Cited by 235Neuroinflammation and Neurodegeneration MechanismsInfectious Encephalopathies and EncephalitisTryptophan and brain disorders

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Infectious immunity in the central nervous system and brain function

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Klein, Robyn S, Garber, Charise, Howard, Nicole·2017·Nature Immunology

DOI 10.1038/ni.3656PMC PMC5815515

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Abstract

Inflammation is emerging as a critical mechanism underlying neurological disorders of various etiologies, yet its role in altering brain function as a consequence of neuroinfectious disease remains unclear. Although acute alterations in mental status due to inflammation are a hallmark of central nervous system (CNS) infections with neurotropic pathogens, post-infectious neurologic dysfunction has traditionally been attributed to irreversible damage caused by the pathogens themselves. More recently, studies indicate that pathogen eradication within the CNS may require immune responses that interfere with neural cell function and communication without affecting their survival. In this Review we explore inflammatory processes underlying neurological impairments caused by CNS infection and discuss their potential links to established mechanisms of psychiatric and neurodegenerative diseases.

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Authors: Klein, R. S., Garber, C., & Howard, N.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Klein, Robyn S
ORCID: Klein, Robyn S
Garber, Charise
Howard, Nicole
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2017-01-16
Volume: 18
Issue: 2
Pages: 132-141
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.3656
PMC: PMC5815515
OpenAlex: W2576931861
Cited by: 235
References: 178
Citations by year: 2026: 13 · 2025: 24 · 2024: 23 · 2023: 25 · 2022: 22 · 2021: 49 · 2020: 37 · 2019: 15 · 2018: 15 · 2017: 12
FWCI: 2.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Multiple Sclerosis Society
National Institutes of Health
National Heart, Lung, and Blood Institute (T32HL007317)
National Institute of Allergy and Infectious Diseases (R01AI126909, U19AI083019, R21AI114549, R01AI101400)
National Institute of Neurological Disorders and Stroke (P01NS059560, UH2NS100126, R01NS052632)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: neuroinflammation, central nervous system infection, brain function, mental status, mental illness, neurodegenerative diseases
MeSH terms: Animals, Brain, Central Nervous System, Humans, Immunity, Nervous System Diseases, Virus Diseases, Neuroimmunomodulation, Viral Load, Neurogenic Inflammation

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Infectious immunity in the central nervous system and brain function

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