Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study
Open accessAbstract
Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are essential for neural development and function. As key components of brain tissue, omega-3 PUFAs play critical roles in brain development and function, and a lack of these fatty acids has been implicated in a number of mental health conditions over the lifespan, including schizophrenia. We have previously shown that a 12-week intervention with omega-3 PUFAs reduced the risk of progression to psychotic disorder in young people with subthreshold psychotic states for a 12-month period compared with placebo. We have now completed a longer-term follow-up of this randomized, double-blind, placebo-controlled trial, at a median of 6.7 years. Here we show that brief intervention with omega-3 PUFAs reduced both the risk of progression to psychotic disorder and psychiatric morbidity in general in this study. The majority of the individuals from the omega-3 group did not show severe functional impairment and no longer experienced attenuated psychotic symptoms at follow-up.
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BG-12 is licensed for the relapsing remitting phase of multiple sclerosis.
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From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [107]
BG-12 has cytoprotective and anti-inflammatory actions attributable to NFE2L2 activation.
“has cytoprotective and anti-inflammatory actions attributable to NFE2L2 activation 107”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [107]
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- Authors
- Amminger, G. P., Schäfer, M. R., Schlögelhofer, M., Klier, C. M., & McGorry, P. D.
- Affiliations
- The University of Melbourne (AU)
- Medical University of Vienna (AT)
- Corresponding author
- Amminger, G. Paul
- Venue
- Nature Communications
- Published
- 2015-08-11
- Volume
- 6
- Issue
- 1
- Pages
- 7934-7934
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4918317
- OpenAlex
- W1718572743
- Cited by
- 188
- References
- 29
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 7 · 2021: 19 · 2020: 17 · 2019: 25 · 2018: 24 · 2017: 27 · 2016: 27 · 2015: 5
- FWCI
- 26.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Stanley Medical Research Institute (03T-315)
- Medical Research Council
- National Health and Medical Research Council (1060996, 1080963)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- omega-3 polyunsaturated fatty acids, subthreshold psychotic symptoms, schizophrenia prevention, long-term follow-up, psychiatric morbidity, functional disability, attenuated psychotic symptoms
- MeSH terms
- Adolescent, Adult, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Psychotic Disorders, Fatty Acids, Omega-3, Young Adult
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