaousidou, E., Xue, S. Y., Brüning, J. C., & Krashes, M. J. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.032 · Cited by 305
Mandelblat-Cerf, Y., Ramesh, R. N., Burgess, C. R., Patella, P., Yang, Z., Lowell, B. B., & Andermann, M. L. (2015) · eLife · doi:10.7554/elife.07122 · Cited by 290
Thirst neurons anticipate the homeostatic consequences of eating and drinking
Zimmerman, C. A., Lin, Y.-C., Leib, D. E., Guo, L., Huey, E. L., Daly, G. E., Chen, Y., & Knight, Z. A. (2016) · Nature · doi:10.1038/nature18950 · Cited by 283
Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state
Padilla, S. L., Qiu, J., Soden, M. E., Sanz, E., Nestor, C. C., Barker, F. D., Quintana, A., Zweifel, L. S., Rønnekleiv, O. K., Kelly, M. J., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4274 · Cited by 285
Dynamics of Gut-Brain Communication Underlying Hunger
Beutler, L. R., Chen, Y., Ahn, J. S., Lin, Y.-C., Essner, R. A., & Knight, Z. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.043 · Cited by 289
Neural mechanisms of social homeostasis
Matthews, G. A., & Tye, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14016 · Cited by 273
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Jaïs, A., & Brüning, J. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab025 · Cited by 298
Evolving Concepts of Emotion and Motivation
Berridge, K. C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01647 · Cited by 273
AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue
Steculorum, S. M., Ruud, J., Karakasilioti, I., Backes, H., Engström, L., Timper, K., Hess, M. E., Tsaousidou, E., Mauer, J., Vogt, M. C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.044 · Cited by 293
Allostasis: A brain-centered, predictive mode of physiological regulation
Schulkin, J., & Sterling, P. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.07.010 · Cited by 265
The melanocortin pathway and control of appetite-progress and therapeutic implications
Baldini, G., & Phelan, K. D. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0596 · Cited by 300
Parabrachial CGRP Neurons Control Meal Termination
Campos, C. A., Bowen, A. J., Schwartz, M. W., & Palmiter, R. D. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.006 · Cited by 262
Neural circuits underlying thirst and fluid homeostasis
Zimmerman, C. A., Leib, D. E., & Knight, Z. A. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.71 · Cited by 268
Central amygdala circuits modulate food consumption through a positive-valence mechanism
Douglass, A. M., Kucukdereli, H., Ponserre, M., Marković, M., Gründemann, J., Strobel, C., Morales, P. L. A., Conzelmann, K., Lüthi, A., & Klein, R. (2017) · Nature Neuroscience · doi:10.1038/nn.4623 · Cited by 264
Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss
Henry, F. E., Sugino, K., Tozer, A., Branco, T., & Sternson, S. M. (2015) · eLife · doi:10.7554/elife.09800 · Cited by 249
Self-citationThe melanocortin pathway and energy homeostasis: From discovery to obesity therapy
Yeo, G. S. H., Chao, D. H. M., Siegert, A., Koerperich, Z. M., Ericson, M. D., Simonds, S. E., Larson, C. M., Luquet, S. H., Clarke, I. J., Sharma, S. D., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101206 · Cited by 254
Estimation of Current and Future Physiological States in Insular Cortex
Livneh, Y., Sugden, A. U., Madara, J. C., Essner, R. A., Flores, V. I., Sugden, L. A., Resch, J. M., Lowell, B. B., & Andermann, M. L. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.027 · Cited by 209
The emergence and influence of internal states
Flavell, S. W., Gogolla, N., Lovett-Barron, M., & Zelikowsky, M. (2022) · Neuron · doi:10.1016/j.neuron.2022.04.030 · Cited by 246
Dynamic GABAergic afferent modulation of AgRP neurons
Garfield, A. S., Shah, B. P., Burgess, C. R., Li, M. M., Li, C., Steger, J. S., Madara, J. C., Campbell, J. N., Kroeger, D., Scammell, T. E., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4392 · Cited by 211
Amygdala ensembles encode behavioral states
Gründemann, J., Bitterman, Y., Lu, T., Krabbe, S., Grewe, B. F., Schnitzer, M. J., & Lüthi, A. (2019) · Science · doi:10.1126/science.aav8736 · Cited by 234
A Neural Circuit for the Suppression of Pain by a Competing Need State
Alhadeff, A. L., Su, Z., Hernandez, E., Klima, M. L., Phillips, S. Z., Holland, R. A., Guo, C., Hantman, A. W., De Jonghe, B. C., & Betley, J. N. (2018) · Cell · doi:10.1016/j.cell.2018.02.057 · Cited by 218
Self-citationOLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin
Li, E., Shan, H., Chen, L., Long, A., Zhang, Y., Liu, Y., Jia, L., Wei, F., Han, J., Li, T., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.022 · Cited by 223
Integrative neurocircuits that control metabolism and food intake
Brüning, J. C., & Fenselau, H. (2023) · Science · doi:10.1126/science.abl7398 · Cited by 214
Nutritive, Post-ingestive Signals Are the Primary Regulators of AgRP Neuron Activity
Su, Z., Alhadeff, A. L., & Betley, J. N. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.036 · Cited by 216
Self-citationHomeostasis Meets Motivation in the Battle to Control Food Intake
Ferrario, C. R., Labouèbe, G., Liu, S., Nieh, E. H., Routh, V. H., Xu, S., & O’Connor, E. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2338-16.2016 · Cited by 227
Self-citationHypothalamic Circuits for Predation and Evasion
Li, Y., Zeng, J., Zhang, J.-E., Yue, C., Zhong, W., Liu, Z., Feng, Q., & Luo, M. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.005 · Cited by 220
Li, M. M., Madara, J. C., Steger, J. S., Krashes, M. J., Balthasar, N., Campbell, J. N., Resch, J. M., Conley, N. J., Garfield, A. S., & Lowell, B. B. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.028 · Cited by 195
Hunger neurons drive feeding through a sustained, positive reinforcement signal.
