Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
European Alzheimer's Disease Initiative (EADI), Lambert, Jean-Charles, Genetic and Environmental Risk in Alzheimer's Disease (GERAD), Alzheimer's Disease Genetic Consortium (ADGC), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), Ibrahim-Verbaas, Carla A, Harold, Denise, Naj, Adam C +178 more·2013·Nature Genetics
DOI 10.1038/ng.2802
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- Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental DiseasesMaría Teresa Flores-Dorantes, Yael E. Díaz‐López, Ruth Gutiérrez‐Aguilar · 2020 · Frontiers in Neuroscience
- Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseasesRachel J. Boyd, Dimitrios Avramopoulos, Lauren L. Jantzie, Andrew S. McCallion · 2022 · Journal of Neuroinflammation
- Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility lociTin Aung, Mineo Ozaki, Mei Lee, Ursula M. Schlötzer-Schrehardt, Guðmar Þorleifsson, Takanori Mizoguchi, Robert P. Igo, Aravind Haripriya, Susan Eileen Isabella Williams, Yury Sergeevich Astakhov et al. · 2017 · Nature Genetics
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- Depression as a risk factor for Alzheimer’s disease: Genes, steroids, cytokines and neurogenesis – What do we need to know?Herbert, Joe, Lucassen, Paul J. · 2016 · Frontiers in Neuroendocrinology
- New roles for Fc receptors in neurodegeneration-the impact on Immunotherapy for Alzheimer's DiseaseFuller, James P., Stavenhagen, Jeffrey B., Teeling, Jessica L. · 2014 · Frontiers in Neuroscience
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- Late-Onset Alzheimer’s Disease Genes and the Potentially Implicated PathwaysSamantha L. Rosenthal, M. Ilyas Kamboh · 2014 · Current Genetic Medicine Reports
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- Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing studyCuyvers, Elise, De Roeck, Arne, Van den Bossche, Tobi, Van Cauwenberghe, Caroline, Bettens, Karolien, Vermeulen, Steven, Mattheijssens, Maria, Peeters, Karin, Engelborghs, Sebastiaan, Vandenbulcke, Mathieu et al. · 2015 · The Lancet Neurology
- Periodontal disease as a possible cause for Alzheimer's diseaseAngela R. Kamer, Ronald G. Craig, Richard Niederman, Juan Fortea, Mony J. de Leon · 2020 · Periodontology 2000
- Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donorsLagomarsino, Valentina N., Pearse, Richard V., Liu, Lei, Hsieh, Yi-Chen, Fernandez, Marty A., Vinton, Elizabeth A., Paull, Daniel, Felsky, Daniel, Tasaki, Shinya, Gaiteri, Chris et al. · 2021 · Neuron
- Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer DiseaseDesikan, Rahul S., Schork, Andrew J., Wang, Yunpeng, Thompson, Wesley K., Dehghan, Abbas, Ridker, Paul M, Chasman, Daniel I., McEvoy, Linda K., Holland, Dominic, Chen, Chi-Hua et al. · 2015 · Circulation
- Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Whyte, Lauren S., Lau, Adeline A., Hemsley, Kim M., Hopwood, John J., Sargeant, Timothy J. · 2017 · Journal of Neurochemistry
- Rare coding mutations identified by sequencing of <scp>A</scp>lzheimer disease genome‐wide association studies lociVardarajan, Badri N., Ghani, Mahdi, Kahn, Amanda, Sheikh, Stephanie, Sato, Christine, Barral, Sandra, Lee, Joseph H., Cheng, Rong, Reitz, Christiane, Lantigua, Rafael et al. · 2015 · Annals of Neurology
- Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locusRahul S. Desikan, Andrew Joseph Schork, Yibin Wang, Aree Witoelar, Manu Sharma, Linda K. McEvoy, Dominic Holland, James B. Brewer, Chun‐Houh Chen, Wesley Kurt Thompson et al. · 2015 · Molecular Psychiatry
- Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization studyEmma Louise Anderson, Laura D Howe, Kaitlin Hazel Wade, Yoav Ben‐Shlomo, William David Hill, Ian J. Deary, Eleanor C. M. Sanderson, Jie Zheng, Roxanna Korologou‐Linden, Evie Stergiakouli et al. · 2020 · International Journal of Epidemiology
- The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseasesFengzhe Xu, Yuanqing Fu, Ting‐yu Sun, Zengliang Jiang, Zelei Miao, Menglei Shuai, Wanglong Gou, Chu-wen Ling, Jian Yang, Jun Wang et al. · 2020 · Microbiome
- Differential Aging Analysis in Human Cerebral Cortex Identifies Variants in TMEM106B and GRN that Regulate Aging PhenotypesRhinn, Herve, Abeliovich, Asa · 2017 · Cell Systems
- A Precision Medicine Initiative for Alzheimer’s disease: the road ahead to biomarker-guided integrative disease modelingHampel, H., O’Bryant, S. E., Durrleman, S., Younesi, E., Rojkova, K., Escott-Price, V., Corvol, J-C., Broich, K., Dubois, B., Lista, S. et al. · 2017 · Climacteric
- ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal PathologyNobutaka Sakae, Chia‐Chen Liu, Mitsuru Shinohara, Jessica L. Frisch‐Daiello, Li Ma, Yu Yamazaki, Masaya Tachibana, Linda H. Younkin, Aishe Kurti, Minerva M. Carrasquillo et al. · 2016 · Journal of Neuroscience
- Analysis of genome-wide association data highlights candidates for drug repositioning in psychiatryHon‐Cheong So, Carlos Kwan‐Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim, Pak Chung Sham · 2017 · Nature Neuroscience
- A critique of life history approaches to human trait covariationBrendan P. Zietsch, Morgan J. Sidari · 2019 · Evolution and Human Behavior
- Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer’s diseaseLaura T. Haas, Santiago V. Salazar, Mikhail A. Kostylev, Ji Won Um, Adam C. Kaufman, Stephen M. Strittmatter · 2015 · Brain
- Genetic correlation between amyotrophic lateral sclerosis and schizophreniaRussell Lewis McLaughlin, Dick Schijven, Wouter van Rheenen, Kristel R. van Eijk, Margaret O’Brien, René S. Kahn, Roel A. Ophoff, An Goris, Daniel G. Bradley, Ammar Al‐Chalabi et al. · 2017 · Nature Communications
- Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s diseaseAngela Jeong, Kiall F. Suazo, W. Gibson Wood, Mark Dewey Distefano, Ling Li · 2018 · Critical Reviews in Biochemistry and Molecular Biology
- Prioritizing Parkinson’s disease genes using population-scale transcriptomic dataLi, Yang I., Wong, Garrett, Humphrey, Jack, Raj, Towfique · 2019 · Nature Communications
- Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal CortexDonna M. Werling, Sirisha Pochareddy, Jinmyung Choi, Joon‐Yong An, Brooke K. Sheppard, Minshi Peng, Zhen Li, Claudia Dastmalchi, Gabriel Santpere, André M. M. Sousa et al. · 2020 · Cell Reports
- Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cellsHasselmann, Jonathan, Blurton‐Jones, Mathew · 2020 · Glia
- Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular diseaseAmand Floriaan Schmidt, Nicholas B. Hunt, María Gordillo‐Marañón, Pimphen Charoen, Fotios Drenos, Juan Pablo Casas, Mika Kivimaki B, Debbie A. Lawlor, Claudia Giambartolomei, Olia Papacosta et al. · 2021 · Nature Communications
- Exercise suppresses neuroinflammation for alleviating Alzheimer’s diseaseMinghui Wang, Hu Zhang, Jiling Liang, Jielun Huang, Ning Chen · 2023 · Journal of Neuroinflammation
- Inferring relevant cell types for complex traits by using single-cell gene expressionCalderon, Diego, Bhaskar, Anand, Knowles, David A., Golan, David, Raj, Towfique, Fu, Audrey Q., Pritchard, Jonathan K. · 2017 · The American Journal of Human Genetics
- Phenome-wide analysis of genome-wide polygenic scoresEva M. L. Krapohl, Jack Euesden, Delilah Zabaneh, Jean‐Baptiste Pingault, Kaili Rimfeld, Sophie von Stumm, Philip S. Dale, Gerome D. Breen, Paul F. O’Reilly, Robert J. Plomin · 2015 · Molecular Psychiatry
