The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Biologic basis for interleukin-1 in disease.

Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 4,344

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466

Toll-like receptors in innate immunity

Takeda, K. (2004) · International Immunology · doi:10.1093/intimm/dxh186 · Cited by 3,328

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759 · cited 1×

IKKε and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Takaoka, A., Wang, Z., Choi, M. K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., et al. (2007) · Nature · doi:10.1038/nature06013 · Cited by 1,704

Use of Anti-Cancer Drugs, Mitocans, to Enhance the Immune Responses against Tumors

Hahn, T., Polanczyk, M. J., Borodovsky, A., Ramanathapuram, L. V., Akporiaye, E. T., & Ralph, S. J. (2013) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201011314030010 · Cited by 22

Activation and evasion of inflammasomes during viral and microbial infection

Ren, D., Ye, X., Chen, R., Jia, X., He, X., Tao, J., Jin, T., Wu, S., & Zhang, H. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05575-2 · Cited by 22

Potential roles of inflammasomes in the pathophysiology of Psoriasis: A comprehensive review

Shahi, A., Afzali, S., Amirzargar, A., Mohaghegh, P., Salehi, S., & Mansoori, Y. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.06.007 · Cited by 21

Zinc homeostasis regulates caspase activity and inflammasome activation

Gong, X., Gu, W., Fu, S., Zou, G., & Jiang, Z. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012805 · Cited by 21

Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture

Cieniewicz, B., Dong, Q., Li, G., Forrest, J. C., Mounce, B. C., Tarakanova, V. L., van der Velden, A. W. M., & Krug, L. T. (2015) · Journal of Virology · doi:10.1128/jvi.00658-15 · Cited by 21

Comparative Phosphoproteomics Reveals Components of Host Cell Invasion and Post-transcriptional Regulation During Francisella Infection

Nakayasu, E. S., Tempel, R., Cambronne, X. A., Petyuk, V., Jones, M. B., Gritsenko, M. A., Monroe, M. E., Yang, F., Smith, R. D., Adkins, J., et al. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.029850 · Cited by 21

Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection

Xu, T., Guo, Y., & Qi, X. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092110 · Cited by 22

The adaptor ASC exacerbates lethal Listeria monocytogenes infection by mediating IL‐18 production in an inflammasome‐dependent and ‐independent manner

Tsuchiya, K., Hara, H., Fang, R., Hernández-Cuellar, E., Sakai, S., Daim, S. J., Chen, X., Dewamitta, S. R., Qu, H., Mitsuyama, M., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201444673 · Cited by 21

Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum

Wang, Q., Liu, X., Zhou, Q., & Wang, C. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1067303 · Cited by 21

The NLRP3 inflammasome in age-related eye disease: Evidence-based connexin hemichannel therapeutics

Mugisho, O. O., & Green, C. R. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108911 · Cited by 20

Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells

Lozano‐Ruiz, B., Tzoumpa, A., Martínez‐Cardona, C., Moreno, D., Aransay, A. M., Cortázar, A. R., Picó, J., Peiró, G., Lozano, J., Zapater, P., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042230 · Cited by 20

Essential Role of NLRP3 Inflammasome in Mediating IL-1β Production and the Pathobiology of Staphylococcus aureus Endophthalmitis

Kumar, A., Singh, P. K., Ahmed, Z., Singh, S., & Kumar, A. (2022) · Infection and Immunity · doi:10.1128/iai.00103-22 · Cited by 20

The Impact of Ly49‐NK Cell‐Dependent Recognition of MCMV Infection on Innate and Adaptive Immune Responses

Pyzik, M., Gendron-Pontbriand, E.-M., & Vidal, S. M. (2011) · BioMed Research International · doi:10.1155/2011/641702 · Cited by 22

Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II

Yashiro, H., Loza, A. J., Skeath, J. B., & Longmore, G. D. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-04-0894 · Cited by 20

