Dopamine is necessary for cue-dependent fear conditioning

Fadok, Jonathan P.; Dickerson, Tavis M. K.; Palmiter, Richard D.

doi:10.1523/jneurosci.1616-09.2009

Cited by 213Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Dopamine is necessary for cue-dependent fear conditioning

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Fadok, Jonathan P., Dickerson, Tavis M. K., Palmiter, Richard D.·2009·The Journal of Neuroscience

DOI 10.1523/jneurosci.1616-09.2009PMC PMC2759996

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Abstract

Dopamine (DA) is implicated in many behaviors, including motor function, cognition, and reward processing; however, the role of DA in fear processing remains equivocal. To examine the role of DA in fear-related learning, dopamine-deficient (DD) mice were tested in a fear-potentiated startle paradigm. DA synthesis can be restored in DD mice through administration of 3, 4-dihydroxy-l-phenylalanine (l-Dopa), thereby permitting the assessment of fear processing in either a DA-depleted or -replete state. Fear-potentiated startle was absent in DD mice but could be restored by l-Dopa administration immediately after fear conditioning. Selective viral-mediated restoration of DA synthesis within the ventral tegmental area fully restored fear learning in DD mice, and restoration of DA synthesis to DA neurons projecting to the basolateral amygdala restored short-term memory but not long-term memory or shock sensitization. We also demonstrate that the DA D(1) receptor (D(1)R) and D(2)-like receptors are necessary for cue-dependent fear learning. These findings indicate that DA acting on multiple receptor subtypes within multiple target regions facilitates the stabilization of fear memory.

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Learning of responses to aversive stimuli in rodents during fear conditioning is inhibited by dopaminergic antagonists.
“learning of responses to aversive stimuli in rodents (ie. during fear conditioning) is inhibited by dopaminergic antagonists [66–68].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [66]

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Eyny YS Horvitz JC 2003 Opposing roles of D1 and D2 receptors in appetitive conditioning J Neurosci 23 1584 1587 12629161 PMC6741989
Ralph RJ Varty GB Kelly MA Wang YM Caron MG Rubinstein M Grandy DK Low MJ Geyer MA 1999 The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice J Neurosci 19 4627 4633 10341260 PMC6782596

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Authors: Fadok, J. P., Dickerson, T. M. K., & Palmiter, R. D.
Affiliations: University of Washington (US)
Howard Hughes Medical Institute (US)
ORCID: Fadok, Jonathan P.
Palmiter, Richard D.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2009-09-09
Volume: 29
Issue: 36
Pages: 11089-11097
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1616-09.2009
PMC: PMC2759996
OpenAlex: W2060210617
Cited by: 213
References: 67
Citations by year: 2026: 6 · 2025: 15 · 2024: 12 · 2023: 13 · 2022: 10 · 2021: 13 · 2020: 10 · 2019: 18 · 2018: 13 · 2017: 8 · 2016: 19 · 2015: 15 · 2014: 9 · 2013: 9 · 2012: 15
FWCI: 6.94
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Human Genome Research Institute (R25HG007153)
National Institute of General Medical Sciences (GM-07270, T32-GM07270, T32GM007270, R25GM058501)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine, fear memory, L-DOPA, ventral tegmental area, basolateral amygdala, dopamine D1 receptor, D2-like receptors, fear-potentiated startle, short-term memory
MeSH terms: Animals, Conditioning, Psychological, Cues, Dopamine, Fear, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Receptors, Dopamine, Reflex, Startle, Mice, Knockout, Mice

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Dopamine is necessary for cue-dependent fear conditioning

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