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Ageing-related chromatin defects through loss of the NURD complex

Pegoraro, Gianluca, Kubben, Nard, Wickert, Ute, Göhler, Heike, Hoffmann, Katrin, Misteli, Tom·2009·Nature Cell Biology
DOI 10.1038/ncb1971PMC PMC2779731
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  • DNA- and histone-modifying enzymes act in concert with key chromosomal proteins, such as HP1α, and chromatin remodeling factors, such as Polycomb group proteins or the NuRD complex, whose levels are diminished in both normally and pathologically aged cells.

    “DNA- and histone-modifying enzymes act in concert with key chromosomal proteins, such as the heterochromatin protein 1α (HP1α), and chromatin remodeling factors, such as Polycomb group proteins or the NuRD complex, whose levels are diminished in both normally and pathologically aged cells (Pegoraro et al., 2009; Pollina and Brunet, 2011).”

    From The Hallmarks of Aging (2013) · cites this paper as Pegoraro et al., 2009

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Research works printed but not linked: 24

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  2. Scaffidi, P. & Misteli, T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nature Med. 11, 440–445 (2005). · DOI · Paper page
  3. Scaffidi, P. & Misteli, T. Lamin A-dependent nuclear defects in human aging. Science 312, 1059–1063 (2006). · DOI · Paper page
  4. Shumaker, D. K. et al. Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc. Natl Acad. Sci. USA 103, 8703–8708 (2006). · DOI · Paper page
  5. Scaffidi, P. & Misteli, T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nature Cell Biol. 10, 452–459 (2008). · DOI
  6. Capell, B. C. & Collins, F. S. Human laminopathies: nuclei gone genetically awry. Nature Rev. 7, 940–952 (2006). · DOI
  7. Eriksson, M. et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423, 293–298 (2003). · DOI · Paper page
  8. De Sandre-Giovannoli, A. et al. Lamin a truncation in Hutchinson-Gilford progeria. Science 300, 2055 (2003). · DOI · Paper page
  9. Verreault, A., Kaufman, P. D., Kobayashi, R. & Stillman, B. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. Curr. Biol. 8, 96–108 (1998). · DOI
  10. Zhang, Y. et al. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13, 1924–1935 (1999). · DOI · Paper page
  11. Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P. & Reinberg, D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16, 2893–2905 (2002). · DOI · Paper page
  12. Verreault, A., Kaufman, P. D., Kobayashi, R. & Stillman, B. Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell 87, 95–104 (1996). · DOI
  13. Hayashi, T. et al. Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres. Cell 118, 715–729 (2004). · DOI
  14. Peters, A. H. et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell 12, 1577–1589 (2003). · DOI
  15. Rizzi, N. et al. Transcriptional activation of a constitutive heterochromatic domain of the human genome in response to heat shock. Mol. Biol. Cell 15, 543–551 (2004). · DOI
  16. Nabatiyan, A., Szuts, D. & Krude, T. Induction of CAF-1 expression in response to DNA strand breaks in quiescent human cells. Mol. Cell. Biol. 26, 1839–1849 (2006). · DOI
  17. Cronshaw, J. M., Krutchinsky, A. N., Zhang, W., Chait, B. T. & Matunis, M. J. Proteomic analysis of the mammalian nuclear pore complex. J. Cell Biol. 158, 915–927 (2002). · DOI
  18. Peng, J. C. & Karpen, G. H. Epigenetic regulation of heterochromatic DNA stability. Curr. Opin. Genet. Dev. 18, 204–211 (2008). · DOI
  19. Jorgensen, S. et al. The histone methyltransferase SET8 is required for S-phase progression. J. Cell Biol. 179, 1337–1345 (2007). · DOI
  20. Tardat, M., Murr, R., Herceg, Z., Sardet, C. & Julien, E. PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J. Cell Biol. 179, 1413–1426 (2007). · DOI
  21. Van Berlo, J. H. et al. A-type lamins are essential for TGF-β1 induced PP2A to dephosphorylate transcription factors. Hum. Mol. Genet. 14, 2839–2849 (2005). · DOI
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Metadata

Authors
Pegoraro, G., Kubben, N., Wickert, U., Göhler, H., Hoffmann, K., & Misteli, T.
Venue
Nature Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2009-09-06
Volume
11
Issue
10
Pages
1261-1267
ISSN
  • 1465-7392
  • 1476-4679
DOI
10.1038/ncb1971
PMC
PMC2779731
Cited by
276
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

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