MicroRNAs and Lipoprotein Metabolism
Open accessAbstract
MicroRNAs(miRNAs; miRs) are small, non-protein-coding RNAs that negatively regulate the gene expression. They bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recently, some miRNAs have been shown to be involved in lipid homoeostasis. In particular, miR122 and miR-33 have a significant impact on lipid homeostasis and are potential therapeutic targets for treating lipid disorders and/or atherosclerosis. In this review, we describe the current understanding of the function of miRNAs in lipid homeostasis, with a focus on lipoprotein metabolism.
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miR-33b is located within intron 17 of SREBF1.
“In contrast, miR-33b is located within intron 17 of SREBF1, which regulates the expression of genes related to fatty acid and triglyceride homeostasis, such as fatty acid synthase (FASN), acetyl-CoA carboxylase α (ACACA) and stearoyl-CoA desaturase 1 (SCD1) 6 - 8) .”
From Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives (2026) · cites this paper as [7]
miR-33a is highly conserved across a broad range of species, including rodents.
“Notably, miR-33a is highly conserved across a broad range of species, including rodents, whereas miR-33b is only found primarily in primates and some other mammals, being entirely absent in commonly used rodent models, such as mice and rats.”
From Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives (2026) · cites this paper as [7]
miR-33a and miR-33b are embedded within intronic regions of SREBF genes.
“miR-33a and miR-33b are embedded within the intronic regions of SREBF genes.”
From Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives (2026) · cites this paper as [7]
miR-33a resides within intron 16 of SREBF2.
“MiR-33a resides within intron 16 of SREBF2, which is primarily involved in the regulation of cholesterol homeostasis genes, such as low-density lipoprotein receptor (LDLR) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR).”
From Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives (2026) · cites this paper as [7]
miR-33b is found primarily in primates and some other mammals and is absent in commonly used rodent models such as mice and rats.
“Notably, miR-33a is highly conserved across a broad range of species, including rodents, whereas miR-33b is only found primarily in primates and some other mammals, being entirely absent in commonly used rodent models, such as mice and rats.”
From Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives (2026) · cites this paper as [7]
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728 · see citing works
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462 · see citing works
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949 · see citing works
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834 · see citing works
miRBase: integrating microRNA annotation and deep-sequencing data
Kozomara, A., & Griffiths-Jones, S. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1027 · Cited by 3,042 · see citing works
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082 · see citing works
LNA-mediated microRNA silencing in non-human primates
Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, S., Lindholm, M., Hedtjärn, M., Hansen, H. F., Berger, U., et al. (2008) · Nature · doi:10.1038/nature06783 · Cited by 1,589 · see citing works
MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
Rayner, K. J., Suárez, Y., Dávalos, A., Parathath, S., Fitzgerald, M. L., Tamehiro, N., Fisher, E. A., Moore, K. J., & Fernández-Hernando, C. (2010) · Science · doi:10.1126/science.1189862 · Cited by 1,260 · see citing works
MicroRNAs in metabolism and metabolic disorders
Rottiers, V., & Näär, A. M. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3313 · Cited by 1,156 · see citing works
MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., Gerszten, R. E., & Näär, A. M. (2010) · Science · doi:10.1126/science.1189123 · Cited by 957 · see citing works
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
Hsu, S., Wang, B., Kota, J., Yu, J., Costinean, S., Kutay, H., Yu, L., Bai, S., Perle, K. L., Chivukula, R. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63539 · Cited by 776 · see citing works
Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
Rayner, K. J., Esau, C. C., Hussain, F. N., McDaniel, A. L., Marshall, S. M., van Gils, J. M., Ray, T. D., Sheedy, F. J., Goedeke, L., Liu, X., et al. (2011) · Nature · doi:10.1038/nature10486 · Cited by 706 · see citing works
