The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Open accessAbstract
Exosomes are lipid-bilayer-enclosed extracellular vesicles that contain proteins and nucleic acids. They are secreted by all cells and circulate in the blood. Specific detection and isolation of cancer-cell-derived exosomes in the circulation is currently lacking. Using mass spectrometry analyses, we identify a cell surface proteoglycan, glypican-1 (GPC1), specifically enriched on cancer-cell-derived exosomes. GPC1(+) circulating exosomes (crExos) were monitored and isolated using flow cytometry from the serum of patients and mice with cancer. GPC1(+) crExos were detected in the serum of patients with pancreatic cancer with absolute specificity and sensitivity, distinguishing healthy subjects and patients with a benign pancreatic disease from patients with early- and late-stage pancreatic cancer. Levels of GPC1(+) crExos correlate with tumour burden and the survival of pre- and post-surgical patients. GPC1(+) crExos from patients and from mice with spontaneous pancreatic tumours carry specific KRAS mutations, and reliably detect pancreatic intraepithelial lesions in mice despite negative signals by magnetic resonance imaging. GPC1(+) crExos may serve as a potential non-invasive diagnostic and screening tool to detect early stages of pancreatic cancer to facilitate possible curative surgical therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Of note, in addition to cell-free DNA, recent studies have also shown that detection of nucleic acid cargo within circulating extracellular microvesicles (including exosomes) provides an alternative avenue for assessing the genomic landscape of PDAC.51,52”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [52]
The cited source says what the claim attributes to it.
In the citing paper
“Of note, in addition to cell-free DNA, recent studies have also shown that detection of nucleic acid cargo within circulating extracellular microvesicles (including exosomes) provides an alternative avenue for assessing the genomic landscape of PDAC.51,52”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
Taylor, D. D., & Gerçel-Taylor, Ç. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.04.033 · Cited by 2,333
RetractedAnalysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
DeLong, E. R., DeLong, D. M., & Clarke-Pearson, D. L. (1988) · Biometrics · doi:10.2307/2531595 · Cited by 22,649
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202
Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,996
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
Cited by
Sorted by citations
Items 501–600 of 1,005
Modularized Extracellular Vesicles: The Dawn of Prospective Personalized and Precision Medicine
Tao, S., Guo, S., & Zhang, C. (2018) · Advanced Science · doi:10.1002/advs.201700449 · Cited by 100
Exosomes: Potential in Cancer Diagnosis and Therapy
Munson, P. B., & Shukla, A. (2015) · Medicines · doi:10.3390/medicines2040310 · Cited by 99
Yu, S.-L., Xu, L.-T., Qi, Q., Geng, Y., Chen, H., Meng, Z.-Q., Wang, P., & Chen, Z. (2017) · Scientific Reports · doi:10.1038/srep45194 · Cited by 100
Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer
Zhang, J., ten Dijke, P., Wuhrer, M., & Zhang, T. (2020) · Protein & Cell · doi:10.1007/s13238-020-00741-7 · Cited by 101
Microfluidics for detection of exosomes and microRNAs in cancer: State of the art
Mousavi, S. M., Mahdian, S. M. A., Ebrahimi, M. S., Taghizadieh, M., Vosough, M., Nahand, J. S., Hosseindoost, S., Vousooghi, N., Javar, H. A., Larijani, B. A., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.04.011 · Cited by 100
Microfluidic Technology for the Isolation and Analysis of Exosomes
Wu, Y., Wang, Y., Lu, Y., Luo, X., Huang, Y., Xie, T., Pilarsky, C., Dang, Y., & Zhang, J. (2022) · Micromachines · doi:10.3390/mi13101571 · Cited by 91
