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Neural ensemble dynamics underlying a long-term associative memory
Open accessAbstract
The brain's ability to associate different stimuli is vital for long-term memory, but how neural ensembles encode associative memories is unknown. Here we studied how cell ensembles in the basal and lateral amygdala encode associations between conditioned and unconditioned stimuli (CS and US, respectively). Using a miniature fluorescence microscope, we tracked the Ca 2+ dynamics of ensembles of amygdalar neurons during fear learning and extinction over 6 days in behaving mice. Fear conditioning induced both up- and down-regulation of individual cells' CS-evoked responses. This bi-directional plasticity mainly occurred after conditioning, and reshaped the neural ensemble representation of the CS to become more similar to the US representation. During extinction training with repetitive CS presentations, the CS representation became more distinctive without reverting to its original form. Throughout the experiments, the strength of the ensemble-encoded CS-US association predicted the level of behavioural conditioning in each mouse. These findings support a supervised learning model in which activation of the US representation guides the transformation of the CS representation.
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“To further explore whether mating or fighting could also induce changes in neuronal activity, we performed a Mahalanobis population vector distance (PVD) analysis (Grewe et al., 2017) and found that the difference in response to female and male cues after the initiation of mating/fighting decreases by 40% from the initial level (Figures S4C–S4F; STAR Methods).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Grewe et al., 2017
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Metadata
- Authors
- Grewe, B. F., Gründemann, J., Kitch, L. J., Lecoq, J. A., Parker, J. G., Marshall, J. D., Larkin, M. C., Jercog, P. E., Grenier, F., Li, J. Z., Lüthi, A., & Schnitzer, M. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Friedrich Miescher Institute (CH)
- Pfizer (United States) (US)
- Stanford University (US)
- University of Basel (CH)
- Corresponding author
- Schnitzer, Mark J.
- ORCID
- Venue
- Nature
- Published
- 2017-03
- Volume
- 543
- Issue
- 7647
- Pages
- 670-675
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC5378308
- OpenAlex
- W2602668040
- Cited by
- 351
- References
- 47
- Citations by year
- 2026: 27 · 2025: 31 · 2024: 44 · 2023: 45 · 2022: 27 · 2021: 34 · 2020: 42 · 2019: 46 · 2018: 36 · 2017: 19
- FWCI
- 22.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- associative memory, neuronal ensembles, basal amygdala, lateral amygdala, fear conditioning, fear extinction, calcium dynamics, supervised learning, conditioned stimulus, unconditioned stimulus, microendoscopy
- MeSH terms
- Amygdala, Animals, Calcium, Conditioning, Classical, Extinction, Psychological, Fear, Male, Microscopy, Fluorescence, Neuronal Plasticity, Neurons, Calcium Signaling, Mice, Memory, Long-Term
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