- Neuroinflammatory responses in Alzheimer’s diseaseCira Dansokho, Michael Thomas Heneka · 2017 · Journal of Neural Transmission
- Genetic variants and functional pathways associated with resilience to Alzheimer’s diseaseLogan C. Dumitrescu, Emily R. Mahoney, Shubhabrata Mukherjee, Michael L. Lee, William S. Bush, Corinne D. Engelman, Qiongshi Lu, David W. Fardo, Emily H. Trittschuh, Jesse B Mez et al. · 2020 · Brain
- Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidenceHarald Juergen Hampel, Robert Nisticò, Nicholas T. Seyfried, Allan I. Levey, Erica S. Modeste, Pablo Lemercier, Filippo Baldacci, Nicola Toschi, Francesco Garaci, George L. Perry et al. · 2021 · Ageing Research Reviews
- Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s diseaseKristi Henjum, Ina S. Almdahl, Vibeke Årskog, Lennart Minthon, Oskar Hansson, Tormod Fladby, Lars N. G. Nilsson · 2016 · Alzheimer s Research & Therapy
- NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseasesCornelis Blauwendraat, Faraz Faghri, Lasse Pihlstrøm, Joshua T. Geiger, Alexis Elbaz, Suzanne Lesage, Jean‐Christophe Corvol, Patrick May, Aude Nicolas, Yevgeniya A. Abramzon et al. · 2017 · Neurobiology of Aging
- Stem cell models of Alzheimer’s disease: progress and challengesArber, Charles, Lovejoy, Christopher, Wray, Selina · 2017 · Alzheimer's Research & Therapy
- Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s diseaseXinzhong Li, Jintao Long, Taigang He, Robert D. Belshaw, James Scott · 2015 · Scientific Reports
- Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patternsMohamad Habes, Deborah Janowitz, Güray Erus, Jon B. Toledo, Susan M. Resnick, Jimit J. Doshi, Sandra Van der Auwera, Katharina Wittfeld, Katrin Hegenscheid, Norbert Hosten et al. · 2016 · Translational Psychiatry
- Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in OceaniaTom Parks, Mariana Mirabel, Joseph H. Kado, Kathryn Auckland, Jarosław Nowak, Anna Rautanen, Alexander J. Mentzer, Éloi Marijon, Xavier Jouven, Mai Ling Perman et al. · 2017 · Nature Communications
- Stem Cells, Genome Editing, and the Path to Translational MedicineFrank Soldner, Rudolf Jaenisch · 2018 · Cell
- Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer DiseaseChristopher H. van Dyck, Haakon B. Nygaard, Kewei Chen, Michael Donohue, Rema Raman, Robert A. Rissman, James B. Brewer, Robert A. Koeppe, Tiffany W. Chow, Michael S. Rafii et al. · 2019 · JAMA Neurology
- Biological and environmental predictors of heterogeneity in neurocognitive ageingLars H Nyberg, Carl‐Johan Boraxbekk, Daniel Eriksson Sörman, Patrik Hansson, Agneta Herlitz, Karolina Kauppi, Jessica K. Ljungberg, Hugo Lövheim, Anders Lundquist, Annelie Nordin Adolfsson et al. · 2020 · Ageing Research Reviews
- Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory responsePimenova, Anna A., Herbinet, Manon, Gupta, Ishaan, Machlovi, Saima I., Bowles, Kathryn R., Marcora, Edoardo, Goate, Alison M. · 2021 · Neurobiology of Disease
- Whole‐exome sequencing in 20,197 persons for rare variants in Alzheimer's diseaseRaghavan, Neha S., Brickman, Adam M., Andrews, Howard, Manly, Jennifer J., Schupf, Nicole, Lantigua, Rafael, Wolock, Charles J., Kamalakaran, Sitharthan, Petrovski, Slave, Tosto, Giuseppe et al. · 2018 · Annals of Clinical and Translational Neurology
- Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s diseaseFang, Jiansong, Zhang, Pengyue, Wang, Quan, Chiang, Chien-Wei, Zhou, Yadi, Hou, Yuan, Xu, Jielin, Chen, Rui, Zhang, Bin, Lewis, Stephen J. et al. · 2022 · Alzheimer's Research & Therapy
- Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s diseaseBroce, Iris J., Tan, Chin Hong, Fan, Chun Chieh, Jansen, Iris, Savage, Jeanne E., Witoelar, Aree, Wen, Natalie, Hess, Christopher P., Dillon, William P., Glastonbury, Christine M. et al. · 2019 · Acta Neuropathologica
- TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex TraitsSini Nagpal, Xiaoran Meng, Michael P. Epstein, Lam C. Tsoi, Matthew T. Patrick, Greg C. Gibson, Philip L. De Jager, David Alan Bennett, Aliza P. Wingo, Thomas S. Wingo et al. · 2019 · The American Journal of Human Genetics
- Prediction of Alzheimer’s disease using blood gene expression dataTaesic Lee, Hyunju Lee · 2020 · Scientific Reports
- Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s diseaseZhang, Lanyu, Silva, Tiago C., Young, Juan I., Gomez, Lissette, Schmidt, Michael A., Hamilton-Nelson, Kara L., Kunkle, Brian W., Chen, Xi, Martin, Eden R., Wang, Lily · 2020 · Nature Communications
- Cardiac cell type–specific gene regulatory programs and disease risk associationJames D. Hocker, Olivier Poirion, Fugui Zhu, Justin Buchanan, Kai Zhang, Joshua Chiou, Tsui‐Min Wang, Qingquan Zhang, Xiaomeng Hou, Yang Eric Li et al. · 2021 · Science Advances
- Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort studyXin You Tai, Michele Veldsman, Donald M. Lyall, Thomas J. Littlejohns, Kenneth M. Langa, Masud Husain B, Janice M. Ranson, David J. Llewellyn · 2022 · The Lancet Healthy Longevity
- Polygenic risk score of sporadic late‐onset Alzheimer's disease reveals a shared architecture with the familial and early‐onset formsCruchaga, Carlos, Del‐Aguila, Jorge L., Saef, Benjamin, Black, Kathleen, Fernandez, Maria Victoria, Budde, John, Ibanez, Laura, Deming, Yuetiva, Kapoor, Manav, Tosto, Giuseppe et al. · 2018 · Alzheimer's & Dementia
- Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's diseaseDaniel L. McCartney, Anna J. Stevenson, Rosie May Walker, Jude Gibson, Stewart W. Morris, Archie Campbell, Alison D. Murray, Heather Clare Whalley, David John Porteous, Andrew Mark McIntosh et al. · 2018 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer’s diseaseBerchtold, Nicole C., Sabbagh, Marwan N., Beach, Thomas G., Kim, Ronald C., Cribbs, David H., Cotman, Carl W. · 2014 · Neurobiology of Aging
- Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteinsSrikant Rangaraju, Eric B. Dammer, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Ranjita S. Betarbet, Duc Minh Duong, James A. Webster, Chadwick M. Hales, James J. Lah et al. · 2018 · Molecular Neurodegeneration
- Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networksA. Hossini, M. Megges, A. Prigione, Bjoern Lichtner, M. Toliat, W. Wruck, F. Schröter, P. Nuernberg, H. Kroll, E. Makrantonaki et al. · 2015 · BMC Genomics
- Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and bloodRoy Lardenoije, Janou A. Y. Roubroeks, Ehsan Pishva, Markus Leber, Holger Wagner, Artemis Iatrou, Adam R. Smith, Rebecca G. Smith, Lars Eijssen, Luca Kleineidam et al. · 2019 · Clinical Epigenetics
- Drug development for alzheimer’s disease: Microglia induced neuroinflammation as a targetDong, Yuan, Li, Xiaoheng, Cheng, Jinbo, Hou, Lin · 2019 · International Journal of Molecular Sciences
- GWAS of longitudinal amyloid accumulation on<sup>18</sup>F-florbetapir PET in Alzheimer’s disease implicates microglial activation gene<i>IL1RAP</i>Ramanan, Vijay K, Risacher, Shannon L., Nho, Kwangsik, Kim, Sungeun, Shen, Li, McDonald, Brenna C., Yoder, Karmen K., Hutchins, Gary D., West, John D., Tallman, Eileen F. et al. · 2015 · Brain
- Characterization of pathogenic SORL1 genetic variants for association with Alzheimer’s disease: a clinical interpretation strategyHenne H. Holstege, Sven J. van der Lee, Marc Hulsman, Tsz Hang Wong, Jeroen van Rooij, Marjan M. Weiss, Eva Louwersheimer, Frank J. Wolters, Najaf Amin, André Gerardus Uitterlinden et al. · 2017 · European Journal of Human Genetics
