The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway
Open accessAbstract
Unlike mammals, teleost fish mount a robust regenerative response to retinal injury that culminates in restoration of visual function. This regenerative response relies on dedifferentiation of Müller glia into a cycling population of progenitor cells. However, the mechanism underlying this dedifferentiation is unknown. Here, we report that genes encoding pluripotency factors are induced following retinal injury. Interestingly, the proneural transcription factor, Ascl1a, and the pluripotency factor, Lin-28, are induced in Müller glia within 6 h following retinal injury and are necessary for Müller glia dedifferentiation. We demonstrate that Ascl1a is necessary for lin-28 expression and that Lin-28 suppresses let-7 microRNA (miRNA) expression. Furthermore, we demonstrate that let-7 represses expression of regeneration-associated genes such as, ascl1a, hspd1, lin-28, oct4, pax6b and c-myc. hspd1, oct4 and c-myca exhibit basal expression in the uninjured retina and let-7 may inhibit this expression to prevent premature Müller glia dedifferentiation. The opposing actions of Lin-28 and let-7 miRNAs on Müller glia differentiation and dedifferentiation are similar to that of embryonic stem cells and suggest novel targets for stimulating Müller glia dedifferentiation and retinal regeneration in mammals.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
Miranda, K. C., Huynh, T., Tay, Y., Ang, Y.-S., Tam, W.-L., Thomson, A. M., Lim, B., & Rigoutsos, I. (2006) · Cell · doi:10.1016/j.cell.2006.07.031 · Cited by 2,063
Proneural genes and the specification of neural cell types
Bertrand, N., Castro, D. S., & Guillemot, F. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn874 · Cited by 1,488
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Kumar, M. S., Lu, J., Mercer, K. L., Golub, T. R., & Jacks, T. (2007) · Nature Genetics · doi:10.1038/ng2003 · Cited by 1,463
Selective Blockade of MicroRNA Processing by Lin28
Viswanathan, S. R., Daley, G. Q., & Gregory, R. I. (2008) · Science · doi:10.1126/science.1154040 · Cited by 1,437
TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation
Heo, I., Joo, C., Kim, Y.-K., Ha, M., Yoon, M.-J., Cho, J., Yeom, K.-H., Han, J., & Kim, V. N. (2009) · Cell · doi:10.1016/j.cell.2009.08.002 · Cited by 798
Rybak, A., Fuchs, H., Smirnova, L., Brandt, C., Pohl, E. E., Nitsch, R., & Wulczyn, F. G. (2008) · Nature Cell Biology · doi:10.1038/ncb1759 · Cited by 787
Wang, W.-X., Rajeev, B. W., Stromberg, A. J., Ren, N., Tang, G., Huang, Q., Rigoutsos, I., & Nelson, P. T. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5065-07.2008 · Cited by 701
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
Melton, C., Judson, R. L., & Blelloch, R. (2010) · Nature · doi:10.1038/nature08725 · Cited by 696
Bernardos, R. L., Barthel, L. K., Meyers, J. R., & Raymond, P. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1624-07.2007 · Cited by 647
Controlling morpholino experiments: don't stop making antisense
Eisen, J. S., & Smith, J. C. (2008) · Development · doi:10.1242/dev.001115 · Cited by 637
Genomic Analysis of Mouse Retinal Development
Blackshaw, S., Harpavat, S., Trimarchi, J., Cai, L., Huang, H., Kuo, W. P., Weber, G., Lee, K., Fraioli, R. E., Cho, S.-H., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020247 · Cited by 585
Epigenetic reprogramming and induced pluripotency
Hochedlinger, K., & Plath, K. (2009) · Development · doi:10.1242/dev.020867 · Cited by 553
A Primer for Morpholino Use in Zebrafish
Bill, B. R., Petzold, A. M., Clark, K. J., Schimmenti, L. A., & Ekker, S. C. (2009) · Zebrafish · doi:10.1089/zeb.2008.0555 · Cited by 474
A Role for 1 Tubulin-Expressing Muller Glia in Regeneration of the Injured Zebrafish Retina
Fausett, B. V., & Goldman, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0332-06.2006 · Cited by 435
Self-citationThe transcriptome of retinal Müller glial cells
Roesch, K., Jadhav, A. P., Trimarchi, J. M., Stadler, M. B., Roska, B., Sun, B. B., & Cepko, C. L. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21730 · Cited by 406
Stimulation of neural regeneration in the mouse retina
Karl, M. O., Hayes, S., Nelson, B. R., Tan, K., Buckingham, B., & Reh, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807453105 · Cited by 368
Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155
Chung, K.-H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl143 · Cited by 306
Regeneration of inner retinal neurons after intravitreal injection of ouabain in zebrafish
Fimbel, S. M., Montgomery, J. E., Burket, C. T., & Hyde, D. R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5317-06.2007 · Cited by 298
Proliferation zones in the brain of adult gymnotiform fish: A quantitative mapping study
Zupanc, G. K. H., & Horschke, I. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903530205 · Cited by 258
The Proneural Basic Helix-Loop-Helix Gene Ascl1a Is Required for Retina Regeneration
Fausett, B. V., Gumerson, J. D., & Goldman, D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4853-07.2008 · Cited by 251