The Genetics of Innate Immunity Sensors and Human Disease

Pothlichet, J., & Quintana‐Murci, L. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.777064 · Cited by 20

Macrophages and Recently Identified Forms of Cell Death

Sanz, A. B., Sánchez-Niño, M. D., Izquierdo, M. C., González–Espinoza, L., Ucero, A. C., Poveda, J., Ruiz‐Andrés, O., Ruiz‐Ortega, M., Selgas, R., Egido, J., et al. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.771183 · Cited by 20

FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes

Duffy, E. B., Periasamy, S., Hunt, D., Drake, J. R., & Harton, J. A. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.2a1215-555rr · Cited by 20

Regulation of Cellular Antiviral Signaling by Modifications of Ubiquitin and Ubiquitin-like Molecules

Li, K., & Zhong, B. (2018) · Immune Network · doi:10.4110/in.2018.18.e4 · Cited by 20

Temporal Manipulation of Mitochondrial Function by Virulent Francisella tularensis To Limit Inflammation and Control Cell Death

Jessop, F., Schwarz, B. H., Heitmann, E., Buntyn, R., Wehrly, T. D., & Bosio, C. M. (2018) · Infection and Immunity · doi:10.1128/iai.00044-18 · Cited by 20

Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression

Nakamura, Y., Nakahata, S., Kondo, Y., Izumi, A., Yamamoto, K., Ichikawa, T., Tamura, T., Kenta, N., Yamashita, Y., & Morishita, K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.066 · Cited by 20

The absent in melanoma 2 (AIM2) inflammasome in microbial infection

Zhu, W., Zu, X., Liu, S., & Zhang, H. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.04.052 · Cited by 20

Fructose-arginine, a non-saponin molecule of Korean Red Ginseng, attenuates AIM2 inflammasome activation

Ahn, H., Han, B.-C., Lee, S., & Lee, G. (2020) · Journal of Ginseng Research · doi:10.1016/j.jgr.2020.06.002 · Cited by 20

Tracing innate immune defences along the path of Listeria monocytogenes infection

Regan, T. W., MacSharry, J. A., & Brint, E. K. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.27 · Cited by 20

A Newly Isolated Pseudomonas sp., Epibiotic on the Seaweed, Padina tetrastromatica, off Southeastern Coast of India, Reveals Antibacterial Action

Ravisankar, A., Gnanambal, K. M. E., & Sundaram, L. (2013) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-013-0473-y · Cited by 20

Caspase-1 activity affects AIM2 speck formation/stability through a negative feedback loop

Juruj, C., Lelogeais, V., Pierini, R., Perret, M., Py, B. F., Jamilloux, Y., Brož, P., Ader, F., Faure, M., & Henry, T. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00014 · Cited by 22

Measuring Inflammasome Activation in Response to Bacterial Infection

Brož, P., & Monack, D. M. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-523-1_6 · Cited by 20

AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner

Shah, S., Qin, S., Luo, Y., Huang, Y., Jing, R., Shah, J. N., Chen, J., Chen, H., & Zhong, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.588278 · Cited by 19

Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injury

Wang, P., Pan, B., Tian, J., Yang, L., Chen, Z., Yang, L., & Fan, Z. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001580 · Cited by 19

Structural mechanism of DNA recognition by the p204 HIN domain

Fan, X., Jiang, J., Zhao, D., Chen, F., Ma, H., Smith, P. T., Unterholzner, L., Xiao, T. S., & Jin, T. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab076 · Cited by 19

Role of Damage-Associated Molecular Pattern/Cell Death Pathways in Vaccine-Induced Immunity

Lee, S. M., Kim, P., You, J., & Kim, E. H. (2021) · Viruses · doi:10.3390/v13122340 · Cited by 21

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

Wang, C., Kaur, K., Xu, C., Abu‐Amer, Y., & Mbalaviele, G. (2024) · eLife · doi:10.7554/elife.92885 · Cited by 20

