Long-range and local circuits for top-down modulation of visual cortex processing
Open accessAbstract
You only see what you want to see: We often focus on a particular item out of a thousand objects in a visual scene. This ability is called selective attention. Selective attention enhances the responses of sensory nerve cells to whatever is being observed and dampens responses to any distractions. Zhang et al. identified a region of the mouse forebrain that modulates responses in the visual cortex. This modulation improved the mouse's performance in a visual task. Science , this issue p. 660
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The circuitry for cingulate-cortex recruitment of VIP interneurons permits VIP effects to be spatially restricted, consistent with the narrow axonal distribution of VIP interneurons.
“This study also provided evidence that the circuitry involved was permissive for the effects of VIP IN recruitment to act in a spatially restricted manner, consistent with the narrow axonal distribution of VIP INs”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Zhang et al., 2014
The circuit-model passage (Fig. 4F; page unavailable) says VIP+ neurons selectively enhance responses at the site of focal cingulate-axon activation through localized inhibition of SOM+ neurons. The optogenetic-inactivation passage (Fig. 4B; page unavailable) likewise reports a VIP+ effect at 0 μm but not at other locations. These passages support spatially restricted VIP effects, but our copy does not establish the claimed narrow axonal distribution of VIP interneurons. (LLM, conf=0.85)
Experimental — accuracy not yet measuredActivating cingulate cortex axons during a visual discrimination task improves behavioral performance, while inactivating them reduces it.
“activating or inactivating Cg axons during a visual discrimination task improved or reduced behavioral performance, respectively.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Zhang et al., 2014
The passage on awake mice (section labelled Abstract; page unavailable) reports that Cg activation improved performance on a visual discrimination task. It reports that inactivating Cg excitatory neurons decreased V1 responses, not behavioral performance. The axon-activation experiment measured V1 responses in anesthetized mice, so the copy does not establish that activating or inactivating Cg axons during the task produced the claimed behavioral effects. (LLM, conf=0.88)
Experimental — accuracy not yet measuredExcitatory projections from cingulate cortex strongly recruit VIP interneurons in V1.
“Another recent study has shown that excitatory projections from the cingulate cortex (Cg) strongly recruit VIP INs in V1 (Zhang et al., 2014).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Zhang et al., 2014
VIP neurons participate in top-down modulation by serving as a major target of feedback cortico-cortical projections.
“The studies by Lee et al. (Lee et al., 2013) and Zhang et al. (Lee et al., 2013) demonstrate a role of VIP neurons in top-down modulation by being a major target of feedback cortico-cortical projections.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Zhang et al., 2014
VIP neurons in V1 receive stronger input from cingulate cortex than other L2/3 interneurons and principal cells.
“VIP neurons in V1 receive the strongest input from Cg when compared to other L2/3 INs and PCs.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Zhang et al., 2014
More recently, a number of functional studies in both hippocampus and neocortex have taken advantage of transgenic animals and modern circuit mapping tools to functionally confirm that subsets of CR- and VIP-expressing interneurons do indeed mediate circuit disinhibition by selectively targeting other interneurons over pyramidal cells.
“More recently, a number of functional studies in both hippocampus and neocortex have taken advantage of transgenic animals and modern circuit mapping tools to functionally confirm that subsets of CR- and VIP-expressing interneurons do indeed mediate circuit disinhibition by selectively targeting other interneurons over pyramidal cells (185, 363, 652, 906, 908, 1145, 1270).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1270]
These driver lines have been successfully used in a number of recent studies to dissect circuit functions of ISIs in both hippocampus and neocortex.
“Indeed, these driver lines have been successfully used in a number of recent studies to dissect circuit functions of ISIs in both hippocampus and neocortex (363, 553, 652, 906, 908, 1145, 1270).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1270]
The targeting of SST interneurons by VIP cells appears to be a generalized motif across brain structures including somatosensory, visual, and auditory cortices, and this specific disinhibitory microcircuit is important in sensory processing that, in some circumstances, demonstrates behavioral state dependence.
“The targeting of SST interneurons by VIP cells appears to be a generalized motif across brain structures including somatosensory, visual, and auditory cortices, and this specific disinhibitory microcircuit is important in sensory processing that, in some circumstances, demonstrates behavioral state dependence (363, 553, 660, 905, 906, 908, 1246, 1270).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1270]
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“M2 projections onto sensory areas play a role in sensory discrimination in multiple modalities, e.g. vision (Zhang et al., 2014) or forelimb somato-sensation (Manita et al., 2015).”
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- Authors
- Zhang, S., Xu, M., Kamigaki, T., Hoang Do, J. P., Chang, W.-C., Jenvay, S., Miyamichi, K., Luo, L., & Dan, Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
- Corresponding author
- Dan, Yang
- Venue
- Science
- Published
- 2014-08-08
- Volume
- 345
- Issue
- 6197
- Pages
- 660-665
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5776147
- OpenAlex
- W2008372697
- Cited by
- 804
- References
- 49
- Citations by year
- 2026: 51 · 2025: 65 · 2024: 76 · 2023: 93 · 2022: 70 · 2021: 76 · 2020: 65 · 2019: 73 · 2018: 59 · 2017: 63 · 2016: 65 · 2015: 45 · 2014: 3
- FWCI
- 32.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Eye Institute (R01EY018861)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- top-down modulation, primary visual cortex, cingulate cortex, corticocortical connections, GABAergic interneurons, somatostatin interneurons, vasoactive intestinal peptide interneurons, surround suppression, visual discrimination, mouse visual system, optogenetics
- MeSH terms
- Animals, Discrimination, Psychological, Gyrus Cinguli, Interneurons, Mice, Inbred C57BL, Neural Inhibition, Photic Stimulation, Somatostatin, Visual Cortex, Visual Perception, Animals, Genetically Modified, Mice, GABAergic Neurons
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