Gradual changes in hippocampal activity support remembering the order of events
Open accessAbstract
The hippocampus is thought to contribute to episodic memory in part by binding stimuli to their spatiotemporal context. The present study examined how hippocampal neuronal populations encode spatial and temporal context as rats performed a task in which they were required to remember the order of trial-unique sequences of odors. The results suggest that a gradual change in the pattern of hippocampal activity served as a temporal context for odor-sampling events and was important for successful subsequent memory of the order of those odors.
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CA1 neurons encode temporal context information during mnemonic learning of odor presentations.
“Thus, the CA1 neurons encode the temporal context information during the mnemonic learning of the odor presentations (Manns et al., 2007).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Manns et al., 2007
Hippocampal neuronal firing patterns reflecting temporal context gradually change from seconds to minutes, hours to days, and weeks.
“The hippocampal neuronal firing patterns reflecting temporal context have also been shown to gradually change from seconds to minutes (Manns et al., 2007), hours to days (Mankin et al., 2012), and weeks (Rangel et al., 2014; Ziv et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Manns et al., 2007
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Self-citation
- Authors
- Manns, J. R., Howard, M. W., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Syracuse University (US)
- Corresponding author
- Eichenbaum, Howard
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 56
- Issue
- 3
- Pages
- 530-540
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2104541
- OpenAlex
- W2067761057
- Cited by
- 397
- References
- 36
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 26 · 2023: 18 · 2022: 21 · 2021: 21 · 2020: 23 · 2019: 24 · 2018: 33 · 2017: 33 · 2016: 20 · 2015: 22 · 2014: 27 · 2013: 21 · 2012: 21
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH051570, MH051570, P50MH071702, MH068982, F32MH068982)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- hippocampus, episodic memory, temporal context, spatial context, sequence memory, olfactory memory, rats
- MeSH terms
- Action Potentials, Animals, Cues, Hippocampus, Male, Memory, Synaptic Transmission, Neurons, Neuropsychological Tests, Odorants, Reaction Time, Smell, Time Factors, Time Perception, Rats, Long-Evans, Rats
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