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Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion
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Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Unravelling the pathogenesis of inflammatory bowel disease
Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861
Pathogenesis and therapy of psoriasis
Lowes, M. A., Bowcock, A. M., & Krueger, J. G. (2007) · Nature · doi:10.1038/nature05663 · Cited by 1,778
The immunological and genetic basis of inflammatory bowel disease
Bouma, G., & Strober, W. (2003) · Nature Reviews Immunology · doi:10.1038/nri1132 · Cited by 1,767
Increased expression of interleukin 17 in inflammatory bowel disease
Fujino, S., Andoh, A., Bamba, S., Ogawa, A., Hata, K., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Gut · doi:10.1136/gut.52.1.65 · Cited by 1,713
Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E., Garren, H., Langer-Gould, A., Strober, S., Cannella, B., Allard, J., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,669
Steinman, L. (2007) · Nature Medicine · doi:10.1038/nm1551 · Cited by 1,376
Sugimoto, Y., & Narumiya, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r600038200 · Cited by 1,196
Self-citationTzartos, J. S., Friese, M. A., Craner, M. J., Palace, J., Newcombe, J., Esiri, M. M., & Fugger, L. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070690 · Cited by 1,187
Prostaglandins as modulators of immunity
Harris, S. G., Padilla, J., Koumas, L., Ray, D., & Phipps, R. P. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02154-8 · Cited by 1,180
Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells
Lowes, M. A., Kikuchi, T., Fuentes-Duculan, J., Cardinale, I., Zaba, L. C., Haider, A. S., Bowman, E. P., & Krueger, J. G. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701213 · Cited by 1,082
Late Developmental Plasticity in the T Helper 17 Lineage
Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.005 · Cited by 1,053
Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,052
Anti–Interleukin-12 Antibody for Active Crohn's Disease
Mannon, P. J., Fuss, I. J., Mayer, L., Elson, C. O., Sandborn, W. J., Present, D., Dolin, B., Goodman, N., Groden, C., Hornung, R. L., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033402 · Cited by 848
Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines
Betz, M., & Fox, B. S. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.1.108 · Cited by 821
PI3K in lymphocyte development, differentiation and activation
Okkenhaug, K., & Vanhaesebroeck, B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1056 · Cited by 810
A Human Interleukin-12/23 Monoclonal Antibody for the Treatment of Psoriasis
Krueger, G. G., Langley, R. G., Leonardi, C., Yeilding, N., Guzzo, C., Wang, Y., Dooley, L. T., & Lebwohl, M. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa062382 · Cited by 807
Regulation of the immune response by prostaglandins
Goodwin, J. S., & Ceuppens, J. (1983) · Journal of Clinical Immunology · doi:10.1007/bf00915791 · Cited by 715
Ziolkowska, M., Koc, A., Luszczykiewicz, G., Ksiezopolska-Pietrzak, K., Klimczak, E., Chwalinska-Sadowska, H., & Maslinski, W. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2832 · Cited by 580
Genetic and pharmacological analysis of prostanoid receptor function
Narumiya, S., & FitzGerald, G. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13455 · Cited by 568
Self-citationLibioulle, C., Louis, E., Hansoul, S., Sandor, C., Farnir, F., Franchimont, D., Vermeire, S., Dewit, O., de Vos, M., Dixon, A., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030058 · Cited by 560
Carpenter, C. L., & Cantley, L. C. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80060-3 · Cited by 534
Epac proteins: multi-purpose cAMP targets
Bos, J. L. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.10.002 · Cited by 532
Boniface, K., Bak-Jensen, K. S., Li, Y., Blumenschein, W. M., McGeachy, M. J., McClanahan, T. K., McKenzie, B. S., Kastelein, R. A., Cua, D. J., & de Waal Malefyt, R. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082293 · Cited by 479
Self-citationHizaki, H., Segi, E., Sugimoto, Y., Hirose, M., Saji, T., Ushikubi, F., Matsuoka, T., Noda, Y., Tanaka, T., Yoshida, N., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10501 · Cited by 465
Self-citationEP2 and EP4 prostanoid receptor signaling
Regan, J. W. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.09.031 · Cited by 420
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214459 · Cited by 418
Self-citationSuzawa, T., Miyaura, C., Inada, M., Maruyama, T., Sugimoto, Y., Ushikubi, F., Ichikawa, A., Narumiya, S., & Suda, T. (2000) · Endocrinology · doi:10.1210/en.141.4.1554 · Cited by 415
Self-citationCapon, F., Di Meglio, P., Szaub, J., Prescott, N. J., Dunster, C., Baumber, L., Timms, K., Gutin, A., Abkevic, V., Burden, A. D., et al. (2007) · Human Genetics · doi:10.1007/s00439-007-0397-0 · Cited by 408
cAMP Analog Mapping of Epac1 and cAMP Kinase
Christensen, A. E., Selheim, F., de Rooij, J., Dremier, S., Schwede, F., Dao, K. K., Martinez, A., Maenhaut, C., Bos, J. L., Genieser, H.-G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302179200 · Cited by 396
Serada, S., Fujimoto, M., Mihara, M., Koike, N., Ohsugi, Y., Nomura, S., Yoshida, H., Nishikawa, T., Terabe, F., Ohkawara, T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802218105 · Cited by 349
