Cited by 70Sleep and Wakefulness ResearchSleep and Work-Related FatigueCircadian rhythm and melatonin

Stereotypic wheel running decreases cortical activity in mice

Open access
Fisher, Simon P., Cui, Nanyi, McKillop, Laura E., Gemignani, Jessica, Bannerman, David M., Oliver, Peter L., Peirson, Stuart N., Vyazovskiy, Vladyslav V.·2016·Nature Communications

Abstract

Prolonged wakefulness is thought to gradually increase 'sleep need' and influence subsequent sleep duration and intensity, but the role of specific waking behaviours remains unclear. Here we report the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somatosensory cortex in mice. We find that stereotypic wheel running is associated with a substantial reduction in firing rates among a large subpopulation of cortical neurons, especially at high speeds. Wheel running also has longer-term effects on spiking activity across periods of wakefulness. Specifically, cortical firing rates are significantly higher towards the end of a spontaneous prolonged waking period. However, this increase is abolished when wakefulness is dominated by running wheel activity. These findings indicate that wake-related changes in firing rates are determined not only by wake duration, but also by specific waking behaviours.

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  • Whether there is net potentiation or depression during waking depends on the task.

    “In general it appears that whether there is net potentiation or depression during waking depends on the task,141”

    From The overfitted brain: Dreams evolved to assist generalization (2021) · cites this paper as [141]

    The Abstract says wake-related changes in cortical firing rates depend on specific waking behaviours, supporting the task-dependence part of the claim. The Discussion cautions that it would be premature to infer changes in synaptic strength from those firing-rate changes. The paper therefore does not establish whether a task produces net potentiation or depression during waking. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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1 of the 81 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Borbély A. A. & Achermann P. in Principles and Practice of Sleep Medicine (eds Kryger M. H., Roth T., Dement W. C. 405– 417Elsevier Saunders (2005).

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Authors
Fisher, S. P., Cui, N., McKillop, L. E., Gemignani, J., Bannerman, D. M., Oliver, P. L., Peirson, S. N., & Vyazovskiy, V. V.
Affiliations
  • University of Oxford (GB)
  • European Space Agency (FR)
Corresponding author
Vyazovskiy, Vladyslav V.
Venue
Nature Communications
Published
2016-10-17
Volume
7
Issue
1
Pages
13138-13138
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2538133955
Cited by
70
References
81
Citations by year
2026: 3 · 2025: 7 · 2024: 3 · 2023: 8 · 2022: 11 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 9
FWCI
4.88
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Padua Research Archive (University of Padova) (submittedVersion, cc-by)
Funders
  • Wellcome Trust (098461, 131/032, 098461/Z/12/Z, MR/L003635/1, BB/K011847/1)
  • European Commission (322050)
  • Medical Research Council (BB/K011847/1, MR/L003635/1, 098461/Z/12/Z, 131/032)
  • Biotechnology and Biological Sciences Research Council (131/032, MR/L003635/1, BB/K011847/1, 1515008, 098461/Z/12/Z)
  • John Fell Fund, University of Oxford (MR/L003635/1, 131/032, BB/K011847/1, 098461/Z/12/Z)
  • FP7 People: Marie-Curie Actions
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
wheel running, stereotypy, wakefulness, cortical neuronal activity, motor cortex, somatosensory cortex, neuronal firing rate, sleep need, prolonged wakefulness, running speed, mice
MeSH terms
Animals, Electroencephalography, Male, Mice, Inbred C57BL, Motor Activity, Motor Cortex, Neurons, Physical Conditioning, Animal, Sleep, Sleep Deprivation, Somatosensory Cortex, Stereotyped Behavior, Wakefulness, Electrophysiological Phenomena

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