Rayner, K. J., Sheedy, F. J., Esau, C. C., Hussain, F. N., Temel, R. E., Parathath, S., van Gils, J. M., Rayner, A. J., Chang, A. N., Suarez, Y., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57275 · Cited by 690 · see citing works
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
Dávalos, A., Goedeke, L., Smibert, P., Ramírez, C. M., Warrier, N. P., Andreo, U., Cirera-Salinas, D., Rayner, K., Suresh, U., Pastor-Pareja, J. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102281108 · Cited by 670 · see citing works
miR-33 links SREBP-2 induction to repression of sterol transporters
Marquart, T. J., Allen, R. M., Ory, D. S., & Baldán, Á. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005191107 · Cited by 562 · see citing works
Horie, T., Ono, K., Horiguchi, M., Nishi, H., Nakamura, T., Nagao, K., Kinoshita, M., Kuwabara, Y., Marusawa, H., Iwanaga, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008499107 · Cited by 384 · see citing works
Self-citationExpression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*
Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382 · see citing works
Sterol regulatory element-binding proteins
Morton, J. D., & Shimomura, L. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199904000-00008 · Cited by 324 · see citing works
Soh, J., Iqbal, J., Queiroz, J., Fernandez-Hernando, C. F., & Hussain, M. M. (2013) · Nature Medicine · doi:10.1038/nm.3200 · Cited by 301 · see citing works
MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism
Iliopoulos, D., Drosatos, K., Hiyama, Y., Goldberg, I. J., & Zannis, V. I. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m004812 · Cited by 300 · see citing works
Ramirez, C. M., Dávalos, A., Goedeke, L., Salerno, A. G., Warrier, N., Cirera-Salinas, D., Suárez, Y., & Fernández-Hernando, C. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.232066 · Cited by 242 · see citing works
MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE <sup>−/−</sup> Mice
Horie, T., Baba, O., Kuwabara, Y., Chujo, Y., Watanabe, S., Kinoshita, M., Horiguchi, M., Nakamura, T., Chonabayashi, K., Hishizawa, M., et al. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.003376 · Cited by 220 · see citing works
Self-citationControl of Cholesterol Metabolism and Plasma High-Density Lipoprotein Levels by microRNA-144
Ramírez, C. M., Rotllan, N., Vlassov, A. V., Dávalos, A., Li, M., Goedeke, L., Aranda, J. F., Cirera-Salinas, D., Araldi, E., Salerno, A., et al. (2013) · Circulation Research · doi:10.1161/circresaha.112.300626 · Cited by 217 · see citing works
Rotllan, N., Ramírez, C. M., Aryal, B., Esau, C. C., & Fernández-Hernando, C. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.113.301732 · Cited by 174 · see citing works
miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression
Kim, J., Yoon, H., Ramírez, C. M., Lee, S.-M., Hoe, H.-S., Fernández-Hernando, C., & Kim, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.010 · Cited by 173 · see citing works
Allen, R. M., Marquart, T. J., Albert, C. J., Suchy, F. J., Wang, D. Q. ‐., Ananthanarayanan, M., Ford, D. A., & Baldán, Á. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201228 · Cited by 159 · see citing works
microRNAs and cholesterol metabolism
Moore, K. J., Rayner, K. J., Suárez, Y., & Fernandez-Hernando, C. F. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.008 · Cited by 151 · see citing works
miR-122 regulates hepatic lipid metabolism and tumor suppression
Wen, J. W., & Friedman, J. R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63966 · Cited by 143 · see citing works
MicroRNA-144 Regulates Hepatic ABCA1 and Plasma HDL Following Activation of the Nuclear Receptor FXR
Vallim, T. Q. D. A., Tarling, E., Kim, T., Civelek, M., Baldán, Á., Esau, C. C., & Edwards, P. (2013) · Circulation Research · doi:10.1161/circresaha.112.300648 · Cited by 142 · see citing works
MiR‐26 controls LXR‐dependent cholesterol efflux by targeting ABCA1 and ARL7
Sun, D., Zhang, J., Xie, J., Wei, W., Chen, M., & Zhao, X. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.068 · Cited by 135 · see citing works
Marquart, T. J., Wu, J., Lusis, A. J., & Baldán, Á. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.300639 · Cited by 110 · see citing works
HDL <i>miR</i> -ed Down by <i>SREBP</i> Introns
Brown, M. S., Ye, J., & Goldstein, J. L. (2010) · Science · doi:10.1126/science.1192409 · Cited by 43 · see citing works
MicroRNAs and lipoproteins: a connection beyond atherosclerosis?
