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MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

Goedeke, Leigh, Rotllan, Noemi, Canfrán-Duque, Alberto, Aranda, Juan F, Ramírez, Cristina M, Araldi, Elisa, Lin, Chin-Sheng, Anderson, Norma N, Wagschal, Alexandre, de Cabo, Rafael, Horton, Jay D, Lasunción, Miguel A, Näär, Anders M, Suárez, Yajaira, Fernández-Hernando, Carlos·2015·Nature Medicine
DOI 10.1038/nm.3949PMC PMC4711995
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Crossref · 10.1038/nm.3949

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  • The truncated 3'UTR lacks binding sites for both miR128-1 and miR-148, while the miR-185 binding site is still present.

    “This truncated 3’UTR lacks binding sites for both miR128-1 and miR-14852,53,67, while the miR-185 binding site is still present54,67.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [52]

    The Results section on LDLR activity reports two miR-148a binding sites in the LDLR 3′ UTR, supporting the premise that those sites exist. It does not establish that the particular truncated 3′ UTR lacks them, or address whether that truncation removes a miR-128-1 site. The miR-185 clause is attached to other citations, so it is not assessed against this source. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • Numerous miRNAs directly bind LDLR mRNA 3′UTR and decrease its expression, including miR-27a, miR-27b, miR-128-1, miR-128-3p, miR-130b, miR-148a, miR-184a, miR-185, and miR-301b.

    “Numerous miRNAs have been shown to directly bind LDLR mRNA 3' UTR and decrease its expression (Fig. 2), including miR-27a, miR-27b, miR-128-1, miR-128-3p, miR-130b, miR-148a, miR-184a, miR-185, and miR-301b [43][44][45][46][47][48].”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [44]

  • miR-27a, miR-27b, miR-128-1, miR-128-3p, miR-130b, miR-148a, miR-184a, miR-185, and miR-301b inhibit expression of the LDLR, decreasing LDLR.

    “miR-27a, miR-27b, miR-128-1, miR-128-3p, miR-130b, miR-148a, miR-184a, miR-185, miR-301b Inhibit expression of the LDLR ↓ [43-48]”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [44]

  • There are two predicted miR-148a binding sites (ACGUGA) in the human 3'UTR of LDLR at positions 872-878 and 1971-1978, with the first being highly conserved across mammalian species.

    “There are two predicted miR-148a binding sites (ACGUGA) in the human 3’UTR of LDLR at positions 872-878 and 1971-1978, the first being highly conserved across mammalian species52.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [52]

  • Anti-sense oligonucleotide-mediated inhibition of miR-148a increases hepatic LDLR abundance and reduces plasma LDL-cholesterol in mice.

    “For example, anti-sense oligonucleotide-mediated inhibition of miR-148a increases hepatic LDLR abundance and reduces plasma LDL-cholesterol in mice [44]”

    From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [44]

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Citations

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Metadata

Authors
Goedeke, L., Rotllan, N., Canfrán-Duque, A., Aranda, J. F., Ramírez, C. M., Araldi, E., Lin, C.-S., Anderson, N. N., Wagschal, A., de Cabo, R., Horton, J. D., Lasunción, M. A., Näär, A. M., Suárez, Y., & Fernández-Hernando, C.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2015-10-05
Volume
21
Issue
11
Pages
1280-1289
ISSN
  • 1078-8956
  • 1546-170X
DOI
10.1038/nm.3949
PMC
PMC4711995
Cited by
238
References
12
Language
en
Licence
www.springer.com/tdm (tdm)

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