- Protective genes and pathways in Alzheimer’s disease: moving towards precision interventionsSeto, Mabel, Weiner, Rebecca L., Dumitrescu, Logan, Hohman, Timothy J. · 2021 · Molecular Neurodegeneration
- Zebrafish as a model organism for neurodegenerative diseaseKelda Chia, Anna Klingseisen, Dirk Sieger, Josef Priller · 2022 · Frontiers in Molecular Neuroscience
- The Coming of Age of the Angiotensin Hypothesis in Alzheimer’s Disease: Progress Toward Disease Prevention and Treatment?Kehoe, Patrick Gavin · 2018 · Journal of Alzheimer’s Disease
- Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer’s diseasePetroula Proitsi, M Kim, Luke Whiley, Megan Pritchard, R Leung, Hilkka S. Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno J. Vellas et al. · 2015 · Translational Psychiatry
- Microglial Malfunction: The Third Rail in the Development of Alzheimer's DiseaseMhatre, Siddhita D., Tsai, Connie A., Rubin, Amanda J., James, Michelle L., Andreasson, Katrin I. · 2015 · Trends in Neurosciences
- Alzheimer’s disease variants with the genome-wide significance are significantly enriched in immune pathways and active in immune cellsJiang, Qinghua, Jin, Shuilin, Jiang, Yongshuai, Liao, Mingzhi, Feng, Rennan, Zhang, Liangcai, Liu, Guiyou, Hao, Junwei · 2017 · Molecular Neurobiology
- The genetic landscape of Alzheimer diseaseSusana Carmona, John Hardy, Rita João Guerreiro · 2018 · Handbook of clinical neurology
- Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficitsKoutsodendris, Nicole, Blumenfeld, Jessica, Agrawal, Ayushi, Traglia, Michela, Grone, Brian, Zilberter, Misha, Yip, Oscar, Rao, Antara, Nelson, Maxine R., Hao, Yanxia et al. · 2023 · Nature Aging
- Genome-wide association study of CSF levels of 59 Alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammationKauwe, John S. K., Bailey, Matthew H., Ridge, Perry G., Perry, Rachel, Wadsworth, Mark E., Hoyt, Kaitlyn L., Staley, Lyndsay A., Karch, Celeste M., Harari, Oscar, Cruchaga, Carlos et al. · 2014 · PLoS Genetics
- Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer’s DiseaseBurcu F. Darst, Rebecca L. Koscik, Annie Marie Racine, Jennifer M. Oh, Rachel A. Krause, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Bradley T. Christian, Barbara B. Bendlin et al. · 2016 · Journal of Alzheimer s Disease
- The relationship between sleep duration, cognition and dementia: a Mendelian randomization studyAlbert Henry, Michail Katsoulis, Stefano Masi, Ghazaleh Fatemifar, Spiros Denaxas, Dionisio Acosta, Victoria Garfield, Caroline E Dale · 2019 · International Journal of Epidemiology
- Independent and Reproducible Hippocampal Radiomic Biomarkers for Multisite Alzheimer's Disease: Diagnosis, Longitudinal Progress and Biological BasisKun Zhao, Yanhui Ding, Ying Han, Yong Fan A, Aaron F. Alexander‐Bloch, Tong Han, Dan Jin, Bing Liu, Jie Lu, Chengyuan Song et al. · 2019 · 中国科学通报:英文版
- Plasma lipidome is dysregulated in Alzheimer’s disease and is associated with disease risk genesYue Liu, Anbupalam Thalamuthu, Karen A. Mather, John D. Crawford, Marina Ulanova, Matthew Wai Kin Wong, Russell Pickford, Perminder Singh Sachdev, Nady Braidy · 2021 · Translational Psychiatry
- Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease ModelQian Shi, Cheng Chang, Afaf Saliba, Manzoor A. Bhat · 2022 · Journal of Neuroscience
- Amyloid Precursor Protein and Alzheimer’s DiseaseOrobets, Kseniia S., Karamyshev, Andrey L. · 2023 · International Journal of Molecular Sciences
- Functional regulatory variants implicate distinct transcriptional networks in dementiaYonatan A. Cooper, Noam Teyssier, Nina M. Dräger, Qiuyu Guo, Jessica E. Davis, Sydney M. Sattler, Zhongan Yang, Abdulsamie M. Patel, Sarah J. Wu, Sriram Kosuri et al. · 2022 · Science
