Sleep Oscillations in the Thalamocortical System Induce Long-Term Neuronal Plasticity
Open accessAbstract
Long-term plasticity contributes to memory formation and sleep plays a critical role in memory consolidation. However, it is unclear whether sleep slow oscillation by itself induces long-term plasticity that contributes to memory retention. Using in vivo prethalamic electrical stimulation at 1 Hz, which itself does not induce immediate potentiation of evoked responses, we investigated how the cortical evoked response was modulated by different states of vigilance. We found that somatosensory evoked potentials during wake were enhanced after a slow-wave sleep episode (with or without stimulation during sleep) as compared to a previous wake episode. In vitro, we determined that this enhancement has a postsynaptic mechanism that is calcium dependent, requires hyperpolarization periods (slow waves), and requires a coactivation of both AMPA and NMDA receptors. Our results suggest that long-term potentiation occurs during slow-wave sleep, supporting its contribution to memory.
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In cats in vivo, somatosensory evoked potentials were enhanced after a short period of SWS (about 5-10 min) compared with the previous wake period.
“Recently, Chauvette and colleagues (187) showed in vivo that somatorsensory evoked potentials in cats were enhanced after a short period of SWS (about 5-10 min) compared with the previous wake period.”
From About Sleep's Role in Memory (2013) · cites this paper as [187]
The Results sections on evoked responses and REM sleep report that somatosensory evoked potentials in cats were enhanced in the waking period after SWS compared with the preceding waking period, and that relatively short SWS periods sufficed. Our copy does not specify that those in vivo SWS periods lasted about 5–10 minutes; the approximately 10-minute duration found elsewhere describes in vitro stimulation sessions. (LLM, conf=0.83)
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- Authors
- Chauvette, S., Seigneur, J., & Timofeev, I.
- Affiliations
- Institut Universitaire en Santé Mentale de Québec (CA)
- Corresponding author
- Timofeev, Igor
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 75
- Issue
- 6
- Pages
- 1105-1113
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3458311
- OpenAlex
- W2103566565
- Cited by
- 304
- References
- 12
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 11 · 2023: 23 · 2022: 27 · 2021: 19 · 2020: 32 · 2019: 21 · 2018: 18 · 2017: 18 · 2016: 11 · 2015: 22 · 2014: 38 · 2013: 31 · 2012: 2
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Corpus Université Laval (Université Laval) (submittedVersion)
- Funders
- National Institutes of Health (5r01ns060870-04, 5r01ns059740-04)
- Canadian Institutes of Health Research (/MOP-67175, /MOP-37862)
- National Institute of Neurological Disorders and Stroke (1R01 NS060870, R01-NS-060870, R01-NS-059740, 1R01-NS059740)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sleep slow waves, thalamocortical system, long-term potentiation, memory consolidation, somatosensory evoked potentials, calcium-dependent plasticity, hyperpolarization, sleep-wake states, sleep oscillations
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Cats, Chelating Agents, Egtazic Acid, Electric Stimulation, Electromyography, Electrooculography, Evoked Potentials, Neuronal Plasticity, Neurons, Sleep, Somatosensory Cortex, Thalamus, Valine, Wakefulness, Rats, Sprague-Dawley, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Statistics, Nonparametric, 6-Cyano-7-nitroquinoxaline-2,3-dione, Rats, In Vitro Techniques
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