Chen, Y., Lin, Y.-C., Zimmerman, C. A., Essner, R. A., & Knight, Z. A. (2016) · eLife · doi:10.7554/elife.18640 · Cited by 196
The timing of action determines reward prediction signals in identified midbrain dopamine neurons
Coddington, L. T., & Dudman, J. T. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0245-7 · Cited by 208
Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles
Xu, S., Yang, H., Menon, V., Lemire, A. L., Wang, L., Henry, F. E., Turaga, S. C., & Sternson, S. M. (2020) · Science · doi:10.1126/science.abb2494 · Cited by 201
Self-citationDREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo
Thompson, K. J., Khajehali, E., Bradley, S. J., Navarrete, J. S., Huang, X., Slocum, S. T., Jin, J. J., Liu, J., Xiong, Y., Olsen, R. H. J., et al. (2018) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.8b00012 · Cited by 200
The Sense of Smell Impacts Metabolic Health and Obesity
Riera, C. E., Tsaousidou, E., Halloran, J., Follett, P., Hahn, O., Pereira, M. M. A., Ruud, L. E., Alber, J., Tharp, K., Anderson, C. M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.015 · Cited by 191
POMC neuronal heterogeneity in energy balance and beyond: an integrated view
Quarta, C., Claret, M., Zeltser, L. M., Williams, K. W., Yeo, G. S. H., Tschöp, M. H., Diano, S., Brüning, J. C., & Cota, D. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00345-3 · Cited by 194
High-fat food biases hypothalamic and mesolimbic expression of consummatory drives
Mazzone, C. M., Liang-Guallpa, J., Li, C., Wolcott, N. S., Boone, M. H., Southern, M., Kobzar, N. P., Salgado, I. D. A., Reddy, D., Sun, F., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0684-9 · Cited by 188
Zhao, Z., Chen, Z., Xiang, X., Hu, M., Xie, H., Jia, X., Cai, F., Cui, Y., Chen, Z., Qian, L., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0404-5 · Cited by 181
Hypothalamic detection of macronutrients via multiple gut-brain pathways
Goldstein, N., McKnight, A. D., Carty, J. R. E., Arnold, M., Betley, J. N., & Alhadeff, A. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.018 · Cited by 182
Self-citationA common neuroendocrine substrate for diverse general anesthetics and sleep
Jiang-Xie, L.-F., Yin, L., Zhao, S., Prevosto, V., Han, B.-X., Dzirasa, K., & Wang, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.033 · Cited by 173
Hierarchical neural architecture underlying thirst regulation
Augustine, V., Gökçe, S. K., Lee, S., Wang, B., Davidson, T. J., Reimann, F. M., Gribble, F. M., Deisseroth, K. A., Lois, C., & Oka, Y. (2018) · Nature · doi:10.1038/nature25488 · Cited by 169
A Taste Circuit that Regulates Ingestion by Integrating Food and Hunger Signals
Yapici, N., Cohn, R., Schusterreiter, C., Ruta, V., & Vosshall, L. B. (2016) · Cell · doi:10.1016/j.cell.2016.02.061 · Cited by 170
The physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168
Adaptive disinhibitory gating by VIP interneurons permits associative learning
Krabbe, S., Paradiso, E., d‘Aquin, S., Bitterman, Y., Courtin, J., Xu, C., Yonehara, K., Marković, M., Müller, C. R., Eichlisberger, T., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0508-y · Cited by 171
A Vagal-NTS Neural Pathway that Stimulates Feeding
Chen, J. W., Cheng, M., Wang, L. Y., Zhang, L., Xu, D., Cao, P., Wang, F., Herzog, H., Song, S., & Zhan, C. (2020) · Current Biology · doi:10.1016/j.cub.2020.07.084 · Cited by 171
Regulation of starvation-induced hyperactivity by insulin and glucagon signaling in adult Drosophila
Yu, Y., Huang, R., Ye, J., Zhang, V., Wu, C., Cheng, G., Jia, J., & Wang, L. (2016) · eLife · doi:10.7554/elife.15693 · Cited by 167
Self-citationFast and accurate sCMOS noise correction for fluorescence microscopy
Mandracchia, B., Hua, X., Guo, C., Son, J., Urner, T. M., & Jia, S. (2020) · Nature Communications · doi:10.1038/s41467-019-13841-8 · Cited by 162