- SORL1 rare variants: a major risk factor for familial early-onset Alzheimer’s diseaseNicolas, G, Charbonnier, C, Wallon, D, Quenez, O, Bellenguez, C, Grenier-Boley, B, Rousseau, S, Richard, A-C, Rovelet-Lecrux, A, Le Guennec, K et al. · 2016 · Molecular Psychiatry
- Loss‐of‐function mutation in <i>ABCA1</i> and risk of Alzheimer's disease and cerebrovascular diseaseNordestgaard, Liv Tybjærg, Tybjærg‐Hansen, Anne, Nordestgaard, Børge G., Frikke‐Schmidt, Ruth · 2015 · Alzheimer's & Dementia
- Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA MethylationCatherine Do, Charles F. Lang, J. P. Lin, Huferesh K. Darbary, Izabela Krupska, Aulona Gaba, Lynn Petukhova, Jean‐Paul Vonsattel, MARY PAT GALLAGHER, Robin Goland et al. · 2016 · The American Journal of Human Genetics
- Whole-genome analyses of whole-brain data: working within an expanded search spaceMedland, Sarah E, Jahanshad, Neda, Neale, Benjamin M, Thompson, Paul M · 2014 · Nature Neuroscience
- The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s DiseaseKokiko-Cochran, Olga N., Godbout, Jonathan P. · 2018 · Frontiers in Immunology
- Complement dysregulation in the central nervous system during development and diseaseJohn D. Lee, Liam G. Coulthard, Trent M. Woodruff · 2019 · Seminars in Immunology
- DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-typesGemma L. Shireby, Emma Louise Dempster, Stefania S S Policicchio, Rebecca G. Smith, Ehsan Pishva, Barry A. Chioza, Jonathan P. Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame et al. · 2022 · Nature Communications
- Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathologyHaure-Mirande, Jean-Vianney, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Klein, William L., Glabe, Charles, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Wang, Minghui et al. · 2017 · Acta Neuropathologica
- Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cellsAlison E. Mungenast, Sandra Siegert, Li‐Huei Tsai · 2015 · Molecular and Cellular Neuroscience
- Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?Sami Piirainen, Andrew M. Youssef, Cai Song, Allan V. Kalueff, Gary E. Landreth, Tarja Malm, Li Tian · 2017 · Neuroscience & Biobehavioral Reviews
- Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer’s diseaseQi Zhang, Cheng Ma, Lih‐Shen Chin, Lian Li · 2020 · Science Advances
- GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementiaMichael Chong, Pedrum Mohammadi‐Shemirani, Nicolas Perrot, Walter Nelson, Robert W. Morton, Sukrit Narula, Ricky Lali, Irfan I. Khan, Mohammad Daud Khan, Conor S. Judge et al. · 2022 · eLife
- Targeting innate immunity for neurodegenerative disorders of the central nervous systemAndreasson, Katrin I., Bachstetter, Adam D., Colonna, Marco, Ginhoux, Florent, Holmes, Clive, Lamb, Bruce, Landreth, Gary, Lee, Daniel C., Low, Donovan, Lynch, Marina A. et al. · 2016 · Journal of Neurochemistry
- The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volumeMichelle K. Lupton, Lachlan T. Strike, Narelle K. Hansell, Wei Xiong Wen, Karen A. Mather, Nicola J. Armstrong, Anbupalam Thalamuthu, Katie Louise McMahon, Greig Ian de Zubicaray, Amelia A. Assareh et al. · 2016 · Neurobiology of Aging
- Major review: Exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiologyInas F. Aboobakar, William M. Johnson, William Daniel Stamer, Michael A. Hauser, R. Rand Allingham · 2016 · Experimental Eye Research
- Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham StudyVincent Antoine Chouraki, Sarah R. Preis, Qiong Yang, Alexa Beiser, Shuo Li, Martin G. Larson, Galit Weinstein, Thomas J. Wang, Robert Edgardo Gerszten, Ramachandran Srini Vasan et al. · 2017 · Alzheimer s & Dementia