Self-citationLopatina, T., Gai, C., Deregibus, M. C., Kholia, S., & Camussi, G. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00125 · Cited by 100
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis
Ahrens, T. D., Bang-Christensen, S. R., Jørgensen, A. M., Løppke, C., Spliid, C. B., Sand, N. T., Clausen, T. M., Salanti, A., & Agerbæk, M. Ø. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00749 · Cited by 99
Advances in microfluidic extracellular vesicle analysis for cancer diagnostics
Cheng, S., Li, Y., Yan, H., Wen, Y., Zhou, X. M., Friedman, L., & Zeng, Y. (2021) · Lab on a Chip · doi:10.1039/d1lc00443c · Cited by 99
A guide to mass spectrometric analysis of extracellular vesicle proteins for biomarker discovery
Jalaludin, I., Lubman, D. M., & Kim, J. (2021) · Mass Spectrometry Reviews · doi:10.1002/mas.21749 · Cited by 100
Ruivo, C. F., Bastos, N., Adem, B., Batista, I. A., Durães, C., Melo, C. A., Castaldo, S. A., Campos-Laborie, F. J., Moutinho-Ribeiro, P., Morão, B., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-324994 · Cited by 102
Self-citationProtein cargo in extracellular vesicles as the key mediator in the progression of cancer
Hánělová, K., Raudenská, M., Masařík, M., & Balvan, J. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01408-6 · Cited by 105
Extracellular Vesicles in the Intrauterine Environment: Challenges and Potential Functions
Nguyen, H. P. T., Simpson, R. J., Salamonsen, L. A., & Greening, D. W. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.116.143503 · Cited by 99
MicroRNAs: tiny molecules with a significant role in mammalian follicular and oocyte development
Tesfaye, D., Gebremedhn, S., Salilew‐Wondim, D., Hailay, T., Hoelker, M., Große‐Brinkhaus, C., & Schellander, K. (2017) · Reproduction · doi:10.1530/rep-17-0428 · Cited by 97
Liquid Biopsy in Endometrial Cancer: New Opportunities for Personalized Oncology
Muinelo‐Romay, L., Casas‐Arozamena, C., & Abal, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082311 · Cited by 97
Chang, L., Ni, J., Zhu, Y., Pang, B., Graham, P., Zhang, H., & Li, Y. (2019) · Theranostics · doi:10.7150/thno.34692 · Cited by 97
Multifunctional Detection of Extracellular Vesicles with Surface Plasmon Resonance Microscopy
Yang, Y., Zhai, C., Zeng, Q., Khan, A. L., & Yu, H. M. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04622 · Cited by 97
Cancer Diagnosis through SERS and Other Related Techniques
Blanco-Formoso, M., & Álvarez‐Puebla, R. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062253 · Cited by 99
Zhang, J., Shi, J., Zhang, H., Zhu, Y., Liu, W., Zhang, K., & Zhang, Z. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12025 · Cited by 97
Extracellular Vesicle Analysis Allows for Identification of Invasive IPMN
Yang, K. S., Ciprani, D., O’Shea, A., Liss, A. S., Yang, R., Fletcher-Mercaldo, S., Mino-Kenudson, M. A., Castillo, C. F. F.-D., & Weissleder, R. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.11.046 · Cited by 97
Carbon-Dot-Enhanced Graphene Field-Effect Transistors for Ultrasensitive Detection of Exosomes
Ramadan, S., Lobo, R., Zhang, Y., Xu, L., Shaforost, O., Tsang, D. K. H., Feng, J., Yin, T., Qiao, M., Rajeshirke, A., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c18293 · Cited by 97
Jingushi, K., Uemura, M., Ohnishi, N., Nakata, W., Fujita, K., Naito, T., Fujii, R., Saichi, N., Nonomura, N., Tsujikawa, K., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.31080 · Cited by 97
MicroRNAs as potential liquid biopsy biomarkers in colorectal cancer: A systematic review
Toiyama, Y., Okugawa, Y., Fleshman, J., Boland, C. R., & Goel, A. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.05.006 · Cited by 96
The glycosylation landscape of pancreatic cancer (Review)
