Systems-level antimicrobial drug and drug synergy discovery

Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection

Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858 · see citing works

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

Boucher, H. W., Talbot, G. H., Bradley, J. S., Edwards, J. E., Gilbert, D. N., Rice, L. B., Scheld, M., Spellberg, B. J., & Bartlett, J. (2008) · Clinical Infectious Diseases · doi:10.1086/595011 · Cited by 4,978 · see citing works

Functional profiling of the Saccharomyces cerevisiae genome

Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316 · see citing works

Functional Characterization of the <i>S. cerevisiae</i> Genome by Gene Deletion and Parallel Analysis

Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science · doi:10.1126/science.285.5429.901 · Cited by 3,953 · see citing works

The Bacterial Cell EnvelopePreprint

Silhavy, T. J., Kahne, D. E., & Walker, S. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000414 · Cited by 3,834 · see citing works

Genes required for mycobacterial growth defined by high density mutagenesis

Sassetti, C. M., Boyd, D. H., & Rubin, E. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03425.x · Cited by 2,544 · see citing works

Drugs for bad bugs: confronting the challenges of antibacterial discovery

Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2201 · Cited by 2,512 · see citing works

Synergy, antagonism, and what the chequerboard puts between them

Odds, F. C. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg301 · Cited by 2,498 · see citing works

A Diarylquinoline Drug Active on the ATP Synthase of <i>Mycobacterium tuberculosis</i>

Andries, K., Verhasselt, P., Guillemont, J., Göhlmann, H. W. H., Neefs, J.-M., Winkler, H., Van Gestel, J., Timmerman, P., Zhu, M., Lee, E., et al. (2005) · Science · doi:10.1126/science.1106753 · Cited by 2,191 · see citing works

The Genetic Landscape of a Cell

Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science · doi:10.1126/science.1180823 · Cited by 2,162 · see citing works

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

Tong, A. H. Y., Evangelista, M., Parsons, A. B., Xu, H., Bader, G. D., Pagé, N., Robinson, M., Raghibizadeh, S., Hogue, C. W. V., Bussey, H., et al. (2001) · Science · doi:10.1126/science.1065810 · Cited by 2,138 · see citing works

Global Mapping of the Yeast Genetic Interaction Network

Tong, A. H. Y., Lesage, G., Bader, G. D., Ding, H., Xu, H., Xin, X., Young, J., Berriz, G. F., Brost, R. L., Chang, M., et al. (2004) · Science · doi:10.1126/science.1091317 · Cited by 2,070 · see citing works

How were new medicines discovered?

Swinney, D. C., & Anthony, J. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3480 · Cited by 1,812 · see citing works

Antibiotics for Emerging Pathogens

Fischbach, M. A., & Walsh, C. T. (2009) · Science · doi:10.1126/science.1176667 · Cited by 1,787 · see citing works

Three Decades of β-Lactamase Inhibitors

Drawz, S. M., & Bonomo, R. A. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00037-09 · Cited by 1,709 · see citing works

Essential Bacillus subtilis genes

Kobayashi, K., Ehrlich, S., Albertini, A., Amati, G., Andersen, K. K., Arnaud, M., Asai, K., Ashikaga, S., Aymerich, S., Bessières, P., et al. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0730515100 · Cited by 1,451 · see citing works

Challenges of Antibacterial Discovery

Silver, L. L. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00030-10 · Cited by 1,376 · see citing works

The antibiotic resistome: the nexus of chemical and genetic diversity

Wright, G. D. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1614 · Cited by 1,373 · see citing works

Comprehensive transposon mutant library of Pseudomonas aeruginosa

Jacobs, M. A., Alwood, A., Thaipisuttikul, I., Spencer, D. H., Haugen, E., Ernst, S., Will, O., Kaul, R., Raymond, C. K., Levy, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2036282100 · Cited by 1,129 · see citing works

New uses for old drugs

Chong, C. R., & Sullivan, D. J. (2007) · Nature · doi:10.1038/448645a · Cited by 996 · see citing works

An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants

Liberati, N. T., Urbach, J. M., Miyata, S., Lee, D. G., Drenkard, E., Wu, G., Villanueva, J. M., Wei, T., & Ausubel, F. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511100103 · Cited by 971 · see citing works

Synergistic drug combinations tend to improve therapeutically relevant selectivity

Lehár, J., Krueger, A., Avery, W., Heilbut, A. M., Johansen, L. M., Price, E. R., Rickles, R. J., Short, G. F., Staunton, J. E., Jin, X., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1549 · Cited by 941 · see citing works

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

Moffatt, J. H., Harper, M., Harrison, P. F., Hale, J. D. F., VINOGRADOV, E. V., Seemann, T., Henry, R., Crane, B., Michael, F. S., Cox, A. D., et al. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00834-10 · Cited by 817 · see citing works

Experimental Determination and System Level Analysis of Essential Genes in Escherichia coli MG1655

Gerdes, S., Scholle, M., Campbell, J., Balázsi, G., Ravasz, E., Daugherty, M., Somera, A., Kyrpides, N., Anderson, I., Gelfand, M., et al. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.19.5673-5684.2003 · Cited by 788 · see citing works

Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

Nikaido, H., & Pagès, J. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00290.x · Cited by 770 · see citing works

Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli

Wu, T., Malinverni, J. C., Ruiz, N., Kim, S., Silhavy, T. J., & Kahne, D. E. (2005) · Cell · doi:10.1016/j.cell.2005.02.015 · Cited by 769 · see citing works

Phenotypic Landscape of a Bacterial Cell

Nichols, R. J., Sen, Ś., Choo, Y. J., Beltrão, P., Zietek, M., Chaba, R., Lee, S., Kazmierczak, K. M., Lee, K. J., Wong, A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.052 · Cited by 702 · see citing works

Antibiotics: Actions, Origins, Resistance

Walsh, C. T. (2003) · Medical Entomology and Zoology · Cited by 675 · see citing works

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

Parsons, A. B., Brost, R. L., Ding, H., Li, Z., Zhang, C., Sheikh, B., Brown, G. W., Kane, P. M., Hughes, T. R., & Boone, C. M. (2003) · Nature Biotechnology · doi:10.1038/nbt919 · Cited by 651 · see citing works

Antibiotics

Walsh, C. T. (2003) · Wiley eBooks · doi:10.1128/9781555817886 · Cited by 630 · see citing works

Systematic discovery of multicomponent therapeutics

Borisy, A. A., Elliott, P. J., Hurst, N. W., Lee, M. S., Lehár, J., Price, E. R., Serbedzija, G., Zimmermann, G. R., Foley, M. A., Stockwell, B. R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1337088100 · Cited by 620 · see citing works

Simultaneous assay of every Salmonella Typhi gene using one million transposon mutantsPreprint

Langridge, G. C., Phan, M., Turner, D., Perkins, T. T., Parts, L., Haase, J. K., Charles, I. G., Maskell, D. J., Peters, S. E., Gordon Dougan, B., et al. (2009) · Genome Research · doi:10.1101/gr.097097.109 · Cited by 618 · see citing works

Exploration of Essential Gene Functions via Titratable Promoter Alleles

Mnaimneh, S., Davierwala, A. P., Haynes, J., Moffat, J., Peng, W.-T., Zhang, W., Yang, X., Pootoolal, J., Chua, G., Lopez, A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.06.013 · Cited by 604 · see citing works

Regulatory circuitry governing fungal development, drug resistance, and disease.

Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576 · see citing works

Genomic profiling of drug sensitivities via induced haploinsufficiency

Giaever, G. N., Shoemaker, D. D., Jones, T., Liang, H., Winzeler, E. A., Astromoff, A., & Davis, R. W. (1999) · Nature Genetics · doi:10.1038/6791 · Cited by 570 · see citing works

Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar–coding strategy

Shoemaker, D. D., Lashkari, D. A., Morris, D., Mittmann, M., & Davis, R. W. (1996) · Nature Genetics · doi:10.1038/ng1296-450 · Cited by 569 · see citing works

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Ejim, L., Farha, M. A., Falconer, S. B., Wildenhain, J., Coombes, B. K., Tyers, M., Brown, E. D., & Wright, G. D. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.559 · Cited by 525 · see citing works

MipZ, a Spatial Regulator Coordinating Chromosome Segregation with Cell Division in Caulobacter

Thanbichler, M. R., & Shapiro, L. (2006) · Cell · doi:10.1016/j.cell.2006.05.038 · Cited by 517 · see citing works

Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery

Roemer, T., Jiang, B., Davison, J., Ketela, T. W., Veillette, K., Breton, A., Tandia, F., Linteau, A., Sillaots, S., Marta, C., et al. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03697.x · Cited by 513 · see citing works

Why is big Pharma getting out of antibacterial drug discovery?

Projan, S. J. (2003) · Current Opinion in Microbiology · doi:10.1016/j.mib.2003.08.003 · Cited by 507 · see citing works

Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast

Giaever, G. N., Flaherty, P., Kumm, J., Proctor, M. J., Nislow, C., Jaramillo, D. F., Chu, A. M., Jordan, M. I., Arkin, A. P., & Davis, R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307490100 · Cited by 506 · see citing works

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

Parsons, A. B., López, A., Givoni, I. E., Williams, D. E., Gray, C. A., Porter, J., Chua, G., Sopko, R., Brost, R. L., Ho, C.-H., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.040 · Cited by 500 · see citing works

A genome‐wide strategy for the identification of essential genes in Staphylococcus aureus

Forsyth, A., Haselbeck, R. J., Ohlsen, K. L., Yamamoto, R. T., Xu, H. H., Trawick, J. D., Wall, D., Wang, L., Brown‐Driver, V., Froelich, J. M., et al. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02832.x · Cited by 488 · see citing works

Susceptibility testing of antimicrobials in liquid media

Amsterdam, D. (1996) · Medical Entomology and Zoology · Cited by 482 · see citing works

Biochemical and genetic analysis of the yeast proteome with a movable ORF collectionPreprint

Gelperin, D. M., White, M. A., Wilkinson, M. L., Kon, Y., Kung, L. A., Wise, K. J., Lopez-Hoyo, N., Jiang, L., Piccirillo, S., Yu, H., et al. (2005) · Genes & Development · doi:10.1101/gad.1362105 · Cited by 479 · see citing works

Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes

Lum, P. Y., Armour, C. D., Stepaniants, S. B., Cavet, G., Wolf, M. K., Butler, J. S., Hinshaw, J. C., Garnier, P., Prestwich, G. D., Leonardson, A. S., et al. (2004) · Cell · doi:10.1016/s0092-8674(03)01035-3 · Cited by 471 · see citing works

Defining genetic interaction

Mani, R., St.Onge, R. P., Hartman, J. L., Giaever, G. N., & Roth, F. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712255105 · Cited by 471 · see citing works

Practical applications and feasibility of efflux pump inhibitors in the clinic—A vision for applied use

Lomovskaya, O., & Bostian, K. A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.008 · Cited by 461 · see citing works

An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

Haydon, D. J., Stokes, N. R., Ure, R., Galbraith, G., Bennett, J. M., Brown, D. R., Baker, P. J., Barynin, V. V., Rice, D. W., Sedelnikova, S. E., et al. (2008) · Science · doi:10.1126/science.1159961 · Cited by 452 · see citing works

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

Grzegorzewicz, A. E., Pham, H., Gundi, V. A. K. B., Scherman, M. S., North, E. J., Hess, T., Jones, V., Gruppo, V., Born, S. E. M., Korduláková, J., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.794 · Cited by 442 · see citing works

An insight into the antifungal pipeline: selected new molecules and beyond

Ostrosky-Zeichner, L., Casadevall, A., Galgiani, J. N., Odds, F. C., & Rex, J. H. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3074 · Cited by 432 · see citing works

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813394106 · Cited by 413 · see citing works

The Neglected Intrinsic Resistome of Bacterial Pathogens

Fajardo-Lubian, A., Martinez-Martín, N., Mercadillo, M., Galán, J. C., Ghysels, B., Matthijs, S., Cornélis, P., Wiehlmann, L., Tümmler, B., Baquero, F., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001619 · Cited by 368 · see citing works

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

Baryshnikova, A., Costanzo, M., Kim, Y., Ding, H., Koh, J., Toufighi, K., Youn, J.-Y., Ou, J., San Luis, B.-J., Bandyopadhyay, S., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1534 · Cited by 364 · see citing works

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

Singh, S. D., Robbins, N., Zaas, A. K., Schell, W. A., Perfect, J. R., & Cowen, L. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000532 · Cited by 362 · see citing works

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae

Akerley, B. J., Rubin, E. J., Novick, V. L., Amaya, K. R., Judson, N., & Mekalanos, J. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012602299 · Cited by 358 · see citing works

Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress.

Cyert, M. S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01552-3 · Cited by 333 · see citing works

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

Brinster, S., Lamberet, G., Staels, B., Trieu‐Cuot, P., Gruss, A., & Poyart, C. (2009) · Nature · doi:10.1038/nature07772 · Cited by 318 · see citing works

Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases

Paradis‐Bleau, C., Markovski, M., Uehara, T., Lupoli, T. J., Walker, S., Kahne, D. E., & Bernhardt, T. G. (2010) · Cell · doi:10.1016/j.cell.2010.11.037 · Cited by 313 · see citing works

Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

Chaudhuri, R. R., Allen, A. G., Owen, P., Shalom, G., Stone, K. M., Harrison, M., Burgis, T. A., Lockyer, M. J., Garcı́a-Lara, J., Foster, S. J., et al. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-291 · Cited by 309 · see citing works

Systematic exploration of synergistic drug pairs

Cokol, M., Chua, H. N., Tasan, M., Mutlu, B., Weinstein, Z., Suzuki, Y., Nergiz, M. E., Costanzo, M., Baryshnikova, A., Giaever, G. N., et al. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.71 · Cited by 308 · see citing works

A complete collection of single‐gene deletion mutants of Acinetobacter baylyi ADP1

de Berardinis, V., Vallenet, D., Castelli, V., Besnard‐Gonnet, M., Pinet, A., Cruaud, C., Samair, S., Lechaplais, C., Gyapay, G., Richez, C., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.10 · Cited by 303 · see citing works

