Stereotypic wheel running decreases cortical activity in mice
Open accessAbstract
Prolonged wakefulness is thought to gradually increase 'sleep need' and influence subsequent sleep duration and intensity, but the role of specific waking behaviours remains unclear. Here we report the effect of voluntary wheel running during wakefulness on neuronal activity in the motor and somatosensory cortex in mice. We find that stereotypic wheel running is associated with a substantial reduction in firing rates among a large subpopulation of cortical neurons, especially at high speeds. Wheel running also has longer-term effects on spiking activity across periods of wakefulness. Specifically, cortical firing rates are significantly higher towards the end of a spontaneous prolonged waking period. However, this increase is abolished when wakefulness is dominated by running wheel activity. These findings indicate that wake-related changes in firing rates are determined not only by wake duration, but also by specific waking behaviours.
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Whether there is net potentiation or depression during waking depends on the task.
“In general it appears that whether there is net potentiation or depression during waking depends on the task,141”
From The overfitted brain: Dreams evolved to assist generalization (2021) · cites this paper as [141]
The Abstract says wake-related changes in cortical firing rates depend on specific waking behaviours, supporting the task-dependence part of the claim. The Discussion cautions that it would be premature to infer changes in synaptic strength from those firing-rate changes. The paper therefore does not establish whether a task produces net potentiation or depression during waking. (LLM, conf=0.86)
Experimental — accuracy not yet measured
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Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice
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Sleep homeostasis during daytime food entrainment in mice
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Effects of chronic caffeine consumption on sleep and the sleep electroencephalogram in mice
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Voluntary exercise ameliorates synaptic pruning deficits in sleep-deprived adolescent mice
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Sleep and ageing: from human studies to rodent models
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Waking experience modulates sleep need in mice
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Is the role of sleep in memory consolidation overrated?
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Sleep-like changes in neural processing emerge during sleep deprivation in early auditory cortex
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Detection of neuronal OFF periods as low amplitude neural activity segments
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Sleep and Memory Consolidation: Conceptual and Methodological Challenges
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Evaluation of the Digital Ventilated Cage® system for circadian phenotyping
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Sleep- and Wake-Like States in Small Networks In Vivo and In Vitro
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The role of the hypothalamus in cortical arousal and sleep homeostasisPreprint
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Effects of clozapine-N-oxide and Compound 21 on sleep in laboratory mice
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Effects of clozapine-N-oxide and compound 21 on sleep in laboratory micePreprint
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Additional file 1 of Detection of neuronal OFF periods as low amplitude neural activity segments
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Additional file 1 of Waking experience modulates sleep need in mice
Milinski, L., Fisher, S. P., Cui, N., McKillop, L. E., Blanco‐Duque, C., Ang, G., Yamagata, T., Bannerman, D. M., & Vyazovskiy, V. V. (2021) · Figshare · doi:10.6084/m9.figshare.14379270
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Methods for measuring neural activity during voluntary wheel running
Letsinger, A. C., Ochoa, B. N., Wu, J. J., Tang, K. U., Youngstrom, D. E., Wang, S., Bridge, M. F., Cui, G., & Yakel, J. L. (2026) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2026.110839
- Authors
- Fisher, S. P., Cui, N., McKillop, L. E., Gemignani, J., Bannerman, D. M., Oliver, P. L., Peirson, S. N., & Vyazovskiy, V. V.
- Affiliations
- University of Oxford (GB)
- European Space Agency (FR)
- Corresponding author
- Vyazovskiy, Vladyslav V.
- ORCID
- Venue
- Nature Communications
- Published
- 2016-10-17
- Volume
- 7
- Issue
- 1
- Pages
- 13138-13138
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5071642
- OpenAlex
- W2538133955
- Cited by
- 70
- References
- 81
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 3 · 2023: 8 · 2022: 11 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 9
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (098461, 131/032, 098461/Z/12/Z, MR/L003635/1, BB/K011847/1)
- European Commission (322050)
- Medical Research Council (BB/K011847/1, MR/L003635/1, 098461/Z/12/Z, 131/032)
- Biotechnology and Biological Sciences Research Council (131/032, MR/L003635/1, BB/K011847/1, 1515008, 098461/Z/12/Z)
- John Fell Fund, University of Oxford (MR/L003635/1, 131/032, BB/K011847/1, 098461/Z/12/Z)
- FP7 People: Marie-Curie Actions
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- wheel running, stereotypy, wakefulness, cortical neuronal activity, motor cortex, somatosensory cortex, neuronal firing rate, sleep need, prolonged wakefulness, running speed, mice
- MeSH terms
- Animals, Electroencephalography, Male, Mice, Inbred C57BL, Motor Activity, Motor Cortex, Neurons, Physical Conditioning, Animal, Sleep, Sleep Deprivation, Somatosensory Cortex, Stereotyped Behavior, Wakefulness, Electrophysiological Phenomena
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