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Cited by 448

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue

Open access
Yang, Seung Yun, O'Cearbhaill, Eoin D., Sisk, Geoffroy C, Park, Kyeng Min, Cho, Woo Kyung, Villiger, Martin, Bouma, Brett E., Pomahac, Bohdan, Karp, Jeffrey M.·2013·Nature Communications
DOI 10.1038/ncomms2715
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Abstract

Achieving significant adhesion to soft tissues while minimizing tissue damage poses a considerable clinical challenge. Chemical-based adhesives require tissue-specific reactive chemistry, typically inducing a significant inflammatory response. Staples are fraught with limitations including high-localized tissue stress and increased risk of infection, and nerve and blood vessel damage. Here inspired by the endoparasite Pomphorhynchus laevis, which swells its proboscis to attach to its host’s intestinal wall, we have developed a biphasic microneedle array that mechanically interlocks with tissue through swellable microneedle tips, achieving ~3.5-fold increase in adhesion strength compared with staples in skin graft fixation, and removal force of ~4.5 N cm−2 from intestinal mucosal tissue. Comprising a poly(styrene)-block-poly(acrylic acid) swellable tip and non-swellable polystyrene core, conical microneedles penetrate tissue with minimal insertion force and depth, yet high adhesion strength in their swollen state. Uniquely, this design provides universal soft tissue adhesion with minimal damage, less traumatic removal, reduced risk of infection and delivery of bioactive therapeutics. Conventional adhesives stick poorly to wet tissue because water severely undermines the adhesive chemicals they rely on. To overcome this, Yang et al. develop a bio-inspired adhesive microneedle array whose tips swell on contact with water, forming a mechanical bond to living tissue.

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Metadata

Authors
Yang, S. Y., O'Cearbhaill, E. D., Sisk, G. C., Park, K. M., Cho, W. K., Villiger, M., Bouma, B. E., Pomahac, B., & Karp, J. M.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2013-04-16
Volume
4
Issue
1
Pages
1702-1702
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms2715
OpenAlex
W2081316578
Cited by
448
References
22
FWCI
21.50
Type
journal article
Language
en
Open access
bronze

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