Self-citationCharacterization of Müller glia and neuronal progenitors during adult zebrafish retinal regeneration
Thummel, R., Kassen, S. C., Enright, J. M., Nelson, C. M., Montgomery, J. E., & Hyde, D. R. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.07.009 · Cited by 209
Development and neurogenic potential of Müller glial cells in the vertebrate retina
Jadhav, A. P., Roesch, K., & Cepko, C. L. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.05.002 · Cited by 206
Kassen, S. C., Ramanan, V., Montgomery, J. E., T. Burket, C., Liu, C., Vihtelic, T. S., & Hyde, D. R. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20362 · Cited by 203
Xu, B., Zhang, K., & Huang, Y. (2009) · RNA · doi:10.1261/rna.1368009 · Cited by 194
Individual Retinal Progenitor Cells Display Extensive Heterogeneity of Gene Expression
Trimarchi, J. M., Stadler, M. B., & Cepko, C. L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001588 · Cited by 189
Ganglion cell regeneration following whole-retina destruction in zebrafish
Sherpa, T., Fimbel, S. M., Mallory, D. E., Maaswinkel, H., Spritzer, S. D., Sand, J. A., Li, L., Hyde, D. R., & Stenkamp, D. L. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20568 · Cited by 174
Inhibition of Müller glial cell division blocks regeneration of the light‐damaged zebrafish retina
Thummel, R., Kassen, S. C., Montgomery, J. E., Enright, J. M., & Hyde, D. R. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20596 · Cited by 168
Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish
Qin, Z., Barthel, L. K., & Raymond, P. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811186106 · Cited by 152
Thummel, R., Enright, J. M., Kassen, S. C., Montgomery, J. E., Bailey, T. J., & Hyde, D. R. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.02.001 · Cited by 148
Thummel, R., Bai, S., Sarras, M. P., Song, P., McDermott, J. P., Brewer, J., Perry, M., Zhang, X., Hyde, D. R., & Godwin, A. R. F. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20630 · Cited by 144
Preferential regeneration of photoreceptor from Müller glia after retinal degeneration in adult rat
Wan, J., Zheng, H., Chen, Z., Xiao, H., Shen, Z.-J., & Zhou, G. (2007) · Vision Research · doi:10.1016/j.visres.2007.11.002 · Cited by 143
Double in Situ Hybridization Techniques in Zebrafish
Jowett, T. (2001) · Methods · doi:10.1006/meth.2000.1147 · Cited by 141
α-Aminoadipate Induces Progenitor Cell Properties of Müller Glia in Adult Mice
Takeda, M., Takamiya, A., Jiao, J., Cho, K., Trevino, S. G., Matsuda, T., & Chen, D. F. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0434 · Cited by 139
An elegant miRror: microRNAs in stem cells, developmental timing and cancer
Nimmo, R. A., & Slack, F. J. (2009) · Chromosoma · doi:10.1007/s00412-009-0210-z · Cited by 132
Fish’n ChIPs: Chromatin Immunoprecipitation in the Zebrafish Embryo
Lindeman, L. C., Vogt-Kielland, L. T., Aleström, P., & Collas, P. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-414-2_5 · Cited by 72
Senut, M., Gulati-Leekha, A., & Goldman, D. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2281-04.2004 · Cited by 71
Self-citationVisual function in regenerating teleost retina following cytotoxic lesioning
MENSINGER, A. F., & POWERS, M. K. (1999) · Visual Neuroscience · doi:10.1017/s0952523899162059 · Cited by 63
Identification and analysis of the mouse basic/Helix-Loop-Helix transcription factor family
Li, J., Liu, Q., Qiu, M. S., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.114 · Cited by 22
[Potential for neural regeneration in the adult mammalian retina].
Ooto, S. (2006) · PubMed · Cited by 6
Cited by
Stimulation of functional neuronal regeneration from Müller glia in adult mice
Jorstad, N. L., Wilken, M. S., Grimes, W. N., Wohl, S. G., VandenBosch, L. S., Yoshimatsu, T., Wong, R. O., Rieke, F., & Reh, T. A. (2017) · Nature · doi:10.1038/nature23283 · Cited by 499
Lin28: Primal Regulator of Growth and Metabolism in Stem Cells
Shyh-Chang, N., & Daley, G. Q. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.03.005 · Cited by 458
Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism
Shyh-Chang, N., Zhu, H., Yvanka de Soysa, T., Shinoda, G., Seligson, M. T., Tsanov, K. M., Nguyen, L., Asara, J. M., Cantley, L. C., & Daley, G. Q. (2013) · Cell · doi:10.1016/j.cell.2013.09.059 · Cited by 363
HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration
Wan, J., Ramachandran, R., & Goldman, D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.020 · Cited by 262
Self-citationRamachandran, R., Zhao, X.-F., & Goldman, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107220108 · Cited by 206
Self-citation
Metadata
- Authors
- Ramachandran, R., Fausett, B. V., & Goldman, D.
- Venue
- Nature Cell Biology
- Published
- 2010-10-10
- Volume
- 12
- Issue
- 11
- Pages
- 1101-1107
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1979509436
- Cited by
- 366
- References
- 40
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-03-27)
- Open access
- green
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
