Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

Wang, Bruce, Zhao, Ludan, Fish, Matt, Logan, Catriona Y., Nusse, Roel·2015·Nature

DOI 10.1038/nature14863

Cited by (675)

Items 101–200 of 675

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Vasiliki Zarkou, Αλέξανδρος Γαλάρας, Antonis Giakountis, Pantelis Hatzis · 2018 · Non-coding RNA Research
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Heinke, Paula, Rost, Fabian, Rode, Julian, Trus, Palina, Simonova, Irina, Lázár, Enikő, Feddema, Joshua, Welsch, Thilo, Alkass, Kanar, Salehpour, Mehran et al. · 2022 · Cell Systems
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Kostallari, Enis, Shah, Vijay H. · 2016 · American Journal of Physiology-Gastrointestinal and Liver Physiology
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Salamah Mohammad Alwahsh, Hassan Rashidi, David C. Hay · 2017 · Cellular and Molecular Life Sciences
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The progenitor cell dilemma: Cellular and functional heterogeneity in assistance or escalation of liver injury
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Wnt/β-catenin signaling regulates ependymal cell development and adult homeostasis
Liujing Xing, Teni Anbarchian, Jonathan M. Tsai, Giles W. Plant, Roel Nusse · 2018 · Proceedings of the National Academy of Sciences
Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure
Jin, Yuanyuan, Zhang, Jiabin, Xu, Yanteng, Yi, Ke, Li, Fenfang, Zhou, Huicong, Wang, Haixia, Chan, Hon Fai, Lao, Yeh-Hsing, Lv, Shixian et al. · 2023 · Bioactive Materials