Quantitative phenotyping via deep barcode sequencingPreprint

Smith, A. M., Heisler, L. E., Mellor, J. C., Kaper, F., Thompson, M. J., Chee, M. S., Roth, F. P., Giaever, G. N., & Nislow, C. (2009) · Genome Research · doi:10.1101/gr.093955.109 · Cited by 297 · see citing works

Systematic Mapping of Genetic Interaction Networks

Dixon, S. J., Costanzo, M., Baryshnikova, A., Andrews, B., & Boone, C. M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.114751 · Cited by 290 · see citing works

Discovery research: the scientific challenge of finding new antibiotics

Livermore, D. M., on behalf of the British Society for Antimicrobial Chemotherapy Working Party on The Urgent Need: Regenerating Antibacterial Drug Discovery and Development, Blaser, M., Carrs, O., Cassell, G., Fishman, N., Guidos, R., Levy, S., Powers, J. H., Norrby, R., et al. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr262 · Cited by 286 · see citing works

Antibiotic Sensitivity Profiles Determined with an Escherichia coli Gene Knockout Collection: Generating an Antibiotic Bar Code

Liu, A., Tran, L., Becket, E., Lee, K., Chinn, L., Park, E. Y., Tran, K. P., & Miller, J. H. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00906-09 · Cited by 284 · see citing works

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

Ho, C. H., Magtanong, L., Barker, S. L., Gresham, D., Nishimura, S., Natarajan, P., Koh, J. L. Y., Porter, J., Gray, C. A., Andersen, R. J., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1534 · Cited by 281 · see citing works

Systematic identification of essential genes by in vitro mariner mutagenesis

Akerley, B. J., Rubin, E. J., Camilli, A., Lampe, D. J., Robertson, H. M., & Mekalanos, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8927 · Cited by 267 · see citing works

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

Stanley, S. A., Grant, S. S., Kawate, T., Iwase, N., Shimizu, M., Wivagg, C. N., Silvis, M. R., Kazyanskaya, E., Aquadro, J. A., Golas, A. J., et al. (2012) · ACS Chemical Biology · doi:10.1021/cb300151m · Cited by 252 · see citing works

Genome-Wide Fitness Test and Mechanism-of-Action Studies of Inhibitory Compounds in Candida albicans

Xu, D., Jiang, B., Ketela, T. W., Lemieux, S., Veillette, K., Martel, N., Davison, J., Sillaots, S., Trosok, S., Bachewich, C., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030092 · Cited by 249 · see citing works

Marcel Faber Roundtable: Is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

Baltz, R. H. (2006) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-005-0077-9 · Cited by 248 · see citing works

Antibiotic adjuvants: multicomponent anti-infective strategies

Kalan, L., & Wright, G. D. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001766 · Cited by 246 · see citing works

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics

Tan, C. M., Therien, A. G., Lu, J., Lee, S. H., Caron, A., Gill, C., Jacob, C. L., Benton-Perdomo, L., Monteiro, J. M., Pereira, P. M., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003592 · Cited by 242 · see citing works

Essential Gene Identification and Drug Target Prioritization in Aspergillus fumigatus

Hu, W., Sillaots, S., Lemieux, S., Davison, J., Kauffman, S., Breton, A., Linteau, A., Xin, C., Bowman, J., Becker, J., et al. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030024 · Cited by 237 · see citing works

Determination of Antibiotic Hypersensitivity among 4,000 Single-Gene-Knockout Mutants of Escherichia coli

Tamae, C., Liu, A., Kim, K. K., Sitz, D., Hong, J., Becket, E., Bui, A., Solaimani, P., Tran, K. P., Yang, H., et al. (2008) · Journal of Bacteriology · doi:10.1128/jb.01982-07 · Cited by 234 · see citing works

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

Farha, M. A., Leung, A. A. C., Sewell, E. W., D’Elia, M. A., Allison, S. E., Ejim, L. J., Pereira, P. M., Pinho, M. G., Wright, G. D., & Brown, E. D. (2012) · ACS Chemical Biology · doi:10.1021/cb300413m · Cited by 217 · see citing works

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures

Pierce, S. E., Davis, R. W., Nislow, C., & Giaever, G. N. (2007) · Nature Protocols · doi:10.1038/nprot.2007.427 · Cited by 208 · see citing works

Tetracycline-Inducible Gene Expression and Gene Deletion in Candida albicans

Park, Y.-N., & Morschhäuser, J. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.8.1328-1342.2005 · Cited by 205 · see citing works

An integrated platform of genomic assays reveals small-molecule bioactivities

Hoon, S. S., Smith, A. M., Wallace, I. M., Suresh, S., Miranda, M., Fung, E., Proctor, M. J., Shokat, K. M., Zhang, C., Davis, R. W., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.100 · Cited by 201 · see citing works

Towards a new tuberculosis drug: pyridomycin – nature's isoniazid

Hartkoorn, R. C., Sala, C., Neres, J., Pojer, F., Magnet, S., Mukherjee, R., Uplekar, S. M., Boy‐Röttger, S., Altmann, K., & Cole, S. T. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201689 · Cited by 188 · see citing works

Genetic Architecture of Intrinsic Antibiotic Susceptibility

Girgis, H. S., Hottes, A. K., & Tavazoie, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005629 · Cited by 178 · see citing works

Resistance of human fungal pathogens to antifungal drugs

Sanglard, D. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00344-2 · Cited by 178 · see citing works

Antibiotics in Laboratory Medicine, 6th Edition

Mathers, A. J. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ078 · Cited by 170 · see citing works

Synergistic Antifungal Activities of Bafilomycin A ₁ , Fluconazole, and the Pneumocandin MK-0991/Caspofungin Acetate (L-743,873) with Calcineurin Inhibitors FK506 and L-685,818 against <i>Cryptococcus neoformans</i>

Del Poeta, M., Cruz, M. C., Cardenas, M. E., Perfect, J. R., & Heitman, J. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.3.739-746.2000 · Cited by 169 · see citing works

Evolution and pathogenesis ofStaphylococcus aureus: lessons learned from genotyping and comparative genomics

Feng, Y., Chen, C., Su, L., Hu, S., Yu, J. M., & Chiu, C. (2007) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00086.x · Cited by 168 · see citing works

Analysis of β-1,3-Glucan Assembly in Saccharomyces cerevisiae Using a Synthetic Interaction Network and Altered Sensitivity to Caspofungin

Lesage, G., Sdicu, A.-M., Ménard, P., Shapiro, J., Hussein, S., & Bussey, H. (2004) · Genetics · doi:10.1534/genetics.167.1.35 · Cited by 166 · see citing works

Tetracycline-Regulatable System To Tightly Control Gene Expression in the Pathogenic Fungus Candida albicans

Nakayama, H., Mio, T., Nagahashi, S., Kokado, M., Arisawa, M., & Aoki, Y. (2000) · Infection and Immunity · doi:10.1128/iai.68.12.6712-6719.2000 · Cited by 157 · see citing works