Pharmacological PKA Inhibition: All May Not Be What It Seems
Murray, A. J. (2008) · Science Signaling · doi:10.1126/scisignal.122re4 · Cited by 327
Kabashima, K., Sakata, D., Nagamachi, M., Miyachi, Y., Inaba, K., & Narumiya, S. (2003) · Nature Medicine · doi:10.1038/nm872 · Cited by 316
Self-citationPatent Ductus Arteriosus and Neonatal Death in Prostaglandin Receptor EP4-Deficient Mice
Segi, E., Sugimoto, Y., Yamasaki, A., Aze, Y., Oida, H., Nishimura, T., Murata, T., Matsuoka, T., Ushikubi, F., Hirose, M., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8461 · Cited by 313
Self-citationReceptors for prostaglandin E2 that regulate cellular immune responses in the mouse
Nataraj, C., Thomas, D. W., Tilley, S. L., Nguyen, M., Mannon, R. B., Koller, B. H., & Coffman, T. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13640 · Cited by 287
Sheibanie, A. F., Yen, J.-H., Khayrullina, T., Emig, F., Zhang, M., Tuma, R., & Ganea, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.8138 · Cited by 284
Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse
Nataraj, C., Thomas, D. W., Tilley, S. L., Nguyen, M., Mannon, R., Koller, B. H., & Coffman, T. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113640 · Cited by 278
Positive and negative regulation of T-cell activation through kinases and phosphatases
MUSTELIN, T., & TASKÉN, K. (2003) · Biochemical Journal · doi:10.1042/bj20021637 · Cited by 274
Role of β-arrestin 1 in the metastatic progression of colorectal cancer
Buchanan, F. G., Gorden, D. L., Matta, P., Shi, Q., Matrisian, L. M., & DuBois, R. N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510562103 · Cited by 267
Hervé, M., Angeli, V., Pinzar, E., Wintjens, R., Faveeuw, C., Narumiya, S., Capron, A., Urade, Y., Capron, M., Riveau, G., et al. (2003) · European Journal of Immunology · doi:10.1002/eji.200324143 · Cited by 256
Self-citationIL-23: a master regulator in Crohn disease
Neurath, M. F. (2007) · Nature Medicine · doi:10.1038/nm0107-26 · Cited by 239
Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion
Chizzolini, C., Chicheportiche, R., Alvarez, M., de Rham, C., Roux-Lombard, P., Ferrari-Lacraz, S., & Dayer, J.-M. (2008) · Blood · doi:10.1182/blood-2008-05-155408 · Cited by 235
Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity
Kabashima, K., Murata, T., Tanaka, H., Matsuoka, T., Sakata, D., Yoshida, N., Katagiri, K., Kinashi, T., Tanaka, T., Miyasaka, M., et al. (2003) · Nature Immunology · doi:10.1038/ni943 · Cited by 191
Self-citationHilkens, C. M. U., Vermeulen, H., van Neerven, R. J. J., Snijdewint, F. G. M., Wierenga, E. A., & Kapsenber, M. L. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250112 · Cited by 179
Steinman, L. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072066 · Cited by 175
Khayrullina, T., Yen, J.-H., Jing, H., & Ganea, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.721 · Cited by 170
Chemnitz, J. M., Driesen, J., Claßen, S., Riley, J. L., Debey, S., Beyer, M., Popov, A., Zander, T., & Schultze, J. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3252 · Cited by 104
Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1
Nagamachi, M., Sakata, D., Kabashima, K., Furuyashiki, T., Murata, T., Segi‐Nishida, E., Soontrapa, K., Matsuoka, T., Miyachi, Y., & Narumiya, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070773 · Cited by 99
Self-citationModulation of helper T cell function by prostaglandins
Gold, K. N., Weyand, C. M., & Goronzy, J. J. (1994) · Arthritis & Rheumatism · doi:10.1002/art.1780370623 · Cited by 96
Hasler, F., Bluestein, H. G., Zvaifler, N. J., & Epstein, L. B. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.131.2.768 · Cited by 95
Nurieva, R., Yang, X. O., Chung, Y., & Dong, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803931 · Cited by 90
Increased release of interleukin-12p40 in MS
Fassbender, K. C., Ragoschke, A., Rossol, S., Schwartz, A., Mielke, O., Paulig, A., & Hennerici, M. G. (1998) · Neurology · doi:10.1212/wnl.51.3.753 · Cited by 89
Physiology and pathophysiology of prostanoid receptors
Narumiya, S. (2007) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.83.296 · Cited by 74
Self-citationMoldovan, I. R., Rudick, R. A., Cotleur, A. C., Born, S. E., Lee, J.-C., Karafa, M., & Pelfrey, C. M. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00221-2 · Cited by 53
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Regulation of inflammation by short chain fatty acids
Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724
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Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors
Kawahara, K., Hohjoh, H., Inazumi, T., Tsuchiya, S., & Sugimoto, Y. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.07.008 · Cited by 488
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Metadata
- Authors
- Yao, C., Sakata, D., Esaki, Y., Li, Y., Matsuoka, T., Kuroiwa, K., Sugimoto, Y., & Narumiya, S.
- Venue
- Nature Medicine
- Published
- 2009-05-24
- Volume
- 15
- Issue
- 6
- Pages
- 633-640
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1983754832
- Cited by
- 566
- References
- 58
- FWCI
- 34.15
- Type
- journal article
- Language
- en
- Open access
- green
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