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Cited by 416

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Injectable cryogel-based whole-cell cancer vaccines

Open access
Bencherif, Sidi A., Warren Sands, R., Ali, Omar A., Li, Weiwei A., Lewin, Sarah A., Braschler, Thomas M., Shih, Ting-Yu, Verbeke, Catia S., Bhatta, Deen, Dranoff, Glenn, Mooney, David J.·2015·Nature Communications
DOI 10.1038/ncomms8556
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Abstract

A biomaterial-based vaccination system that uses minimal extracorporeal manipulation could provide in situ enhancement of dendritic cell (DC) numbers, a physical space where DCs interface with transplanted tumour cells, and an immunogenic context. Here we encapsulate GM-CSF, serving as a DC enhancement factor, and CpG ODN, serving as a DC activating factor, into sponge-like macroporous cryogels. These cryogels are injected subcutaneously into mice to localize transplanted tumour cells and deliver immunomodulatory factors in a controlled spatio-temporal manner. These vaccines elicit local infiltrates composed of conventional and plasmacytoid DCs, with the subsequent induction of potent, durable and specific anti-tumour T-cell responses in a melanoma model. These cryogels can be delivered in a minimally invasive manner, bypass the need for genetic modification of transplanted cancer cells and provide sustained release of immunomodulators. Altogether, these findings indicate the potential for cryogels to serve as a platform for cancer cell vaccinations. Immune responses are induced in the organized, cytokine-rich environment of lymph nodes, which can be mimicked by biomaterials. Here the authors show that injectable sponge-like gels decorated with immunostimulatory factors attract dendritic cells and boost antitumour immune responses in mice.

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Crossref · 10.1038/ncomms8556

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Metadata

Authors
Bencherif, S. A., Warren Sands, R., Ali, O. A., Li, W. A., Lewin, S. A., Braschler, T. M., Shih, T.-Y., Verbeke, C. S., Bhatta, D., Dranoff, G., & Mooney, D. J.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2015-08-12
Volume
6
Issue
1
Pages
7556-7556
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms8556
OpenAlex
W1854274831
Cited by
416
References
54
FWCI
11.95
Type
journal article
Language
en
Open access
gold

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