Essentiality of FASII pathway for Staphylococcus aureus

Balemans, W., Lounis, N., Gilissen, R., Guillemont, J., Simmen, K., Andries, K., & Koul, A. (2010) · Nature · doi:10.1038/nature08667 · Cited by 154 · see citing works

Phylogeny and beyond: Scientific, historical, and conceptual significance of the first tree of life

Pace, N. R., Sapp, J., & Goldenfeld, N. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109716109 · Cited by 149 · see citing works

Confronting the challenges of natural product-based antifungal discovery

Roemer, T., Xu, D., Singh, S. B., Parish, C. A., Harris, G., Wang, H., Davies, J. E., & Bills, G. F. (2011) · Chemistry &amp; Biology · doi:10.1016/j.chembiol.2011.01.009 · Cited by 147 · see citing works

Caspofungin: the first in a new class of antifungal agents

Kartsonis, N. A., NIELSEN, J. B. K., & Douglas, C. M. (2003) · Drug Resistance Updates · doi:10.1016/s1368-7646(03)00064-5 · Cited by 146 · see citing works

Global Phenotypic Screening for Antimalarials

Guiguemde, W. A., Shelat, A. A., Garcia-Bustos, J., Diagana, T. T., Gamo, F., & Guy, R. K. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.01.004 · Cited by 136 · see citing works

Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model

Becker, J. M., Kauffman, S., Hauser, M., Huang, L.-Y., Lin, M. T.-Y., Sillaots, S., Jiang, B., Xu, D., & Roemer, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009845107 · Cited by 135 · see citing works

New triazoles and echinocandins: mode of action, in vitro activity and mechanisms of resistance

Fera, M. T., Camera, E. L., & Sarro, A. D. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.67 · Cited by 134 · see citing works

An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae

Lesage, G., Shapiro, B. J., Specht, C. A., Sdicu, A., Ménard, P., Hussein, S., Tong, A. H. Y., Boone, C. M., & Bussey, H. (2005) · BMC Genetics · doi:10.1186/1471-2156-6-8 · Cited by 123 · see citing works

Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus

Huber, J. L., Donald, R. G. K., Lee, S. H., Jarantow, L. W., Salvatore, M. J., Meng, X., Painter, R. E., Onishi, R., Occi, J., Dorso, K., et al. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.05.012 · Cited by 116 · see citing works

Identification and in vitro Analysis of the GatD/MurT Enzyme-Complex Catalyzing Lipid II Amidation in Staphylococcus aureus

Münch, D., Roemer, T., Lee, S. H., Engeser, M., Sahl, H. G., & Schneider, T. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002509 · Cited by 114 · see citing works

The antibiotic resistome

Wright, G. D. (2010) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2010.497535 · Cited by 109 · see citing works

Reversal of resistance in microorganisms by help of non-antibiotics

Kristiansen, J. E., Hendricks, O., Delvin, T., Butterworth, T. S., Aagaard, L., Christensen, J. B., Flores, V. C., & Keyzer, H. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm071 · Cited by 109 · see citing works

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers

Yan, Z., Costanzo, M., Heisler, L. E., Paw, J., Kaper, F., Andrews, B., Boone, C. M., Giaever, G. N., & Nislow, C. (2008) · Nature Methods · doi:10.1038/nmeth.1231 · Cited by 105 · see citing works

A Staphylococcus aureus Fitness Test Platform for Mechanism-Based Profiling of Antibacterial Compounds

Donald, R. G. K., Skwish, S., Forsyth, A., Anderson, J. W., Zhong, T., Burns, C. M., Lee, S., Meng, X., LoCastro, L., Jarantow, L. W., et al. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.07.004 · Cited by 98 · see citing works

Gene Annotation and Drug Target Discovery in Candida albicans with a Tagged Transposon Mutant Collection

Oh, J., Fung, E., Schlecht, U., Davis, R. W., Giaever, G. N., St.Onge, R. P., Deutschbauer, A. M., & Nislow, C. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001140 · Cited by 96 · see citing works

Yeast chemical genomics and drug discovery: an update

Hoon, S. S., St.Onge, R. P., Giaever, G. N., & Nislow, C. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.07.006 · Cited by 96 · see citing works

A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor

Nam, T., McNamara, C. W., Bopp, S. E. R., Dharia, N. V., Meister, S., Bonamy, G. M. C., Plouffe, D., Kato, N., McCormack, S., Bursulaya, B. D., et al. (2011) · ACS Chemical Biology · doi:10.1021/cb200105d · Cited by 95 · see citing works

Chitin Synthase Inhibitors as Antifungal Agents

Chaudhary, P. M., Tupe, S. G., & Deshpande, M. V. (2013) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955713804805256 · Cited by 93 · see citing works

Genes Involved in Intrinsic Antibiotic Resistance of Acinetobacter baylyi

Gomez, M. J., & Neyfakh, A. A. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00579-06 · Cited by 88 · see citing works

PAP Inhibitor with In Vivo Efficacy Identified by Candida albicans Genetic Profiling of Natural Products

Jiang, B., Xu, D., Allocco, J., Parish, C. A., Davison, J., Veillette, K., Sillaots, S., Hu, W., Rodriguez-Suarez, R. J., Trosok, S., et al. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.016 · Cited by 82 · see citing works

Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics

Lee, S. H., Jarantow, L. W., Wang, H., Sillaots, S., Cheng, H. S., Meredith, T. C., Thompson, J. R., & Roemer, T. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.08.015 · Cited by 78 · see citing works

Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

Therien, A. G., Huber, J. L., Wilson, K. E., Beaulieu, P., Caron, A., Claveau, D., Deschamps, K., Donald, R. G. K., Galgoci, A. M., Gallant, M., et al. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00726-12 · Cited by 76 · see citing works

Characterization of Novel Mycobacterium tuberculosis and Mycobacterium smegmatis Mutants Hypersusceptible to β-Lactam Antibiotics

Flores, A. R., Parsons, L. M., & Pavelka, M. S. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.6.1892-1900.2005 · Cited by 67 · see citing works

Chitin synthase III: Synthetic lethal mutants and “stress related” chitin synthesis that bypasses the CSD3/CHS6 localization pathway

Osmond, B. C., Specht, C. A., & Robbins, P. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11206 · Cited by 66 · see citing works

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus Isolates from Transplant and Nontransplant Patients

Steinbach, W. J., Singh, N., Miller, J. L., Benjamin, D. K., Schell, W. A., Heitman, J., & Perfect, J. R. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.12.4922-4925.2004 · Cited by 66 · see citing works

Reshuffling of Aspergillus fumigatus Cell Wall Components Chitin and β-Glucan under the Influence of Caspofungin or Nikkomycin Z Alone or in Combination

Verwer, P. E. B., VanDuijn, M. M., Tavakol, M., Bakker‐Woudenberg, I. A. J. M., & van de Sande, W. W. J. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05323-11 · Cited by 58 · see citing works

Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from theFusarium larvarumcomplex and other Hypocrealean fungi

Bills, G. F., Platas, G., Overy, D. P., Collado, J., Fillola, A., Jiménez, M. R., Martı́n, J., del Val, A. G., Vicente, F., Tormo, J. R., et al. (2009) · Mycologia · doi:10.3852/08-163 · Cited by 56 · see citing works

