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microRNAs in lipoprotein metabolism and cardiometabolic disorders

Rotllan, Noemi, Price, Nathan, Pati, Paramita, Goedeke, Leigh, Fernández-Hernando, Carlos·2016·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2016.01.025PMC PMC5357236
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  • Several miRNAs are known to directly interact with the 3'UTR of LDLR, including miR-148a, miR-130b, miR-301b, miR-128-1, miR-185, and miR-27a/b.

    “More specifically, several miRNAs are known to directly interact with the 3’UTR of LDLR, such as miR-148a, miR-130b, miR-301b, miR-128-1, miR-185, and miR-27a/b47–49.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [49]

    The ‘miRNA regulation of LDLR activity’ section lists all six miRNAs as negative regulators of LDLR expression and explicitly describes direct targeting by miR-27a/b. ‘Other miRNAs regulating LDL metabolism’ also describes direct targeting by miR-185. Our copy does not specify interaction with the LDLR 3′UTR or explicitly establish direct targeting for every miRNA in the list. (LLM, conf=0.85)

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Metadata

Authors
Rotllan, N., Price, N., Pati, P., Goedeke, L., & Fernández-Hernando, C.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2016-03
Volume
246
Pages
352-360
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2016.01.025
PMC
PMC5357236
Cited by
100
References
18
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
National Institutes of Health (R01HL107953, R01HL106063, 1F31AG043318, 5F32DK103489-03)

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