Pyroptosis and neurological diseases

Zhao, G., & Xie, Z. (2014) · Neuroimmunology and Neuroinflammation · doi:10.4103/2347-8659.139716 · Cited by 19

Cellular Exit Strategies of Intracellular Bacteria

Hybiske, K., & Stephens, R. S. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0002-2014 · Cited by 19

IL-1R and Inflammasomes Mediate Early Pulmonary Protective Mechanisms in Respiratory Brucella Abortus Infection

Hielpos, M. S., Fernández, A. G., Falivene, J., Paiva, I. M. A., González, F. M., Ferrero, M. C., Campos, P. C., Vieira, A. T., Oliveira, S. C., & Baldi, P. C. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00391 · Cited by 19

Emerging roles of absent in melanoma 2 in cardiovascular diseases

Zhan-zhi, Z., Zheng, X., & Jiang, Z. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.08.031 · Cited by 20

AIM2 Suppresses Inflammation and Epithelial Cell Proliferation during Glomerulonephritis

Chung, H., Komada, T., Lau, A. N., Chappellaz, M., Platnich, J. M., de Koning, H. D., Petri, B., Luque, Y., Walker, S., Benediktsson, H., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100483 · Cited by 19

Inflammasomes and intestinal tumorigenesis

Zaki, H., Lamkanfi, M., & Kanneganti, T. (2011) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2011.11.003 · Cited by 19

PANoptosis: a potential target of atherosclerotic cardiovascular disease

Jin, X., Zhu, Y., Xing, L., Ding, X., & Liu, Z. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02089-x · Cited by 18

Inflammasome Priming Is Similar for Francisella Species That Differentially Induce Inflammasome Activation

Ghonime, M. G., Mitra, S., El-Domany, R. A., Wewers, M. D., & Gavrilin, M. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127278 · Cited by 18

Programmed Cell Death-Dependent Host Defense in Ocular Herpes Simplex Virus Infection

Guo, H., Koehler, H. S., Dix, R. D., & Mocarski, E. S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.869064 · Cited by 20

Recognition of Intracellular Bacteria by Inflammasomes

Brož, P. (2020) · John Wiley & Sons, Inc. eBooks · doi:10.1128/9781683670261.ch20 · Cited by 18

AIM2 inflammasome activation benefits the therapeutic effect of BCG in bladder carcinoma

Zhou, H., Zhang, L., Luo, W., Hong, H., Tang, D., Zhou, D., Zhou, L., & Li, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1050774 · Cited by 18

AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes

Marques-da-Silva, C., Poudel, B., Baptista, R. P., Peissig, K. B., Hancox, L. S., Shiau, J. C., Pewe, L. L., Shears, M. J., Kanneganti, T., Sinnis, P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210181120 · Cited by 18

Microbial and Host Metabolites at the Backstage of Fever: Current Knowledge about the Co-Ordinate Action of Receptors and Molecules Underlying Pathophysiology and Clinical Implications

Santacroce, L., Colella, M., Charitos, I. A., Domenico, M. D., Palmirotta, R., & Jirillo, E. (2023) · Metabolites · doi:10.3390/metabo13030461 · Cited by 18

Inflammasomes and Cardiovascular Disease: Linking Inflammation to Cardiovascular Pathophysiology

Saadh, M. J., Muhammad, F. A., Albadr, R. J., Sanghvi, G. V., Jyothi, S. R., Kundlas, M., Joshi, K. K., Rakhmatullaev, A., Taher, W. M., Alwan, M., et al. (2025) · Scandinavian Journal of Immunology · doi:10.1111/sji.70020 · Cited by 19

A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis

Davis, J. M., Knutson, K. L., Skinner, J. A., Strausbauch, M. A., Crowson, C. S., Therneau, T. M., Wettstein, P. J., Matteson, E. L., & Gabriel, S. E. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3706 · Cited by 19

