The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Injectable bioadhesive hydrogels with innate antibacterial properties
Open accessAbstract
Surgical site infections cause significant postoperative morbidity and increased healthcare costs. Bioadhesives used to fill surgical voids and support wound healing are typically devoid of antibacterial activity. Here we report novel syringe-injectable bioadhesive hydrogels with inherent antibacterial properties prepared from mixing polydextran aldehyde and branched polyethylenimine. These adhesives kill both Gram-negative and Gram-positive bacteria, while sparing human erythrocytes. An optimal composition of 2.5 wt% oxidized dextran and 6.9 wt% polyethylenimine sets within seconds forming a mechanically rigid (~\n1,700 Pa) gel offering a maximum adhesive stress of ~\n2.8 kPa. A murine infection model showed that the adhesive is capable of killing Streptococcus pyogenes introduced subcutaneously at the bioadhesive’s surface, with minimal inflammatory response. The adhesive was also effective in a cecal ligation and puncture model, preventing sepsis and significantly improving survival. These bioadhesives represent novel, inherently antibacterial materials for wound-filling applications. Bioadhesives are materials frequently used as surgical sealants, though to date, these typically possess limited antibacterial properties. Here, the authors present a novel injectable and antibacterial bioadhesive hydrogel and demonstrate its performance in vivo.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Guideline for Prevention of Surgical Site Infection, 1999
Mangram, A. J., Horan, T. C., Pearson, M. L., Silver, L. C., Jarvis, W. R., & The Hospital Infection Control Practices Advisory Committee (1999) · Infection Control & Hospital Epidemiology · doi:10.1086/501620 · Cited by 4,595
Mechanisms of Antimicrobial Peptide Action and Resistance
Yeaman, M. R., & Yount, N. Y. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.2 · Cited by 3,001
A reversible wet/dry adhesive inspired by mussels and geckos
Lee, H., Lee, B. P., & Messersmith, P. B. (2007) · Nature · doi:10.1038/nature05968 · Cited by 2,043
Mechanisms of polymer degradation and erosion
Göpferich, A. (1996) · Biomaterials · doi:10.1016/0142-9612(96)85755-3 · Cited by 1,781
A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy
Moghimi, S. M., Symonds, P., Murray, J. C., Hunter, A. C., Debska, G., & Szewczyk, A. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.02.010 · Cited by 1,092
Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2297 · Cited by 1,062
Surgical site infections: epidemiology, microbiology and prevention
Owens, C. D., & Stoessel, K. (2008) · Journal of Hospital Infection · doi:10.1016/s0195-6701(08)60017-1 · Cited by 987
Multifunctional chondroitin sulphate for cartilage tissue–biomaterial integration
Wang, D.-A., Varghese, S., Sharma, B., Strehin, I., Fermanian, S., Gorham, J., Fairbrother, D. H., Cascio, B., & Elisseeff, J. H. (2007) · Nature Materials · doi:10.1038/nmat1890 · Cited by 693
A biodegradable and biocompatible gecko-inspired tissue adhesive
Mahdavi, A., Ferreira, L., Sundback, C., Nichol, J. W., Chan, E. P., Carter, D. J. D., Bettinger, C. J., Patanavanich, S., Chignozha, L., Ben-Joseph, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712117105 · Cited by 554
Design Strategies and Applications of Tissue Bioadhesives
Mehdizadeh, M., & Yang, J. (2013) · Macromolecular Bioscience · doi:10.1002/mabi.201200332 · Cited by 448
Cited by
Liang, Y., Li, Z., Huang, Y., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,083
Mussel‐Inspired Hydrogels for Self‐Adhesive Bioelectronics
Xie, C., Wang, X., He, H., Ding, Y., & Lu, X. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909954 · Cited by 482
Progress in Hydrogels for Skin Wound Repair
Qi, L., Zhang, C., Wang, B., Yin, J., & Yan, S. (2022) · Macromolecular Bioscience · doi:10.1002/mabi.202100475 · Cited by 267
Wang, B., Liu, J., Niu, D., Wu, N., Yun, W., Wang, W., Zhang, K., Li, G., Yan, S., Xu, G., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c06058 · Cited by 109
Metadata
- Authors
- Giano, M. C., Ibrahim, Z., Medina, S. H., Sarhane, K. A., Christensen, J. M., Yamada, Y., Brandacher, G., & Schneider, J. P.
- Venue
- Nature Communications
- Published
- 2014-06-24
- Volume
- 5
- Issue
- 1
- Pages
- 4095-4095
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2130728966
- Cited by
- 355
- References
- 34
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Injectable bioadhesive hydrogels with innate antibacterial properties. https://app.cochat.ai/papers/10.1038/ncomms5095
- The paper
- Giano, M. C., Ibrahim, Z., Medina, S. H., Sarhane, K. A., Christensen, J. M., Yamada, Y., Brandacher, G., & Schneider, J. P. (2014). Injectable bioadhesive hydrogels with innate antibacterial properties. Nature Communications. https://doi.org/10.1038/ncomms5095
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
