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Cited by 301

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion

Open access
Soh, James, Iqbal, Jahangir, Queiroz, Joyce, Fernandez-Hernando, Carlos, Hussain, M Mahmood·2013·Nature Medicine
DOI 10.1038/nm.3200
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Abstract

Hyperlipidemia is a risk factor for various cardiovascular and metabolic disorders. Overproduction of lipoproteins, a process that is dependent on microsomal triglyceride transfer protein (MTP), can contribute to hyperlipidemia. We show that microRNA-30c (miR-30c) interacts with the 3′ untranslated region of MTP mRNA and induces its degradation, leading to reductions in MTP activity and in apolipoprotein B (APOB) secretion. miR-30c also reduces lipid synthesis independently of MTP. Hepatic overexpression of miR-30c reduced hyperlipidemia in Western diet–fed mice by decreasing lipid synthesis and the secretion of triglyceride-rich ApoB-containing lipoproteins and decreased atherosclerosis in Apoe−/− mice. Furthermore, inhibition of hepatic miR-30c by anti–miR-30c increased hyperlipidemia and atherosclerosis. Therefore, miR-30c coordinately reduces lipid biosynthesis and lipoprotein secretion, thereby regulating hepatic and plasma lipid concentrations. Raising miR-30c levels might be useful in treating hyperlipidemias and associated disorders.

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Metadata

Authors
Soh, J., Iqbal, J., Queiroz, J., Fernandez-Hernando, C., & Hussain, M. M.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2013-06-09
Volume
19
Issue
7
Pages
892-900
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3200
OpenAlex
W2007381960
Cited by
301
References
42
FWCI
26.64
Type
journal article
Language
en
Open access
green

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