Norata, G., Sala, F., Catapano, A., & Fernández-Hernando, C. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.11.019 · Cited by 43 · see citing works
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Nishiga, M., Horie, T., Kuwabara, Y., Nagao, K., Baba, O., Nakao, T., Nishino, T., Hakuno, D., Nakashima, Y., Nishi, H., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.309528 · Cited by 71 · see citing works
Self-citationHorie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Nakazeki, F., Ide, Y., et al. (2014) · Scientific Reports · doi:10.1038/srep05312 · Cited by 49 · see citing works
Self-citationStanding your ground to exoribonucleases: Function of Flavivirus long non-coding RNAs
Charley, P. A., & Wilusz, J. (2015) · Virus Research · doi:10.1016/j.virusres.2015.09.009 · Cited by 35 · see citing works
Banerjee, N., Das, S., Tripathy, S., Bandyopadhyay, A. K., Sarma, N., Bandyopadhyay, A., & Giri, A. K. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-05980-8 · Cited by 24 · see citing works
Microsomal Triglyceride Transfer Protein: From Lipid Metabolism to Metabolic Diseases
Iqbal, J., Jahangir, Z., & Qarni, A. A. A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6082-8_4 · Cited by 23 · see citing works
Increased hepatic expression of miRNA-122 in patients infected with HCV genotype 3
de Oliveira, K. G., Malta, F. D. M., Nastri, A. C. D. S. S., Widman, A., Faria, P., Santana, R. A. F., Alves, V. A. F., Carrilho, F. J., & Pinho, J. R. R. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0431-0 · Cited by 23 · see citing works
The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical Application
Xiang, Y., Mao, L., Zuo, M., Song, G.-L., Tan, L.-M., & Yang, Z.-B. (2022) · Mediators of Inflammation · doi:10.1155/2022/3101900 · Cited by 17 · see citing works
Dutta, P., Haller, E. M., Sharp, A., & Nanjundan, M. (2016) · BMC Cancer · doi:10.1186/s12885-016-2053-3 · Cited by 21 · see citing works
CXCL16 in Vascular Pathology Research: from Macro Effects to microRNAs
Jovanović, I. B., Živković, M., Djurić, T., Popović, M., Alavantić, D., & Stanković, A. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.29942 · Cited by 20 · see citing works
Zhang, J., Jazii, F. R., Haghighi, M. M., ALVARES, D. C. L., Liu, L., Khosraviani, N., & Adeli, K. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00276.2019 · Cited by 19 · see citing works
Development of Antisense Drugs for Dyslipidemia
Yamamoto, T., Wada, F., & Harada‐Shiba, M. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv16001 · Cited by 17 · see citing works
Deng, X., Qin, S., Chen, Y., Liu, H.-Y., Yuan, E., Deng, H., & Liu, S. (2018) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2018.03.024 · Cited by 17 · see citing works
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Lu, T., Li, X., Long, C., Ji, W., Jiang, L., & Tian, J. (2021) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296211057903 · Cited by 16 · see citing works
Kimura, Y., Tamasawa, N., Matsumura, K., Murakami, H., Yamashita, M., Matsuki, K., Tanabe, J., Murakami, H., Matsui, J., & Daimon, M. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.33670 · Cited by 15 · see citing works
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Li, D., & Pan, J. (2022) · British Journal of Biomedical Science · doi:10.3389/bjbs.2022.10592 · Cited by 11 · see citing works
Torres-Paz, Y. E., Huesca‐Gómez, C., Sánchez‐Muñoz, F., Martínez-Alvarado, M. R., Soto, M. E., Torres‐Tamayo, M., Fuentevilla-Álvarez, G., & Gamboa, R. (2018) · Journal of Human Hypertension · doi:10.1038/s41371-018-0102-x · Cited by 11 · see citing works
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Horie, T., Kimura, T., & Ono, K. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.ed028 · Cited by 8 · see citing works
Self-citationHemostatic disorders of the menopausal period: the role of microRNA
Stachowiak, G., Zając, A. E., Nowak, M., Stetkiewicz, T., & Wilczyński, J. (2015) · Przeglad menopauzalny = Menopause review · doi:10.5114/pm.2015.52155 · Cited by 7 · see citing works
Li, C., Li, H.-J., Nie, J., Chen, X., & Zhou, X. (2017) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Developing role of microRNA-33 in lipid metabolism and atherosclerosis
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Human MicroRNA-33b Promotes Atherosclerosis in Apoe −/− Mice
Hussain, M. M., & Goldberg, I. J. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311617 · Cited by 6 · see citing works
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Mair, K. S., Baumgartner-Kaut, M., Lischka, J., Nigmann, C., Neyer, M., Schanzer, A., Gradwohl, M., Giurgea, G., Pesau, G., Willfort‐Ehringer, A., et al. (2026) · Pediatric Research · doi:10.1038/s41390-026-04894-9 · Cited by 2 · see citing works
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Shcheglova, N., & Калинкин, М. Н. (2014) · I P Pavlov Russian Medical Biological Herald · doi:10.17816/pavlovj201425-9
- Authors
- Horie, T., Baba, O., Kuwabara, Y., Yokode, M., Kita, T., Kimura, T., & Ono, K.
- Affiliations
- Kyoto University (JP)
- Kobe City Medical Center General Hospital (JP)
- Venue
- Journal of Atherosclerosis and Thrombosis
- Publisher
- Japan Atherosclerosis Society
- Published
- 2014
- Volume
- 21
- Issue
- 1
- Pages
- 17-22
- ISSN
- 1340-3478 (ISSN-L)
- 1880-3873
- OpenAlex
- W2087215504
- Cited by
- 29
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 5 · 2014: 2
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Atherosclerosis and Thrombosis (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Suzuken Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology (18–19)
- Japan Society for the Promotion of Science (25462136)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- microRNA, lipoprotein metabolism, lipid homeostasis, miR-122, miR-33, atherosclerosis, lipid metabolism disorders, post-transcriptional regulation, therapeutic target
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Lipoproteins, MicroRNAs, Adipogenesis, Atherosclerosis, Lipid Metabolism
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