Implication of Pattern-Recognition Receptors in Cardiovascular Diseases

Wang, X., & Yi, F. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6184 · Cited by 18

Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host

Cieniewicz, B., Santana, A. L., Minkah, N. K., & Krug, L. T. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01202 · Cited by 18

Control of immune escaped human papilloma virus is regained after therapeutic vaccination

Ma, W., Melief, C. J. M., & van der Burg, S. H. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2017.02.005 · Cited by 18

Critical roles of NLRP3 inflammasome in IL-1β secretion induced by Corynebacterium pseudotuberculosis in vitro

Zhou, Z., Li, H., Tian, S., Yi, W., Zhou, Y., Yang, H., Li, X., Wu, B. J., Li, X., Wu, J., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.09.016 · Cited by 18

Expression and activity of AIM2-inflammasome in rheumatoid arthritis patients

Méndez-Frausto, G., Medina-Rosales, M. N., Uresti‐Rivera, E. E., Baranda-Candido, L., Zapata-Zúñiga, M., Bastián, Y., Amaro, R. G., Enciso‐Moreno, J. A., & García-Hernández, M. H. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.11.015 · Cited by 18

Single-Nucleotide Variants in the AIM2 – Absent in Melanoma 2 Gene (rs1103577) Associated With Protection for Tuberculosis

Figueira, M. B. D. A., de Lima, D. S., Boechat, A. L., Filho, M. G. D. N., Antunes, I. A., Matsuda, J. D. S., Ribeiro, T. R. D. A., Felix, L. S., Gonçalves, A. S. F., Costa, A. G., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.604975 · Cited by 18

Aeromonas hydrophila inhibits autophagy triggering cytosolic translocation of mtDNA which activates the pro-apoptotic caspase-1/IL-1β-nitric oxide axis in headkidney macrophages

Kumar, M., Shelly, A., Dahiya, P., Ray, A., & Mazumder, S. (2021) · Virulence · doi:10.1080/21505594.2021.2018767 · Cited by 18

Aim2 suppresses cigarette smoke‐induced neutrophil recruitment, neutrophil caspase‐1 activation and anti‐Ly6G‐mediated neutrophil depletion

Donovan, C., Kim, R., Galvão, I., Jarnicki, A., Brown, A. C., Jones, B., Gomez, H. M., Wadhwa, R., Hortle, E., Jayaraman, R., et al. (2022) · Immunology and Cell Biology · doi:10.1111/imcb.12537 · Cited by 18

Ubiquitin Ligases in Control: Regulating NLRP3 Inflammasome Activation

Beesetti, S. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl25970 · Cited by 18

Instructions for Flow Cytometric Detection of ASC Specks as a Readout of Inflammasome Activation in Human Blood

Wittmann, N., Behrendt, A.-K., Mishra, N., Bossaller, L., & Meyer‐Bahlburg, A. (2021) · Cells · doi:10.3390/cells10112880 · Cited by 19

The emerging role of PANoptosis in viral infections disease

Xu, C., Zeng, T., Xu, Y., & Xiong, Y. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111497 · Cited by 18

Cytosolic DNA Triggers Mitochondrial Apoptosis via DNA Damage Signaling Proteins Independently of AIM2 and RNA Polymerase III

Wenzel, M., Wunderlich, M. T., Besch, R., Poeck, H., Willms, S., Schwantes, A., Kremer, M., Sutter, G., Endres, S., Schmidt, A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100523 · Cited by 17

Absent in Melanoma 2 (AIM2) Expressed in Human Dental Pulp Mediates IL-1β Secretion in Response to Cytoplasmic DNA

Huang, S., Song, Z., Jiang, L., Chen, L., Wang, R., Qin, W., Liu, P., & Lin, Z. (2014) · Inflammation · doi:10.1007/s10753-014-9963-5 · Cited by 17

