Expectation modulates neural responses to pleasant and aversive stimuli in primate amygdala

Belova, Marina A.; Paton, Joseph J.; Morrison, Sara E.; Salzman, C. Daniel

doi:10.1016/j.neuron.2007.08.004

Cited by 349Memory and Neural MechanismsNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

Expectation modulates neural responses to pleasant and aversive stimuli in primate amygdala

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Belova, Marina A., Paton, Joseph J., Morrison, Sara E., Salzman, C. Daniel·2007·Neuron

DOI 10.1016/j.neuron.2007.08.004PMC PMC2042139

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Abstract

Animals and humans learn to approach and acquire pleasant stimuli and to avoid or defend against aversive ones. However, both pleasant and aversive stimuli can elicit arousal and attention, and their salience or intensity increases when they occur by surprise. Thus, adaptive behavior may require that neural circuits compute both stimulus valence--or value--and intensity. To explore how these computations may be implemented, we examined neural responses in the primate amygdala to unexpected reinforcement during learning. Many amygdala neurons responded differently to reinforcement depending upon whether or not it was expected. In some neurons, this modulation occurred only for rewards or aversive stimuli, but not both. In other neurons, expectation similarly modulated responses to both rewards and punishments. These different neuronal populations may subserve two sorts of processes mediated by the amygdala: those activated by surprising reinforcements of both valences-such as enhanced arousal and attention-and those that are valence-specific, such as fear or reward-seeking behavior.

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OT modulates context-specific processing associated with both negative and positive valence in the amygdala, consistent with the encoding of both positive and negative motivational values by the primate amygdala neurons.
“These findings suggest that OT modulates context-specific processing associated with both negative and positive valence in the amygdala, consistent with the encoding of both positive and negative motivational values by the primate amygdala neurons (Belova et al., 2007; Paton et al., 2006).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Belova et al., 2007
Separate populations of amygdala neurons mediate aversive and appetitive processing.
“In addition to being essential for aversively motivated learning, plasticity in the LA is also required for several forms of appetitively motivated learning (43–45) and a number of studies have found that separate populations of amygdala neurons mediate aversive and appetitive processing (46–48).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [48]

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“In monkeys, Belova et al. (2007) have shown that fix-spot responses can be regarded as the earliest predictors of reward.”
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Neuron Article Expectation Modulates Neural Responses to Pleasant and Aversive Stimuli in Primate Amygdala
Belova, M. A., Paton, J. J., Morrison, S. E., Salzman, C. D., & Department Of Neuroscience (2013)
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NEURAL CODES IN THE PRIMATE BRAIN UNDERLYING GENERALIZATION AND EXPLORATION DURING AVERSIVE LEARNING
Paz, R. (2023) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.08.2166

Authors: Belova, M. A., Paton, J. J., Morrison, S. E., & Salzman, C. D.
Affiliations: Columbia University (US)
New York State Psychiatric Institute (US)
Corresponding author: Salzman, C. Daniel
ORCID: Paton, Joseph J.
Morrison, Sara E.
Salzman, C. Daniel
Venue: Neuron
Publisher: Elsevier BV
Published: 2007-09
Volume: 55
Issue: 6
Pages: 970-984
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2007.08.004
PMC: PMC2042139
OpenAlex: W2133622401
Cited by: 349
References: 65
Citations by year: 2026: 5 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 11 · 2021: 17 · 2020: 15 · 2019: 18 · 2018: 16 · 2017: 28 · 2016: 17 · 2015: 32 · 2014: 22 · 2013: 23 · 2012: 29
FWCI: 10.85
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2146 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institute on Drug Abuse
National Eye Institute
National Science Foundation
National Institute of Mental Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: amygdala, expectations, surprise, reinforcement learning, reward, punishment, aversive stimuli, stimulus valence, stimulus intensity, arousal, attention, fear, reward seeking
MeSH terms: Amygdala, Animals, Arousal, Data Interpretation, Statistical, Learning, Macaca mulatta, Neurons, Psychomotor Performance, Reinforcement, Psychology, ROC Curve, Excitatory Postsynaptic Potentials

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Expectation modulates neural responses to pleasant and aversive stimuli in primate amygdala

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