Depletion of the Squalene Synthase ( ERG9 ) Gene Does Not Impair Growth of Candida glabrata in Mice

Nakayama, H., Izuta, M., Nakayama, N., Arisawa, M., & Aoki, Y. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2411-2418.2000 · Cited by 53 · see citing works

Staphylococcus aureus TargetArray: Comprehensive Differential Essential Gene Expression as a Mechanistic Tool To Profile Antibacterials

Xu, H. H., Trawick, J. D., Haselbeck, R. J., Forsyth, A., Yamamoto, R. T., Archer, R., Patterson, J., Allen, M., Froelich, J. M., Taylor, I., et al. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00308-10 · Cited by 51 · see citing works

Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144

Fukumoto, A., Kim, Y.-P., Hanaki, H., Shiomi, K., Tomoda, H., & Ōmura, S. (2008) · The Journal of Antibiotics · doi:10.1038/ja.2008.102 · Cited by 51 · see citing works

Compound Prioritization Methods Increase Rates of Chemical Probe Discovery in Model Organisms

Wallace, I. M., Urbanus, M. L., Luciani, G. M., Burns, A. R., Han, M. K. L., Wang, H., Arora, K., Heisler, L. E., Proctor, M. J., St.Onge, R. P., et al. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.07.018 · Cited by 47 · see citing works

Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B

Sandovsky‐Losica, H., Shwartzman, R., Lahat, Y., & Segal, E. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn216 · Cited by 42 · see citing works

Development of Genomic Array Footprinting for Identification of Conditionally Essential Genes inStreptococcus pneumoniae

Bijlsma, J. J. E., Burghout, P., Kloosterman, T. G., Bootsma, H. J., de Jong, A., Hermans, P. W. M., & Kuipers, O. P. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01900-06 · Cited by 41 · see citing works

In Vitro and In Vivo Effects of 14α-Demethylase ( ERG11 ) Depletion in Candida glabrata

Nakayama, H., Nakayama, N., Arisawa, M., & Aoki, Y. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.11.3037-3045.2001 · Cited by 39 · see citing works

Genomewide Screening for Novel Genetic Variations Associated with Ciprofloxacin Resistance in Bacillus anthracis

Serizawa, M., Sekizuka, T., Okutani, A., Banno, S., Sata, T., Inoue, S., & Kuroda, M. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01405-09 · Cited by 34 · see citing works

Whither antibacterial drug discovery?

Projan, S. J. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.03.010 · Cited by 32 · see citing works

Harnessing the power of transposon mutagenesis for antibacterial target identification and evaluation

Meredith, T. C., Wang, H., Beaulieu, P., Gründling, A., & Roemer, T. (2012) · Mobile Genetic Elements · doi:10.4161/mge.21647 · Cited by 26 · see citing works

Parsimonious Discovery of Synergistic Drug Combinations

Severyn, B. S., Liehr, R. A., Wolicki, A., Nguyen, K. H., Hudak, E. M., Ferrer, M., Caldwell, J. S., Hermes, J. D., Li, J., & Tudor, M. (2011) · ACS Chemical Biology · doi:10.1021/cb2003225 · Cited by 26 · see citing works

Chemical Genomic Approaches to Study Model Microbes

Barker, C. A., Farha, M. A., & Brown, E. D. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.05.010 · Cited by 22 · see citing works

The re-emergence of natural products for drug discovery in the genomics era

Harvey, A. L., Edrada‐Ebel, R., & Quinn, R. J. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4510 · Cited by 2,601 · see citing works

A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science · doi:10.1126/science.aaf1420 · Cited by 1,240 · see citing works

Target identification and mechanism of action in chemical biology and drug discovery

Schenone, M., Dančík, V., Wagner, B. K., & Clemons, P. A. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1199 · Cited by 1,107 · see citing works

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

Tyers, M., & Wright, G. D. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0141-x · Cited by 825 · see citing works

Antifungal Drug Resistance: Molecular Mechanisms in <i>Candida albicans</i> and Beyond

Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801 · see citing works

Combenefit: an interactive platform for the analysis and visualization of drug combinations

Veroli, G. Y. D., Fornari, C., Wang, D. Y. Q., Mollard, S., Bramhall, J. L., Richards, F. M., & Jodrell, D. I. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw230 · Cited by 736 · see citing works

Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

Roemer, T., & Krysan, D. J. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019703 · Cited by 593 · see citing works

Exogenous Alanine and/or Glucose plus Kanamycin Kills Antibiotic-Resistant Bacteria

Peng, B., Su, Y., Li, H., Han, Y., Guo, C., Tian, Y., & Peng, X. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.008 · Cited by 486 · see citing works

How to bolster the antifungal pipeline

Denning, D. W., & Bromley, M. (2015) · Science · doi:10.1126/science.aaa6097 · Cited by 481 · see citing works

The rapid spread of carbapenem-resistant Enterobacteriaceae

Potter, R. F., D’Souza, A. W., & Dantas, G. A. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.09.002 · Cited by 408 · see citing works

Whole-genome sequencing to control antimicrobial resistance

Köser, C. U., Ellington, M. J., & Peacock, S. J. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.07.003 · Cited by 333 · see citing works

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0002-2016 · Cited by 271 · see citing works

Infection microenvironment-related antibacterial nanotherapeutic strategies

Wang, Z., Liu, X., Duan, Y., & Huang, Y. P. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121249 · Cited by 269 · see citing works

Tunable protein degradation in bacteria

Cameron, D. E., & Collins, J. J. (2014) · Nature Biotechnology · doi:10.1038/nbt.3053 · Cited by 255 · see citing works

Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery

Zhang, W., Huai, Y., Miao, Z., Qian, A., & Wang, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00743 · Cited by 250 · see citing works

Combinatorial strategies for combating invasive fungal infections

Spitzer, M., Robbins, N., & Wright, G. D. (2016) · Virulence · doi:10.1080/21505594.2016.1196300 · Cited by 218 · see citing works

Large-scale exploration and analysis of drug combinations

Li, P., Huang, C., Fu, Y., Wang, J., Wu, Z., Ru, J., Zheng, C., Guo, Z., Chen, X., Zhou, W., et al. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv080 · Cited by 196 · see citing works

Supramolecular Assemblies of Heterogeneous Mesoporous Silica Nanoparticles to Co-deliver Antimicrobial Peptides and Antibiotics for Synergistic Eradication of Pathogenic Biofilms

Yu, Q., Deng, T., Lin, F.-C., Zhang, B., & Zink, J. I. (2020) · ACS Nano · doi:10.1021/acsnano.0c01336 · Cited by 187 · see citing works

Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi

McCarthy, M. W., Kontoyiannis, D. P., Cornely, O. A., Perfect, J. R., & Walsh, T. J. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix130 · Cited by 171 · see citing works

Antimicrobial lipopeptide tridecaptin A 1 selectively binds to Gram-negative lipid II

Cochrane, S. A., Findlay, B., Bakhtiary, A., Acedo, J. Z., Rodriguez-Lopez, E. M., Mercier, P., & Vederas, J. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608623113 · Cited by 138 · see citing works

Challenges and strategies in drug delivery systems for treatment of pulmonary infections

