The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

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The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection

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Cutting Edge: SHARPIN Is Required for Optimal NLRP3 Inflammasome Activation

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Interaction between HCMV pUL83 and human AIM2 disrupts the activation of the AIM2 inflammasome

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Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling

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Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection

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AIM2 is a potential therapeutic target in human renal carcinoma and suppresses its invasion and metastasis via enhancing autophagy induction

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Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation

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Generating protective immunity against genital herpes

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AIM2 senses Brucella abortus DNA in dendritic cells to induce IL-1β secretion, pyroptosis and resistance to bacterial infection in mice

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The IL‐21‐TET2‐AIM2‐c‐MAF pathway drives the T follicular helper cell response in lupus‐like disease

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Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages

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Inflammasomes and Anti-Viral Immunity

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Rift Valley fever virus infection induces activation of the NLRP3 inflammasome

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A clear and present danger: inflammasomes DAMPing down disorders of pregnancy

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COPs and POPs Patrol Inflammasome Activation

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IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection

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Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

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Gut–Liver Axis: Role of Inflammasomes

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NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease

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Expression of AIM2 is correlated with increased inflammation in chronic hepatitis B patients

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AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection

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Protect this house: cytosolic sensing of viruses

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Catechin ameliorates Porphyromonas gingivalis‐ induced inflammation via the regulation of TLR2/4 and inflammasome signaling

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Deficiency in AIM2 induces inflammation and adipogenesis in white adipose tissue leading to obesity and insulin resistance

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Toll-Like Receptors (TLRs) in Health and Disease: An Overview

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Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity

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TLR2 Signaling Contributes to Rapid Inflammasome Activation during F. novicida Infection

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Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2

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AIM2 regulates viability and apoptosis in human colorectal cancer cells via the PI3K/Akt pathway

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Poxvirus Immune Evasion

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Intracellular Antiviral Immunity

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Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome

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In Vivo IFN-γ Secretion by NK Cells in Response to Salmonella Typhimurium Requires NLRC4 Inflammasomes

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Molecular requirements for sensing of intracellular microbial nucleic acids by the innate immune system

Luecke, S., & Paludan, S. R. (2016) · Cytokine · doi:10.1016/j.cyto.2016.10.003 · Cited by 44

A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness

Souquette, A. H., Frere, J. J., Smithey, M. J., Sauce, D., & Thomas, P. G. (2017) · GeroScience · doi:10.1007/s11357-017-9982-x · Cited by 44

Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16–STING–Type I IFN Pathway and AIM2 Sensor

Liu, F., Niu, Q., Fan, X., Liu, C., Zhang, J., Wei, Z., Hou, W., Kanneganti, T., Robb, M. L., Kim, J. H., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700698 · Cited by 44

Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions

Dou, Y., Xing, J., Kong, G., Wang, G., Lou, X., Xiao, X., Vivier, É., Li, X. C., & Zhang, Z. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900171 · Cited by 44

Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense

Guise, A., Budayeva, H., Diner, B., & Cristea, I. (2013) · Viruses · doi:10.3390/v5071607 · Cited by 43

Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT)

Zhou, J. Y., Sarkar, M. K., Okamura, K., Harris, J. E., Gudjonsson, J. E., & Fitzgerald, K. A. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2213777120 · Cited by 43

Manipulation of autophagy by bacteria for their own benefit

Ogawa, M., Mimuro, H., Yoshikawa, Y., Ashida, H., & Sasakawa, C. (2011) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2011.00343.x · Cited by 43

Intracellular Invasion of Orientia tsutsugamushi Activates Inflammasome in ASC-Dependent Manner

Koo, J., Hong, H.-J., Dearth, A. T., Kobayashi, K. S., & Koh, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039042 · Cited by 44

DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota

Man, S. M., Karki, R., & Kanneganti, T. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw028 · Cited by 44

Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients

Ahmad, F., Mishra, N., Ahrenstorf, G., Franklin, B. S., Latz, E., Schmidt, R. E., & Bossaller, L. (2017) · AIDS · doi:10.1097/qad.0000000000001693 · Cited by 43

The role of inflammasome modulation in virulence

Lupfer, C. R., & Kanneganti, T. (2012) · Virulence · doi:10.4161/viru.20266 · Cited by 43

Linking indirect effects of cytomegalovirus in transplantation to modulation of monocyte innate immune function

Sen, P., Wilkie, A. R., Ji, F., Yang, Y., Taylor, I., Velazquez-palafox, M. A., Vanni, E. A. H., Pesola, J. M., Fernandez, R., Chen, H., et al. (2020) · Science Advances · doi:10.1126/sciadv.aax9856 · Cited by 46

Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation

Nissen, S. K., Højen, J. F., Andersen, K. L. D., Kofod‐Olsen, E., Berg, R., Paludan, S. R., Østergaard, L. J., Jakobsen, M. R., Tolstrup, M., & Mogensen, T. H. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12317 · Cited by 44

IFN-β Mediates Suppression of IL-12p40 in Human Dendritic Cells following Infection with Virulent Francisella tularensis

Bauler, T. J., Chase, J. C., & Bosio, C. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100377 · Cited by 42

Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo

Uchiyama, R., Yonehara, S., Taniguchi, S., Ishido, S., Ishii, K. J., & Tsutsui, H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601373 · Cited by 42

Cytosolic DNA sensing by AIM2 inflammasome is integral to anti-microbial defense (157.5)

Rathinam, V. A. K., Waggoner, S. N., Jiang, Z., Sharma, S., Monks, B. G., Waggoner, L., & Fitzgerald, K. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.186.supp.157.5

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

Fernandes-Alnemri, T., Yu, J.-W., Juliana, C., Solorzano, L., Kang, S., Wu, J., Datta, P., McCormick, M., Huang, L., McDermott, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1859 · Cited by 732

The DNA sensing inflammasome, AIM2, is critical for protection from influenza infection (P6140)

Schattgen, S., Kurt‐Jones, E. A., & Fitzgerald, K. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.190.supp.66.3 · Cited by 1

AIM2 in health and disease: Inflammasome and beyond

Kumari, P. H., Russo, A. J., Shivcharan, S., & Rathinam, V. A. K. (2020) · Immunological Reviews · doi:10.1111/imr.12903 · Cited by 250

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831