Promyelocytic Leukemia Protein Interacts with the Apoptosis-associated Speck-like Protein to Limit Inflammasome Activation

Dowling, J. K., Becker, C., Bourke, N. M., Corr, S. C., Connolly, D. J., Quinn, S. R., Pandolfi, P. P., Mansell, A. S., & O'Neill, L. A. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.539692 · Cited by 18

Nucleic Acid Sensing and Innate Immunity: Signaling Pathways Controlling Viral Pathogenesis and Autoimmunity

Ahlers, L. R. H., & Goodman, A. G. (2016) · Current Clinical Microbiology Reports · doi:10.1007/s40588-016-0043-5 · Cited by 17

AIM2 Co-immunization with VP1 Is Associated with Increased Memory CD8 T Cells and Mounts Long Lasting Protection against Coxsackievirus B3 Challenge

Yin, L., Chai, D., Yue, Y., Dong, C., & Xiong, S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00247 · Cited by 17

The hepatoprotective effects of XCHD and MgIG against methotrexate-induced liver injury and inflammation in rats through suppressing the activation of AIM2 inflammasomes

Chen, C., Liu, Y., Cheng, S.-B., Wu, S., & Zhai, X. (2020) · Pathology - Research and Practice · doi:10.1016/j.prp.2020.152875 · Cited by 17

The neutrophil inflammasome

Tyrkalska, S. D., Candel, S., & Mulero, V. (2020) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2020.103874 · Cited by 18

Inflammasome as an Effective Platform for Fibrosis Therapy

Chen, T., Xiao, F., Li, N., Shan, S., Qi, M., Wang, Z., Zhang, S., Wei, W., & Sun, W. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s304180 · Cited by 17

Innate immunity against Legionella pneumophila during pulmonary infections in mice

Park, B., Park, G., Kim, J., Lim, S. A., & Lee, K. (2017) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0859-9 · Cited by 17

Inflammasomes in Cardiovascular Diseases: Current Knowledge and Future Perspectives

Caldarelli, M., Franza, L., Cutrupi, S., Menegolo, M., Franceschi, F., Gasbarrini, A., Gambassi, G., & Cianci, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125439 · Cited by 16

Regulation of cancer by inflammasomes: from inflammation to tumorigenesis

Malvankar, S., Jaiswal, P., Bhat, P. P., & Mehto, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1611719 · Cited by 16

Inflammation and hematopoietic stem cells aging

He, H., & Wang, J. (2020) · Blood Science · doi:10.1097/bs9.0000000000000063 · Cited by 16

Caspase cleavage of RIPK3 after Asp333 is dispensable for mouse embryogenesis

Newton, K., Wickliffe, K. E., Maltzman, A., Dugger, D. L., Webster, J. D., Guo, H., & Dixit, V. M. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-023-01255-5 · Cited by 17

Programmed cell death in Helicobacter pylori infection and related gastric cancer

Lin, Y., Liu, K., Lu, F., Zhai, C., & Cheng, F. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1416819 · Cited by 16

Francisella tularensis subsp. tularensis Induces a Unique Pulmonary Inflammatory Response: Role of Bacterial Gene Expression in Temporal Regulation of Host Defense Responses

Walters, K., Olsufka, R., Kuestner, R. E., Cho, J. H., Li, H., Zornetzer, G. A., Wang, K., Skerrett, S. J., & Ozinsky, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062412 · Cited by 16

Sensing sterile injury: Opportunities for pharmacological control

Menezes, G. B., Mansur, D. S., McDonald, B., Kubes, P., & Teixeira, M. M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.07.002 · Cited by 17

Evaluation of pyroptosis in macrophages using cytosolic delivery of purified flagellin

Lage, S. L., Amarante-Mendes, G. P., & Bortoluci, K. R. (2013) · Methods · doi:10.1016/j.ymeth.2013.02.010 · Cited by 17