Munkley, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.9885 · Cited by 96
Smolarz, M., Pietrowska, M., Matysiak, N., Mielańczyk, Ł., & Widłak, P. (2019) · Proteomes · doi:10.3390/proteomes7020018 · Cited by 96
Sequential phosphoproteomics and N-glycoproteomics of plasma-derived extracellular vesicles
Aguilar, H. A., Iliuk, A. B., Chen, I.-H., & Tao, W. A. (2019) · Nature Protocols · doi:10.1038/s41596-019-0260-5 · Cited by 97
Microvesicles and exosomes in metabolic diseases and inflammation
Dini, L., Tacconi, S., Carata, E., Tata, A. M., Vergallo, C., & Panzarini, E. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.12.008 · Cited by 100
Role of extracellular vesicles in tumour microenvironment
Tao, S., & Guo, S. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00643-5 · Cited by 102
Lou, P., Liu, S., Xu, X., Pan, C., Lu, Y., & Liu, J. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.11.001 · Cited by 98
A protein corona-enabled blood test for early cancer detection
Caputo, D. D., Papi, M., Coppola, R., Palchetti, S., Digiacomo, L., Caracciolo, G., & Pozzi, D. (2016) · Nanoscale · doi:10.1039/c6nr05609a · Cited by 96
Oscillatory inertial focusing in infinite microchannels
Mutlu, B. R., Jon, F., & Toner, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721420115 · Cited by 95
Advances of Microfluidics in Biomedical Engineering
Zhong, Q., Ding, H., Gao, B., He, Z., & Gu, Z. (2019) · Advanced Materials Technologies · doi:10.1002/admt.201800663 · Cited by 101
Zhang, Y., Wang, F., Zhang, H., Wang, H., & Liu, Y. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03427 · Cited by 95
AuNP-Amplified Surface Acoustic Wave Sensor for the Quantification of Exosomes
Wang, C., Wang, C., Jin, D., Yu, Y., Yang, F., Zhang, Y., Yao, Q., & Zhang, G. (2020) · ACS Sensors · doi:10.1021/acssensors.9b01869 · Cited by 95
Cheng, L., Zhang, K., Qing, Y., Li, D., Cui, M., Jin, P., & Xu, T. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-0609-y · Cited by 95
Yang, Y., Wang, Y., Wei, S., Zhou, C., Yu, J., Wang, G., Wang, W., & Zhao, L. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02775-9 · Cited by 102
Role of Exosomes for Delivery of Chemotherapeutic Drugs
Gebeyehu, A., Kommineni, N., Meckes, D. G., & Sachdeva, M. S. (2021) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2021036301 · Cited by 96
Platelets, circulating tumor cells, and the circulome
Marie, P. K., Lam, M. S., Menter, D. G., & Kopetz, S. (2017) · Cancer and Metastasis Reviews · doi:10.1007/s10555-017-9681-1 · Cited by 94
Masamune, A., Yoshida, N., Hamada, S., Takikawa, T., Nabeshima, T., & Shimosegawa, T. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.141 · Cited by 98
Clinical significance of exosomes as potential biomarkers in cancer
Wong, C. H., & Chen, Y. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i2.171 · Cited by 98
Ning, C.-F., Wang, L., Tian, Y., Yin, B., & Ye, B. (2020) · The Analyst · doi:10.1039/c9an02180a · Cited by 94
Wang, C., Zhang, S., Liu, J., Tian, Y., Ma, B., Xu, S., Fu, Y., & Luo, Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.037 · Cited by 95
Decoding Melanoma Development and Progression: Identification of Therapeutic Vulnerabilities
Eddy, K., Shah, R., & Chen, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.626129 · Cited by 104
The Key Role of Exosomes on the Pre-metastatic Niche Formation in Tumors
Yang, X., Zhang, Y., Zhang, Y., Zhang, S., Qiu, L., Zhuang, Z., Wei, M., Deng, X., Wang, Z., & Han, J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.703640 · Cited by 97
Yin, T., Xu, L., Rosa, B. M. G., Merali, N., Sokolikova, M. S., Gaboriau, D. C. A., Liu, D., Mustafa, A. N. M., Alodan, S., Chen, M., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c01812 · Cited by 94
Extracellular vesicles for liquid biopsy in prostate cancer: where are we and where are we headed?