Ho, D., Nichols, B. L. B., Edgar, K. J., Murgia, X., Loretz, B., & Lehr, C. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.09.002 · Cited by 138 · see citing works

Combinatorial drug discovery in nanoliter droplets

Kulesa, A. B., Kehe, J., Hurtado, J. E., Tawde, P., & Blainey, P. C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802233115 · Cited by 135 · see citing works

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

Fisher, J. F., & Mobashery, S. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01010 · Cited by 127 · see citing works

Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning

Wildenhain, J., Spitzer, M., Dolma, S., Jarvik, N., White, R., Roy, M. M., Griffiths, E., Bellows, D. S., Wright, G. D., & Tyers, M. (2015) · Cell Systems · doi:10.1016/j.cels.2015.12.003 · Cited by 122 · see citing works

Chemogenomics and orthology‐based design of antibiotic combination therapies

Chandrasekaran, S., Çakmak, M. Ç., Sahin, N., Yılancıoğlu, K., Kazan, H., Collins, J. J., & Cokol, M. (2016) · Molecular Systems Biology · doi:10.15252/msb.20156777 · Cited by 117 · see citing works

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci

Lee, S. H., Wang, H., Labroli, M. A., Koseoglu, S., Zuck, P. D., Mayhood, T., Gill, C., Mann, P. A., Sher, X., Ha, S., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7364 · Cited by 110 · see citing works

Functional annotation of chemical libraries across diverse biological processes

Piotrowski, J. S., Li, S. C., Deshpande, R., Simpkins, S. W., Nelson, J., Yashiroda, Y., Barber, J. M., Safizadeh, H., Wilson, E. H., Okada, H., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2436 · Cited by 93 · see citing works

Antifungal Resistance, Metabolic Routes as Drug Targets, and New Antifungal Agents: An Overview about Endemic Dimorphic Fungi

Parente-Rocha, J. A., Bailão, A. M., Amaral, A. C., Taborda, C. P., Paccez, J. D., Borges, C. L., & Pereira, M. (2017) · Mediators of Inflammation · doi:10.1155/2017/9870679 · Cited by 93 · see citing works

Understanding the Composition of Food Waste

Ogwu, M. C. (2019) · Advances in environmental engineering and green technologies book series · doi:10.4018/978-1-5225-7706-5.ch011 · Cited by 93 · see citing works

Constructing and deconstructing the bacterial cell wall

Fisher, J. F., & Mobashery, S. (2019) · Protein Science · doi:10.1002/pro.3737 · Cited by 93 · see citing works

Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets

Fu, C., Zhang, X., Veri, A. O., Iyer, K. R., Lash, E., Xue, A., Yan, H., Revie, N. M., Wong, C. J., Lin, Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26850-3 · Cited by 82 · see citing works

SynLethDB 2.0: a web-based knowledge graph database on synthetic lethality for novel anticancer drug discovery

Wang, J., Wu, M., Huang, X., Wang, L., Zhang, S., Liu, H., & Zheng, J. (2022) · Database · doi:10.1093/database/baac030 · Cited by 82 · see citing works

Emerging peptide antibiotics with therapeutic potential

Upert, G., Luther, A., Obrecht, D., & Ermert, P. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100078 · Cited by 79 · see citing works

Affinity-based target identification for bioactive small molecules

Kawatani, M., & Osada, H. (2013) · MedChemComm · doi:10.1039/c3md00276d · Cited by 78 · see citing works

Novel antimicrobial peptide–modified azithromycin-loaded liposomes against methicillin-resistant Staphylococcus aureus

Liu, X., Li, Z., Wang, X., Chen, Y., Wu, F., Men, K., Xu, T., Luo, Y., & Yang, L. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s107107 · Cited by 71 · see citing works

Nanomaterials for Biosensors and Implantable Biodevices

Luz, R. A. S., Iost, R. M., & Crespilho, F. N. (2012) · Springer eBooks · doi:10.1007/978-3-642-29250-7_2 · Cited by 65 · see citing works

Using adjuvants and environmental factors to modulate the activity of antimicrobial peptides

Walkenhorst, W. F. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.12.034 · Cited by 65 · see citing works

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

Wambaugh, M. A., Shakya, V. P. S., Lewis, A. J., Mulvey, M. A., & Brown, J. C. S. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2001644 · Cited by 63 · see citing works

Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections

Zhang, F., Smolen, J. A., Zhang, S., Li, R., Shah, P. N., Cho, S., Wang, H., Raymond, J. E., Cannon, C. L., & Wooley, K. L. (2015) · Nanoscale · doi:10.1039/c4nr07103d · Cited by 62 · see citing works

Antiparasitic Chemotherapy: From Genomes to Mechanisms

Horn, D., & Duraisingh, M. T. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135915 · Cited by 61 · see citing works

L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake

Deng, W., Fu, T., Zhang, Z., Jiang, X. Y., Xie, J., Sun, H., Hu, P., Ren, H., Zhou, P., Liu, Q., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1740611 · Cited by 60 · see citing works

BIONIC: biological network integration using convolutions

Forster, D. T., Li, S. C., Yashiroda, Y., Yoshimura, M., Li, Z., Isuhuaylas, L. A. V., Itto‐Nakama, K., Yamanaka, D., Ohya, Y., Osada, H., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01616-x · Cited by 56 · see citing works

Application of Omics Technologies for Evaluation of Antibacterial Mechanisms of Action of Plant-Derived Products

dos Santos, B. S., da Silva, L. C. N., da Silva, T. D., Rodrigues, J. F. S., Grisotto, M. A. G., Correia, M. T. D. S., Napoleão, T. H., da Silva, M. V., & Paiva, P. M. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01466 · Cited by 58 · see citing works

Target Prediction for an Open Access Set of Compounds Active against Mycobacterium tuberculosis

Martínez-Jiménez, F., Papadatos, G., Yang, L., Wallace, I. M., Kumar, V. D., Pieper, U., Šali, A., Brown, J. R., Overington, J. P., & Martı́-Renom, M. A. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003253 · Cited by 55 · see citing works

Synthesis of Tridecaptin–Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria

Cochrane, S. A., Li, X., He, S., Yu, M., Wu, M., & Vederas, J. C. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01578 · Cited by 54 · see citing works

Studies on tridecaptin B 1 , a lipopeptide with activity against multidrug resistant Gram-negative bacteria

Cochrane, S. A., Lohans, C. T., van Belkum, M. J., Bels, M. A., & Vederas, J. C. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00780a · Cited by 50 · see citing works

Advances in macrocyclic peptide-based antibiotics

Luther, A., Bisang, C., & Obrecht, D. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.08.006 · Cited by 48 · see citing works

Endless resistance. Endless antibiotics?

