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miRNA regulation of LDL-cholesterol metabolism

Goedeke, Leigh, Wagschal, Alexandre, Fernández-Hernando, Carlos, Näär, Anders M.·2016·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2016.03.007PMC PMC5375104
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  • LDLR mRNA is regulated via multiple microRNAs, alternative splicing to produce non-functional LDLR protein, and regulation of LDLR mRNA decay.

    “At the post-transcriptional level, LDLR mRNA is regulated via several mechanisms including multiple microRNAs [30], alternative splicing to produce non-functional LDLR protein [31], and regulation of LDLR mRNA decay [32].”

    From Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation (2024) · cites this paper as [30]

  • Several miRNAs are known to directly interact with the 3'UTR of LDLR, including miR-148a, miR-130b, miR-301b, miR-128-1, miR-185, and miR-27a/b.

    “More specifically, several miRNAs are known to directly interact with the 3’UTR of LDLR, such as miR-148a, miR-130b, miR-301b, miR-128-1, miR-185, and miR-27a/b47–49.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [47]

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Research works printed but not linked: 42

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  19. Elmen, 2008, Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver, Nucleic Acids Res., 36, 1153, 10.1093/nar/gkm1113 · DOI
  20. Hsu, 2012, Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver, J. Clin. Invest., 122, 2871, 10.1172/JCI63539 · DOI
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  23. Jeon, 2013, An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis, Cell Metab., 18, 51, 10.1016/j.cmet.2013.06.010 · DOI
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Metadata

Authors
Goedeke, L., Wagschal, A., Fernández-Hernando, C., & Näär, A. M.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2016-12
Volume
1861
Issue
12
Pages
2047-2052
ISSN
1388-1981
DOI
10.1016/j.bbalip.2016.03.007
PMC
PMC5375104
Cited by
39
References
11
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Institutes of Health
  • Leducq Transatlantic Network

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