DNA targeting specificity of RNA-guided Cas9 nucleases

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Items 501–600 of 1,041

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14. Genome engineering using the CRISPR/Cas system
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15. Patterns of CRISPR/Cas9 activity in plants, animals and microbes
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16. Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease
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17. CRISPR/Cas9-mediated genome editing and gene replacement in plants: Transitioning from lab to field
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21. Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites
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22. CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington’s Disease Mouse Model
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23. Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9
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25. Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
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26. Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting
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27. CRISPR interference-based specific and efficient gene inactivation in the brain
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28. Systematic analysis of CRISPR–Cas9 mismatch tolerance reveals low levels of off-target activity
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29. AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A
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30. 5S rRNA Promoter for Guide RNA Expression Enabled Highly Efficient CRISPR/Cas9 Genome Editing in Aspergillus niger
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31. Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein–coupled receptors
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32. Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes
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33. Enhancement of target specificity of CRISPR–Cas12a by using a chimeric DNA–RNA guide
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34. Precise Gene Deletion and Replacement Using the CRISPR/Cas9 System in Human Cells
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35. Mouse Genome Editing Using the CRISPR/Cas System
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36. Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
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37. CRISPR-Cas9/Cas12a biotechnology and application in bacteria
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38. Quantifying on- and off-target genome editing
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39. Optimization of Genome Engineering Approaches with the CRISPR/Cas9 System
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40. Genome-editing technologies and their potential application in horticultural crop breeding
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41. Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at Single Genes in Live Cells
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42. Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome
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43. Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase
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44. Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets
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45. CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects
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46. Which Factors Affect the Occurrence of Off-Target Effects Caused by the Use of CRISPR/Cas: A Systematic Review in Plants
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47. Genome Editing in Bacteria: CRISPR-Cas and Beyond
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48. Genome engineering via TALENs and CRISPR/Cas9 systems: challenges and perspectives
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49. CRISPR/Cas9 in insects: Applications, best practices and biosafety concerns
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50. Nontransgenic Marker-Free Gene Disruption by an Episomal CRISPR System in the Oleaginous Microalga, Nannochloropsis oceanica CCMP1779
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51. Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing
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52. A human multi-lineage hepatic organoid model for liver fibrosis
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53. Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System
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55. Rewiring human cellular input–output using modular extracellular sensors
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56. Targeted mutagenesis in cotton (Gossypium hirsutum L.) using the CRISPR/Cas9 system
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57. Functional dissection of NEAT1 using genome editing reveals substantial localization of the NEAT1_1 isoform outside paraspeckles
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58. Lentiviral Vectors for Delivery of Gene-Editing Systems Based on CRISPR/Cas: Current State and Perspectives
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60. High-efficiency targeted editing of large viral genomes by RNA-guided nucleases
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62. Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease
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64. Efficient CRISPR-Cas9-Mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus
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