Minciacchi, V. R., Zijlstra, A., Rubin, M. A., & Vizio, D. D. (2017) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2017.7 · Cited by 93
Review: Microfluidics technologies for blood-based cancer liquid biopsies
Sun, Y., Haglund, T. A., Rogers, A. J., Ghanim, A. F., & Sethu, P. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.12.050 · Cited by 94
Dourado, M. R., Korvala, J., Åström, P., de Oliveira, C. E., Cervigne, N. K., Mofatto, L. S., Bastos, D. C., Messetti, A. C., Graner, E., Leme, A. F. P., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1578525 · Cited by 93
Guo, S., Shi, X., Shen, J., Gao, S., Wang, H., Shen, S., Pan, Y., Li, B., Xu, X., Shao, Z., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0704-2 · Cited by 94
Effects of exercise on exosome release and cargo in in vivo and ex vivo models: A systematic review
Estébanez, B., Jiménez‐Pavón, D., Huang, C., Cuevas, M. J., & González‐Gallego, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30094 · Cited by 94
Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model
Villasante, A., Marturano-Kruik, A., Ambati, S. R., Liu, Z., Godier-Furnémont, A., Parsa, H., Lee, B. W., Moore, M. A. S., & Vunjak‐Novakovic, G. (2016) · Theranostics · doi:10.7150/thno.13944 · Cited by 93
Salivary exosomes as potential biomarkers in cancer
Nair, S., Tang, K. D., Kenny, L., & Punyadeera, C. (2018) · Oral Oncology · doi:10.1016/j.oraloncology.2018.07.001 · Cited by 92
Guo, Y., Tao, J., Li, Y., Feng, Y., Ju, H., Wang, Z., & Ding, L. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.9b12182 · Cited by 94
Emerging Function and Clinical Significance of Exosomal circRNAs in Cancer
Wang, M., Yu, F., Li, P., & Wang, K. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.06.008 · Cited by 94
Pathophysiology of Preeclampsia: The Role of Exosomes
Matsubara, K., Matsubara, Y., Uchikura, Y., & Sugiyama, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052572 · Cited by 97
Pancreatic cancer stem cell markers and exosomes - the incentive push
Heiler, S., Wang, Z., & Zöller, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i26.5971 · Cited by 91
The Role of Exosomes in Pancreatic Cancer
Lan, B., Zeng, S., Grützmann, R., & Pilarsky, C. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184332 · Cited by 94
Self-citationExosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients
Wang, J., Zhang, H., Sun, X., Wang, X., Ren, T., Huang, Y., Zhang, R., Zheng, B., & Guo, W. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00710-6 · Cited by 91
Xiong, H., Huang, Z., Lin, Q., Yang, B., Yan, F., Liu, B., Chen, H., & Kong, J. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03535 · Cited by 91
Lin, A., Xiong, M., Jiang, A., Huang, L., Wong, H. Z. H., Feng, S., Zhang, C., Yu, H., Chen, L., Chi, H., et al. (2025) · iMeta · doi:10.1002/imt2.70070 · Cited by 99
Extracellular vesicles and aging
Robbins, P. D. (2017) · Stem Cell Investigation · doi:10.21037/sci.2017.12.03 · Cited by 93
Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia
Haider, S. A., McIntyre, A., van Stiphout, R. G. P. M., Winchester, L. M., Wigfield, S., Harris, A. L., & Buffa, F. M. (2016) · Genome biology · doi:10.1186/s13059-016-0999-8 · Cited by 92
Wang, T., Ning, K., Lu, T., Sun, X., Jin, L., Qi, X., Jin, J., & Hua, D. (2016) · Cancer Science · doi:10.1111/cas.13150 · Cited by 92
He, D., Ho, S., Chan, H., Wang, H., Hai, L., He, X., Wang, K., & Li, H. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04509 · Cited by 90
Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review
Pathak, M. P., Pathak, K., Saikia, R., Gogoi, U., Ahmad, M. Z., Patowary, P., & Das, A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112901 · Cited by 91
Dimastromatteo, J., Brentnall, T. A., & Kelly, K. A. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.144 · Cited by 92
Zhu, Y., Chen, X., Pan, Q., Wang, Y., Su, S., Jiang, C., Li, Y., Xu, N., Wu, L., Lou, X., et al. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00770 · Cited by 89