An appetite for life: brain regulation of hunger and satiety
Heisler, L. K., & Lam, D. D. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.09.002 · Cited by 166
AgRP neurons: Regulators of feeding, energy expenditure, and behavior
Deem, J. D., Faber, C. L., & Morton, G. J. (2021) · FEBS Journal · doi:10.1111/febs.16176 · Cited by 171
Alcantara, I. C., Tapia, A. P. M., Aponte, Y., & Krashes, M. J. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00611-y · Cited by 155
NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways
Aklan, İ., Sayar, N., Yavuz, Y., Ateş, T., Çoban, İ., Alkan, F. K., Filiz, G., Topcu, I. C., Öncül, M., Dilsiz, P., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.016 · Cited by 160
MIN1PIPE: A Miniscope 1-Photon-Based Calcium Imaging Signal Extraction Pipeline
Lu, J., Li, C., Alvarado, J. S., Zhou, Z., Frӧhlich, F., MOONEY, R. D., & Wang, F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.062 · Cited by 158
Rapid, biphasic CRF neuronal responses encode positive and negative valence
Kim, J., Lee, S., Fang, Y., Shin, A., Park, S., Hashikawa, K., Bhat, S., Kim, D., Sohn, J., Lin, D., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0342-2 · Cited by 160
Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger
Augustine, V., Lee, S., & Oka, Y. (2020) · Cell · doi:10.1016/j.cell.2019.11.040 · Cited by 135
Reward Inhibits Paraventricular CRH Neurons to Relieve Stress
Yuan, Y., Wu, W., Chen, M., Cai, F., Fan, C., Shen, W., Sun, W., & Hu, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.02.048 · Cited by 151
An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding
Sweeney, P., & Yang, Y. (2015) · Nature Communications · doi:10.1038/ncomms10188 · Cited by 155
60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH
Anderson, E. J. P., Çakır, I., Carrington, S. J. S., Cone, R. D., Ghamari‐Langroudi, M., Gillyard, T. R., Gimenez, L. E., & Litt, M. J. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0014 · Cited by 158
Li, C., Navarrete, J. S., Liang-Guallpa, J., Lü, C., Funderburk, S. C., Chang, R. B., Liberles, S. D., Olson, D. P., & Krashes, M. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.016 · Cited by 147
Ventromedial Hypothalamus and the Generation of Aggression
Hashikawa, Y., Hashikawa, K., Falkner, A. L., & Lin, D. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00094 · Cited by 146
Reverse-translational identification of a cerebellar satiation network
Low, A. Y. T., Goldstein, N., Gaunt, J. R., Huang, K.-P., Zainolabidin, N., Yip, A. K. K., Carty, J. R. E., Choi, J. Y., Miller, A. M., Ho, H. S. T., et al. (2021) · Nature · doi:10.1038/s41586-021-04143-5 · Cited by 135
Self-citationNeural control of parental behaviors
Kohl, J., & Dulac, C. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.002 · Cited by 136
Alhadeff, A. L., Goldstein, N., Park, O., Klima, M. L., Vargas, A. P.-D., & Betley, J. N. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.050 · Cited by 133
Self-citationChemogenetic Tools for Causal Cellular and Neuronal Biology
Atasoy, D., & Sternson, S. M. (2017) · Physiological Reviews · doi:10.1152/physrev.00009.2017 · Cited by 137
Self-citationImaging large-scale cellular activity in spinal cord of freely behaving mice
Sekiguchi, K. J., Shekhtmeyster, P., Merten, K., Arena, A., Cook, D., Hoffman, E. A., Ngo, A., & Nimmerjahn, A. (2016) · Nature Communications · doi:10.1038/ncomms11450 · Cited by 134
Calcium imaging of sleep-wake related neuronal activity in the dorsal pons
Cox, J., Pinto, L., & Dan, Y. (2016) · Nature Communications · doi:10.1038/ncomms10763 · Cited by 133
Optogenetics: 10 years after ChR2 in neurons—views from the community
Adamantidis, A., Arber, S., Bains, J. S., Bamberg, E., Bonci, A., Buzsáki, G., Cardin, J. A., Costa, R. M., Dan, Y., Goda, Y., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4106 · Cited by 136
