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Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
Abstract
Anti-MicroRNA Antiviral: MicroRNAs (miRNAs) are small noncoding RNAs found in eukaryotes and viruses. They are critical regulators of a wide range of cellular processes. The highly conserved miRNA miR-122 is required for infection by hepatitis C virus (HCV), a leading cause of liver disease in humans. Present HCV treatment regimes can have serious side effects and are effective in only 50% of cases. In order to try to tackle HCV infection, Lanford et al. (p. 198 , published online 3 December) targeted miR-122 using a complementary locked nucleic acid (LNA) oligonucleotide. Treatment of chimpanzees infected by HCV with the LNA antagonist resulted in a long-term reduction of disease symptoms without the concomitant appearance of resistant strains of the virus.
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Anti-microRNA antisense oligonucleotides efficiently blocked microRNA function, thereby alleviating diseases in rodents and nonhuman primates.
“Recently, some reports have shown that an anti-microRNA antisense oligonucleotide efficiently blocked the function of the microRNA, thereby alleviating diseases in rodents and nonhuman primates (29,30).”
From ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) · cites this paper as [30]
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Metadata
- Authors
- Lanford, R. E., Hildebrandt-Eriksen, E. S., Petri, A., Persson, R., Lindow, M., Munk, M. E., Kauppinen, S., & Ørum, H.
- Affiliations
- Department of Virology and Immunology and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA.
- Santaris Pharma, Kogle Allé 6, DK-2970 Hørsholm, Denmark.
- Venue
- Science
- Published
- 2010-01-08
- Volume
- 327
- Issue
- 5962
- Pages
- 198-201
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC3436126
- Cited by
- 1,459
- References
- 0
- Language
- en
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