Cited by 133Sleep and Wakefulness ResearchNeuroscience of respiration and sleepNeural dynamics and brain function

Calcium imaging of sleep-wake related neuronal activity in the dorsal pons

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Cox, Julia, Pinto, Lucas, Dan, Yang·2016·Nature Communications

Abstract

The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca(2+) imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max). Furthermore, the activity of glutamatergic neurons exhibits a medio-lateral spatial gradient, with medially located neurons more selectively active during REM sleep.

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  • Sleep is an emergent set of many physiologic processes under primarily neurobiological regulation that impact many physiologic systems.

    “Sleep represents an emergent set of many physiologic processes under primarily neurobiological regulation that impact many physiologic systems.”

    From Sleep, Health, and Society (2017) · cites this paper as [9]

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  1. Paxinos G. & Franklin K. B. J. The Mouse Brain in Stereotaxic Coordinates Academic Press (2008).

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Authors
Cox, J., Pinto, L., & Dan, Y.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Dan, Yang
Venue
Nature Communications
Published
2016-02-25
Volume
7
Issue
1
Pages
10763-10763
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2301439114
Cited by
133
References
37
Citations by year
2026: 5 · 2025: 20 · 2024: 8 · 2023: 15 · 2022: 6 · 2021: 15 · 2020: 11 · 2019: 18 · 2018: 18 · 2017: 14 · 2016: 3
FWCI
11.24
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Neurological Disorders and Stroke (F31NS084696)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
dorsal pons, REM sleep, sleep-wake transition, laterodorsal tegmental nucleus, glutamatergic neurons, GABAergic neurons, neuronal activity, calcium imaging
MeSH terms
Animals, Calcium, Electroencephalography, Electromyography, Image Processing, Computer-Assisted, Neurons, Sleep, Sleep, REM, Wakefulness, Cluster Analysis, Glutamic Acid, Microscopy, Fluorescence, Multiphoton, Mice, GABAergic Neurons, Optical Imaging, Pontine Tegmentum

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