Self-citationXia, G., Han, Y., Meng, F., He, Y., Srisai, D., Farías, M., Dang, M., Palmiter, R. D., Xu, Y., & Wu, Q. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01053-w · Cited by 136
The neurobiology of parenting: A neural circuit perspective
Kohl, J., Autry, A. E., & Dulac, C. G. (2016) · BioEssays · doi:10.1002/bies.201600159 · Cited by 143
Homeostatic and non-homeostatic controls of feeding behavior: Distinct vs. common neural systems
Liu, C. M., & Kanoski, S. E. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.02.011 · Cited by 131
PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding
Jais, A., Paeger, L., Sotelo-Hitschfeld, T., Bremser, S., Prinzensteiner, M., Klemm, P., Mykytiuk, V., Widdershooven, P. J. M., Vesting, A. J., Grzelka, K., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.022 · Cited by 129
Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
Brandt, C., Nolte, H., Henschke, S., Engström, L., Awazawa, M., Morgan, D. A., Gabel, P., Sprenger, H., Hess, M. E., Günther, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.015 · Cited by 133
Essner, R. A., Smith, A. G., Jamnik, A. A., Ryba, A. R., Trutner, Z. D., & Carter, M. E. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0798-17.2017 · Cited by 132
The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement
Leib, D. E., Zimmerman, C. A., Poormoghaddam, A., Huey, E. L., Ahn, J. S., Lin, Y.-C., Tan, C. L., Chen, Y., & Knight, Z. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.041 · Cited by 128
A gut-to-brain signal of fluid osmolarity controls thirst satiation
Zimmerman, C. A., Huey, E. L., Ahn, J. S., Beutler, L. R., Tan, C. L., Kosar, S., Bai, L., Chen, Y., Corpuz, T. V., Madisen, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1066-x · Cited by 130
Sustained NPY signaling enables AgRP neurons to drive feeding
Chen, Y., Essner, R. A., Kosar, S., Miller, O. H., Lin, Y.-C., Mesgarzadeh, S., & Knight, Z. A. (2019) · eLife · doi:10.7554/elife.46348 · Cited by 128
The Neural Basis of Escape Behavior in Vertebrates
Branco, T., & Redgrave, P. (2020) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-100219-122527 · Cited by 134
The cellular mechanism for water detection in the mammalian taste system
Zocchi, D., Wennemuth, G., & Oka, Y. (2017) · Nature Neuroscience · doi:10.1038/nn.4575 · Cited by 127
Vagal sensory neurons and gut-brain signaling
Yu, C. D., Xu, Q. J., & Chang, R. B. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.03.006 · Cited by 135
Gotthardt, J. D., Verpeut, J. L., Yeomans, B. L., Yang, J., Yasrebi, A., Roepke, T. A., & Bello, N. T. (2015) · Endocrinology · doi:10.1210/en.2015-1622 · Cited by 125
An open source, wireless capable miniature microscope system
Liberti, W. A., Perkins, L. N., Leman, D. P., & Gardner, T. J. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa6806 · Cited by 123
Metadata
- Authors
- Betley, J. N., Xu, S., Cao, Z. F. H., Gong, R., Magnus, C. J., Yu, Y., & Sternson, S. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Sternson, Scott M.
- ORCID
- Venue
- Nature
- Published
- 2015-04-27
- Volume
- 521
- Issue
- 7551
- Pages
- 180-185
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4567040
- OpenAlex
- W2101995469
- Cited by
- 704
- References
- 49
- Citations by year
- 2026: 32 · 2025: 73 · 2024: 70 · 2023: 68 · 2022: 50 · 2021: 72 · 2020: 65 · 2019: 73 · 2018: 64 · 2017: 62 · 2016: 54 · 2015: 21
- FWCI
- 37.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- hunger, thirst, homeostasis, AgRP neurons, subfornical organ, negative valence, teaching signal, motivation in learning, avoidance conditioning, energy homeostasis, fluid homeostasis
- MeSH terms
- Animals, Cues, Dehydration, Drinking, Eating, Food, Food Preferences, Homeostasis, Hunger, Hypothalamus, Male, Neurons, Starvation, Thirst, Models, Animal, Mice, Agouti-Related Protein
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