NLRP3 inflammasome activation contributes to Listeria monocytogenes-induced animal pregnancy failure

Li, W., Chang, Y., Liang, S., Zhong, Z., Li, X., Wen, J., Zhang, Y., Zhang, J., Wang, L., Lin, H., et al. (2016) · BMC Veterinary Research · doi:10.1186/s12917-016-0655-2 · Cited by 16

Activation of the Innate Immune Receptors: Guardians of the Micro Galaxy

Nardo, D. D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5987-2_1 · Cited by 16

The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression

Ghosh, S., Wallerath, C., Covarrubias, S., Hornung, V., Carpenter, S. B., & Fitzgerald, K. A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700823 · Cited by 17

Innate immune response in astrocytes infected with herpes simplex virus 1

Bansode, Y. D., Chattopadhyay, D., & Saha, B. (2019) · Archives of Virology · doi:10.1007/s00705-019-04197-x · Cited by 16

cAbl Kinase Regulates Inflammasome Activation and Pyroptosis via ASC Phosphorylation

Gavrilin, M. A., Prather, E. R., Vompe, A. D., McAndrew, C. C., & Wewers, M. D. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000969 · Cited by 17

Multiple Autonomous Cell Death Suppression Strategies Ensure Cytomegalovirus Fitness

Mandal, P., Nagrani, L. N., Hernández, L., McCormick, A. L., Dillon, C. P., Koehler, H. S., Roback, L., Alnemri, E. S., Green, D. R., & Mocarski, E. S. (2021) · Viruses · doi:10.3390/v13091707 · Cited by 16

Microinjection of Francisella tularensis and Listeria monocytogenes Reveals the Importance of Bacterial and Host Factors for Successful Replication

Meyer, L., Bröms, J. E., Liu, X., Rottenberg, M. E., & Sjöstedt, A. B. (2015) · Infection and Immunity · doi:10.1128/iai.00416-15 · Cited by 16

The unexpected link between infection-induced apoptosis and a T h 17 immune response

Brereton, C. F., & Blander, J. M. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0710421 · Cited by 16

Fusobacterium nucleatum-derived extracellular vesicles carrying virulence factor DNA trigger AIM2 inflammasome activation to facilitate UC progression

Zhao, Y.-Q., Wu, R., Duan, Y., Kong, X., Zhang, Y., You, Y., Zhang, J., Wang, Y., Zhou, L., & Duan, L. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00817-4 · Cited by 15

Posttranslational Regulation of Inflammasomes, Its Potential as Biomarkers and in the Identification of Novel Drugs Targets

Nanda, S. K., Vollmer, S., & Pérez‐Oliva, A. B. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.887533 · Cited by 15

Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1

Ma, Y., Zhao, R., Guo, H., Tong, Q., Langdon, W. Y., Liu, W., Zhang, J., & Zhang, J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112726 · Cited by 16

Unanticipated Loss of Inflammasomes in Birds

Billman, Z. P., Hancks, D. C., & Miao, E. A. (2024) · Genome Biology and Evolution · doi:10.1093/gbe/evae138 · Cited by 15

Differential Inflammatory-Response Kinetics of Human Keratinocytes upon Cytosolic RNA- and DNA-Fragment Induction

Danis, J., Janovák, L., Gubán, B., Göblös, A., Szabó, K., Kemény, L., Bata‐Csörgõ, Z., & Széll, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030774 · Cited by 15

Characterization and expression analysis of tandemly-replicated asc genes in the Japanese medaka, Oryzias latipes

Morimoto, N., Okamura, Y., Kono, T., Sakai, M., & Hikima, J.-I. (2020) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2020.103894 · Cited by 15

Inhibition of SET domain–containing (lysine methyltransferase) 7 alleviates cognitive impairment through suppressing the activation of NOD-like receptor protein 3 inflammasome in isoflurane-induced aged mice

