Temporally selective contextual encoding in the dentate gyrus of the hippocampus
Open accessAbstract
A recent model of the hippocampus predicts that the unique properties of the dentate gyrus allow for temporal separation of events. This temporal separation is accomplished in part through the continual generation of new neurons, which, due to a transient window of hyperexcitability, could allow for preferential encoding of information present during their development. Here we obtain in vivo electrophysiological recordings and identify a cell population exhibiting activity that is selective to single contexts when rats experience a long temporal separation between context exposures during training. This selectivity is attenuated as the temporal separation between context exposures is shortened and is further attenuated when neurogenesis is reduced. Our data reveal the existence of a temporal orthogonalizing neuronal code within the dentate gyrus, a hallmark feature of episodic memory.
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Hippocampal neuronal firing patterns reflecting temporal context gradually change from seconds to minutes, hours to days, and weeks.
“The hippocampal neuronal firing patterns reflecting temporal context have also been shown to gradually change from seconds to minutes (Manns et al., 2007), hours to days (Mankin et al., 2012), and weeks (Rangel et al., 2014; Ziv et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Rangel et al., 2014
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- Authors
- Rangel, L. M., Alexander, A. S., Aimone, J. B., Wiles, J., Gage, F. H., Chiba, A. A., & Quinn, L. K.
- Affiliations
- University of California San Diego (US)
- Salk Institute for Biological Studies (US)
- The University of Queensland (AU)
- Corresponding author
- Quinn, L.K.
- Venue
- Nature Communications
- Published
- 2014-02-12
- Volume
- 5
- Issue
- 1
- Pages
- 3181-3181
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC3929785
- OpenAlex
- W2012225083
- Cited by
- 91
- References
- 32
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 12 · 2016: 9 · 2015: 9 · 2014: 6
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Science Foundation (0542013)
- James S. McDonnell Foundation
- National Institutes of Health
- Directorate for Biological Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dentate gyrus, hippocampus, contextual encoding, neurogenesis, adult neurogenesis, hyperexcitability, episodic memory, rats
- MeSH terms
- Animals, Male, Dentate Gyrus, Rats, Long-Evans, Rats, Neurogenesis
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