Fisher, J. F., & Mobashery, S. (2015) · MedChemComm · doi:10.1039/c5md00394f · Cited by 46 · see citing works

Innovative perspectives on the discovery of small molecule antibiotics

Cardona, S. T., Rahman, A. S. M. Z., & Nechcoff, J. N. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-025-00089-0 · Cited by 48 · see citing works

Mimicry of a Non-ribosomally Produced Antimicrobial, Brevicidine, by Ribosomal Synthesis and Post-translational Modification

Zhao, X., Li, Z., & Kuipers, O. P. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.07.005 · Cited by 44 · see citing works

A combined solid- and solution-phase approach provides convenient access to analogues of the calcium-dependent lipopeptide antibiotics

Hart, P. ‘., Kleijn, L. H. J., de Bruin, G., Oppedijk, S. F., Kemmink, J., & Martin, N. I. (2013) · Organic & Biomolecular Chemistry · doi:10.1039/c3ob42238k · Cited by 41 · see citing works

Essential Two-Component Systems Regulating Cell Envelope Functions: Opportunities for Novel Antibiotic Therapies

Cardona, S. T., Choy, M., & Hogan, A. M. (2017) · The Journal of Membrane Biology · doi:10.1007/s00232-017-9995-5 · Cited by 40 · see citing works

Unconventional Antibacterials and Adjuvants

Chang, M., Mahasenan, K. V., Hermoso, J. A., & Mobashery, S. (2021) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00776 · Cited by 38 · see citing works

Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase

Concha, N. O., Huang, J., Bai, X., Benowitz, A. B., Brady, P. G., Grady, L. C., Kryn, L. H., Holmes, D. J., Ingraham, K. A., Jin, Q., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00746 · Cited by 37 · see citing works

Prediction of synergistic drug combinations

Weinstein, Z., Bender, A., & Cokol, M. (2017) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2017.05.005 · Cited by 37 · see citing works

Advances in fungal chemical genomics for the discovery of new antifungal agents

Xue, A., Robbins, N., & Cowen, L. E. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14484 · Cited by 37 · see citing works

Searching for synergy in silico, in vitro and in vivo

Sucher, N. J. (2014) · Synergy · doi:10.1016/j.synres.2014.07.004 · Cited by 36 · see citing works

The Tipper–Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA)

Fishovitz, J., Taghizadeh, N., Fisher, J. F., Chang, M., & Mobashery, S. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b01374 · Cited by 35 · see citing works

Key Residues in Octyl‐Tridecaptin A1 Analogues Linked to Stable Secondary Structures in the Membrane

Cochrane, S. A., Findlay, B., Vederas, J. C., & Ratemi, E. (2014) · ChemBioChem · doi:10.1002/cbic.201402024 · Cited by 35 · see citing works

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Mount, H. O., Revie, N. M., Todd, R. T., Anstett, K., Collins, C., Costanzo, M., Boone, C., Robbins, N., Selmecki, A., & Cowen, L. E. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007319 · Cited by 34 · see citing works

β-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus

Ferrer-González, E., Kaul, M., Parhi, A. K., LaVoie, E. J., & Pilch, D. S. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00863-17 · Cited by 32 · see citing works

Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems

Klobucar, K., & Brown, E. D. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux054 · Cited by 29 · see citing works

Unacylated tridecaptin A1 acts as an effective sensitiser of Gram-negative bacteria to other antibiotics

Cochrane, S. A., & Vederas, J. C. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.08.008 · Cited by 31 · see citing works

Chemogenomic Profiling of the Fungal Pathogen Candida albicans

Chen, Y., Mallick, J., Maqnas, A., Sun, Y., Choudhury, B. I., Côte, P., Yan, L., Ni, T., Li, Y., Zhang, D., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02365-17 · Cited by 30 · see citing works

Antisense Peptide Nucleic Acid–Diaminobutanoic Acid Dendron Conjugates with SbmA-Independent Antimicrobial Activity against Gram-Negative Bacteria

Iubatti, M., Gabas, I. M., Cavaco, L. M., Mood, E. H., Lim, E. W. K., Bonanno, F., Yavari, N., Brolin, C., & Nielsen, P. E. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00089 · Cited by 28 · see citing works

Antifungal Drugs: The Current Armamentarium and Development of New Agents

Robbins, N., Wright, G. D., & Cowen, L. E. (2017) · ASM Press eBooks · doi:10.1128/9781555819583.ch44 · Cited by 26 · see citing works

FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p

Helliwell, S. B., Karkare, S., Bergdoll, M., Rahier, A., Leighton-Davis, J. R., Fioretto, C., Aust, T., Filipuzzi, I., Frederiksen, M. U., Gounarides, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms9613 · Cited by 23 · see citing works

Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1

Cochrane, S. A., Surgenor, R. R., Khey, K. M. W., & Vederas, J. C. (2015) · Organic Letters · doi:10.1021/acs.orglett.5b02779 · Cited by 24 · see citing works

Recent Advances in Genome Editing Tools in Medical Mycology Research

Nargesi, S., Kaboli, S., Thekkiniath, J., Heidari, S., Keramati, F., Seyedmousavi, S., & Hedayati, M. T. (2021) · Journal of Fungi · doi:10.3390/jof7040257 · Cited by 22 · see citing works

Optimizing Antimicrobial Therapy by Integrating Multi-Omics With Pharmacokinetic/Pharmacodynamic Models and Precision Dosing

Yow, H.-Y., Govindaraju, K., Lim, A. H., & Rahim, N. A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.915355 · Cited by 22 · see citing works

A defect in cell wall recycling confers antibiotic resistance and sensitivity in Staphylococcus aureus

Tan, S., Cho, K., & Nodwell, J. R. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102473 · Cited by 22 · see citing works

Additivity and synergy between an antimicrobial peptide and inhibitory ions

Walkenhorst, W. F., Sundrud, J. N., & Laviolette, J. M. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.05.005 · Cited by 22 · see citing works

Genetic Approaches to Facilitate Antibacterial Drug DevelopmentPreprint

Schnappinger, D. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a021139 · Cited by 20 · see citing works

Genomic tools to profile antibiotic mode of action

Cardona, S. T., Selin, C., & Gislason, A. S. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2013.866073 · Cited by 19 · see citing works

A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

Morisaki, J. H., Smith, P. A., Date, S. V., Kajihara, K. K., Truong, C.-L., Modrusan, Z. D., Yan, D., Kang, J., Xu, M. J., Shah, I. M., et al. (2016) · mBio · doi:10.1128/mbio.00412-16 · Cited by 19 · see citing works

Transcriptome and network analyses in Saccharomyces cerevisiae reveal that amphotericin B and lactoferrin synergy disrupt metal homeostasis and stress response

Pang, C. N. I., Lai, Y.-W., Campbell, L. T., Chen, S. C.-A., Carter, D. A., & Wilkins, M. R. (2017) · Scientific Reports · doi:10.1038/srep40232 · Cited by 19 · see citing works

Elucidating the Mechanism of Action of the Gram-Negative-Pathogen-Selective Cyclic Antimicrobial Lipopeptide Brevicidine

Zhao, X., Zhong, X., Yang, S., Deng, K., Liu, L., Song, X., Zou, Y., Li, L., Zhou, X. C., Jia, R., et al. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00010-23 · Cited by 19 · see citing works

Assay and recommendations for the detection of vapour‐phase‐mediated antimicrobial activities

Feyaerts, A. F., Mathé, L., Luyten, W. H. M. L., Tournu, H., Dyck, K. V., Broekx, L., & Dijck, P. V. (2017) · Flavour and Fragrance Journal · doi:10.1002/ffj.3400 · Cited by 17 · see citing works

Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity

Kim, D., Cho, S., Lee, K.-Y., Cheon, S., Yoon, H. J., Lee, J.-Y., Kim, D., Shin, K.-S., Koh, C., Koo, J. S., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03490-2 · Cited by 17 · see citing works

Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism

Wildenhain, J., Spitzer, M., Dolma, S., Jarvik, N., White, R., Roy, M. M., Griffiths, E., Bellows, D. S., Wright, G. D., & Tyers, M. (2016) · Scientific Data · doi:10.1038/sdata.2016.95 · Cited by 17 · see citing works

Synthetic Studies with Bacitracin A and Preparation of Analogues Containing Alternative Zinc Binding Groups

Buijs, N. P., Vlaming, H. C., van Haren, M. J., & Martin, N. I. (2022) · ChemBioChem · doi:10.1002/cbic.202200547 · Cited by 16 · see citing works

Predicting drug synergy for precision medicine using network biology and machine learning

Cüvitoğlu, A., Zhou, J., Huang, S., & Işık, Z. (2019) · Journal of Bioinformatics and Computational Biology · doi:10.1142/s0219720019500124 · Cited by 16 · see citing works

Double Orthogonal Click Reactions for the Development of Antimicrobial Peptide Nanotubes

González‐Freire, E., Novelli, F., Pérez‐Estévez, A., Seoane, R., Amorín, M., & Granja, J. R. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202004127 · Cited by 15 · see citing works

Micro- and Nanoscale Approaches in Antifungal Drug Discovery

Willaert, R. (2018) · Fermentation · doi:10.3390/fermentation4020043 · Cited by 17 · see citing works

Genetic interaction analysis in microbial pathogens: unravelling networks of pathogenesis, antimicrobial susceptibility and host interactions

Halder, V., McDonnell, B., Uthayakumar, D., Usher, J., & Shapiro, R. S. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa055 · Cited by 14 · see citing works

Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages

Javed, A., Slingerland, C. J., Wood, T. M., Martin, N. I., Broere, F., Weingarth, M. H., & Veldhuizen, E. J. A. (2023) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00518 · Cited by 14 · see citing works

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus

Yang, S., Pan, J., Yang, C., Labroli, M. A., Pan, W., Caldwell, J. P., Ha, S., Koseoglu, S., Xiao, J. C., Mayhood, T., et al. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.08.036 · Cited by 14 · see citing works

Unveiling the Synergistic Interaction Between Liposomal Amphotericin B and Colistin

Teixeira‐Santos, R., Ricardo, E., Branco, R. J. F., Azevedo, M. M., Rodrigues, A. G., & Pina‐Vaz, C. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01439 · Cited by 14 · see citing works

Recent Molecular Tools for the Genetic Manipulation of Highly Industrially Important Mucoromycota Fungi

Mohamed, H., Naz, T., Yang, J., Shah, A. M., Nazir, Y., & Song, Y. (2021) · Journal of Fungi · doi:10.3390/jof7121061 · Cited by 14 · see citing works

Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens

Liston, S. D., Whitesell, L., Kapoor, M., Shaw, K. J., & Cowen, L. E. (2022) · Journal of Fungi · doi:10.3390/jof8101102 · Cited by 12 · see citing works

Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhibitors of ethylene biosynthesis in plants

Heslop-Harrison, G., Nakabayashi, K., Espinosa‐Ruíz, A., Robertson, F., Baines, R., Thompson, C. R. L., Hermann, K., Alabadı́, D., Leubner‐Metzger, G., & Williams, R. S. B. (2024) · Plant Communications · doi:10.1016/j.xplc.2024.100846 · Cited by 12 · see citing works

Genomic Approaches to Antifungal Drug Target Identification and Validation

Robbins, N., & Cowen, L. E. (2022) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041020-094524 · Cited by 13 · see citing works

Antibacterial New Target Discovery: Sentinel Examples, Strategies, and Surveying Success

Sutterlin, H. A., Malinverni, J. C., Lee, S. H., Balibar, C. J., & Roemer, T. (2017) · Topics in medicinal chemistry · doi:10.1007/7355_2016_31 · Cited by 12 · see citing works

Building a unified model for drug synergy analysis powered by large language models

Liu, T., Chu, T., Luo, X., & Zhao, H. (2025) · Nature Communications · doi:10.1038/s41467-025-59822-y · Cited by 14 · see citing works

In vitro activity of meropenem/piperacillin/tazobactam triple combination therapy against clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus pseudintermedius and vancomycin-resistant Enterococcus spp

Yoneda, A., Thänert, R., Burnham, C. D., & Dantas, G. A. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.105864 · Cited by 11 · see citing works

Antibiotic Adjuvants

Melander, R. J., & Melander, C. (2017) · Topics in medicinal chemistry · doi:10.1007/7355_2017_10 · Cited by 11 · see citing works

Dual transposon sequencing profiles the genetic interaction landscape in bacteria

Zik, J. J., Price, M. N., Mayra, K. H. A., Santoso, A. A., Arkin, A. P., Deutschbauer, A. M., & Sham, L. (2025) · Science · doi:10.1126/science.adt7685 · Cited by 10 · see citing works

Mitigation of Human-Pathogenic Fungi that Exhibit Resistance to Medical Agents: Can Clinical Antifungal Stewardship Help?

Hull, C. M., Purdy, N. J., & Moody, S. C. (2014) · Future Microbiology · doi:10.2217/fmb.13.160 · Cited by 10 · see citing works

Omics Technologies in the Plant–Microbe Interactions

Baştaş, K. K., & Kumar, A. (2023) · Microorganisms for sustainability · doi:10.1007/978-981-99-3947-3_13 · Cited by 10 · see citing works

Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus

Kaul, M., Ferrer-González, E., Mark, L., Parhi, A. K., LaVoie, E. J., & Pilch, D. S. (2022) · Medicinal Chemistry Research · doi:10.1007/s00044-022-02960-5 · Cited by 9 · see citing works

Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems

Klobucar, K., & Brown, E. D. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux054 · Cited by 29 · see citing works

Novel approaches to the discovery of antimicrobial agents

Schmid, M. B. (1998) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(98)80130-0 · Cited by 46 · see citing works

Emerging Strategies in Antimicrobial Drug Discovery: A Review of Target-Based and Phenotypic Screening Approaches

Aliyu, I. I., Isaiah, Z., Gebre, S. T., Mustapha, M., Abdulkadir, M. Y., Ndagi, A. A., & Usman, D. M. K. (2026) · South Asian Journal of Research in Microbiology · doi:10.9734/sajrm/2026/v20i9522

Antibacterial New Target Discovery: Sentinel Examples, Strategies, and Surveying Success

Sutterlin, H. A., Malinverni, J. C., Lee, S. H., Balibar, C. J., & Roemer, T. (2017) · Topics in medicinal chemistry · doi:10.1007/7355_2016_31 · Cited by 12 · see citing works

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

Wambaugh, M. A., Shakya, V. P. S., Lewis, A. J., Mulvey, M. A., & Brown, J. C. S. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2001644 · Cited by 63 · see citing works