Ma, C., Yu, X., Li, D., Fan, Y., Tao, Q., Tang, Y., & Zheng, L. (2022) · Human & Experimental Toxicology · doi:10.1177/09603271211061497 · Cited by 15

Artificial Loading of ASC Specks with Cytosolic Antigens

Sahillioğlu, A. C., & Özören, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134912 · Cited by 17

Brucella abortus DNA is a major bacterial agonist to activate the host innate immune system

Campos, P. C., Gomes, M. T. R., Guimarães, G. R., Franco, M. M. S. C., Marim, F. M., & Oliveira, S. C. (2014) · Microbes and Infection · doi:10.1016/j.micinf.2014.08.010 · Cited by 15

Evaluating vaccinia virus cytokine co‐expression in TLR GKO mice

Sutherland, D. B., Ranasinghe, C., Regner, M., Phipps, S., Matthaei, K. I., Day, S., & Ramshaw, I. A. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.157 · Cited by 15

Age-Dependent Differences in Systemic and Cell-Autonomous Immunity toL. monocytogenes

Sherrid, A. M., & Kollmann, T. R. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/917198 · Cited by 15

Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?

Pawaria, S., Sharma, S., Baum, R., Nündel, K., Busto, P., Gravallese, E. M., Fitzgerald, K. A., & Marshak‐Rothstein, A. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0316-115r · Cited by 15

Common Differences: The Ability of Inflammasomes to Distinguish Between Self and Pathogen Nucleic Acids During Infection

Lupfer, C. R., Rippee‐Brooks, M. D., & Anand, P. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.10.001 · Cited by 17

Host immune response in chronic hepatitis C infection: involvement of cytokines and inflammasomes

Boldeanu, M. V., Medico Science SRL – Stem Cell Bank Unit, C., Siloşi, I., Bărbulescu, A. L., Sandu, R. E., Geormăneanu, C., Pădureanu, V., Popescu-Drigă, M. V., Poenariu, I. S., Siloşi, C. A., et al. (2020) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.61.1.04 · Cited by 15

Expression and Cell Type-specific Localization of Inflammasome Sensors in the Spinal Cord of SOD1(G93A) Mice and Sporadic Amyotrophic lateral sclerosis Patients

Hummel, C., Leylamian, O., Pösch, A., Weis, J., Aronica, E., Beyer, C., & Johann, S. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.03.023 · Cited by 15

Yeast Virus-Derived Stimulator of the Innate Immune System Augments the Efficacy of Virus Vector-Based Immunotherapy

Claudepierre, M., Hortelano, J., Schaedler, E., Kleinpeter, P., Geist, M., Remy‐Ziller, C., Brandely, R., Tosch, C., Laruelle, L., Jawhari, A., et al. (2014) · Journal of Virology · doi:10.1128/jvi.03819-13 · Cited by 15

Strategies of bacterial detection by inflammasomes

Jastrab, J. B., & Kagan, J. C. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.03.009 · Cited by 14

Cytosolic DNA sensing by AIM2 inflammasome is integral to anti-microbial defense (157.5)

Rathinam, V. A. K., Waggoner, S. N., Jiang, Z., Sharma, S., Monks, B. G., Waggoner, L., & Fitzgerald, K. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.186.supp.157.5

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

Fernandes-Alnemri, T., Yu, J.-W., Juliana, C., Solorzano, L., Kang, S., Wu, J., Datta, P., McCormick, M., Huang, L., McDermott, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1859 · Cited by 732

The DNA sensing inflammasome, AIM2, is critical for protection from influenza infection (P6140)

Schattgen, S., Kurt‐Jones, E. A., & Fitzgerald, K. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.190.supp.66.3 · Cited by 1

AIM2 in health and disease: Inflammasome and beyond

Kumari, P. H., Russo, A. J., Shivcharan, S., & Rathinam, V. A. K. (2020) · Immunological Reviews · doi:10.1111/imr.12903 · Cited by 250

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831