The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion
Open accessAbstract
Hyperlipidemia is a risk factor for various cardiovascular and metabolic disorders. Overproduction of lipoproteins, a process that is dependent on microsomal triglyceride transfer protein (MTP), can contribute to hyperlipidemia. We show that microRNA-30c (miR-30c) interacts with the 3′ untranslated region of MTP mRNA and induces its degradation, leading to reductions in MTP activity and in apolipoprotein B (APOB) secretion. miR-30c also reduces lipid synthesis independently of MTP. Hepatic overexpression of miR-30c reduced hyperlipidemia in Western diet–fed mice by decreasing lipid synthesis and the secretion of triglyceride-rich ApoB-containing lipoproteins and decreased atherosclerosis in Apoe−/− mice. Furthermore, inhibition of hepatic miR-30c by anti–miR-30c increased hyperlipidemia and atherosclerosis. Therefore, miR-30c coordinately reduces lipid biosynthesis and lipoprotein secretion, thereby regulating hepatic and plasma lipid concentrations. Raising miR-30c levels might be useful in treating hyperlipidemias and associated disorders.
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Metadata
- Authors
- Soh, J., Iqbal, J., Queiroz, J., Fernandez-Hernando, C., & Hussain, M. M.
- Venue
- Nature Medicine
- Published
- 2013-06-09
- Volume
- 19
- Issue
- 7
- Pages
- 892-900
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2007381960
- Cited by
- 301
- References
- 42
- FWCI
- 26.64
- Type
- journal article
- Language
- en
- Open access
- green
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