The functions and clinical applications of tumor-derived exosomes
Shao, Y., Shen, Y., Chen, T., Xu, F., Chen, X., & Zheng, S. S. (2016) · Oncotarget · doi:10.18632/oncotarget.11177 · Cited by 90
Liu, C., Yang, Y., & Wu, Y. (2018) · The AAPS Journal · doi:10.1208/s12248-018-0201-1 · Cited by 91
RNA cargos in extracellular vesicles derived from blood serum in pancreas associated conditions
Kumar, S. R., Kimchi, E. T., Manjunath, Y., Gajagowni, S., Stuckel, A. J., & Kaifi, J. T. (2020) · Scientific Reports · doi:10.1038/s41598-020-59523-0 · Cited by 92
Sancho‐Albero, M., Sebastián, V., Sese, J., Pazo-Cid, R., Mendoza, G., Arruebo, M., Martín-Duque, P., & Santamarı́a, J. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00701-7 · Cited by 89
Extracellular vesicles in cancer´s communication: messages we can read and how to answer
Semerádtová, A., Liegertová, M., Herma, R., Čapková, M., Brignole, C., & Zotto, G. D. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02282-1 · Cited by 95
Nanomechanical sandwich assay for multiple cancer biomarkers in breast cancer cell-derived exosomes
Etayash, H., McGee, A. R., Kaur, K., & Thundat, T. G. (2016) · Nanoscale · doi:10.1039/c6nr03478k · Cited by 89
Wang, L., Pan, Y., Liu, Y., Sun, Z., Huang, Y., Li, J., Yang, J. A., Xiang, Y., & Li, G. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b18869 · Cited by 88
The dark side of foetal bovine serum in extracellular vesicle studies
Urzì, O., Bagge, R. O., & Crescitelli, R. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12271 · Cited by 93
Wang, X., Shang, H., Ma, C., & Chen, L. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00796 · Cited by 88
Nigri, J., Leca, J., Tubiana, S.-S., Finetti, P., Guillaumond, F., Martinez, S., Lac, S., Iovanna, J., Audebert, S., Camoin, L., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abg8191 · Cited by 92
Enhancing clinical potential of liquid biopsy through a multi-omic approach: A systematic review
Sario, G. D., Rossella, V., Famulari, E. S., Maurizio, A., Lazarević, D., Giannese, F., & Felici, C. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1152470 · Cited by 88
Inflammasome-Derived Exosomes Activate NF-κB Signaling in Macrophages
Zhang, Y., Liu, F., Yuan, Y., Jin, C., Chang, C., Zhu, Y., Zhang, X., Tian, C., He, F., & Wang, J. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00599 · Cited by 88
Shen, Y., Guo, D., Weng, L., Wang, S., Ma, Z., Yang, Y., Wang, P., Wang, J., & Cai, Z. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1362527 · Cited by 88
Ko, J., Bhagwat, N., Black, T. A., Yee, S. S., Na, Y.-J., Fisher, S., Kim, J., Carpenter, E. L., Stanger, B. Z., & Issadore, D. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3703 · Cited by 86
Cufaro, M. C., Pieragostino, D., Lanuti, P., Rossi, C., Cicalini, I., Federici, L., Laurenzi, V. D., & Boccio, P. D. (2019) · Journal of Oncology · doi:10.1155/2019/1639854 · Cited by 89
Shen, T., Huang, Z., Shi, C., Pu, X., Xu, X., Wu, Z., Ding, G., & Cao, L. (2020) · The FASEB Journal · doi:10.1096/fj.201902186r · Cited by 88
The Role of Glypicans in Cancer Progression and Therapy
Li, N., Spetz, M. R., & Ho, M. (2020) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155420933709 · Cited by 88
Hou, J., Li, X., & Xie, K. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01309-7 · Cited by 86
Tian, C., Yang, Y., Bai, B., Wang, S., Liu, M., Sun, R., Yu, T., & Chu, X. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.58786 · Cited by 88
Extracellular Vesicles in Brain Tumor Progression
D’Asti, E., Chennakrishnaiah, S., Lee, T. H., & Rak, J. W. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0296-1 · Cited by 91
KRASmutations in blood circulating cell-free DNA: a pancreatic cancer case-control
Calvez‐Kelm, F. L., Foll, M., Wozniak, M. B., Delhomme, T. M., Durand, G., Chopard, P., Pertesi, M., Fabiánová, E., Adamčáková, Z. K., Holcátová, I., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12386 · Cited by 85
