DNA targeting specificity of RNA-guided Cas9 nucleases

Cited by (1,041)

Items 1,001–1,041 of 1,041

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7. Lactation improves pancreatic β cell mass and function through serotonin production
   Moon, Joon Ho, Kim, Hyeongseok, Kim, Hyunki, Park, Jungsun, Choi, Wonsuk, Choi, Wongun, Hong, Hyun Jung, Ro, Hyun-Joo, Jun, Sangmi, Choi, Sung Hee et al. · 2020 · Science Translational Medicine
8. Genome Editing in iPSC-Based Neural Systems: From Disease Models to Future Therapeutic Strategies
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11. Cas9 protein delivery non-integrating lentiviral vectors for gene correction in sickle cell disease
    Uchida, Naoya, Drysdale, Claire M., Nassehi, Tina, Gamer, Jackson, Yapundich, Morgan, DiNicola, Julia, Shibata, Yoshitaka, Hinds, Malikiya, Gudmundsdottir, Bjorg, Haro-Mora, Juan J. et al. · 2021 · Molecular Therapy - Methods & Clinical Development
12. Recent Progress and Challenges in CRISPR-Cas9 Engineered Algae and Cyanobacteria
    Patel, Vikas Kumar, Das, Anima, Kumari, Ritu, Kajla, Sachin · 2023 · Algal Research
13. Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells
    Tran, Ngoc Tung, Danner, Eric, Li, Xun, Graf, Robin, Lebedin, Mikhail, de la Rosa, Kathrin, Kühn, Ralf, Rajewsky, Klaus, Chu, Van Trung · 2022 · Science Advances
14. Crisflash: Open-source software to generate CRISPR guide RNAs against genomes annotated with individual variation
    Jacquin, Adrien L S, Odom, Duncan T, Lukk, Margus · 2019 · Bioinformatics
15. Concerns regarding ‘off-target’activity of genome editing endonucleases
    Kadam, Ulhas Sopanrao, Shelake, Rahul Mahadev, Chavhan, Rahul L., Suprasanna, Penna · 2018 · Plant Physiology and Biochemistry
16. Genetically modified large animal models for investigating neurodegenerative diseases
    Yang, Weili, Chen, Xiusheng, Li, Shihua, Li, Xiao-Jiang · 2021 · Cell & Bioscience
17. Emerging applications of gene editing technologies for the development of climate-resilient crops
    Chavhan, R. L., Jaybhaye, S. G., Hinge, V. R., Deshmukh, A. S., Shaikh, U. S., Jadhav, P. K., Kadam, U. S., Hong, J. C. · 2025 · Frontiers in Genome Editing
18. Comparative analysis of CRISPR off-target discovery tools following ex vivo editing of CD34(+) hematopoietic stem and progenitor cells
    Cromer, M. Kyle, Majeti, Kiran R., Rettig, Garrett R., Murugan, Karthik, Kurgan, Gavin L., Bode, Nicole M., Hampton, Jessica P., Vakulskas, Christopher A., Behlke, Mark A., Porteus, Matthew H. · 2023 · Molecular Therapy
19. Massively targeted evaluation of therapeutic CRISPR off-targets in cells
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20. Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS
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21. CRISPR/Cas9-Mediated Phage Resistance Is Not Impeded by the DNA Modifications of Phage T4
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22. Utilization of CRISPR-Cas genome editing technology in filamentous fungi: function and advancement potentiality
    Shen, Qiqing, Ruan, Haihua, Zhang, Hongyang, Wu, Tao, Zhu, Kexin, Han, Wenying, Dong, Rui, Ming, Tianwei, Qi, Haikun, Zhang, Yan · 2024 · Frontiers in Microbiology
23. Targeted Knockout of the Vegfa Gene in the Retina by Subretinal Injection of RNP Complexes Containing Cas9 Protein and Modified SgRNAs
    Holmgaard, Andreas Braae, Askou, Anne Louise, Jensen, Emilie Grarup, Alsing, Sidsel, Bak, Rasmus O., Mikkelsen, Jacob Giehm, Corydon, Thomas J. · 2021 · Molecular Therapy
24. crisprSQL: a novel database platform for CRISPR/Cas off-target cleavage assays
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25. Specificity profiling of CRISPR system reveals greatly enhanced off-target gene editing
    Wang, Yao, Wang, Mingrui, Zheng, Ting, Hou, Yingzi, Zhang, Pingjing, Tang, Tao, Wei, Jing, Du, Quan · 2020 · Scientific Reports
26. Gene Therapy for Inherited Retinal Degeneration
    Arbabi, Amirmohsen, Liu, Amelia, Ameri, Hossein · 2019 · Journal of Ocular Pharmacology and Therapeutics
27. Machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing
    Li, Jianbo, Wu, Panfeng, Cao, Zhoutao, Huang, Guanlan, Lu, Zhike, Yan, Jianfeng, Zhang, Heng, Zhou, Yangfan, Liu, Rong, Chen, Hui et al. · 2024 · Cell Reports
28. Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR
    Skoufou-Papoutsaki, Nefeli, Adler, Sam, D'Santos, Paula, Mannion, Liz, Mehmed, Shenay, Kemp, Richard, Smith, Amy, Perrone, Francesca, Nayak, Komal, Russell, Alasdair et al. · 2023 · Disease Models & Mechanisms
29. Learning to quantify uncertainty in off-target activity for CRISPR guide RNAs
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30. A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells
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31. A systematic evaluation of data processing and problem formulation of CRISPR off-target site prediction
    Yaish, Ofir, Asif, Maor, Orenstein, Yaron · 2022 · Briefings in Bioinformatics
32. Hybrid multitask learning reveals sequence features driving specificity in the CRISPR/Cas9 system
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33. CRISPR off-target analysis platforms
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34. Electroporation Delivery of Cas9 sgRNA ribonucleoprotein-Mediated Genome Editing in Sheep IVF Zygotes
    Pi, Wenhui, Feng, Guangyu, Liu, Minghui, Nie, Cunxi, Chen, Cheng, Wang, Jingjing, Wang, Limin, Wan, Pengcheng, Liu, Changbin, Zhou, Ping et al. · 2024
35. Detection of CRISPR/Cas9-Generated off-target effect by integration-defective lentiviral vector
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36. New genetic modification techniques: challenges and prospects
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37. CRISPR/Cas9 Ribonucleoprotein Nucleofection for Genome Editing in Primary Human Keratinocytes: Knockouts, Deletions, and Homology‐Directed Repair Mutagenesis
    Bamundo, Martina, Palumbo, Sara, D'Auria, Ludovica, Missero, Caterina, Di Girolamo, Daniela · 2024 · Current Protocols
38. Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation
    Omura, Satoshi N., Nakagawa, Ryoya, Kajimoto, Shohei, Okazaki, Sae, Ishiguro, Soh, Mori, Hideto, Onishi, Kosuke, Kashiwakura, Yuji, Hiramoto, Takafumi, Horinaka, Kio et al. · 2026 · Nature Communications
39. Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies
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40. Kinetic mechanism for fidelity of CRISPR-Cas9 variants
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41. COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites
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