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Cited by 128

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO

Liu, Juan, Han, Chaofeng, Xie, Bin, Wu, Yue, Liu, Shuxun, Chen, Kun, Xia, Meng, Zhang, Yuan, Song, Lijun, Li, Zhiqing, Zhang, Ting, Ma, Feng, Wang, Qingqing, Wang, Jianli, Deng, Kejing, Zhuang, Yuan, Wu, Xiaohui, Yu, Yizhi, Xu, Tian, Cao, Xuetao·2014·Nature Immunology
DOI 10.1038/ni.2898
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Abstract

Excessive activation of dendritic cells (DCs) leads to the development of autoimmune and inflammatory diseases, which has prompted a search for regulators of DC activation. Here we report that Rhbdd3, a member of the rhomboid family of proteases, suppressed the activation of DCs and production of interleukin 6 (IL-6) triggered by Toll-like receptors (TLRs). Rhbdd3-deficient mice spontaneously developed autoimmune diseases characterized by an increased abundance of the TH17 subset of helper T cells and decreased number of regulatory T cells due to the increase in IL-6 from DCs. Rhbdd3 directly bound to Lys27 (K27)-linked polyubiquitin chains on Lys302 of the modulator NEMO (IKKγ) via the ubiquitin-binding-association (UBA) domain in endosomes. Rhbdd3 further recruited the deubiquitinase A20 via K27-linked polyubiquitin chains on Lys268 to inhibit K63-linked polyubiquitination of NEMO and thus suppressed activation of the transcription factor NF-κB in DCs. Our data identify Rhbdd3 as a critical regulator of DC activation and indicate K27-linked polyubiquitination is a potent ubiquitin-linked pattern involved in the control of autoimmunity.

Overview

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Crossref · 10.1038/ni.2898

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Metadata

Authors
Liu, J., Han, C., Xie, B., Wu, Y., Liu, S., Chen, K., Xia, M., Zhang, Y., Song, L., Li, Z., Zhang, T., Ma, F., Wang, Q., Wang, J., Deng, K., Zhuang, Y., Wu, X., Yu, Y., Xu, T., & Cao, X.
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2014-05-25
Volume
15
Issue
7
Pages
612-622
ISSN
  • 1529-2908
  • 1529-2916
DOI
10.1038/ni.2898
Cited by
128
References
48
Language
en
Licence

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CoChat. (2026). Citation check: Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. https://app.cochat.ai/papers/10.1038/ni.2898
The paper
Liu, J., Han, C., Xie, B., Wu, Y., Liu, S., Chen, K., Xia, M., Zhang, Y., Song, L., Li, Z., Zhang, T., Ma, F., Wang, Q., Wang, J., Deng, K., Zhuang, Y., Wu, X., Yu, Y., Xu, T., & Cao, X. (2014). Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. Nature Immunology. https://doi.org/10.1038/ni.2898

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.