Zhang, N., Sun, N., & Deng, C. (2020) · Talanta · doi:10.1016/j.talanta.2020.121571 · Cited by 85
Advanced nanomaterials as sample technique for bio-analysis
Sun, N., Yu, H., Wu, H., Shen, X., & Deng, C. (2021) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2020.116168 · Cited by 85
Sun, X., Lin, F., Sun, W., Zhu, W., Fang, D., Luo, L., Li, S., Zhang, W., & Jiang, L. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.02.022 · Cited by 87
Tumor-penetrating therapy for β5 integrin-rich pancreas cancer
de Mendoza, T. H., Mose, E. S., Botta, G. P., Braun, G. B., Kotamraju, V. R., French, R. P., Suzuki, K., Miyamura, N., Teesalu, T., Ruoslahti, E. I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21858-1 · Cited by 87
Extracellular Vesicles as Next-Generation Diagnostics and Advanced Therapy Medicinal Products
Stawarska, A., Bamburowicz‐Klimkowska, M., Rundén‐Pran, E., Dušinská, M., Cimpan, M. R., Ríos-Mondragón, I., & Grudziński, I. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126533 · Cited by 89
Circulating Liquid Biopsy Biomarkers in Glioblastoma: Advances and Challenges
Seyhan, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147974 · Cited by 87
Digestive cancers: mechanisms, therapeutics and management
Zhan, T., Betge, J., Schulte, N., Dreikhausen, L., Hirth, M., Li, M., Weidner, P., Leipertz, A., Teufel, A., & Ebert, M. P. A. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02097-4 · Cited by 90
Lovett, J. A. C., Durcan, P., & Myburgh, K. H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01149 · Cited by 85
Liu, W., Li, J., Wu, Y., Xing, S., Lai, Y., & Zhang, G. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.11.033 · Cited by 84
Role of T cell-derived exosomes in immunoregulation
Lu, J., Wu, J., Tian, J., & Wang, S. (2018) · Immunologic Research · doi:10.1007/s12026-018-9000-0 · Cited by 86
Evaluation of serum extracellular vesicles as noninvasive diagnostic markers of glioma
Wang, H., Jiang, D., Li, W., Xiang, X., Zhao, J., Yu, B., Wang, C., He, Z., Zhu, L., & Yang, Y. (2019) · Theranostics · doi:10.7150/thno.33114 · Cited by 85
The pre-analytical phase of the liquid biopsy
Salvianti, F., Gelmini, S., Costanza, F., Mancini, I., Sonnati, G., Simi, L., Pazzagli, M., & Pinzani, P. (2019) · New Biotechnology · doi:10.1016/j.nbt.2019.09.006 · Cited by 86
Metadata
- Authors
- Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., Reissfelder, C., Pilarsky, C., Fraga, M. F., Piwnica-Worms, D., & Kalluri, R.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Technische Universität Dresden (DE)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Kalluri, Raghu
- ORCID
- Venue
- Nature
- Published
- 2015-06-24
- Volume
- 523
- Issue
- 7559
- Pages
- 177-182
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4825698
- OpenAlex
- W1500925570
- Cited by
- 2,880
- References
- 63
- Citations by year
- 2026: 129 · 2025: 200 · 2024: 253 · 2023: 305 · 2022: 277 · 2021: 371 · 2020: 320 · 2019: 271 · 2018: 269 · 2017: 234 · 2016: 195 · 2015: 52
- FWCI
- 108.75
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-10-05)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (5u24ca126577-05)
- National Cancer Institute (P30CA16672, U01CA151925, CA-16672, U24-CA-126577, P50CA094056, 5U24CA126577, R01CA155370, CA 155370, CA 151925, P30CA016672)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 081576, R01DK081576)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- glypican-1, tumor-derived exosomes, extracellular vesicles, pancreatic cancer, early cancer detection, circulating exosomes, cell surface proteoglycans, KRAS mutation, non-invasive biomarkers, tumor burden
- MeSH terms
- Animals, Female, Humans, Male, Pancreatic Neoplasms, Proto-Oncogene Proteins, Biomarkers, Proto-Oncogene Proteins p21(ras), ras Proteins, NIH 3T3 Cells, HCT116 Cells, Cell Line, Tumor, Mice, Glypicans, Exosomes, MCF-7 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
