The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging
Open accessAbstract
Strong autofluorescence from living tissues, and the scattering and absorption of short-wavelength light in living tissues, significantly reduce sensitivity of in vivo fluorescence imaging. These issues can be tackled by using imaging probes that emit in the near-infrared wavelength range. Here we describe self-luminescing near-infrared-emitting nanoparticles employing an energy transfer relay that integrates bioluminescence resonance energy transfer and fluorescence resonance energy transfer, enabling in vivo near-infrared imaging without external light excitation. Nanoparticles were 30–40 nm in diameter, contained no toxic metals, exhibited long circulation time and high serum stability, and produced strong near-infrared emission. Using these nanoparticles, we successfully imaged lymphatic networks and vasculature of xenografted tumours in living mice. The self-luminescing feature provided excellent tumour-to-background ratio (>100) for imaging very small tumours (2–3 mm in diameter). Our results demonstrate that these new nanoparticles are well suited to in vivo imaging applications such as lymph-node mapping and cancer imaging. Fluorescence imaging in vivo is hampered by autofluorescence and the scattering and absorption of short-wavelength light. To address these problems, Xiong et al. produce self-luminescing nanoparticles that enable in vivonear-infrared imaging without external light excitation.
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Metadata
- Authors
- Xiong, L., Shuhendler, A. J., & Rao, J.
- Venue
- Nature Communications
- Published
- 2012-11-13
- Volume
- 3
- Issue
- 1
- Pages
- 1193-1193
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2046487009
- Cited by
- 253
- References
- 33
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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