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Cited by 737Skin Protection and AgingAdvancements in Transdermal Drug Deliverymelanin and skin pigmentation

Epidermal thickness at different body sites: Relationship to age, gender, pigmentation, blood content, skin type and smoking habits

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Sandby-Møller, Jane, Poulsen, Thomas, Wulf, Hans Christian·2003·Acta Dermato-Venereologica
DOI 10.1080/00015550310015419
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Abstract

Epidermal thickness and its relationship to age, gender, skin type, pigmentation, blood content, smoking habits and body site is important in dermatologic research and was investigated in this study. Biopsies from three different body sites of 71 human volunteers were obtained, and thickness of the stratum corneum and cellular epidermis was measured microscopically using a preparation technique preventing tissue damage. Multiple regressions analysis was used to evaluate the effect of the various factors independently of each other. Mean (SD) thickness of the stratum corneum was 18.3 (4.9) microm at the dorsal aspect of the forearm, 11.0 (2.2) microm at the shoulder and 14.9 (3.4) microm at the buttock. Corresponding values for the cellular epidermis were 56.6 (11.5) microm, 70.3 (13.6) microm and 81.5 (15.7) microm, respectively. Body site largely explains the variation in epidermal thickness, but also a significant individual variation was observed. Thickness of the stratum corneum correlated positively to pigmentation (p = 0.0008) and negatively to the number of years of smoking (p < 0.0001). Thickness of the cellular epidermis correlated positively to blood content (P = 0.028) and was greater in males than in females (P < 0.0001). Epidermal thickness was not correlated to age or skin type.

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  • Species differences in epidermal thickness have been reported.

    “Similar to the present results, species differences in the epidermal thickness have also been reported9, 22, 23.”

    From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [23]

  • Thickness of the stratum corneum correlates positively with pigmentation and negatively with years of smoking, and this skin pigmentation is more obvious in the upper lip than in the gums.

    “The thickness of the stratum corneum correlates positively with pigmentation and negatively with years of smoking, and this skin pigmentation is more obvious in the upper lip than in the gums [76,77].”

    From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [77]

  • Smoking can change skin cuticle thickness and accelerates skin pigmentation.

    “Smoking can change skin cuticle thickness and accelerates skin pigmentation.”

    From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [77]

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Authors
Sandby-Møller, J., Poulsen, T., & Wulf, H. C.
ORCID
Wulf, Hans Christian
Venue
Acta Dermato-Venereologica
Publisher
MJS Publishing, Medical Journals Sweden AB
Published
2003-11-01
Volume
83
Issue
6
Pages
410-413
ISSN
0001-5555 (ISSN-L)
DOI
10.1080/00015550310015419
OpenAlex
W1982974441
Cited by
737
References
18
Citations by year
2026: 29 · 2025: 39 · 2024: 58 · 2023: 53 · 2022: 58 · 2021: 47 · 2020: 36 · 2019: 60 · 2018: 40 · 2017: 48 · 2016: 38 · 2015: 46 · 2014: 25 · 2013: 25 · 2012: 32
FWCI
8.18
Type
journal article
Language
en
Open access
Locations
  • Acta Dermato Venereologica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
epidermal thickness, stratum corneum, skin pigmentation, smoking, skin type, age, sex differences, body site variation, forearm, shoulder, buttocks
MeSH terms
Adult, Aged, Analysis of Variance, Biopsy, Needle, Epidermis, Female, Humans, Male, Middle Aged, Probability, Reference Values, Regional Blood Flow, Sensitivity and Specificity, Skin, Skin Physiological Phenomena, Skin Pigmentation, Smoking, Cohort Studies, Skin Aging, Risk Assessment

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